Book The Best Hotels in La Mesa for 2026 from CA $66 - Fully Refundable Options

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Our top choices for La Mesa hotels

A room with two beds, a desk with chairs, a television, and a window with blinds.

A small kitchenette with a microwave, a coffee maker, and a refrigerator. There are two chairs and a sofa.

A kitchen with a wooden cabinet, a TV mounted on the wall, and three bar stools.

A bathroom with a sink, toilet, and shower curtain.

1. B&B Lodgings

24 de Diciembre

Pedro

CA $69

CA $76 total

includes taxes & fees

Oct 22 - Oct 23

A room with a bed, a desk with a chair, a television, and a door.

A hotel room with a bed, a desk, a TV, and a kitchenette.

A bathroom with a black toilet, a black sink, a shower curtain, and a window.

A small kitchenette with a microwave, coffee maker, and a toaster. There are two black bar stools and a TV mounted on the wall displaying movie recommendations.

2. Tocumen Comfort Stay

24 de Diciembre

CA $64

CA $71 total

includes taxes & fees

Oct 22 - Oct 23

A room with a bed, a desk with a computer, a TV, and a fan.

A small, modern room with a kitchenette, a flat-screen TV mounted on the wall, and a herringbone-patterned wooden floor.

A bedroom with two beds, a ceiling fan, an air conditioning unit, and a mirror on the wall.

A room with a tiled floor, a flat-screen TV mounted on the wall, a small refrigerator, a microwave, and two bar stools.

3. PLEASANT HOSTAL PANAMA

24 de Diciembre

CA $60

CA $66 total

includes taxes & fees

Oct 24 - Oct 25

A modern cabin with a sloped roof, surrounded by trees, and a gravel path leading to the entrance.

A modern room with a bed, a small table, and a chair. There is a window with a view of trees and a hammock outside.

A modern outdoor seating area with a hammock and two chairs, a wooden deck, and a glass wall offering a view of the surrounding trees.

A modern kitchen with a built-in refrigerator, a coffee maker, and a dining area with a table and chairs.

4. Tiny Cabin

Panamá

CA $189

CA $207 total

includes taxes & fees

Oct 27 - Oct 28

A hotel room with two single beds, a small table with a chair, a TV mounted on the wall, and a marble-patterned headboard.

A modern building with a tiled patio, a mural with palm trees and the word "Panama," and a large window.

A rectangular swimming pool with blue tiles and a brick border.

A modern interior with a staircase, a seating area with a bench and tables, and a counter with a sign reading "NISATO".

5. Express Inn Panama International Airport Hostel

Tocumen Airport

domingo caba

CA $60

CA $67 total

includes taxes & fees

Nov 20 - Nov 21

A spacious lobby with a high ceiling, modern lighting fixtures, and a glass entrance leading to a lower level.

A swimming pool with a clear water surface, surrounded by a covered area with lounge chairs and a bar area.

A modern bar area with a central island, bar stools, and a television mounted on the ceiling.

A modern dining area with a wooden table and chairs, a built-in bookshelf, and a decorative hanging light fixture.

6. Crowne Plaza Panama Airport by IHG

Tocumen Airport

Duran

CA $172

CA $199 total

includes taxes & fees

Nov 19 - Nov 20

A bedroom with a large bed, a nightstand, a dresser, and decorative wall art.

A room with a cream-colored sofa with gold accents, a red carpet, and a small table with candles.

A cozy living room with a television, a lamp, and a sofa.

A multi-level interior with a wooden staircase, decorative lighting, and a blue wall.

7. ORHO Hotel Boutique 15 Minutes from PTY Airport

Tocumen Airport

Kendy

CA $123

CA $166 total

includes taxes & fees

Oct 28 - Oct 29

A table and two chairs in a shaded outdoor area with a view of a water body and greenery.

A reception desk with a clock and a no-smoking sign.

A hotel room with two beds, a desk, a chair, a television, and an air conditioning unit.

A restaurant with a modern interior, featuring a mix of seating arrangements and a view of the outdoor area.

8. Riande Aeropuerto Hotel & Casino

Tocumen Airport

Lidia

CA $129

CA $142 total

includes taxes & fees

Oct 27 - Oct 28

A building with a sign reading 'Lilia House' and a decorative wall with a sign stating 'Cada Familia tiene una.'

A dining area with a table set for two, chairs, a TV mounted on the wall, a decorative plant, and a window with decorative bars.

9. Swette Love 10 Minutes From the Airport Tocumen

Las Mañanitas

CA $79

CA $103 total

includes taxes & fees

Nov 1 - Nov 2

A buffet with various food items including fruits, juices, and cheeses.

An aerial view of a rectangular swimming pool with two lounge chairs and a ladder.

A gym with treadmills, weight machines, and dumbbells.

A hotel reception area with a wooden reception desk, seating area with chairs and ottomans, and a large window providing natural light.

10. Courtyard by Marriott Panama Metromall

San Antonio

Hector

CA $143

CA $157 total

includes taxes & fees

Nov 6 - Nov 7

A hotel entrance with a central water feature, seating areas, and potted plants.

A spacious lobby with a wooden ceiling, a central wooden table surrounded by potted plants, and a marble wall with a large window in the background.

A pool with a central water feature, surrounded by seating areas and potted plants.

The entrance of The Santa Maria with a covered walkway and a view of the interior.

11. The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

Juan Diaz

Carmen

CA $441

CA $485 total

includes taxes & fees

Nov 8 - Nov 9

A rooftop pool with a city view, lounge chairs, and a clear sky.

A modern kitchen with a marble countertop, a refrigerator, and a dining area with a table set for two.

A modern lobby with a curved grey sofa, a round coffee table, and an orange armchair. There are potted plants and a reception desk in the background.

A modern lounge area with a bar, seating, and a large window offering a city view.

12. Corporate Stays Arcadia | Executive Furnished Apartments

Costa del Este

Gloria

CA $115

CA $138 total

includes taxes & fees

Nov 20 - Nov 21

A rooftop pool with a city view, modern architecture, and outdoor seating.

A spacious lobby with a modern design, featuring a sofa, chairs, and large potted plants.

A high-rise building with a view of the ocean and a parking area with palm trees.

A narrow street with multi-story buildings, balconies, and a central building with a red roof.

13. The Westin Panama

Costa del Este

Luke

CA $363

CA $399 total

includes taxes & fees

Nov 6 - Nov 7

A swimming pool with lounge chairs, surrounded by greenery and tall buildings in the background.

A modern living room with a sofa, a dining table, and a staircase leading to an upper level.

A modern apartment with a kitchen, dining area, and living room.

A modern building with the sign 'DOVILLE' and 'CIRCUNVENTENARIO' indicating a hotel or similar establishment.

14. Apex Executive Apartments - Dovle

Parque Lefevre

CA $140

CA $276 total

includes taxes & fees

Oct 30 - Oct 31

A swimming pool with lounge chairs, surrounded by greenery and modern buildings.

A pathway lined with greenery, a small pavilion, and tall buildings in the background.

A modern building with a glass facade and the name 'DOVIL' prominently displayed.

A modern apartment with a dining area, kitchen, and a large window with curtains.

15. Pty Loft-style 1br Cincuentenario Bay

San Francisco

CA $152

CA $215 total

includes taxes & fees

Oct 23 - Oct 24

A modern outdoor swimming pool with a clear view of a tall building in the background.

A modern urban pathway lined with lush greenery and a pool, leading to a building with balconies and a clear sky.

A modern reception area with a brick wall, wooden paneling, and a neon sign.

A modern kitchen with a curved island, bar stools, pendant lighting, and wooden shelving with plants.

16. Dovle Residences by HMS-Preferred Member

San Francisco

David

CA $197

CA $218 total

includes taxes & fees

Nov 9 - Nov 10

A modern living room with a sofa, a coffee table with flowers, a TV, and a large window with a city view.

A bedroom with a large bed, a view through a sliding door, and two framed pictures on the wall.

A modern living room with a large window, a sofa, a coffee table, a TV on a wooden cabinet, and a dining table with chairs.

A modern living room with a sofa, a TV, and a dining area with a table and chairs.

17. Boutique Apartments Panamá Coco del Mar

San Francisco

purabi

CA $66

CA $270 total

includes taxes & fees

Oct 26 - Oct 27

A modern hotel with a prominent entrance, multiple floors, and a well-lit facade.

A spacious lobby with a pool table, comfortable seating areas, and a bar with a variety of beverages.

A modern lounge area with seating, a bar, and a staircase.

A modern interior with two escalators leading to upper floors, a prominent 'a loft Panama' sign, and a staircase with glass railings.

18. Aloft by Marriott Panama

San Francisco

Brittney

CA $166

CA $182 total

includes taxes & fees

Nov 1 - Nov 2

A living room with a dark-colored sofa, a white side table, a decorative lamp, and a window with blinds.

A living room with a sectional sofa, a ceiling fan, a decorative wall piece, and a window with blinds.

A compact kitchen with a gas stove, a microwave, a toaster, and a sink.

An elevator with a digital display showing the number 3, a sign above it reading 'PISO-3', and two safety signs on the wall.

19. Charming 3 Bedroom Apartment in San Miguelito, Panama City

José Domingo Espinar

caleb

CA $99

CA $138 total

includes taxes & fees

Oct 27 - Oct 28

A rooftop pool with lounge chairs, offering a city view.

A modern living room with a grey sofa, a dining table set for four, and a kitchen area with a sink and countertop.

A modern balcony with white chairs and a city view.

A spacious living room with a large window, a flat-screen TV, a sofa, and a coffee table.

20. Boutique Apartments Atlapa

San Francisco

Gary

CA $46

CA $206 total

includes taxes & fees

Oct 28 - Oct 29

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Top La Mesa Hotel Reviews

Dovle Residences by HMS-Preferred Member

10/10 Excellent

"Kind staff, well located, very well decorated, outstanding amenities. Found dirty towels at the toilet. Only three options for breakfast: scrambled eggs, croissant with creme or chocolate bread. No other salted option. Good coffee."

Corporate Stays Arcadia | Executive Furnished Apartments

10/10 Excellent

"Everything was great except the tv. Doesn’t work, I asked for help but they didn’t do anything about that"

Ramada Plaza by Wyndham Panama Punta Pacifica

10/10 Excellent

"There should be a ten star rating for the staff. They are all amazing."

Express Inn Panama International Airport Hostel

8/10 Good

"Is a good place to stay , not luxury , but good enough , clean , air conditioner and hot water , close to the airport, shuttle to airport, i will keep using it every time I need."

B&B Lodgings

10/10 Excellent

"I had a wonderful experience staying at this hotel! Although it is a small hotel, the hospitality and personal attention were exceptional. The owner was absolutely amazing, welcoming, and attentive to every detail. The place was very clean, and I felt genuinely cared for throughout my stay. What impressed me the most was how thoughtful and helpful the owner was. They contacted me through WhatsApp to make sure I arrived at the correct location, offered to pick me up and drop me off, and even waited for me at the door. That level of kindness and hospitality truly made a difference and made me feel safe and welcome. I highly recommend this hotel to anyone looking for a clean, comfortable place with outstanding personal service. Sometimes, the smallest hotels offer the biggest hearts, and this place is a perfect example. I would absolutely stay here again!"

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

10/10 Excellent

"Best hotel in Panama"

San Francisco by Wynwood House

8/10 Good

"La limpieza del lugar es buena excepto que cuando llegué a las 3pm aún no estaba lista y tocó esperar unos 20 minutos El servicio de parking por un cargo adicional es muy bueno El ambiente es seguro y muy agradable"

The Westin Panama

10/10 Excellent

"Lovely rooms, food and service. Nice location, very close to the airport."

More cheap stays in La Mesa

Tocumen Comfort Stay

07168 24 de Diciembre Panama

CA $64

CA $71 total

Oct 22 - Oct 23

includes taxes & fees

B&B Lodgings

C. Tercera El Valle de Cerro Azul 24 de Diciembre Panamá Province

CA $69

CA $76 total

Oct 22 - Oct 23

includes taxes & fees

8/10 Very good! (99 reviews)

ORHO Hotel Boutique 15 Minutes from PTY Airport

Av. Domingo Díaz Tocumen Provincia de Panamá

CA $123

CA $166 total

Oct 28 - Oct 29

includes taxes & fees

Orho Hotel Boutique 15 Minutes From PTY Airport

Calle Aeropuerto Tocumen Panamá Province

CA $150

CA $166 total

Oct 30 - Oct 31

includes taxes & fees

Cozy Urban Loft 1br Near Coast

Panama City Panamá Province

CA $152

CA $215 total

Oct 22 - Oct 23

includes taxes & fees

Apex Executive Apartments - Dovle

Vía Cincuentenario 313 Panamá Panamá

CA $140

CA $276 total

Oct 30 - Oct 31

includes taxes & fees

Frequently asked questions

Where is the best place to stay in La Mesa?

Crowne Plaza Panama Airport by IHG, located 9.9 mi (15.9 km) from the heart of La Mesa, is a top choice for your stay based on our traveler data. Other good options for your stay in the area are Ramada Plaza by Wyndham Panama Punta Pacifica and Aloft by Marriott Panama. See all available top hotels, or vacation rentals in La Mesa.

What are some of the best vacation home rentals in La Mesa?

Cozy 3-bedroom townhome with WiFi, AC in fabulous Panamá: You might want to consider this vacation home rental near La Mesa, which is equipped with a selection of books, air-conditioning, and laundry facilities to help you feel comfortable during your stay. It has 3 bedrooms as well as a kitchen with a fridge, an oven, and a microwave, so you can cook with friends or family. See all vacation rentals in La Mesa.

If I need to cancel my hotel reservation in La Mesa, will I receive a refund?

Yes, the majority of room reservations are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If you booked a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in La Mesa.

What is staying in La Mesa like?

Visitors to La Mesa are sure to find plenty to explore and enjoy. There are 581 hotels and other accommodations in the surrounding area. Find out more about La Mesa.

What are the top places to visit in La Mesa?

Places to visit in the wider area include Metromall Panama, Los Pueblos Commercial Center, and Estadio Rommel Fernandez. You'll also find Chagres National Park and Chepo Youth Recreation Center in the area. Check out what more to see and do in Expedia's La Mesa guide.

What's the weather like in La Mesa?

The hottest months are usually April and March with an average temp of 80°F, while the coldest months are January and February with an average of 79°F. The rainiest months in La Mesa are July, August, October, and June, with each month seeing an average of 14 inches of rainfall.

Explore a world of travel with Expedia

Visit Pacora

Find hotels in La Mesa from CA $66

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in La Mesa

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for La Mesa hotels

1. B&B Lodgings

2. Tocumen Comfort Stay

3. PLEASANT HOSTAL PANAMA

4. Tiny Cabin

5. Express Inn Panama International Airport Hostel

6. Crowne Plaza Panama Airport by IHG

7. ORHO Hotel Boutique 15 Minutes from PTY Airport

8. Riande Aeropuerto Hotel & Casino

9. Swette Love 10 Minutes From the Airport Tocumen

10. Courtyard by Marriott Panama Metromall

11. The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

12. Corporate Stays Arcadia | Executive Furnished Apartments

13. The Westin Panama

14. Apex Executive Apartments - Dovle

15. Pty Loft-style 1br Cincuentenario Bay

16. Dovle Residences by HMS-Preferred Member

17. Boutique Apartments Panamá Coco del Mar

18. Aloft by Marriott Panama

19. Charming 3 Bedroom Apartment in San Miguelito, Panama City

20. Boutique Apartments Atlapa

Top La Mesa Hotel Reviews

Dovle Residences by HMS-Preferred Member

Corporate Stays Arcadia | Executive Furnished Apartments

Ramada Plaza by Wyndham Panama Punta Pacifica

Express Inn Panama International Airport Hostel

B&B Lodgings

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

San Francisco by Wynwood House

The Westin Panama

More cheap stays in La Mesa

Tocumen Comfort Stay

B&B Lodgings

ORHO Hotel Boutique 15 Minutes from PTY Airport

Orho Hotel Boutique 15 Minutes From PTY Airport

Cozy Urban Loft 1br Near Coast

Apex Executive Apartments - Dovle

Frequently asked questions

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