Missouri may have travel restrictions in place due to COVID-19.

Find out moreOpens in new tab or window

Find Business Hotels in St. Louis, MO from CA $73

Search over 1 million properties and 550 airlines worldwide

Members save 10% more on select hotels, cars, activities and vacation rentals. Sign up.

Free cancellation on most hotels. Because flexibility matters.

Top St. Louis Business Hotels

Hyatt Place St. Louis/Chesterfield
3 out of 5
333 Chesterfield Center East, Chesterfield, MO
Free cancellation
The price is CA $110 per night from Nov 8 to Nov 9
4.7/5Exceptional! (959 reviews)

"We enjoyed the property and location was perfect for us"…"

Reviewed on Oct. 19, 2020

Hyatt Place St. Louis/Chesterfield
Drury Plaza Hotel St. Louis at the Arch
3 out of 5
2 South 4th Street, St. Louis, MO
Free cancellationReserve now, pay when you stay
The price is CA $118 per night from Nov 24 to Nov 25
4.6/5Exceptional! (1,817 reviews)

"The hotel was nice and so was the staff. I wish more guests wore their masks but all the staff did. Overall it was a good stay and our room was clean, nice, and I had a great time."…"

Reviewed on Oct. 20, 2020

Drury Plaza Hotel St. Louis at the Arch
Courtyard by Marriott St Louis Westport Plaza
3 out of 5
11888 Westline Industrial Dr, Maryland Heights, MO
Free cancellationReserve now, pay when you stay
The price is CA $99 per night from Nov 3 to Nov 4
4.4/5Wonderful! (993 reviews)

"The room overall was clean. And I like that the bathroom didn't have a rust stuff around the bath tube. Bathroom was clean too."…"

Reviewed on Sep. 10, 2020

Courtyard by Marriott St Louis Westport Plaza

You could be seeing lower prices

With member prices, you could save 10% or more right now on thousands of properties.
Courtyard by Marriott St Louis Creve Coeur
3 out of 5
828 N New Ballas Rd, St. Louis, MO
Free cancellationReserve now, pay when you stay
The price is CA $99 per night from Nov 6 to Nov 7
4.4/5Excellent! (976 reviews)

"The location was great- the hotel was clean. The hotel staff was friendly"…"

Reviewed on Oct. 5, 2020

Courtyard by Marriott St Louis Creve Coeur
The Wildwood Hotel
3.5 out of 5
2801 Fountain Pl, Wildwood, MO
Free cancellationReserve now, pay when you stay
The price is CA $116 per night from Oct 25 to Oct 26
4.4/5Excellent! (965 reviews)

"It’s a fab hotel. Unfortunately the breakfast was not happening due to sars cov"…"

Reviewed on Oct. 20, 2020

The Wildwood Hotel
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
4 out of 5
421 N 8th St, St. Louis, MO
The price is CA $104 per night from Nov 22 to Nov 23
4.3/5Excellent! (977 reviews)

"This property had beautiful historical features while being modern and updated. The rooms were so cute and quaint the beds were super comfortable, and the staff was always friendly and courteous."…"

Reviewed on Oct. 17, 2020

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
Hyatt Regency St. Louis at The Arch
4 out of 5
315 Chestnut St, St. Louis, MO
Free cancellation
The price is CA $130 per night from Oct 30 to Oct 31
4.3/5Excellent! (3,532 reviews)

"The location is the greatest plus, the cost of parking is the greatest disappointment."…"

Reviewed on Oct. 20, 2020

Hyatt Regency St. Louis at The Arch
Clayton Plaza Hotel
3.5 out of 5
7750 Carondelet Avenue, St. Louis, MO
Free cancellationReserve now, pay when you stay
The price is CA $115 per night from Oct 29 to Oct 30
4.3/5Excellent! (1,183 reviews)

"Very friendly staff. The hotel is older but they have made great efforts to keep it very clean and comfortable."…"

Reviewed on Oct. 19, 2020

Clayton Plaza Hotel
St. Louis Union Station Hotel, Curio Collection by Hilton
4 out of 5
1820 Market Street, St. Louis, MO
Free cancellationReserve now, pay when you stay
The price is CA $134 per night from Oct 25 to Oct 26
4.2/5Excellent! (931 reviews)

"This place is unique & there is so much do do on the property. We had an emergency while there & the security team and valet desk acted so quickly & with great care."…"

Reviewed on Oct. 14, 2020

St. Louis Union Station Hotel, Curio Collection by Hilton
La Quinta Inn & Suites by Wyndham St. Louis Westport
2.5 out of 5
11805 Lackland Rd, Maryland Heights, MO
Free cancellationReserve now, pay when you stay
The price is CA $73 per night from Oct 31 to Nov 1
4.1/5Very Good! (984 reviews)

"Friendly staff. Clean room. Overall nice. Also quite."…"

Reviewed on Aug. 9, 2020

La Quinta Inn & Suites by Wyndham St. Louis Westport
Renaissance St. Louis Airport Hotel
4 out of 5
9801 Natural Bridge Road, St. Louis, MO
Free cancellationReserve now, pay when you stay
The price is CA $105 per night from Nov 20 to Nov 21
4.1/5Very Good! (957 reviews)

"Nice comfortable beds, and service was awesome. I stay here exciting in I’m Missouri. It’s close to my relatives"…"

Reviewed on Oct. 7, 2020

Renaissance St. Louis Airport Hotel
Best Western Plus St. Louis West - Chesterfield
3 out of 5
32 Research Park Circle, St. Charles, MO
Free cancellationReserve now, pay when you stay
The price is CA $92 per night from Nov 1 to Nov 2
4.1/5Very Good! (984 reviews)

"Nice place great location quite area friendly and kind staff"…"

Reviewed on Aug. 11, 2020

Best Western Plus St. Louis West - Chesterfield
Hollywood Casino & Hotel St. Louis
3.5 out of 5
777 Casino Center Drive, Maryland Heights, MO
Free cancellationReserve now, pay when you stay
The price is CA $117 per night from Nov 1 to Nov 2
4/5Very Good! (1,675 reviews)

"Some things were closed like the fitness center but the casino was open!"…"

Reviewed on Oct. 20, 2020

Hollywood Casino & Hotel St. Louis
Hilton St. Louis Downtown at the Arch
4 out of 5
400 Olive St, St. Louis, MO
Free cancellationReserve now, pay when you stay
The price is CA $123 per night from Nov 22 to Nov 23
3.9/5Very Good! (969 reviews)

"It was great, we had an amazing time. Staff was very nice."…"

Reviewed on Sep. 20, 2020

Hilton St. Louis Downtown at the Arch
La Quinta Inn & Suites by Wyndham St Louis Airport-Riverport
3 out of 5
13615 Riverport Drive, I-70 & Earth City Expswy, Maryland Heights, MO
Get Rates
3.9/5Very Good! (1,062 reviews)
March 2020 trip to MO

"The manager was very helpful with arranging my return of may rental car and trip back to the hotel"…"

Reviewed on Mar. 27, 2020

La Quinta Inn & Suites by Wyndham St Louis Airport-Riverport
Comfort Inn St Louis - Westport
3 out of 5
12031 Lackland Rd, Maryland Heights, MO
Free cancellationReserve now, pay when you stay
The price is CA $88 per night from Oct 26 to Oct 27
3.8/5Good! (987 reviews)

"Great building overall. Lots of space to walk around on the first floor. Very friendly staff! The hotel room itself what's very nice as well! I would definitely make another trip."…"

Reviewed on Aug. 29, 2020

Comfort Inn St Louis - Westport
OYO Hotel St. Louis Downtown MO
3.5 out of 5
400 S 14th St, St. Louis, MO
Free cancellationReserve now, pay when you stay
The price is CA $96 per night from Oct 25 to Oct 26
3.2/5 (1,490 reviews)

"Clean rooms, friendly staff, only thing I wish I had was a window to the outside"…"

Reviewed on Oct. 9, 2020

OYO Hotel St. Louis Downtown MO
City Place St. Louis Downtown
3.5 out of 5
N 4Th Street, 200, St. Louis, MO
Get Rates
2.4/5 (2,046 reviews)
Terrible Experience

"Terrible everything. Don’t bring anything valuable or that you want to keep. There are no safes in room and CCTV is not for YOUR protection."…"

Reviewed on Nov. 24, 2019

City Place St. Louis Downtown
Don't see what you're looking for?
We've got more Business Hotels. Find the right one for you.
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Pocket Guide: Business Hotels in St. Louis

Search for hotels in St. Louis on Expedia. You can easily find your hotels in St. Louis using one of the methods below:

  • View our selection of featured hotels in St. Louis
  • Use the map to find hotels in the St. Louis neighborhood you prefer
  • Use the filters to see hotels in a specific area of St. Louis, select a specific theme, brand, or hotel class from basic (1 Star) to luxury hotels (5 Stars) in St. Louis
  • Enter your travel dates to view the best deals on hotels in St. Louis - while they last

More trip options

Travelers Loved These Business Hotels