Title: Hotels by Independent in Mesilla from CA $71 | Expedia.ca [Mesilla Travel Guide](https://expedia.ca/Mesilla.dx132684)[Hotels in Mesilla](https://expedia.ca/Mesilla-Hotels.d132684.Travel-Guide-Hotels)[Vacation Rentals in Mesilla](https://expedia.ca/Mesilla-Vacation-Rentals.d132684.Travel-Guide-VacationRentals)[Flights to Mesilla](https://expedia.ca/Cheap-Flights-To-Mesilla.d132684.Travel-Guide-Flights)[Mesilla Car Rentals](https://expedia.ca/Car-Rentals-In-Mesilla.d132684.Car-Rental-Guide)[Mesilla Vacation Packages](https://expedia.ca/Mesilla.d132684.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/2/249a9bad94be11a6d3feebf081ee28b9.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Lane # Find Hotels by Independent in Mesilla from CA $71 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Nov 3 - Nov 4](https://www.expedia.ca/Hotel-Search?regionId=132684&startDate=2025-11-03&endDate=2025-11-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Nov 4 - Nov 5](https://www.expedia.ca/Hotel-Search?regionId=132684&startDate=2025-11-04&endDate=2025-11-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=132684&startDate=2025-11-07&endDate=2025-11-09&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Nov 14 - Nov 16](https://www.expedia.ca/Hotel-Search?regionId=132684&startDate=2025-11-14&endDate=2025-11-16&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Mesilla Independent Hotels ![Outdoor pool, open 8:00 AM to 10:00 PM, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/30000/21300/21267/5b5c1a96.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/1000000/30000/21300/21267/679005c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21300/21267/7f7a0786.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor wedding area](https://images.trvl-media.com/lodging/1000000/30000/21300/21267/3f2542a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Encanto de Las Cruces Las Cruces 9.0/10 Wonderful (1545) "I am from Las Cruces, we stay at Encanto everytime we come home. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Robert CA $160 CA $223 total includes taxes & fees Nov 22 - Nov 23 [](https://www.expedia.ca/Las-Cruces-Hotels-Hotel-Encanto-De-Las-Cruces.h21267.Hotel-Information) ![Pool](https://images.trvl-media.com/lodging/60000000/59870000/59861000/59860905/ddad0a7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/60000000/59870000/59861000/59860905/2c6cb195.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/60000000/59870000/59861000/59860905/b46c0d63.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite | Private kitchen](https://images.trvl-media.com/lodging/60000000/59870000/59861000/59860905/18caa7c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 9 Las Cruces Las Cruces 6.2/10 (220) "Staff clean rooms " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Valerie CA $59 CA $71 total includes taxes & fees Nov 4 - Nov 5 [](https://www.expedia.ca/Las-Cruces-Hotels-Motel-9-Las-Cruces.h59860905.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/93000000/92190000/92186700/92186674/0ee34930.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/93000000/92190000/92186700/92186674/352afc71.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/93000000/92190000/92186700/92186674/84d1ed9f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, free WiFi, bed sheets](https://images.trvl-media.com/lodging/93000000/92190000/92186700/92186674/b2471ccd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Big Chile Inn & Suites Las Cruces 6.8/10 (51) "Really clean peaceful staff very helpful reasonably priced would definitely recommend " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Julian CA $100 CA $117 total includes taxes & fees Nov 5 - Nov 6 [](https://www.expedia.ca/Las-Cruces-Hotels-Big-Chile-Inn-Suites.h92186674.Hotel-Information) ![Room, 1 Queen Bed, Non Smoking](https://images.trvl-media.com/lodging/18000000/17520000/17517100/17517011/a37e3f7d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/18000000/17520000/17517100/17517011/448db2ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/18000000/17520000/17517100/17517011/feab0b40.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/18000000/17520000/17517100/17517011/9f91d875.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Century 21 Motel Las Cruces 6.6/10 (163) "Nice hotel at a reasonable price." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Seth CA $80 CA $104 total includes taxes & fees Nov 5 - Nov 6 [](https://www.expedia.ca/Las-Cruces-Hotels-Century-21-Motel.h17517011.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/120000000/119460000/119453800/119453789/2e3e8863.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/120000000/119460000/119453800/119453789/cfdbd388.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/120000000/119460000/119453800/119453789/52479f84.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/120000000/119460000/119453800/119453789/93854e6e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Las Cruces - Modern 3BR Near Downtown, Mesilla, White Sands + Backyard Oasis Las Cruces 9.6/10 Exceptional (9) CA $124 CA $263 total includes taxes & fees Nov 5 - Nov 6 [](https://www.expedia.ca/Las-Cruces-Hotels-Las-Cruces-Modern-3BR-Near-Downtown.h119453789.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/90000000/89780000/89779800/89779763/8b9b87b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/90000000/89780000/89779800/89779763/f83eea01.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/90000000/89780000/89779800/89779763/3eeb353c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/90000000/89780000/89779800/89779763/7220791f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Casa Elena Adobe casita in historic Mesilla Las Cruces 9.0/10 Wonderful (20) "Property was very nice, well equipped, great communication, and location was ideal for dining and shopping. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Susan [](https://www.expedia.ca/Las-Cruces-Hotels-Casa-Elena-Adobe-Casita-In-Historic-Mesilla.h89779763.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/94000000/93840000/93834800/93834720/w1080h1059x0y0-3ee29ec6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/94000000/93840000/93834800/93834720/5446b68e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/94000000/93840000/93834800/93834720/8b4714b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/94000000/93840000/93834800/93834720/a151ef50.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Serene Spa hot tub Sanctuary with patio for the whole family Las Cruces 9.8/10 Exceptional (38) "We loved everything about this house. very comfortable stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Vikram P. CA $154 CA $295 total includes taxes & fees Nov 16 - Nov 17 [](https://www.expedia.ca/Las-Cruces-Hotels-Serene-Spa-Hot-Tub-Sanctuary-With-Patio-For-The-Whole-Family.h93834720.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/27000000/26810000/26806800/26806766/c2d6c0dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/27000000/26810000/26806800/26806766/a74cc027.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/27000000/26810000/26806800/26806766/e0c9968e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, desk, iron/ironing board, travel crib](https://images.trvl-media.com/lodging/27000000/26810000/26806800/26806766/392231ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Desert Pool Oasis located in the heart of Las Cruces Las Cruces 9.8/10 Exceptional (127) "We love it!!! I’ll definitely stay again if in Las Cruces " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Margaret G. [](https://www.expedia.ca/Las-Cruces-Hotels-Desert-Pool-Oasis-Located-In-The-Heart-Of-Las-Cruces.h26806766.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/88000000/87800000/87796300/87796251/13a9dcf7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/88000000/87800000/87796300/87796251/47bb0497.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/88000000/87800000/87796300/87796251/4361071c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace, computer monitors](https://images.trvl-media.com/lodging/88000000/87800000/87796300/87796251/f1af3810.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Yucca House | Views, Jetted Bath, Central Retreat Las Cruces 10/10 Exceptional (33) "We’ve stayed at Yucca House a few times and it is always clean and as described. Wendy is very responsive A great place to stay when in Las Cruces" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Chantel G. CA $129 CA $433 total includes taxes & fees Nov 19 - Nov 20 [](https://www.expedia.ca/Las-Cruces-Hotels-Yucca-House-Views.h87796251.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/94000000/93500000/93494600/93494538/0233181d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/94000000/93500000/93494600/93494538/9c6ea49b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/94000000/93500000/93494600/93494538/fa527983.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace](https://images.trvl-media.com/lodging/94000000/93500000/93494600/93494538/w6016h4012x0y4-ba94043f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 4 Bedroom Contemporary Model Home Las Cruces 9.4/10 Exceptional (28) "We had a great family weekend. Everything we needed was supplied and the house was very clean. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) K H. CA $101 CA $298 total includes taxes & fees Nov 16 - Nov 17 [](https://www.expedia.ca/Las-Cruces-Hotels-4-Bedroom-Contemporary-Model-Home.h93494538.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-17&endDate=2025-11-18®ionId=132684&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FMesilla-Hotels-Independent.0-0-d132684--bIndependent.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FMesilla-Hotels-Independent.0-0-d132684--bIndependent.Travel-Guide-Filter-Hotels) ## Top Mesilla Hotel Reviews ![La Quinta Inn & Suites by Wyndham Las Cruces Organ Mountain](//images.trvl-media.com/lodging/1000000/80000/75400/75365/62ae9c45_y.jpg) ### La Quinta Inn & Suites by Wyndham Las Cruces Organ Mountain 10/10 Excellent "Pleasant staff" [](https://expedia.ca/Las-Cruces-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Las-Cruces-Organ-Mountain.h75365.Hotel-Information) ![Hotel Encanto de Las Cruces](//images.trvl-media.com/lodging/1000000/30000/21300/21267/5b5c1a96_y.jpg) ### Hotel Encanto de Las Cruces 10/10 Excellent "The staff was amazing The room was comfortable and we had a great view The property is well maintained w a beautiful pool and the rooms are super clean" [](https://expedia.ca/Las-Cruces-Hotels-Hotel-Encanto-De-Las-Cruces.h21267.Hotel-Information) ![Drury Inn & Suites Las Cruces](//images.trvl-media.com/lodging/2000000/1730000/1723300/1723204/0bffe062_y.jpg) ### Drury Inn & Suites Las Cruces 10/10 Excellent "Staff was very accommodating and professional " [](https://expedia.ca/Las-Cruces-Hotels-Drury-Inn-Suites-Las-Cruces.h1723204.Hotel-Information) ![Days Inn by Wyndham Las Cruces](//images.trvl-media.com/lodging/1000000/20000/15100/15035/4e26c2df_y.jpg) ### Days Inn by Wyndham Las Cruces 10/10 Excellent "Spotless great service " [](https://expedia.ca/Las-Cruces-Hotels-Days-Inn-By-Wyndham-Las-Cruces.h15035.Hotel-Information) ![Best Western Mission Inn](//images.trvl-media.com/lodging/1000000/30000/20600/20506/90d9a325_y.jpg) ### Best Western Mission Inn 10/10 Excellent "Clean, comfortable, quiet. With an excellent breakfast. " [](https://expedia.ca/Las-Cruces-Hotels-Best-Western-Mission-Inn.h20506.Hotel-Information) ![Hilton Garden Inn Las Cruces](//images.trvl-media.com/lodging/3000000/2880000/2870400/2870330/a3f63928_y.jpg) ### Hilton Garden Inn Las Cruces 10/10 Excellent "Great " [](https://expedia.ca/Las-Cruces-Hotels-Hilton-Garden-Inn-Las-Cruces.h2870330.Hotel-Information) ![Hampton Inn & Suites Las Cruces I-25](//images.trvl-media.com/lodging/2000000/1670000/1665200/1665185/b0473335_y.jpg) ### Hampton Inn & Suites Las Cruces I-25 10/10 Excellent "Great " [](https://expedia.ca/Las-Cruces-Hotels-Hampton-Inn-Suites-Las-Cruces-I-25.h1665185.Hotel-Information) ![Comfort Inn & Suites Las Cruces Mesilla](//images.trvl-media.com/lodging/2000000/1360000/1353900/1353805/518ac77c_y.jpg) ### Comfort Inn & Suites Las Cruces Mesilla 10/10 Excellent "Fit in well with the local culture" [](https://expedia.ca/Las-Cruces-Hotels-Comfort-Inn-Suites-Las-Cruces-Mesilla.h1353805.Hotel-Information) ![Comfort Suites University Las Cruces](//images.trvl-media.com/lodging/1000000/50000/43200/43179/3f986bbe_y.jpg) ### Comfort Suites University Las Cruces 10/10 Excellent "We booked a quick weekend getaway to attend a wedding. The day we arrived, it was raining, and the front desk allowed us to check in early with no issues. The rooms were clean, the location was perfect for the venue, and the staff were extremely friendly and accommodating. " [](https://expedia.ca/Las-Cruces-Hotels-Comfort-Suites-University-Las-Cruces.h43179.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - Other - More ways to book - [5 Star Hotels in Las Cruces](https://www.expedia.ca/5Star-Las-Cruces-Hotels.s50-0-d2137.Travel-Guide-Filter-Hotels) - [B&B in Dona Ana](https://www.expedia.ca/Dona-Ana-Bed-And-Breakfast.d3000350236-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Guest Houses in Dona Ana](https://www.expedia.ca/Dona-Ana-Guest-Houses.d3000350236-aaGuestHouses.Travel-Guide-Accommodation) - [Dona Ana Hotels](https://www.expedia.ca/Dona-Ana-Hotels.d3000350236.Travel-Guide-Hotels) - [Motels in Dona Ana](https://www.expedia.ca/Dona-Ana-Motels.d3000350236-aaMotels.Travel-Guide-Accommodation) - [Aparthotels in Fairacres](https://www.expedia.ca/Fairacres-Apart-Hotels.d3000447742-aaApartHotels.Travel-Guide-Accommodation) - [Aparthotels in La Mesa](https://www.expedia.ca/La-Mesa-Apart-Hotels.d3000447775-aaApartHotels.Travel-Guide-Accommodation) - 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[Visit Las Cruces](https://www.expedia.ca/Las-Cruces.dx2137) - [Visit Organ](https://www.expedia.ca/Organ.dx553248635975864567) - [Visit Radium Springs](https://www.expedia.ca/Radium-Springs.dx3000447875) - [White Sands Vacations](https://www.expedia.ca/White-Sands.d6208412.Destination-Travel-Guides) - [Car rental Las Cruces](https://www.expedia.ca/Car-Rentals-In-Las-Cruces.d2137.Car-Rental-Guide) - [Sixt Rental Cars in Las Cruces](https://www.expedia.ca/Sixt-Car-Rentals-In-Las-Cruces.d2137-c35.Car-Rental-Guide-Suppliers) - [Las Cruces Vacation Rentals](https://www.expedia.ca/Las-Cruces-Vacation-Rentals.d2137.Travel-Guide-VacationRentals) - [White Sands Vacation Rentals](https://www.expedia.ca/White-Sands-Vacation-Rentals.d6208412.Travel-Guide-VacationRentals) - [Things to do in Las Cruces](https://www.expedia.ca/Things-To-Do-In-Las-Cruces.d2137.Travel-Guide-Activities) - [Book Independent in Mesilla on Expedia.com](https://www.expedia.com/Mesilla-Hotels-Independent.0-0-d132684--bIndependent.Travel-Guide-Filter-Hotels)