Title: The 10 Best Hotels Near UCSF Mission Bay, San Francisco from CA $115 | Expedia.ca

[Downtown San Francisco Travel Guide](https://expedia.ca/San-Francisco-Downtown-San-Francisco.dx6151902)[UCSF Mission Bay Car Rentals](https://expedia.ca/Car-Rentals-In-UCSF-Mission-Bay.d553248635389801411.Car-Rental-Guide)[UCSF Mission Bay Vacations](https://expedia.ca/UCSF-Mission-Bay-Downtown-San-Francisco.d553248635389801411.Vacation-Attraction)

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## Check prices for these dates

Tonight

[Jan 14 - Jan 15](https://www.expedia.ca/Hotel-Search?regionId=553248635389801411&startDate=2026-01-14&endDate=2026-01-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Jan 15 - Jan 16](https://www.expedia.ca/Hotel-Search?regionId=553248635389801411&startDate=2026-01-15&endDate=2026-01-16&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Jan 16 - Jan 18](https://www.expedia.ca/Hotel-Search?regionId=553248635389801411&startDate=2026-01-16&endDate=2026-01-18&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Jan 23 - Jan 25](https://www.expedia.ca/Hotel-Search?regionId=553248635389801411&startDate=2026-01-23&endDate=2026-01-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Recommended

Price (low to high)

Distance

Star rating

## Our top choices for UCSF Mission Bay hotels

![Tapas bar](https://images.trvl-media.com/lodging/71000000/70100000/70097200/70097106/58dd339c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Restaurant](https://images.trvl-media.com/lodging/71000000/70100000/70097200/70097106/76aa0c86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/71000000/70100000/70097200/70097106/f72650f9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property - evening/night](https://images.trvl-media.com/lodging/71000000/70100000/70097200/70097106/44e1b72d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### LUMA Hotel San Francisco 

[](https://www.expedia.ca/San-Francisco-Hotels-LUMA-Hotel-San-Francisco.h70097106.Hotel-Information)

Mission Bay, 0.7 km from UCSF Mission Bay

9.6/10

Exceptional

(2,418 reviews)

"Great stay! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jeremy

CA $271

CA $319 total

includes taxes & fees

Jan 31 - Feb 1

[](https://www.expedia.ca/San-Francisco-Hotels-LUMA-Hotel-San-Francisco.h70097106.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/32000000/31420000/31419900/31419890/91986f78.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Daily buffet breakfast (USD 16 per person)](https://images.trvl-media.com/lodging/32000000/31420000/31419900/31419890/f9d4387a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/32000000/31420000/31419900/31419890/6945eefa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Hypo-allergenic bedding, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/32000000/31420000/31419900/31419890/b089b5be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hyatt Place San Francisco Downtown

[](https://www.expedia.ca/San-Francisco-Hotels-Hyatt-Place-San-Francisco-Downtown.h31419890.Hotel-Information)

1.1 km from UCSF Mission Bay

9.4/10

Exceptional

(1,931 reviews)

"Great overall stay, friendly staff"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Brian

CA $207

CA $244 total

includes taxes & fees

Jan 23 - Jan 24

[](https://www.expedia.ca/San-Francisco-Hotels-Hyatt-Place-San-Francisco-Downtown.h31419890.Hotel-Information)

![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/30000/20600/20547/944f985c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Bar (on property)](https://images.trvl-media.com/lodging/1000000/30000/20600/20547/d2ce10c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room safe, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/30000/20600/20547/aff7fa14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 1 Bedroom (Corporate) | Living area](https://images.trvl-media.com/lodging/1000000/30000/20600/20547/57a12208.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Chancellor Hotel on Union Square

[](https://www.expedia.ca/San-Francisco-Hotels-Chancellor-Hotel-On-Union-Square.h20547.Hotel-Information)

2.6 km from UCSF Mission Bay

9.4/10

Exceptional

(3,141 reviews)

"Fantastic....kindest hotel and such a comfortable stay!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Amy

CA $124

CA $146 total

includes taxes & fees

Jan 15 - Jan 16

[](https://www.expedia.ca/San-Francisco-Hotels-Chancellor-Hotel-On-Union-Square.h20547.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/2000000/1770000/1766700/1766605/5800bbe5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/2000000/1770000/1766700/1766605/f7c5f6c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/2000000/1770000/1766700/1766605/7856c00e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room amenity](https://images.trvl-media.com/lodging/2000000/1770000/1766700/1766605/5517eff5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### InterContinental San Francisco by IHG

[](https://www.expedia.ca/San-Francisco-Hotels-InterContinental-San-Francisco.h1766605.Hotel-Information)

South of Market, 1.8 km from UCSF Mission Bay

9.2/10

Wonderful

(1,054 reviews)

"Beautiful Hotel. Room was spotless and the staff was very friendly. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Yana

CA $249

CA $350 total

includes taxes & fees

Jan 23 - Jan 24

[](https://www.expedia.ca/San-Francisco-Hotels-InterContinental-San-Francisco.h1766605.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/2000000/1330000/1322000/1321986/a5681857.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/2000000/1330000/1322000/1321986/w4000h2662x0y0-fc84c036.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/2000000/1330000/1322000/1321986/w4000h2662x0y0-41a38e25.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 1 Bedroom, Corner](https://images.trvl-media.com/lodging/2000000/1330000/1322000/1321986/29f2f698.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The St. Regis San Francisco

[](https://www.expedia.ca/San-Francisco-Hotels-The-St-Regis-San-Francisco.h1321986.Hotel-Information)

South of Market, 2.1 km from UCSF Mission Bay

9.4/10

Exceptional

(701 reviews)

"The service was spectacular, enjoyed the restaurant as well as room service, and the room was very clean and spacious "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Lauren

CA $554

CA $715 total

includes taxes & fees

Jan 23 - Jan 24

[](https://www.expedia.ca/San-Francisco-Hotels-The-St-Regis-San-Francisco.h1321986.Hotel-Information)

![Property entrance](https://images.trvl-media.com/lodging/2000000/1520000/1516000/1515923/72e31d9d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room, 1 King Bed, Terrace](https://images.trvl-media.com/lodging/2000000/1520000/1516000/1515923/63c9cbdc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby sitting area](https://images.trvl-media.com/lodging/2000000/1520000/1516000/1515923/ed3ae5f9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![View from property](https://images.trvl-media.com/lodging/2000000/1520000/1516000/1515923/c2437688.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Orchard Garden Hotel

[](https://www.expedia.ca/San-Francisco-Hotels-Orchard-Garden-Hotel.h1515923.Hotel-Information)

Chinatown, 2.7 km from UCSF Mission Bay

9.6/10

Exceptional

(1,003 reviews)

"Great location "

![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg)

Jorge

CA $195

CA $233 total

includes taxes & fees

Jan 29 - Jan 30

[](https://www.expedia.ca/San-Francisco-Hotels-Orchard-Garden-Hotel.h1515923.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/1000000/800000/791800/791769/bff475ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/800000/791800/791769/ab6ff173.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![LED TV, DVD player, iPod dock, first-run movies](https://images.trvl-media.com/lodging/1000000/800000/791800/791769/7040d302.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Presidential Suite, 1 King Bed](https://images.trvl-media.com/lodging/1000000/800000/791800/791769/bd897e6b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Four Seasons Hotel San Francisco

[](https://www.expedia.ca/San-Francisco-Hotels-Four-Seasons-Hotel-San-Francisco.h791769.Hotel-Information)

South of Market, 2.2 km from UCSF Mission Bay

9.4/10

Exceptional

(1,002 reviews)

"great location, amazing hotel. great rooms. wonderful staff "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Majd

CA $618

CA $727 total

includes taxes & fees

Jan 31 - Feb 1

[](https://www.expedia.ca/San-Francisco-Hotels-Four-Seasons-Hotel-San-Francisco.h791769.Hotel-Information)

![Daily buffet breakfast (USD 22 per person)](https://images.trvl-media.com/lodging/70000000/69560000/69551600/69551553/w5519h4629x0y0-614e04d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room, 1 King Bed (High Floor)](https://images.trvl-media.com/lodging/70000000/69560000/69551600/69551553/4835e3a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![View from property](https://images.trvl-media.com/lodging/70000000/69560000/69551600/69551553/cadb58e5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/70000000/69560000/69551600/69551553/1ab366ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### citizenM San Francisco Union Square

[](https://www.expedia.ca/San-Francisco-Hotels-CitizenM-San-Francisco-Union-Square.h69551553.Hotel-Information)

Union Square, 2.3 km from UCSF Mission Bay

9.4/10

Exceptional

(1,446 reviews)

"Great location!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Hunter

CA $186

CA $219 total

includes taxes & fees

Jan 23 - Jan 24

[](https://www.expedia.ca/San-Francisco-Hotels-CitizenM-San-Francisco-Union-Square.h69551553.Hotel-Information)

![3 bars/lounges](https://images.trvl-media.com/lodging/28000000/27120000/27110600/27110513/abad6cd0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bars/lounges](https://images.trvl-media.com/lodging/28000000/27120000/27110600/27110513/5335e149.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/28000000/27120000/27110600/27110513/04a59767.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 1 King Bed, Fireplace (Landmark View) | Living area](https://images.trvl-media.com/lodging/28000000/27120000/27110600/27110513/3012b8f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Canopy by Hilton San Francisco SoMa

[](https://www.expedia.ca/San-Francisco-Hotels-Canopy-By-Hilton-San-Francisco-SoMa.h27110513.Hotel-Information)

South Park, 1.7 km from UCSF Mission Bay

9.0/10

Wonderful

(1,000 reviews)

"Great place to stay"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Raquel

CA $249

CA $294 total

includes taxes & fees

Jan 30 - Jan 31

[](https://www.expedia.ca/San-Francisco-Hotels-Canopy-By-Hilton-San-Francisco-SoMa.h27110513.Hotel-Information)

![Indoor pool](https://images.trvl-media.com/lodging/1000000/30000/23500/23406/b53af55a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/30000/23500/23406/c1d68595.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property entrance](https://images.trvl-media.com/lodging/1000000/30000/23500/23406/308976ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Executive lounge](https://images.trvl-media.com/lodging/1000000/30000/23500/23406/b267e1c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hotel Nikko San Francisco

[](https://www.expedia.ca/San-Francisco-Hotels-Hotel-Nikko-San-Francisco.h23406.Hotel-Information)

Union Square, 2.4 km from UCSF Mission Bay

9.4/10

Exceptional

(2,683 reviews)

"Very well kept hotel , staff keep it good vibes and fun all around the area to be had!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Robert

CA $235

CA $340 total

includes taxes & fees

Jan 23 - Jan 24

[](https://www.expedia.ca/San-Francisco-Hotels-Hotel-Nikko-San-Francisco.h23406.Hotel-Information)

![Serves dinner and happy hour](https://images.trvl-media.com/lodging/1000000/700000/693700/693658/69c56718.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Courtyard](https://images.trvl-media.com/lodging/1000000/700000/693700/693658/e282d47e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Hypo-allergenic bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/700000/693700/693658/100ffc4f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Serves dinner and happy hour](https://images.trvl-media.com/lodging/1000000/700000/693700/693658/da0bd574.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

###  The Clancy, Autograph Collection by Marriott

[](https://www.expedia.ca/San-Francisco-Hotels-The-Clancy.h693658.Hotel-Information)

South Park, 1.9 km from UCSF Mission Bay

9.2/10

Wonderful

(1,006 reviews)

"It was an amazing hotel. The staff was amazing and friendly. What a great place to stay."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Samuel

CA $229

CA $327 total

includes taxes & fees

Jan 23 - Jan 24

[](https://www.expedia.ca/San-Francisco-Hotels-The-Clancy.h693658.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/290000/287200/287112/7fe7eb3b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Flat-screen TV, pay movies, MP3 dock](https://images.trvl-media.com/lodging/1000000/290000/287200/287112/398a6ca9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/1000000/290000/287200/287112/f11ecdc1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Flat-screen TV, pay movies, MP3 dock](https://images.trvl-media.com/lodging/1000000/290000/287200/287112/0c9770db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### W San Francisco

[](https://www.expedia.ca/San-Francisco-Hotels-W-San-Francisco.h287112.Hotel-Information)

South Park, 2 km from UCSF Mission Bay

9.0/10

Wonderful

(1,001 reviews)

"The check-in staff and location and were excellent! Great Wi-Fi reception and the location and ambience was the best. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Randolph

CA $232

CA $322 total

includes taxes & fees

Jan 23 - Jan 24

[](https://www.expedia.ca/San-Francisco-Hotels-W-San-Francisco.h287112.Hotel-Information)

![Cocktail bar](https://images.trvl-media.com/lodging/1000000/10000/700/660/27f19182.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/1000000/10000/700/660/1d0c1fa8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/1000000/10000/700/660/87dba6c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/1000000/10000/700/660/7ebf7bbb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hotel Emblem San Francisco

[](https://www.expedia.ca/San-Francisco-Hotels-Hotel-Emblem-San-Francisco.h660.Hotel-Information)

2.7 km from UCSF Mission Bay

9.4/10

Exceptional

(1,004 reviews)

"We enjoyed our stay, close to cable cars shopping dining bars "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

HALEY

CA $177

CA $264 total

includes taxes & fees

Jan 25 - Jan 26

[](https://www.expedia.ca/San-Francisco-Hotels-Hotel-Emblem-San-Francisco.h660.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/10000/6700/6666/b8dfc462.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/10000/6700/6666/18d49d8b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool, a heated pool, open 8 AM to 8 PM, sun loungers](https://images.trvl-media.com/lodging/1000000/10000/6700/6666/4fd95a3a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premier Room, 1 King Bed](https://images.trvl-media.com/lodging/1000000/10000/6700/6666/9e50e45c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Handlery Union Square Hotel

[](https://www.expedia.ca/San-Francisco-Hotels-Handlery-Union-Square-Hotel.h6666.Hotel-Information)

Union Square, 2.5 km from UCSF Mission Bay

8.8/10

Excellent

(2,815 reviews)

"Great location, room was clean and staff was helpful."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Laura

CA $176

CA $207 total

includes taxes & fees

Jan 23 - Jan 24

[](https://www.expedia.ca/San-Francisco-Hotels-Handlery-Union-Square-Hotel.h6666.Hotel-Information)

![Breakfast and dinner served](https://images.trvl-media.com/lodging/1000000/230000/225900/225819/b5cc10dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Junior Suite, 1 King Bed, City View, Corner](https://images.trvl-media.com/lodging/1000000/230000/225900/225819/94c0b9bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Bar (on property)](https://images.trvl-media.com/lodging/1000000/230000/225900/225819/48cf15fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/230000/225900/225819/de5c5a74.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hotel Zelos San Francisco

[](https://www.expedia.ca/San-Francisco-Hotels-Hotel-Zelos-San-Francisco.h225819.Hotel-Information)

South of Market, 2.2 km from UCSF Mission Bay

9.0/10

Wonderful

(1,123 reviews)

"Clean room, friendly staff, convenient location. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Elizabeth

CA $238

CA $337 total

includes taxes & fees

Jan 25 - Jan 26

[](https://www.expedia.ca/San-Francisco-Hotels-Hotel-Zelos-San-Francisco.h225819.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/20000/15300/15254/6f8c6b2f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Restaurant](https://images.trvl-media.com/lodging/1000000/20000/15300/15254/c499b2e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Restaurant](https://images.trvl-media.com/lodging/1000000/20000/15300/15254/7caaf63b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Restaurant](https://images.trvl-media.com/lodging/1000000/20000/15300/15254/4e0348a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Beacon Grand, A Union Square Hotel 

[](https://www.expedia.ca/San-Francisco-Hotels-Sir-Francis-Drake-Hotel.h15254.Hotel-Information)

Union Square, 2.6 km from UCSF Mission Bay

9.2/10

Wonderful

(1,857 reviews)

"Nice and clean hotel."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Nelofar

CA $202

CA $295 total

includes taxes & fees

Jan 30 - Jan 31

[](https://www.expedia.ca/San-Francisco-Hotels-Sir-Francis-Drake-Hotel.h15254.Hotel-Information)

![Rooftop terrace](https://images.trvl-media.com/lodging/1000000/10000/6600/6505/41a2cb6e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![View from room](https://images.trvl-media.com/lodging/1000000/10000/6600/6505/91a3ba7a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property entrance](https://images.trvl-media.com/lodging/1000000/10000/6600/6505/54bc54cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, down comforters, pillowtop beds, minibar](https://images.trvl-media.com/lodging/1000000/10000/6600/6505/90ac212c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Four Seasons Hotel San Francisco at Embarcadero

[](https://www.expedia.ca/San-Francisco-Hotels-Four-Seasons-Hotel-San-Francisco-At-Embarcadero.h6505.Hotel-Information)

Financial District, 2.7 km from UCSF Mission Bay

9.6/10

Exceptional

(1,003 reviews)

"Staff is amazing, location is outstanding"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jennifer

CA $596

CA $702 total

includes taxes & fees

Jan 30 - Jan 31

[](https://www.expedia.ca/San-Francisco-Hotels-Four-Seasons-Hotel-San-Francisco-At-Embarcadero.h6505.Hotel-Information)

![55-inch TV with digital channels, pay movies](https://images.trvl-media.com/lodging/1000000/30000/21100/21073/9e51cedf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room (Private Apartment)](https://images.trvl-media.com/lodging/1000000/30000/21100/21073/7626c0a6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/30000/21100/21073/c731c06a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room (Private Apartment)](https://images.trvl-media.com/lodging/1000000/30000/21100/21073/174738f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Clift Royal Sonesta San Francisco

[](https://www.expedia.ca/San-Francisco-Hotels-The-Clift-Royal-Sonesta-San-Francisco.h21073.Hotel-Information)

Theater District, 2.6 km from UCSF Mission Bay

9.2/10

Wonderful

(1,386 reviews)

"Room was extremely spacious, clean and the staff was very nice. Location was perfect! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Monique

CA $174

CA $259 total

includes taxes & fees

Jan 25 - Jan 26

[](https://www.expedia.ca/San-Francisco-Hotels-The-Clift-Royal-Sonesta-San-Francisco.h21073.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/97000000/96820000/96810700/96810663/febae001.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/97000000/96820000/96810700/96810663/b1b7eea9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/97000000/96820000/96810700/96810663/bf217857.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Deluxe Double Room](https://images.trvl-media.com/lodging/97000000/96820000/96810700/96810663/00836df3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hotel Fiona

[](https://www.expedia.ca/San-Francisco-Hotels-Hotel-Fiona.h96810663.Hotel-Information)

South of Market, 1.9 km from UCSF Mission Bay

8.6/10

Excellent

(994 reviews)

"Room was nice, staff friendly, and light breakfast was good."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Tracy

CA $106

CA $153 total

includes taxes & fees

Jan 25 - Jan 26

[](https://www.expedia.ca/San-Francisco-Hotels-Hotel-Fiona.h96810663.Hotel-Information)

![Lobby sitting area](https://images.trvl-media.com/lodging/39000000/38770000/38769100/38769067/236fb341.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lounge](https://images.trvl-media.com/lodging/39000000/38770000/38769100/38769067/498ee792.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Private Queen Room Ensuite](https://images.trvl-media.com/lodging/39000000/38770000/38769100/38769067/f2adbb17.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lounge](https://images.trvl-media.com/lodging/39000000/38770000/38769100/38769067/318477ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### HI San Francisco Downtown Hostel

[](https://www.expedia.ca/San-Francisco-Hotels-HI-San-Francisco-Downtown-Hostel.h38769067.Hotel-Information)

Union Square, 2.5 km from UCSF Mission Bay

9.0/10

Wonderful

(372 reviews)

"Clean room, friendly staff"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

mark ryan

CA $99

CA $115 total

includes taxes & fees

Jan 26 - Jan 27

[](https://www.expedia.ca/San-Francisco-Hotels-HI-San-Francisco-Downtown-Hostel.h38769067.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.ca/Hotel-Search?startDate=2026-01-28&endDate=2026-01-29&regionId=553248635389801411&adults=2&sort=RECOMMENDED&openPlayBack=true)

## Top UCSF Mission Bay Hotel Reviews

![Hotel Riu Plaza Fisherman's Wharf](https://images.trvl-media.com/lodging/1000000/30000/24700/24625/6fb55356_y.jpg)

### Hotel Riu Plaza Fisherman's Wharf

10/10 Excellent

"Very good service and clean 👍"

[](https://expedia.ca/San-Francisco-Hotels-Hotel-Riu-Plaza-Fishermans-Wharf.h24625.Hotel-Information)

![LUMA Hotel San Francisco ](https://images.trvl-media.com/lodging/71000000/70100000/70097200/70097106/f72650f9_y.jpg)

### LUMA Hotel San Francisco 

10/10 Excellent

"Great location for Warriors games. Walking distance to Chase centre."

[](https://expedia.ca/San-Francisco-Hotels-LUMA-Hotel-San-Francisco.h70097106.Hotel-Information)

![Hilton San Francisco Financial District](https://images.trvl-media.com/lodging/1000000/10000/4400/4302/77af977e_y.jpg)

### Hilton San Francisco Financial District

10/10 Excellent

"A great View and a great value. Staff was friendly!"

[](https://expedia.ca/San-Francisco-Hotels-Hilton-San-Francisco-Financial-District.h4302.Hotel-Information)

![Holiday Inn Golden Gateway by IHG](https://images.trvl-media.com/lodging/1000000/20000/10600/10538/9ba9bb1f_y.jpg)

### Holiday Inn Golden Gateway by IHG

10/10 Excellent

"the toilet was leaking on floor, no room safe, the hot tub was out of order"

[](https://expedia.ca/San-Francisco-Hotels-Holiday-Inn-Golden-Gateway.h10538.Hotel-Information)

![The Westin St. Francis San Francisco on Union Square](https://images.trvl-media.com/lodging/1000000/30000/26800/26760/99dd32f8_y.jpg)

### The Westin St. Francis San Francisco on Union Square

10/10 Excellent

"Great accommodations and excellent customer service."

[](https://expedia.ca/San-Francisco-Hotels-The-Westin-St-Francis-San-Francisco-On-Union-Square.h26760.Hotel-Information)

![InterContinental San Francisco by IHG](https://images.trvl-media.com/lodging/2000000/1770000/1766700/1766605/5800bbe5_y.jpg)

### InterContinental San Francisco by IHG

10/10 Excellent

"Beautiful Hotel. Room was spotless and the staff was very friendly. "

[](https://expedia.ca/San-Francisco-Hotels-InterContinental-San-Francisco.h1766605.Hotel-Information)

![Club Quarters Hotel in San Francisco](https://images.trvl-media.com/lodging/1000000/920000/913000/912982/5ee1ba27_y.jpg)

### Club Quarters Hotel in San Francisco

10/10 Excellent

"Very clean and big rooms we had. The hotel was walking distance to Ferry Building and Pier 39\. Loved the stay here."

[](https://expedia.ca/San-Francisco-Hotels-Club-Quarters-Hotel-In-San-Francisco.h912982.Hotel-Information)

![Chancellor Hotel on Union Square](https://images.trvl-media.com/lodging/1000000/30000/20600/20547/944f985c_y.jpg)

### Chancellor Hotel on Union Square

10/10 Excellent

"Room was very clean and hotel had a water bottle filler in the lobby which was very convenient. Staff was incredibly friendly and made an effort to make our anniversary special. The hotel also had a great view and was conveniently located to everything. "

[](https://expedia.ca/San-Francisco-Hotels-Chancellor-Hotel-On-Union-Square.h20547.Hotel-Information)

![Fairmont San Francisco](https://images.trvl-media.com/lodging/1000000/20000/18200/18200/6f6889e4_y.jpg)

### Fairmont San Francisco

10/10 Excellent

"Friendly staff & beautiful room."

[](https://expedia.ca/San-Francisco-Hotels-Fairmont-San-Francisco.h18200.Hotel-Information)

## Hotels near other UCSF Mission Bay attractions

![Chase Center San Francisco Skyline Aerial Photography](https://images.trvl-media.com/place/553248635997928290/197c9322-47b4-4ac5-bc8c-d25b082862ed.jpg)

### Chase Center

Catch an event at Chase Center during your trip to San Francisco. Amble around this vibrant area's Chinatown or experience its acclaimed theater scene. 

[See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248635997928290)

![Anchor Brewing Company](https://images.trvl-media.com/place/6155048/89f44ad0-efe6-42e1-ae0f-9ec45d9f9269.jpg)

### Anchor Brewing Company

During your trip to San Francisco, you can search for that perfect souvenir at Anchor Brewing Company. Discover the top-notch restaurants and acclaimed art scene in this vibrant area. 

[See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=6155048)

![Always packed, lose or win. ](https://images.trvl-media.com/place/3132/6844d9ff-7d63-4da9-a600-a1e532dde0fd.jpg)

Photo by Zhou You

### Oracle Park

4.3/5 (2,839 reviews)

Whether or not you’re a baseball fan, this charming ballpark with outstanding views should be on your San Francisco sightseeing list.

[See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=6063199)

### Mission Bay Conference Center at UCSF

Learn about the events happening at Mission Bay Conference Center at UCSF during your trip to San Francisco. Amble around this vibrant area's Chinatown or experience its entertainment choices. 

[See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=818566843354574848)

### Mission Creek Park

Mission Creek Park is just one of the places to see in San Francisco, so why not enjoy the other things to explore during your travels? Experience the fascinating museums and acclaimed theater scene in this vibrant area. 

[See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621555612179)

### Lefty O'Doul Bridge

You can find out about the history of San Francisco with a trip to Lefty O'Doul Bridge. Take in the acclaimed theater scene and beautiful sunsets in this vibrant area. 

[See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=6155190)

### Letterform Archive

You can find out about the history of San Francisco when you stop by Letterform Archive. Take in the live music and sunsets in this walkable area. 

[See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=866963133062057984)

### McLellan Botanicals

Enjoy the beautiful sunsets and explore McLellan Botanicals, a lovely green space in San Francisco. Experience the fascinating museums and acclaimed theater scene in this vibrant area. 

[See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621555612177)

## Frequently asked questions

### What's the area like around UCSF Mission Bay?

### Where is the best place to stay near UCSF Mission Bay?

### How many hotels are there close to UCSF Mission Bay?

### If I need to cancel the hotel reservation for my stay near UCSF Mission Bay, will I receive a refund?

### What can I see and do near UCSF Mission Bay?

### How can I get to UCSF Mission Bay?

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- [Cheap Hotels in South of Market ](https://www.expedia.ca/South-Of-Market-San-Francisco-Hotels-Cheap-Hotels.0-n160166-0-tCheapHotels.Travel-Guide-Filter-Hotels)
- [Honeymoon Resorts and in South of Market ](https://www.expedia.ca/South-Of-Market-San-Francisco-Hotels-Honeymoon-Hotels.0-n160166-0-tHoneymoonHotels.Travel-Guide-Filter-Hotels)
- [Hotels with Free Parking in South of Market ](https://www.expedia.ca/South-Of-Market-San-Francisco-Hotels-Hotels-With-Free-Parking.0-n160166-0-tHotelswithFreeParking.Travel-Guide-Filter-Hotels)
- [Hotels with Hot Tubs in South of Market ](https://www.expedia.ca/South-Of-Market-San-Francisco-Hotels-Hotels-With-Hot-Tubs.0-n160166-0-tHotelsWithHotTubs.Travel-Guide-Filter-Hotels)
- [Lgbt Friendly Hotels in South of Market ](https://www.expedia.ca/South-Of-Market-San-Francisco-Hotels-LGBT-Friendly-Hotel.0-n160166-0-tLGBTFriendlyHotel.Travel-Guide-Filter-Hotels)
- [Luxury Hotels in South of Market ](https://www.expedia.ca/South-Of-Market-San-Francisco-Hotels-Luxury-Hotel.0-n160166-0-tLuxuryHotel.Travel-Guide-Filter-Hotels)
- [Oceanfront Hotels in South of Market ](https://www.expedia.ca/South-Of-Market-San-Francisco-Hotels-Oceanfront-Hotels.0-n160166-0-tOceanfrontHotels.Travel-Guide-Filter-Hotels)
- [Waterpark Hotels in South of Market ](https://www.expedia.ca/South-Of-Market-San-Francisco-Hotels-Waterpark-Hotels.0-n160166-0-tWaterparkHotels.Travel-Guide-Filter-Hotels)
- [Hotel Wedding Venues Hotels in South of Market ](https://www.expedia.ca/South-Of-Market-San-Francisco-Hotels-Wedding-Hotels.0-n160166-0-tWeddingHotels.Travel-Guide-Filter-Hotels)
- [South of Market Hotels ](https://www.expedia.ca/South-Of-Market-San-Francisco-Hotels.0-n160166-0.Travel-Guide-Filter-Hotels)
- [South Park Hotels ](https://www.expedia.ca/South-Park-San-Francisco-Hotels.0-n553248621533114848-0.Travel-Guide-Filter-Hotels)
- [Vacation Homes in UCSF Mission Bay Stop ](https://www.expedia.ca/UCSF-Mission-Bay-Stop-Private-Vacation-Homes.d553248635996308167-aaPrivateVacationHomes.Travel-Guide-Accommodation)
- [Guest Houses in UCSF/Chase Center Stop ](https://www.expedia.ca/UCSFChase-Center-Stop-Guest-Houses.d553248635995265822-aaGuestHouses.Travel-Guide-Accommodation)
- [Hotels near UCSF/Chase Center Stop ](https://www.expedia.ca/UCSFChase-Center-Stop-Hotels.d553248635995265822.Travel-Guide-Hotels)
- [Resorts in UCSF/Chase Center Stop ](https://www.expedia.ca/UCSFChase-Center-Stop-Resort-Hotels.d553248635995265822-aaResortHotels.Travel-Guide-Accommodation)
- [Union Square Hotels ](https://www.expedia.ca/Union-Square-San-Francisco-Hotels.0-n800129-0.Travel-Guide-Filter-Hotels)
- [Hotels near Westfield Metreon ](https://www.expedia.ca/Westfield-Metreon-Hotels.0-l6151549-0.Travel-Guide-Filter-Hotels)
- [Hotels near Yerba Buena Center for the Performing Arts ](https://www.expedia.ca/Yerba-Buena-Center-For-The-Performing-Arts-Hotels.0-l6069415-0.Travel-Guide-Filter-Hotels)
- [Hotels near Yerba Buena Gardens ](https://www.expedia.ca/Yerba-Buena-Gardens-Hotels.0-l6155654-0.Travel-Guide-Filter-Hotels)
- [Hotels near Yerba Buena Ice Skating Center ](https://www.expedia.ca/Yerba-Buena-Ice-Skating-Center-Hotels.0-l6155657-0.Travel-Guide-Filter-Hotels)

- [Flights to San Francisco ](https://www.expedia.ca/Cheap-Flights-To-San-Francisco.d178305.Travel-Guide-Flights)
- [Flights from Vancouver (YVR) to San Francisco (SFO) ](https://www.expedia.ca/lp/flights/yvr/sfo/vancouver-to-san-francisco)
- [Flights from Toronto (YYZ) to San Francisco (SFO) ](https://www.expedia.ca/lp/flights/yyz/sfo/toronto-to-san-francisco)

- [Chase Center ](https://www.expedia.ca/Chase-Center-Downtown-San-Francisco.d553248635997928290.Vacation-Attraction)
- [Moscone Convention Center ](https://www.expedia.ca/Moscone-Convention-Center-Downtown-San-Francisco.d502553.Vacation-Attraction)
- [Oracle Park ](https://www.expedia.ca/Oracle-Park-Downtown-San-Francisco.d6063199.Vacation-Attraction)
- [Visit China Basin ](https://www.expedia.ca/San-Francisco-China-Basin.dx553248635976476972)
- [Visit Dogpatch ](https://www.expedia.ca/San-Francisco-Dogpatch.dx553248635976007381)
- [Visit Downtown San Francisco ](https://www.expedia.ca/San-Francisco-Downtown-San-Francisco.dx6151902)
- [Visit Rincon Hill ](https://www.expedia.ca/San-Francisco-Rincon-Hill.dx553248635976481615)
- [Visit South of Market ](https://www.expedia.ca/San-Francisco-South-Of-Market.dx160166)
- [Visit Union Square ](https://www.expedia.ca/San-Francisco-Union-Square.dx800129)
- [San Francisco Vacations ](https://www.expedia.ca/San-Francisco.d178305.Destination-Travel-Guides)

- [Car rentals near San Francisco ](https://www.expedia.ca/Car-Rentals-In-San-Francisco.d178305.Car-Rental-Guide)
- [Enterprise Rental Cars in South Beach ](https://www.expedia.ca/Enterprise-Car-Rentals-In-South-Beach.d6203131-c15.Car-Rental-Guide-Suppliers)

- [Things to do in San Francisco ](https://www.expedia.ca/Things-To-Do-In-San-Francisco.d178305.Travel-Guide-Activities)