Title: Hotels by Independent in Mesilla from CA $75 | Expedia.ca [Mesilla Travel Guide](https://expedia.ca/Mesilla.dx132684)[Hotels in Mesilla](https://expedia.ca/Mesilla-Hotels.d132684.Travel-Guide-Hotels)[Vacation Rentals in Mesilla](https://expedia.ca/Mesilla-Vacation-Rentals.d132684.Travel-Guide-VacationRentals)[Flights to Mesilla](https://expedia.ca/Cheap-Flights-To-Mesilla.d132684.Travel-Guide-Flights)[Mesilla Car Rentals](https://expedia.ca/Car-Rentals-In-Mesilla.d132684.Car-Rental-Guide)[Mesilla Vacation Packages](https://expedia.ca/Mesilla.d132684.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/2/249a9bad94be11a6d3feebf081ee28b9.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Lane # Find Hotels by Independent in Mesilla from CA $75 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Oct 16 - Oct 17](https://www.expedia.ca/Hotel-Search?regionId=132684&startDate=2025-10-16&endDate=2025-10-17&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 17 - Oct 18](https://www.expedia.ca/Hotel-Search?regionId=132684&startDate=2025-10-17&endDate=2025-10-18&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=132684&startDate=2025-10-17&endDate=2025-10-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=132684&startDate=2025-10-24&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Mesilla Independent Hotels ![Outdoor pool, open 8:00 AM to 10:00 PM, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/30000/21300/21267/5b5c1a96.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21300/21267/7f7a0786.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor wedding area](https://images.trvl-media.com/lodging/1000000/30000/21300/21267/3f2542a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/1000000/30000/21300/21267/679005c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Encanto de Las Cruces Las Cruces 9.0/10 Wonderful (1539) "Hotel is beautiful. " CA $172 CA $236 total includes taxes & fees Nov 8 - Nov 9 [](https://www.expedia.ca/Las-Cruces-Hotels-Hotel-Encanto-De-Las-Cruces.h21267.Hotel-Information) ![Pool](https://images.trvl-media.com/lodging/60000000/59870000/59861000/59860905/ddad0a7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite | Private kitchen](https://images.trvl-media.com/lodging/60000000/59870000/59861000/59860905/18caa7c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/60000000/59870000/59861000/59860905/b46c0d63.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/60000000/59870000/59861000/59860905/2c6cb195.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 9 Las Cruces Las Cruces 6.2/10 (217) "Great staff members" CA $63 CA $75 total includes taxes & fees Oct 17 - Oct 18 [](https://www.expedia.ca/Las-Cruces-Hotels-Motel-9-Las-Cruces.h59860905.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/93000000/92190000/92186700/92186674/0ee34930.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/93000000/92190000/92186700/92186674/84d1ed9f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, free WiFi, bed sheets](https://images.trvl-media.com/lodging/93000000/92190000/92186700/92186674/b2471ccd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/93000000/92190000/92186700/92186674/352afc71.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Big Chile Inn & Suites Las Cruces 6.6/10 (49) "Clean peaceful helpful staff reasonable price would definitely recommend " CA $100 CA $117 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/Las-Cruces-Hotels-Big-Chile-Inn-Suites.h92186674.Hotel-Information) ![Room, 1 Queen Bed, Non Smoking](https://images.trvl-media.com/lodging/18000000/17520000/17517100/17517011/a37e3f7d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/18000000/17520000/17517100/17517011/feab0b40.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/18000000/17520000/17517100/17517011/83951f46.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/18000000/17520000/17517100/17517011/9f91d875.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Century 21 Motel Las Cruces 6.6/10 (163) "Nice hotel at a reasonable price." CA $80 CA $104 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/Las-Cruces-Hotels-Century-21-Motel.h17517011.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/120000000/119460000/119453800/119453789/2e3e8863.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/120000000/119460000/119453800/119453789/cfdbd388.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/120000000/119460000/119453800/119453789/93854e6e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV, fireplace](https://images.trvl-media.com/lodging/120000000/119460000/119453800/119453789/c1e00df6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Las Cruces - Modern 3BR Near Downtown, Mesilla, White Sands + Backyard Oasis Las Cruces 9.6/10 Exceptional (9) CA $114 CA $253 total includes taxes & fees Oct 22 - Oct 23 [](https://www.expedia.ca/Las-Cruces-Hotels-Las-Cruces-Modern-3BR-Near-Downtown.h119453789.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/90000000/89780000/89779800/89779763/8b9b87b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/90000000/89780000/89779800/89779763/3eeb353c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/90000000/89780000/89779800/89779763/7220791f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, DVD player](https://images.trvl-media.com/lodging/90000000/89780000/89779800/89779763/2b6aceb6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Casa Elena Adobe casita in historic Mesilla Las Cruces 9.0/10 Wonderful (19) "Property was very nice, well equipped, great communication, and location was ideal for dining and shopping. " [](https://www.expedia.ca/Las-Cruces-Hotels-Casa-Elena-Adobe-Casita-In-Historic-Mesilla.h89779763.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/94000000/93840000/93834800/93834720/w1080h1059x0y0-3ee29ec6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/94000000/93840000/93834800/93834720/5446b68e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/94000000/93840000/93834800/93834720/a151ef50.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Living area](https://images.trvl-media.com/lodging/94000000/93840000/93834800/93834720/72a20846.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Serene Spa hot tub Sanctuary with patio for the whole family Las Cruces 9.8/10 Exceptional (34) "You could really feel the love of owners put into the place. It was a home away from home. We would definitely stay again!" CA $162 CA $298 total includes taxes & fees Nov 14 - Nov 15 [](https://www.expedia.ca/Las-Cruces-Hotels-Serene-Spa-Hot-Tub-Sanctuary-With-Patio-For-The-Whole-Family.h93834720.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/27000000/26810000/26806800/26806766/c2d6c0dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/27000000/26810000/26806800/26806766/e0c9968e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, desk, iron/ironing board, travel crib](https://images.trvl-media.com/lodging/27000000/26810000/26806800/26806766/392231ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, a heated pool](https://images.trvl-media.com/lodging/27000000/26810000/26806800/26806766/a74cc027.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Desert Pool Oasis located in the heart of Las Cruces Las Cruces 9.8/10 Exceptional (126) "A great house with a central location. The kids loved swimming in the pool and the house was clean and everything was labeled. I loved how easy the check in and check out process was. We visit family often in Las Cruces and will be back. " [](https://www.expedia.ca/Las-Cruces-Hotels-Desert-Pool-Oasis-Located-In-The-Heart-Of-Las-Cruces.h26806766.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/88000000/87800000/87796300/87796251/13a9dcf7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/88000000/87800000/87796300/87796251/47bb0497.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace, computer monitors](https://images.trvl-media.com/lodging/88000000/87800000/87796300/87796251/f1af3810.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/88000000/87800000/87796300/87796251/4361071c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Yucca House | Views, Jetted Bath, Central Retreat Las Cruces 10/10 Exceptional (33) "We’ve stayed at Yucca House a few times and it is always clean and as described. Wendy is very responsive A great place to stay when in Las Cruces" CA $129 CA $436 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/Las-Cruces-Hotels-Yucca-House-Views.h87796251.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/94000000/93500000/93494600/93494538/0233181d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/94000000/93500000/93494600/93494538/9c6ea49b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace](https://images.trvl-media.com/lodging/94000000/93500000/93494600/93494538/c7b17bae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace](https://images.trvl-media.com/lodging/94000000/93500000/93494600/93494538/w6016h4012x0y4-ba94043f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 4 Bedroom Contemporary Model Home Las Cruces 9.4/10 Exceptional (28) "We had a great family weekend. Everything we needed was supplied and the house was very clean. " CA $91 CA $282 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/Las-Cruces-Hotels-4-Bedroom-Contemporary-Model-Home.h93494538.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-30&endDate=2025-10-31®ionId=132684&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FMesilla-Hotels-Independent.0-0-d132684--bIndependent.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FMesilla-Hotels-Independent.0-0-d132684--bIndependent.Travel-Guide-Filter-Hotels) ## Top Mesilla Hotel Reviews ![Comfort Inn & Suites Las Cruces Mesilla](//images.trvl-media.com/lodging/2000000/1360000/1353900/1353805/518ac77c_y.jpg) ### Comfort Inn & Suites Las Cruces Mesilla 10/10 Excellent "The room was clean and comfortable. The bed was very comfortable and the staff was able to accommodate our extra request for a quiet room. " [](https://expedia.ca/Las-Cruces-Hotels-Comfort-Inn-Suites-Las-Cruces-Mesilla.h1353805.Hotel-Information) ![Hotel Encanto de Las Cruces](//images.trvl-media.com/lodging/1000000/30000/21300/21267/5b5c1a96_y.jpg) ### Hotel Encanto de Las Cruces 10/10 Excellent "Staff and hot tub " [](https://expedia.ca/Las-Cruces-Hotels-Hotel-Encanto-De-Las-Cruces.h21267.Hotel-Information) ![Comfort Suites Las Cruces I-25 North](//images.trvl-media.com/lodging/11000000/10330000/10320300/10320201/c5bb6ea5_y.jpg) ### Comfort Suites Las Cruces I-25 North 10/10 Excellent "Large clean rooms and free breakfast" [](https://expedia.ca/Las-Cruces-Hotels-Comfort-Suites-Las-Cruces-I-25-North.h10320201.Hotel-Information) ![Best Western Mission Inn](//images.trvl-media.com/lodging/1000000/30000/20600/20506/90d9a325_y.jpg) ### Best Western Mission Inn 10/10 Excellent "Air conditioner was actually quiet and cooled well. Room was spacious and clean. " [](https://expedia.ca/Las-Cruces-Hotels-Best-Western-Mission-Inn.h20506.Hotel-Information) ![Days Inn by Wyndham Las Cruces](//images.trvl-media.com/lodging/1000000/20000/15100/15035/4e26c2df_y.jpg) ### Days Inn by Wyndham Las Cruces 10/10 Excellent "Clean rooms convenient location and welcomes.pets!" [](https://expedia.ca/Las-Cruces-Hotels-Days-Inn-By-Wyndham-Las-Cruces.h15035.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Las Cruces Organ Mountain](//images.trvl-media.com/lodging/1000000/80000/75400/75365/62ae9c45_y.jpg) ### La Quinta Inn & Suites by Wyndham Las Cruces Organ Mountain 10/10 Excellent "Nice property " [](https://expedia.ca/Las-Cruces-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Las-Cruces-Organ-Mountain.h75365.Hotel-Information) ![Comfort Suites University Las Cruces](//images.trvl-media.com/lodging/1000000/50000/43200/43179/3f986bbe_y.jpg) ### Comfort Suites University Las Cruces 10/10 Excellent "The staff was super friendly. The house keepers were really nice and friendly! " [](https://expedia.ca/Las-Cruces-Hotels-Comfort-Suites-University-Las-Cruces.h43179.Hotel-Information) ![Hampton Inn & Suites Las Cruces I-25](//images.trvl-media.com/lodging/2000000/1670000/1665200/1665185/b0473335_y.jpg) ### Hampton Inn & Suites Las Cruces I-25 10/10 Excellent "The room was larger then i though it would be. The lady at the front desk was sweet. Even wished us safe travels when we left." [](https://expedia.ca/Las-Cruces-Hotels-Hampton-Inn-Suites-Las-Cruces-I-25.h1665185.Hotel-Information) ![Casita Azul, Mesilla Plaza Only Steps Away](//images.trvl-media.com/lodging/35000000/34210000/34201100/34201060/3d9c53e2_y.jpg) ### Casita Azul, Mesilla Plaza Only Steps Away 10/10 Excellent "This is the second time we have stayed at this lovely Casita. It’s roomy and comfortable with a full kitchen and laundry. The host was very helpful with providing everything we needed for our stay and gracious with gifting us a nice bottle of wine waiting for us on our arrival. The location is perfect for staying in Mesilla and Southern New Mexico. We will definitely stay here again." [](https://expedia.ca/Mesilla-Hotels-Casita-Azul.h34201060.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - Other - More ways to book - [5 Star Hotels in Las Cruces](https://www.expedia.ca/5Star-Las-Cruces-Hotels.s50-0-d2137.Travel-Guide-Filter-Hotels) - [B&B in Dona Ana](https://www.expedia.ca/Dona-Ana-Bed-And-Breakfast.d3000350236-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Guest Houses in Dona Ana](https://www.expedia.ca/Dona-Ana-Guest-Houses.d3000350236-aaGuestHouses.Travel-Guide-Accommodation) - [Dona Ana Hotels](https://www.expedia.ca/Dona-Ana-Hotels.d3000350236.Travel-Guide-Hotels) - [Motels in Dona Ana](https://www.expedia.ca/Dona-Ana-Motels.d3000350236-aaMotels.Travel-Guide-Accommodation) - [Aparthotels in Fairacres](https://www.expedia.ca/Fairacres-Apart-Hotels.d3000447742-aaApartHotels.Travel-Guide-Accommodation) - [Aparthotels in La Mesa](https://www.expedia.ca/La-Mesa-Apart-Hotels.d3000447775-aaApartHotels.Travel-Guide-Accommodation) - 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[Visit Las Cruces](https://www.expedia.ca/Las-Cruces.dx2137) - [Visit Organ](https://www.expedia.ca/Organ.dx553248635975864567) - [Visit Radium Springs](https://www.expedia.ca/Radium-Springs.dx3000447875) - [White Sands Vacations](https://www.expedia.ca/White-Sands.d6208412.Destination-Travel-Guides) - [Car rental Las Cruces](https://www.expedia.ca/Car-Rentals-In-Las-Cruces.d2137.Car-Rental-Guide) - [Sixt Rental Cars in Las Cruces](https://www.expedia.ca/Sixt-Car-Rentals-In-Las-Cruces.d2137-c35.Car-Rental-Guide-Suppliers) - [Las Cruces Vacation Rentals](https://www.expedia.ca/Las-Cruces-Vacation-Rentals.d2137.Travel-Guide-VacationRentals) - [White Sands Vacation Rentals](https://www.expedia.ca/White-Sands-Vacation-Rentals.d6208412.Travel-Guide-VacationRentals) - [Things to do in Las Cruces](https://www.expedia.ca/Things-To-Do-In-Las-Cruces.d2137.Travel-Guide-Activities) - [Book Independent in Mesilla on Expedia.com](https://www.expedia.com/Mesilla-Hotels-Independent.0-0-d132684--bIndependent.Travel-Guide-Filter-Hotels)