Title: Book The Best Hotels in Santee, NE for 2026 from CA $129 - Fully Refundable Options - Hotels.com - Expedia.ca [Vacation Rentals in Santee](https://expedia.ca/Santee-Vacation-Rentals.d553248634983588478.Travel-Guide-VacationRentals)[Santee Car Rentals](https://expedia.ca/Car-Rentals-In-Santee.d553248634983588478.Car-Rental-Guide)[Santee Vacation Packages](https://expedia.ca/Santee.d553248634983588478.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in Santee Family friendly [](https://www.expedia.ca/Hotel-Search?destination=Santee%2C+Nebraska%2C+United+States+of+America®ionId=553248634983588478&latLong=42.84111%2C-97.850901&adults=2&startDate=2026-03-08&d1=2026-03-08&endDate=2026-03-10&d2=2026-03-10&travelerType=family_friendly) Pet friendly [](https://www.expedia.ca/Hotel-Search?destination=Santee%2C+Nebraska%2C+United+States+of+America®ionId=553248634983588478&latLong=42.84111%2C-97.850901&adults=2&startDate=2026-03-08&d1=2026-03-08&endDate=2026-03-10&d2=2026-03-10&amenities=PETS) Cabin [](https://www.expedia.ca/Hotel-Search?destination=Santee%2C+Nebraska%2C+United+States+of+America®ionId=553248634983588478&latLong=42.84111%2C-97.850901&adults=2&startDate=2026-03-08&d1=2026-03-08&endDate=2026-03-10&d2=2026-03-10&lodging=CABIN) ## Check prices for these dates Tonight [Feb 22 - Feb 23](https://www.expedia.ca/Hotel-Search?regionId=553248634983588478&startDate=2026-02-22&endDate=2026-02-23&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Feb 23 - Feb 24](https://www.expedia.ca/Hotel-Search?regionId=553248634983588478&startDate=2026-02-23&endDate=2026-02-24&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Feb 27 - Mar 1](https://www.expedia.ca/Hotel-Search?regionId=553248634983588478&startDate=2026-02-27&endDate=2026-03-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Mar 6 - Mar 8](https://www.expedia.ca/Hotel-Search?regionId=553248634983588478&startDate=2026-03-06&endDate=2026-03-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Santee hotels ![Family House, 4 Bedrooms, Lake View, Lakeside | Living area](https://images.trvl-media.com/lodging/12000000/11270000/11268000/11267995/d9482fb8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/12000000/11270000/11268000/11267995/bfa0d3b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family House, 4 Bedrooms, Lake View, Lakeside | Private kitchen](https://images.trvl-media.com/lodging/12000000/11270000/11268000/11267995/7c824038.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/12000000/11270000/11268000/11267995/d845bf74.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lewis and Clark Resort [](https://www.expedia.ca/Vermillion-Hotels-Lewis-And-Clark-Resort.h11267995.Hotel-Information) Yankton 8.8/10 Excellent (292 reviews) "Beautiful view, easy check in, and spacious accommodations! We loved our stay and can’t wait to come back!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jessica CA $122 CA $129 total includes taxes & fees Feb 24 - Feb 25 [](https://www.expedia.ca/Vermillion-Hotels-Lewis-And-Clark-Resort.h11267995.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-03-09&endDate=2026-03-10®ionId=553248634983588478&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.ca/deals?rfrr=HTG_SPRING_PROMO_553248634983588478) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSantee-Hotels.d553248634983588478.Travel-Guide-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSantee-Hotels.d553248634983588478.Travel-Guide-Hotels) ## Top Santee Hotel Reviews ## Recent Reviews in Santee ![Lewis and Clark Resort](https://images.trvl-media.com/lodging/12000000/11270000/11268000/11267995/a76b5f6a_y.jpg) ### Lewis and Clark Resort 10/10 Excellent "Great view. Clean. " [](https://expedia.ca/Vermillion-Hotels-Lewis-And-Clark-Resort.h11267995.Hotel-Information) ![Haven by the Lake](https://images.trvl-media.com/lodging/83000000/82960000/82951700/82951676/77c0b851_y.jpg) ### Haven by the Lake 10/10 Excellent "GREAT HOST!" [](https://expedia.ca/Yankton-Hotels-Haven-By-The-Lake.h82951676.Hotel-Information) ![Spacious Lakeview Cabin Minutes from Private Beach](https://images.trvl-media.com/lodging/105000000/104180000/104179200/104179194/w902h683x61y0-0a0c6d21_y.jpg) ### Spacious Lakeview Cabin Minutes from Private Beach 10/10 Excellent "The host was great and the stay was better!" [](https://expedia.ca/Crofton-Hotels-Spacious-Lakeview-Cabin-Minutes-From-Private-Beach.h104179194.Hotel-Information) ![Leather&Spruce - Luxury Lake area fun funky home with amenities. Great for 2-18!](https://images.trvl-media.com/lodging/66000000/65410000/65400200/65400139/a3e44d9e_y.jpg) ### Leather&Spruce - Luxury Lake area fun funky home with amenities. Great for 2-18! 10/10 Excellent "Excellent set up, clean and furnished beautifully. " [](https://expedia.ca/Vermillion-Hotels-Luxury-Lake-Location-With-Great-Amenities.h65400139.Hotel-Information) ![Overlooks Lewis & Clark Lake/Missouri River Basin-3 Hours Northwest of Omaha](https://images.trvl-media.com/lodging/35000000/34430000/34429200/34429107/4c2f576b_y.jpg) ### Overlooks Lewis & Clark Lake/Missouri River Basin-3 Hours Northwest of Omaha 10/10 Excellent "This house works out perfectly for us. We stay there for hunting in the fall. It has a great kitchen and wonderful views. A big bonus is the large hot tub that looks out over the bluffs to the Missouri River.This is our 2nd year here for our trip and would recommend this for anyone hunting or fishing the area." [](https://expedia.ca/Springfield-Hotels-Overlooks-Lewis-Clark-LakeMissouri-River-Basin-3-Hours-Northwest-Of-Omaha.h34429107.Hotel-Information) ![Lewis & Clark Trail Hideaway, SD side / 2 min to the lake / 10 min to Yankton. ](https://images.trvl-media.com/lodging/104000000/103440000/103430100/103430081/69c2489d_y.jpg) ### Lewis & Clark Trail Hideaway, SD side / 2 min to the lake / 10 min to Yankton. 10/10 Excellent "Had a quick get-away with two of my grown boys and the house had everything we needed. The Blackstone grill is how I love to cook and the Hot-Tub was an added bonus. " [](https://expedia.ca/Yankton-Hotels-Lewis-Clark-Trail-Hideaway.h103430081.Hotel-Information) ![Charming Lake House within Walking Distance from Lake](https://images.trvl-media.com/lodging/28000000/27120000/27116700/27116625/d37f9a63_y.jpg) ### Charming Lake House within Walking Distance from Lake 10/10 Excellent "Nice place, lots of space. Different areas to hang out, play games, watch TV. Nice outdoor patio area. Good location, easy access to Lewis & Clark recreation area. " [](https://expedia.ca/Vermillion-Hotels-Charming-Lake-House-Within-Walking-Distance-From-Lake.h27116625.Hotel-Information) ![Cozy cabin near Lewis and Clark Lake and CJ’s at the Lake](https://images.trvl-media.com/lodging/105000000/104180000/104178500/104178423/a3df54c4_y.jpg) ### Cozy cabin near Lewis and Clark Lake and CJ’s at the Lake 10/10 Excellent "Very nice cabin, very great location, we had a good time there, everyone there very friendly, planning on conning back again " [](https://expedia.ca/Crofton-Hotels-Cozy-Cabin-Near-Lewis-And-Clark-Lake-And-CJs-At-The-Lake.h104178423.Hotel-Information) ![The Lake House - Lakeview with 6 bedrooms - Yankton, SD](https://images.trvl-media.com/lodging/36000000/35850000/35847300/35847221/0a799912_y.jpg) ### The Lake House - Lakeview with 6 bedrooms - Yankton, SD 10/10 Excellent "Great stay like always " [](https://expedia.ca/Yankton-Hotels-The-Lake-House-Lakeview-With-6-Bedrooms-Yankton.h35847221.Hotel-Information) ## More cheap stays in Santee ![Lewis and Clark Resort](https://images.trvl-media.com/lodging/12000000/11270000/11268000/11267995/a76b5f6a_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Lewis and Clark Resort 43496 Shore Drive Yankton SD CA $122 CA $129 total Feb 24 - Feb 25 includes taxes & fees 8.8/10 Excellent! (292 reviews) [](https://expedia.ca/Vermillion-Hotels-Lewis-And-Clark-Resort.h11267995.Hotel-Information) ![Santee Hunting Cabin!](https://images.trvl-media.com/lodging/122000000/121720000/121714900/121714833/795e9024_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Santee Hunting Cabin! Niobrara NE [Get rates](https://expedia.ca/Hotel-Search?startDate=09%2F03%2F2026&endDate=10%2F03%2F2026&selected=121714833&PinnedHotelID=121714833&HadPinnedHotel=true®ionId=553248634983588478) [](https://expedia.ca/Niobrara-Hotels-Santee-Hunting-Cabin.h121714833.Hotel-Information) ![Inviting 3-bedroom house near Gavins Point Dam and Lewis and Clark Lake area.](https://images.trvl-media.com/lodging/123000000/122120000/122112900/122112850/00d8303f_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Inviting 3-bedroom house near Gavins Point Dam and Lewis and Clark Lake area. Yankton SD [Get rates](https://expedia.ca/Hotel-Search?startDate=09%2F03%2F2026&endDate=10%2F03%2F2026&selected=122112850&PinnedHotelID=122112850&HadPinnedHotel=true®ionId=553248634983588478) [](https://expedia.ca/Yankton-Hotels-Inviting-3-Bedroom-House-Near-Gavins-Point-Dam-And-Lewis-And-Clark-Lake-Area.h122112850.Hotel-Information) ## Hotels in Santee with star rating ![3 Star Hotels](https://images.trvl-media.com/lodging/20000000/19690000/19681400/19681371/84fffc75_z.jpg) 3 Star Hotels 6 properties [](https://expedia.ca/3Star-Santee-Hotels.s30-0-d553248634983588478.Travel-Guide-Filter-Hotels) ![2 Star Hotels](https://images.trvl-media.com/lodging/92000000/91830000/91828000/91827910/6717a2ac_z.jpg) 2 Star Hotels 3 properties [](https://expedia.ca/2Star-Santee-Hotels.s20-0-d553248634983588478.Travel-Guide-Filter-Hotels) ## Frequently asked questions ### What is the best area to stay in Santee? > This area is the main attraction for visitors, offering direct access to the park's natural beauty. It's characterised by rolling hills, forested bluffs, and the two significant rivers, providing a scenic backdrop for outdoor activities. The park entrance is generally found off Highway 12. > > > For families, staying within or very close to Niobrara State Park is ideal. The park offers numerous activities such as hiking trails, fishing, and opportunities for canoeing or kayaking on the rivers. There are also designated picnic areas and wildlife viewing spots, making it easy to keep everyone entertained in a natural setting. > > > Couples looking for a peaceful escape will also appreciate the Niobrara State Park area. The serene environment is great for quiet walks, birdwatching, and enjoying the natural landscape away from the hustle and bustle. ### Can I cancel my hotel reservation on Expedia? ### How can I save on a Santee hotel booking with Expedia? ### How much is the nightly rate at a Santee hotel? ## Explore a world of travel with Expedia - Lodging - Packages - Cars - Vacation Rental - More ways to book - [5 Star Hotels in Verdel ](https://www.expedia.ca/5Star-Verdel-Hotels.s50-0-d553248634983181199.Travel-Guide-Filter-Hotels) - [Belden Hotels ](https://www.expedia.ca/Belden-Hotels.d553248634983094285.Travel-Guide-Hotels) - [Cheap Hotels in Bloomfield ](https://www.expedia.ca/Bloomfield-Hotels-Cheap-Hotels.0-0-d3000445933-tCheapHotels.Travel-Guide-Filter-Hotels) - [Bloomfield Hotels ](https://www.expedia.ca/Bloomfield-Hotels.d3000445933.Travel-Guide-Hotels) - [Luxury Hotels in Butte ](https://www.expedia.ca/Butte-Hotels-Luxury-Hotel.0-0-d553248634983555716-tLuxuryHotel.Travel-Guide-Filter-Hotels) - 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