Santa Ana
Panama City
Popular places to visit
Multiplaza Pacific Mall
You can enjoy some retail therapy when you visit Multiplaza Pacific Mall, a popular shopping spot in Panama City. You can enjoy the restaurants while in the area.
Amador Causeway
You can learn about the history of Ancon with a stop at Amador Causeway. Stroll along the seaside or visit the shops in this vibrant area.
Cinta Costera
Explore the great outdoors at Cinta Costera, a lovely green space in Panama City. While you're in the area, stroll along the seaside.
Avenida Balboa
You can find the perfect gifts to bring home at Avenida Balboa during your trip to Panama City. While you're in the area, wander around the natural setting.
Uruguay Street
During your visit to Panama City, you can do some window-shopping at Uruguay Street. While in this family-friendly area, you can savor the top-notch restaurants.
Calle 50
You can find out about the history of Panama City with a trip to Calle 50. Discover the area's casinos, or seek out its local tours.
Things to do
Panama City: Poin Glass Observation Deck Ticket with VR Tour
Tour to a waterfall and Embera village with lunch included
All-inclusive 8-hour catamaran tour to Isla Taboga from Panama City
Legends of Casco Viejo Tour: Uncover Hidden Gems
Santa Ana Hotel Deals
Casco View Apartments
The space was very nice.
Reviewed on Feb 1, 2026
Hotel Riu Plaza Panama
Excellent stay for the second time! wonderful staff, good location and great value for the price.
Reviewed on Feb 13, 2026
Hotel El Panama by Faranda Grand, a member of Radisson Individuals
The first rooms on the first floor 141 & 139 was horrible. But the room was change to the 8 floor 801&806 the rooms was prefect nice an clean i loved them rooms. Staff was prefect even though i was mad at them for putting us in the first rooms they still was professional.
Reviewed on Feb 10, 2026
Crowne Plaza Panama Airport by IHG
Staff very friendly. Nice hotel
Reviewed on Feb 13, 2026
Sheraton Grand Panama
Room was always clean. Staff was courteous it was also close proximity to Multiplaza mall which was great. Breakfast was ok.
Reviewed on Feb 9, 2026
W Panama
Room
Reviewed on Feb 10, 2026
Other neighbourhoods around Santa Ana
Casco Viejo
Unique features of Casco Viejo include the historic sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.
San Felipe
If you're spending some time in San Felipe, Independence Square and Interoceanic Canal Museum are top sights worth seeing.
El Chorrillo
While there might not be top attractions in El Chorrillo, you can explore the larger area and discover places like Albrook Shopping Mall and Flag of Cerro Ancón.
Calidonia
You might enjoy the shopping while in Calidonia. Cinta Costera is a notable sight, and you can get around town at Estación Lotería or Santo Tomas Station to see more of the city.
Balboa
The restaurants and shopping are a few reasons travelers visit Balboa. Though there aren't many top sights in the neighborhood, you can visit Albrook Shopping Mall and Flag of Cerro Ancón, a few notable attractions nearby.
Marbella
You'll enjoy the restaurants and parks in Marbella. You might want to make time for a stop at Multicentro Panama or Avenida Balboa.
