Monroe County Vacation Rentals

Compare and save

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
Sep 5 - Sep 7
In two weeks
Sep 12 - Sep 14
In one month
Sep 26 - Sep 28
In two months
Oct 24 - Oct 26

Featured Vacation Homes in Monroe County

Cozy 3 bed, 2 bath home close to historic downtown Hannibal
Fridge, microwave, oven, stovetop

Cozy 3 bed, 2 bath home close to historic downtown Hannibal

10.0 out of 10, Exceptional, (41)
"it was very clean, well stocked and so cozy...the host was very accessible and so kind..would certainly stay here again if we are back in the area"
Cozy 3 bed, 2 bath home close to historic downtown Hannibal
“Peaceful Retreat” @ MTL
Property grounds

“Peaceful Retreat” @ MTL

10.0 out of 10, Exceptional, (102)
"Beautiful property with gracious hosts. As close to Indian creek marina as you can be. "
“Peaceful Retreat” @ MTL
Newly Built Shouse Near Mark Twain Lake!
Smart TV, fireplace

Newly Built Shouse Near Mark Twain Lake!

10.0 out of 10, Exceptional, (2)
"We had a great stay here! Perfect place for a weekend get away. A quick drive to the marina and having the stocked pond was entertainment for the evening! Great and responsive hosts as well, highly recommend! "
The price is CA $303
CA $407 total
includes taxes & fees
Sep 10 - Sep 11
Newly Built Shouse Near Mark Twain Lake!
Tastefully restored historic home in quaint town, 20 minute drive to Columbia MO
Outdoor dining

Tastefully restored historic home in quaint town, 20 minute drive to Columbia MO

10.0 out of 10, Exceptional, (149)
"Beautiful house and very clean! Communication was timely! "
Tastefully restored historic home in quaint town, 20 minute drive to Columbia MO
A real charmer built in 1915 , pet friendly , located next to Mark Twain lake.
Interior

A real charmer built in 1915 , pet friendly , located next to Mark Twain lake.

10.0 out of 10, Exceptional, (20)
"Cozy and comfortable stay during our church conference. The home was clean, well-equipped, and peaceful—just what we needed. Would definitely recommend and stay again!"
A real charmer built in 1915 , pet friendly , located next to Mark Twain lake.
Family-Friendly Home. Sleeps 14. Just minutes away from Mark Twain Lake.
Fridge, microwave, oven, stovetop

Family-Friendly Home. Sleeps 14. Just minutes away from Mark Twain Lake.

10.0 out of 10, Exceptional, (10)
"Great place to stay for family fishing trip "
Family-Friendly Home. Sleeps 14. Just minutes away from Mark Twain Lake.
Mark Twain lake getaway at Blue Lagoon!
Property grounds

Mark Twain lake getaway at Blue Lagoon!

10.0 out of 10, Exceptional, (31)
"Not far from Twain lake, this cabin has everything you’ll ever need for a quiet relaxing stay!"
Mark Twain lake getaway at Blue Lagoon!
Unwind on Vine
Fridge, microwave, oven, stovetop

Unwind on Vine

9.4 out of 10, Exceptional, (15)
"Extremely happy with our visit. No issues at all. "
The price is CA $192
CA $219 total
includes taxes & fees
Sep 7 - Sep 8
Unwind on Vine
3-bedroom 2 bath New construction house in Hallsville
Fridge, microwave, oven, stovetop

3-bedroom 2 bath New construction house in Hallsville

3-bedroom 2 bath New construction house in Hallsville
STORMFIELD WEST Country charm nestled in Perry Mo, 3 miles from Mark Twain Lake
Dining

STORMFIELD WEST Country charm nestled in Perry Mo, 3 miles from Mark Twain Lake

9.2 out of 10, Wonderful, (7)
"Check in was easy. plenty of room for the 10 of us. "
STORMFIELD WEST Country charm nestled in Perry Mo, 3 miles from Mark Twain Lake
Peaceful Lakeside Getaway with Private Dock surrounded with Serene Wilderness
Terrace/patio

Peaceful Lakeside Getaway with Private Dock surrounded with Serene Wilderness

10.0 out of 10, Exceptional, (18)
"The place was just as beautiful as the pictures. The place and everything we needed and they even provided some staples for breakfast. "
Peaceful Lakeside Getaway with Private Dock surrounded with Serene Wilderness
Charming 2-bedroom house at Mark Twain Lake
Exterior

Charming 2-bedroom house at Mark Twain Lake

9.8 out of 10, Exceptional, (18)
"Place was nice and clean and had everything we needed. Quiet neighborhood and within short distance to boat launch. "
Charming 2-bedroom house at Mark Twain Lake
Spacious Home w/ Pond ~ 13 Mi to Columbia!
Interior

Spacious Home w/ Pond ~ 13 Mi to Columbia!

8.0 out of 10, Very good, (11)
"Our family gathered from CA, CO, IL, WV, VT, DC, MO, and Mexico City, Mexico here to celebrate the life of a beloved grandfather. The home gave us a wonderful respite before and following our time at a cemetery and gathering with a wider community. We enjoyed everything about the pond - the frogs, tadpoles, blue gills, a quite evasive enormous bass that no one was able to catch, the water snakes, the song bird chorus. It was wonderful - and we are so grateful for a comfortable place to lay...
Spacious Home w/ Pond ~ 13 Mi to Columbia!
Sweet Retreat at Mark Twain Lake! Historic 4BR/2BA Dog & Family Friendly Home!
Fridge, microwave, oven, stovetop

Sweet Retreat at Mark Twain Lake! Historic 4BR/2BA Dog & Family Friendly Home!

10.0 out of 10, Exceptional, (3)
"The house was great - just as advertised, safe, quiet. A real architectural gem. We had 7 and a puppy and it all worked out great. Loved the patio and fire pit. "
The price is CA $356
CA $591 total
includes taxes & fees
Sep 10 - Sep 11
Sweet Retreat at Mark Twain Lake! Historic 4BR/2BA Dog & Family Friendly Home!
3 Bedroom 2 Bath Cabin nestled in the woods minutes from Mark Twain Lake.
Fridge, microwave, oven, stovetop

3 Bedroom 2 Bath Cabin nestled in the woods minutes from Mark Twain Lake.

10.0 out of 10, Exceptional, (77)
"All we could ask for in a place to stay! Three of us came to deer hunt and it was a perfect spot for us!"
3 Bedroom 2 Bath Cabin nestled in the woods minutes from Mark Twain Lake.
Holder House at Beautiful Mark Twain Lake.
Fridge, microwave, oven, stovetop

Holder House at Beautiful Mark Twain Lake.

9.8 out of 10, Exceptional, (53)
"The location was perfect, near the boat ramp and our families property. House was just as pictured and described. Loved the time spent here and will definitely be back! "
Holder House at Beautiful Mark Twain Lake.
Totally Renovated Home on 5 Acres - Just 4 Miles From Mark Twain Lake
Fridge, microwave, oven, stovetop

Totally Renovated Home on 5 Acres - Just 4 Miles From Mark Twain Lake

2.0 star property
10.0 out of 10, Exceptional, (5)
"Great facilities very clean"
Totally Renovated Home on 5 Acres - Just 4 Miles From Mark Twain Lake
The Benjamin House, Comfortable Townhouse with small town feel
Living area

The Benjamin House, Comfortable Townhouse with small town feel

10.0 out of 10, Exceptional, (2)
"This townhome is beautifully outfitted and the owner has thought of everything needed for a pleasant stay. Location is an easy commute to Columbia and located in a quiet neighborhood. We were in town to visit our son and his family. We were concerned it would be a bit far to his home in CoMo but it was an easy commute on well-maintained roads.Beds are extremely comfortable. My 85 year old mother said it was the best night sleep she has had in forever. The living room was outfitted with a...
The Benjamin House, Comfortable Townhouse with small town feel
Beautiful historic home in downtown Centralia, just 20 minutes from Columbia, MO
Dining

Beautiful historic home in downtown Centralia, just 20 minutes from Columbia, MO

10.0 out of 10, Exceptional, (42)
"Beautiful cozy and comfortable!!! This property had everything you needed!!! Everything!!!! 9 out of 10!!!! Love love love this place! The host was Awesome!!!!!!"
Beautiful historic home in downtown Centralia, just 20 minutes from Columbia, MO
Briggs Convenience Haven, Briggs Convenience Haven
Fridge, microwave, oven, stovetop

Briggs Convenience Haven, Briggs Convenience Haven

2.0 star property
10.0 out of 10, Exceptional, (2)
"The host was extremely friendly and helpful. The house was beautiful and located in an amazing area. Overall the stay was excellent! "
The price is CA $208
CA $362 total
includes taxes & fees
Sep 22 - Sep 23
Briggs Convenience Haven, Briggs Convenience Haven
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Monroe County Hotel Reviews

Find out more about Monroe County

Find out more about Monroe County

Monroe County Vacation Homes information

Number of reviews
242
Accommodation
40 Vacation Homes
Lowest Price
CA $192
Highest Price
CA $356

Explore a world of travel with Expedia

Explore a world of travel with Expedia