Hotels near San Diego Santa Fe Depot

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Check prices for these dates

This weekend
May 22 - May 24
Next weekend
May 29 - May 31

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Our top choices for San Diego Santa Fe Depot hotels

Superior Room, 1 King Bed, Private Bathroom, City View (Self check-in)

Keating Hotel By At Mine Hospitality

Keating Hotel By At Mine Hospitality
2.0 star property
East Village, 1.2 km from San Diego Santa Fe Depot
9.8 out of 10, Exceptional, (7 reviews)
"I love how close it was to the night life in Gaslamp!"
United States
julian
The price is CA $59
CA $175 total
includes taxes & fees
May 27 - May 28
Keating Hotel By At Mine Hospitality
Restaurant

Springhill Suites San Diego Downtown/Bayfront

Springhill Suites San Diego Downtown/Bayfront
3.5 star property
0.2 km from San Diego Santa Fe Depot
9.2 out of 10, Wonderful, (1,002 reviews)
"Would definitely stay here again, the location is great, staff are friendly & helpful & the breakfast has a great variety of food."
Canada
Marc
The price is CA $296
CA $343 total
includes taxes & fees
Jun 7 - Jun 8
Springhill Suites San Diego Downtown/Bayfront
Restaurant

Residence Inn by Marriott San Diego Downtown/Bayfront

Residence Inn by Marriott San Diego Downtown/Bayfront
3.0 star property
0.2 km from San Diego Santa Fe Depot
9.2 out of 10, Wonderful, (666 reviews)
"I will definitely stay there again !"
United States
Diana
The price is CA $356
CA $413 total
includes taxes & fees
Jun 14 - Jun 15
Residence Inn by Marriott San Diego Downtown/Bayfront
Deluxe 2 King Bedrooms, Multiple Beds, Sleeps 11ppl | Terrace/patio

City24 Hotel Little Italy Mission Hills

City24 Hotel Little Italy Mission Hills
4.5 star property
1.9 km from San Diego Santa Fe Depot
9.8 out of 10, Exceptional, (151 reviews)
"Beautiful fully appointed rooms and excellent location."
United States
Michelle
The price is CA $155
CA $221 total
includes taxes & fees
May 25 - May 26
City24 Hotel Little Italy Mission Hills
Interior entrance

Westgate Hotel

Westgate Hotel
4.5 star property
0.6 km from San Diego Santa Fe Depot
9.2 out of 10, Wonderful, (1,002 reviews)
"Beautiful and very clean hotel! Would definitely stay again!"
United States
Nancy
The price is CA $221
CA $304 total
includes taxes & fees
May 25 - May 26
Westgate Hotel
Premium bedding, pillowtop beds, desk, laptop workspace

Hotel Z

Hotel Z
3.0 star property
Gaslamp Quarter, 1.1 km from San Diego Santa Fe Depot
9.4 out of 10, Exceptional, (1,002 reviews)
"Friendly staff, clean room, very quiet! Enjoyed our stay! "
United States
Jayda
The price is CA $132
CA $201 total
includes taxes & fees
May 26 - May 27
Hotel Z
Terrace/patio

The Guild Hotel, San Diego Downtown, a Marriott Tribute Portfolio Hotel

The Guild Hotel, San Diego Downtown, a Marriott Tribute Portfolio Hotel
4.0 star property
0.1 km from San Diego Santa Fe Depot
9.0 out of 10, Wonderful, (1,154 reviews)
"Very nice cute hotel. Wonderful experience."
United States
Rondelle
The price is CA $232
CA $269 total
includes taxes & fees
May 25 - May 26
The Guild Hotel, San Diego Downtown, a Marriott Tribute Portfolio Hotel
Exterior

Marriott Vacation Club®, San Diego

Marriott Vacation Club®, San Diego
3.5 star property
1.1 km from San Diego Santa Fe Depot
9.4 out of 10, Exceptional, (1,084 reviews)
"We had a wonderful stay, and it was conveniently located near the San Diego Zoo and downtown San Diego! My only minor complaint would be going up the parking structure!"
United States
Jocelyn
The price is CA $232
CA $270 total
includes taxes & fees
May 28 - May 29
Marriott Vacation Club®, San Diego
2 bars/lounges, rooftop bar

Hotel Republic San Diego, Autograph Collection

Hotel Republic San Diego, Autograph Collection
4.0 star property
0.3 km from San Diego Santa Fe Depot
9.0 out of 10, Wonderful, (1,184 reviews)
"Thank you for your hospitality!"
United States
Emese
The price is CA $214
CA $312 total
includes taxes & fees
May 28 - May 29
Hotel Republic San Diego, Autograph Collection
Pillowtop beds, in-room safe, blackout drapes, iron/ironing board

Best Western Plus Bayside Inn

Best Western Plus Bayside Inn
3.0 star property
0.4 km from San Diego Santa Fe Depot
9.0 out of 10, Wonderful, (1,006 reviews)
"Nice place to stay and close to the harbor."
United States
Dorothy
The price is CA $206
CA $238 total
includes taxes & fees
May 26 - May 27
Best Western Plus Bayside Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels close to San Diego Santa Fe Depot

Property
Star rating
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
Superior Room, 1 King Bed, Private Bathroom, City View (Self check-in)
Keating Hotel By At Mine Hospitality
2.0 star property
9.8
Exceptional
7 reviews
View
Restaurant
Springhill Suites San Diego Downtown/Bayfront
3.5 star property
9.2
Wonderful
1,002 reviews
View
Restaurant
Residence Inn by Marriott San Diego Downtown/Bayfront
3.0 star property
9.2
Wonderful
666 reviews
View
Deluxe 2 King Bedrooms, Multiple Beds, Sleeps 11ppl | Terrace/patio
City24 Hotel Little Italy Mission Hills
4.5 star property
9.8
Exceptional
151 reviews
View
Interior entrance
Westgate Hotel
4.5 star property
9.2
Wonderful
1,002 reviews
View

Top San Diego Santa Fe Depot Hotel Reviews

The Sofia Hotel

The Sofia Hotel

8/10 Good
"A solid downtown base with a few caveats The Sofia does what it needs to do and does it well. The room was clean, the staff was genuinely friendly, and the location is hard to beat — right in the heart of the Gaslamp Quarter, walking distance from restaurants, and a city bus stop. That said, a couple of things worth knowing before you book: the carpets and hallways carry a musty smell that reminds you this is an older building. And my room had no operable window — sealed shut, no fresh air whatsoever. For some that won’t matter, but if you like to crack a window at night, this isn’t the place. Overall, good value for the location. Just go in with the right expectations and you’ll be happy."
Kanjana Yotjan 4-night trip
Posted 7 hours ago
The Sofia Hotel

Frequently asked questions

What's the area like around San Diego Santa Fe Depot?

San Diego Santa Fe Depot is located in a scenic area of San Diego known for its array of dining options and popular zoo. If you're looking for a convenient place to stay, check out the 848 hotels and other accommodations located within a mile of the station.

What's the best hotel to stay close to San Diego Santa Fe Depot?

Adjacent to San Diego Santa Fe Depot, The Sofia Hotel is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and a 24-hour fitness center. Other good options close by include Manchester Grand Hyatt San Diego and Hard Rock Hotel San Diego.

How many hotels will I find close to San Diego Santa Fe Depot?

Expedia has 848 hotels and other accommodations within a mile from the station.

What can I see and do near San Diego Santa Fe Depot?

Study the collections at USS Midway Museum, Maritime Museum of San Diego, or San Diego Air and Space Museum. Hotel del Coronado, House of Pacific Relations International Cottages, and Casa de Balboa are monuments to see when you're exploring the area around San Diego Santa Fe Depot. You can watch performances at San Diego Civic Theatre, The Rady Shell at Jacobs Park, and Humphreys Concerts by the Bay if you're interested in local theater.

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