Title: Visit São Tomé: Best of São Tomé Tourism | Expedia Travel Guide - Expedia.ca [Hotels in São Tomé](https://expedia.ca/Sao-Tome-Hotels.d553248634664607275.Travel-Guide-Hotels)[Vacation Rentals in São Tomé](https://expedia.ca/Sao-Tome-Vacation-Rentals.d553248634664607275.Travel-Guide-VacationRentals)[São Tomé Car Rentals](https://expedia.ca/Car-Rentals-In-Sao-Tome.d553248634664607275.Car-Rental-Guide)[São Tomé Vacation Packages](https://expedia.ca/Sao-Tome.d553248634664607275.Destination-Travel-Guides) # São Tomé ## Travel Guide ## Visit São Tomé ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.ca/deals?rfrr=DX_SPRING_PROMO_553248634664607275) - São Tomé Hotel Deals - Vacation Rentals in São Tomé ![Pousada Santo Mel](https://images.trvl-media.com/lodging/121000000/120090000/120088600/120088564/6a8d3aff_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Pousada Santo Mel R. Jose Lopes Pereira São Tomé RN CA $21 CA $22 total Mar 13 - Mar 14 includes taxes & fees Stay at this pousada in São Tomé. Enjoy free WiFi, free parking, and daily housekeeping. [](https://expedia.ca/Hotel-Search?startDate=13%2F03%2F2026&endDate=14%2F03%2F2026&selected=120088564&PinnedHotelID=120088564&HadPinnedHotel=true®ionId=553248634664607275) ![Hotel Imperial](https://images.trvl-media.com/lodging/125000000/124870000/124860900/124860872/3968a245_edited_841e_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hotel Imperial Avenida Trairi 2992 Santa Cruz RN CA $51 CA $53 total Mar 7 - Mar 8 includes taxes & fees Stay at this hotel in Santa Cruz. Enjoy free WiFi, breakfast (surcharge), and a 24-hour front desk. [](https://expedia.ca/Hotel-Search?startDate=07%2F03%2F2026&endDate=08%2F03%2F2026&selected=124860872&PinnedHotelID=124860872&HadPinnedHotel=true®ionId=553248634664607275) [See all 3 properties in São Tomé](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=07%2F03%2F2026&endDate=08%2F03%2F2026®ionId=553248634664607275) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![Coral Plaza Apart Hotel](https://images.trvl-media.com/lodging/5000000/4600000/4598300/4598222/4c0529bb_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Coral Plaza Apart Hotel Rua Francisco Gurgel, 9005 Natal RN Book a stay at this beach aparthotel in Natal. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Ponta Negra Beach and Artesanato Villarte ... 9.4/10 Exceptional! (429 reviews) Absolutely fantastic service Reviewed on Feb 9, 2026 [](https://expedia.ca/Natal-Hotels-Coral-Plaza-Apart-Hotel.h4598222.Hotel-Information) ![Apart Hotel Serantes](https://images.trvl-media.com/lodging/5000000/4120000/4111400/4111305/2e9c9f75_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Apart Hotel Serantes Rua Silvino Meira E Sa Bezerra, 130 Natal RN Book a stay at this business-friendly aparthotel in Natal. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Ponta Negra Beach and Morro ... 8.6/10 Excellent! (144 reviews) Cobblestone road, horrible Reviewed on Dec 1, 2023 [](https://expedia.ca/Natal-Hotels-Apart-Hotel-Serantes.h4111305.Hotel-Information) ![Economy HOTEL](https://images.trvl-media.com/lodging/77000000/76720000/76717600/76717585/e89b293b_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Economy HOTEL 8976 Av. Praia de Ponta Negra Natal RN Stay at this aparthotel in Natal. Enjoy free parking. Popular attractions Ponta Negra Beach and Craft Fair of Ponta Negra are located nearby. [](https://expedia.ca/Natal-Hotels-Economy-HOTEL.h76717585.Hotel-Information) [See all 1,214 properties in Rio Grande do Norte](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience®ionId=6052642&sort=VACATION_RENTAL) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Check São Tomé hotel availability [Tonight ](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248634664607275&startDate=2026-03-06&endDate=2026-03-07)[Mar 6 - Mar 7](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248634664607275&startDate=2026-03-06&endDate=2026-03-07) [Tomorrow night ](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248634664607275&startDate=2026-03-07&endDate=2026-03-08)[Mar 7 - Mar 8](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248634664607275&startDate=2026-03-07&endDate=2026-03-08) [This weekend ](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248634664607275&startDate=06%2F03%2F2026&endDate=08%2F03%2F2026)[Mar 6 - Mar 8](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248634664607275&startDate=06%2F03%2F2026&endDate=08%2F03%2F2026) - Cities near São Tomé ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels and earn double points when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. 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