The 10 Best Hotels Near UCSF Mission Bay, San Francisco from CA $147

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Our top choices for UCSF Mission Bay hotels

A spacious lobby with large windows, a seating area with a sofa and chairs, and a counter with a coffee station.

A modern hotel with a glass facade, large windows, and a vibrant, illuminated exterior.

A modern reception area with a large screen displaying a desert landscape, wooden reception desk, comfortable seating, and a large window offering a view.

A bar area with a long counter, multiple seating options, and a city view.

1. LUMA Hotel San Francisco

0.7 km from UCSF Mission Bay

Jennifer

CA $361

CA $424 total

includes taxes & fees

Oct 2 - Oct 3

An outdoor seating area with wicker furniture and a fire feature, adjacent to a bar and dining area with modern decor.

A modern dining area with a large rectangular table surrounded by upholstered chairs, a decorative chandelier, and a view of the outdoors through large windows.

A modern kitchen with wooden cabinets, white countertops, and a central island with fruits and jars.

A modern lounge area with sofas, armchairs, and tables.

2. Hyatt Place San Francisco Downtown

1.1 km from UCSF Mission Bay

Greg

CA $279

CA $328 total

includes taxes & fees

Oct 23 - Oct 24

A rooftop terrace with tables and potted plants, overlooking a cityscape with a prominent tower and a bridge.

A modern room with a large window offering a city view, a red chair, a white table, and a bowl of apples.

A modern living room with a sofa, a coffee table, and a view of a cityscape and bridge.

A modern hotel entrance with a prominent sign for "California Center" and "Porte Seasons."

3. Four Seasons Hotel San Francisco at Embarcadero

Financial District, 2.7 km from UCSF Mission Bay

Ariane

CA $667

CA $785 total

includes taxes & fees

Oct 23 - Oct 24

A marble-floored hallway leading to a living area with a sofa and a fireplace.

A bar cart with gin bottles and glasses on a carpeted floor.

A hotel with a brick facade, a red awning, and a sign for 'Galleria Park Hotel'.

A spacious, elegantly furnished living area with a high ceiling, a fireplace, and a large abstract painting.

4. Galleria Park Hotel

Financial District, 2.5 km from UCSF Mission Bay

Oleg

CA $211

CA $307 total

includes taxes & fees

Oct 23 - Oct 24

An indoor swimming pool with multiple lounge chairs and a high ceiling with skylights.

A spacious living area with a city view, modern furniture, and a patterned carpet.

A spacious lobby with a blue sofa, armchairs, and a patterned carpet.

A modern restaurant with a central bar area, seating arrangements, and large windows offering a view of greenery.

5. Hotel Nikko San Francisco

Union Square, 2.4 km from UCSF Mission Bay

Isaac

CA $252

CA $362 total

includes taxes & fees

Oct 23 - Oct 24

The exterior of an Orchard Hotel with a prominent entrance, large windows, and a well-lit facade.

A restaurant with multiple tables, each set with white tablecloths, plates, and cutlery.

A reception area with a wooden reception desk, a receptionist, a statue, and a potted plant.

A modern kitchen with a bar area, wooden cabinets, and a chandelier.

6. Orchard Garden Hotel

Chinatown, 2.7 km from UCSF Mission Bay

John

CA $200

CA $238 total

includes taxes & fees

Oct 25 - Oct 26

A modern building facade with vertical wooden slats, a glass entrance, and a sign reading "La Société Bar & Cafe".

A modern bar area with multiple seating options, a large pillar, and a television screen.

A hotel room with a large bed, a desk, a chair, a small table with a plant, and a view of a cityscape at dusk.

A modern living room with a sofa, coffee table, and ottoman, a kitchen area with wooden cabinets and a flat-screen TV, and a large window offering a city view.

7. Hyatt Regency San Francisco Downtown SOMA

South of Market, 2.2 km from UCSF Mission Bay

Sonia

CA $239

CA $338 total

includes taxes & fees

Oct 16 - Oct 17

A buffet area with a variety of food items and condiments.

A modern hotel room with a large window offering a city view, a neatly made bed, and a hanging light fixture.

A modern bar area with a colorful ceiling, wooden stools, and a bar counter.

A modern building with a glass facade, large windows, and a prominent entrance with illuminated signage.

8. citizenM San Francisco Union Square

Union Square, 2.3 km from UCSF Mission Bay

Andranik

CA $235

CA $276 total

includes taxes & fees

Oct 16 - Oct 17

A modern hotel with a glass facade, a covered entrance, and a sign indicating it is a Marriott hotel.

A modern reception area with a round mirror, seating, and a wooden panel wall.

A modern lounge area with a large mirror, comfortable seating, a coffee table with a tray, and a view of the cityscape through large windows.

A modern dining area with a large wooden table, purple chairs, and pendant lighting.

9. The St. Regis San Francisco

South of Market, 2.1 km from UCSF Mission Bay

Christopher

CA $655

CA $835 total

includes taxes & fees

Oct 2 - Oct 3

A modern hotel with a sleek exterior and a parked sports car in front.

A modern lobby with a curved sofa, round tables, a reception desk, and a large blue wall feature.

A modern restaurant with multiple dining tables and chairs, a cityscape mural on the wall, and pendant lighting.

A rooftop bar with outdoor seating, a view of the cityscape, and a clock tower in the background.

10. Hotel VIA

1.2 km from UCSF Mission Bay

David

CA $291

CA $343 total

includes taxes & fees

Oct 4 - Oct 5

A restaurant with wooden flooring, black chairs, white tables, hanging plants, and pendant lights.

A bar area with wooden shelves stocked with bottles, a curved wall decoration, hanging plants, and bar stools with woven backrests.

A hotel room with a bed, a desk, a sofa, a window with a view of a clock tower, and a staircase.

A spacious living room with a large sofa, multiple seating options, and a ceiling fan.

11. 1 Hotel San Francisco

Financial District, 2.7 km from UCSF Mission Bay

Gloria

CA $635

CA $827 total

includes taxes & fees

Oct 23 - Oct 24

A modern living room with a large window overlooking a bridge, a flat-screen TV, a clock, and a brown leather sofa.

A room with large windows overlooking a bridge and a body of water.

A group of people dining at a restaurant with a table set for a meal, including a bottle of wine and various dishes.

12. Harbor Court Hotel

South of Market, 2.6 km from UCSF Mission Bay

Yoojin

CA $287

CA $406 total

includes taxes & fees

Oct 17 - Oct 18

A rooftop terrace with outdoor seating, a view of the city skyline, and modern buildings in the background.

A modern hotel room with a sofa, armchair, coffee table, and a desk with a lamp. There is a bed with a white headboard and a view of the city through large windows.

A modern living room with a sofa, coffee table, and television. There are chairs, a bookshelf, and a large window with a view of buildings.

A modern building with a unique angular design, surrounded by other high-rise structures.

13. Four Seasons Hotel San Francisco

South of Market, 2.3 km from UCSF Mission Bay

Nirav

CA $673

CA $876 total

includes taxes & fees

Oct 11 - Oct 12

A hotel room with a large window, a sofa, two armchairs, a coffee table, a lamp, and a TV.

An indoor swimming pool with clear water, a ceiling with a blue marble pattern, and a window with a view of the outside.

A waterfront pier with wooden platforms where seals are resting.

A modern building with a glass facade and a prominent entrance.

14. InterContinental San Francisco by IHG

South of Market, 1.8 km from UCSF Mission Bay

Jose

CA $293

CA $424 total

includes taxes & fees

Oct 23 - Oct 24

A hotel room with a bed, two armchairs, a small table with a laptop and a glass of water, a lamp, a TV displaying a scenic image, and a large window with curtains.

A red sign for The Inn at Union Square, 440 Post Street, with a dark wooden door and green walls.

A modern dining area with a long table and chairs, a kitchen counter with breakfast items, and geometric pendant lighting.

A modern living room with a fireplace, a flat-screen TV mounted above it, a sofa with a cushion, and a floor lamp.

15. Inn At Union Square

2.6 km from UCSF Mission Bay

Jochen

CA $238

CA $280 total

includes taxes & fees

Oct 24 - Oct 25

A lobby with a brown leather sofa, a wooden coffee table with books, a blue staircase, and a wall with a map and text.

A reception desk with wooden panels, two pendant lights, and a bulletin board with various notices.

A hotel room with a bed, a chair, a window with curtains, a sink, and a door.

A cozy living room with a patterned carpet, a blue sofa, a brown leather couch, and a guitar leaning against the wall.

16. HI San Francisco Downtown Hostel

Union Square, 2.5 km from UCSF Mission Bay

Paris

CA $126

CA $147 total

includes taxes & fees

Oct 18 - Oct 19

A grand hall with a high arched ceiling and chandeliers, featuring multiple dining tables and chairs arranged for service.

A grand lobby with a chandelier, large arched windows, and a central floral arrangement.

A grand lobby with marble columns, a chandelier, and a spacious seating area.

A grand hallway with high ceilings, ornate columns, and chandeliers.

17. Palace Hotel, a Luxury Collection Hotel, San Francisco

Financial District, 2.3 km from UCSF Mission Bay

Sean

CA $457

CA $604 total

includes taxes & fees

Oct 16 - Oct 17

A bar area with a marble countertop, leather bar stools, and shelves stocked with bottles and glasses.

The entrance to the Taj Hotel in San Francisco, featuring a prominent blue awning and a red carpet leading to the doors.

A hotel room with a bed, two bedside tables, a window with curtains, and a view of buildings outside.

A person in a white robe standing by a window with curtains, looking out at a cityscape with buildings and snow.

18. Taj Campton Place

Union Square, 2.6 km from UCSF Mission Bay

Vince

CA $312

CA $417 total

includes taxes & fees

Oct 4 - Oct 5

A spacious lobby with a staircase, comfortable seating areas, and large windows offering views of the city.

An outdoor seating area with round tables and chairs, a fire feature, and string lights.

A modern building with a prominent entrance and a sign that reads "THE CLANCY".

A spacious lobby with a modern bar area, seating arrangements, and a geometric wall design.

19. The Clancy, Autograph Collection by Marriott

South Park, 1.9 km from UCSF Mission Bay

Samantha

CA $246

CA $353 total

includes taxes & fees

Oct 23 - Oct 24

A modern hotel room with a grey sofa, a dining table, a TV, and a large window with curtains.

A spacious room with large windows, two armchairs, a small table with books, and a lamp.

A spacious hotel lobby with large windows, wooden beams, and a central bar area.

A modern hotel room with a dining area, a fireplace, a sofa set, and large windows offering city views.

20. The Clift Royal Sonesta San Francisco

2.6 km from UCSF Mission Bay

Jalicia

CA $267

CA $370 total

includes taxes & fees

Oct 23 - Oct 24

View all properties

Compare popular hotels close to UCSF Mission Bay

Property	Star rating	Guest rating
LUMA Hotel San Francisco	9.6 Exceptional 2,626 reviews	View
Hyatt Place San Francisco Downtown	9.4 Exceptional 2,339 reviews	View
Four Seasons Hotel San Francisco at Embarcadero	9.6 Exceptional 1,002 reviews	View
Galleria Park Hotel	9.6 Exceptional 1,032 reviews	View
Hotel Nikko San Francisco	9.4 Exceptional 3,100 reviews	View

Top UCSF Mission Bay Hotel Reviews

Hotel Riu Plaza Fisherman's Wharf

8/10 Good

"El desayuno abundante y variado"

Hyatt Regency San Francisco

10/10 Excellent

"Spacious, clean rooms with comfortable beds and bedding. Friendly housekeepers. Lots of things to do right inside the hotel."

The Pickwick Hotel

8/10 Good

"Great location and we liked our room and the hotel overall. It was very loud outside from homeless people screaming, garbage trucks, other vehicles and seemed to happen early every morning. Location was great and close to public transportation,"

Parc 55 San Francisco - A Hilton Hotel

8/10 Good

"Great location. A bit worn. Very dirty windows spoil the view."

Handlery Union Square Hotel

10/10 Excellent

"This is a historic hotel so you can expect some differences from a modern box. We asked for a quiet room which we certainly got. It was reached down a maze of corridors and the view was a wall. However it was beautifully quiet compared to the place we had at Fisherman's Wharf the night before."

Hotel VIA

10/10 Excellent

"1000 out of 10 experience best hotel in town"

Hilton San Francisco Union Square

10/10 Excellent

"We had a great stay with them. We will most definitely be back!!"

Holiday Inn Golden Gateway by IHG

10/10 Excellent

"Everyone was helpful from the desk to the restaurant. We enjoyed our stay."

LUMA Hotel San Francisco

10/10 Excellent

"This hotel is beautiful and beautifully maintained! The staff are willing to help at the drop of a hat. There are staff members everywhere so you don’t have to go far if you do need assistance. Luma is within walking distance to just about everything fun. Restaurants! Oracle Park! Chase Center!"

Frequently asked questions

What's the area like around UCSF Mission Bay?

UCSF Mission Bay is located in a vibrant area of San Francisco known for its top museums and stunning architecture. If you're looking for a convenient place to stay, check out the 42 hotels and other accommodations you'll find within a mile.

Where is the best place to stay near UCSF Mission Bay?

LUMA Hotel San Francisco is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and a fitness center. It's located just a short 0.4 mi (0.7 km) from UCSF Mission Bay. Another good choice is Hyatt Place San Francisco Downtown, located just 0.7 mi (1.1 km) away.

How many hotels are there close to UCSF Mission Bay?

Expedia has 42 hotels and other accommodations within a mile from UCSF Mission Bay.

If I need to cancel the hotel reservation for my stay near UCSF Mission Bay, will I receive a refund?

Yes! You'll find that most room reservations are refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your arrival date. If you have a non-refundable reservation, you might still have the option to cancel and receive a refund within 24 hours of your booking. Enter your dates, click on "Search", then you can filter by "fully refundable" to get the best options available near UCSF Mission Bay.

What can I see and do near UCSF Mission Bay?

Study the collections at San Francisco Museum of Modern Art, Asian Art Museum of San Francisco, or Market Street Railway Museum. Sights like San Francisco Mint, Palace Hotel, and 450 Sutter Building are landmarks to visit in the area. You can check out the local talent at The Midway, Warfield Theatre, and Golden Gate Theatre.

How can I get to UCSF Mission Bay?

With so many transportation options, seeing the area around UCSF Mission Bay is easy. Take advantage of metro transit at Market St & 5th St Stop, Market St & Taylor St Stop, and Powell St & Market St Stop. If you're taking a train into town, San Francisco Station is the closest station to Downtown San Francisco.

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Find hotels near UCSF Mission Bay, San Francisco from CA $147

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for UCSF Mission Bay hotels

1. LUMA Hotel San Francisco

2. Hyatt Place San Francisco Downtown

3. Four Seasons Hotel San Francisco at Embarcadero

4. Galleria Park Hotel

5. Hotel Nikko San Francisco

6. Orchard Garden Hotel

7. Hyatt Regency San Francisco Downtown SOMA

8. citizenM San Francisco Union Square

9. The St. Regis San Francisco

10. Hotel VIA

11. 1 Hotel San Francisco

12. Harbor Court Hotel

13. Four Seasons Hotel San Francisco

14. InterContinental San Francisco by IHG

15. Inn At Union Square

16. HI San Francisco Downtown Hostel

17. Palace Hotel, a Luxury Collection Hotel, San Francisco

18. Taj Campton Place

19. The Clancy, Autograph Collection by Marriott

20. The Clift Royal Sonesta San Francisco

Compare popular hotels close to UCSF Mission Bay

Top UCSF Mission Bay Hotel Reviews

Hotel Riu Plaza Fisherman's Wharf

Hyatt Regency San Francisco

The Pickwick Hotel

Parc 55 San Francisco - A Hilton Hotel

Handlery Union Square Hotel

Hotel VIA

Hilton San Francisco Union Square

Holiday Inn Golden Gateway by IHG

LUMA Hotel San Francisco

Frequently asked questions

Explore a world of travel with Expedia