Title: Book the Best BUSINESS Hotels in Mesilla in 2026 | Expedia.ca [Hotels in Mesilla](https://expedia.ca/Mesilla-Hotels.d132684.Travel-Guide-Hotels)[Vacation Rentals in Mesilla](https://expedia.ca/Mesilla-Vacation-Rentals.d132684.Travel-Guide-VacationRentals)[Mesilla Car Rentals](https://expedia.ca/Car-Rentals-In-Mesilla.d132684.Car-Rental-Guide)[Mesilla Vacation Packages](https://expedia.ca/Mesilla.d132684.Destination-Travel-Guides) ![Red chile doorway Mesilla NM](https://images.trvl-media.com/place/132684/621c4b20-e7ee-452c-9495-0ec62a9d9908.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Business Hotels in Mesilla, NM from CA $79 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Mesilla Business Hotels Tonight [Dec 8 - Dec 9](https://www.expedia.ca/Hotel-Search?regionId=132684&startDate=2025-12-08&endDate=2025-12-09&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [Dec 9 - Dec 10](https://www.expedia.ca/Hotel-Search?regionId=132684&startDate=2025-12-09&endDate=2025-12-10&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) This weekend [Dec 12 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=132684&startDate=2025-12-12&endDate=2025-12-14&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=132684&startDate=2025-12-19&endDate=2025-12-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Top Mesilla Business Hotels ![Lobby](https://images.trvl-media.com/lodging/1000000/80000/75400/75365/62ae9c45.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 King Bed, Non Smoking (Executive, Mountain/Pool View)](https://images.trvl-media.com/lodging/1000000/80000/75400/75365/5579b7c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free continental breakfast](https://images.trvl-media.com/lodging/1000000/80000/75400/75365/74e32868.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/80000/75400/75365/b35a57be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Las Cruces Organ Mountain Las Cruces 8.2/10 Very good (2286) "Staff was lovely. Room is dated but had a great view." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Patricia CA $76 CA $89 total includes taxes & fees Dec 15 - Dec 16 [](https://www.expedia.ca/Las-Cruces-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Las-Cruces-Organ-Mountain.h75365.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/2000000/1730000/1723300/1723204/0bffe062.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/2000000/1730000/1723300/1723204/affa980e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1730000/1723300/1723204/63a091eb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/2000000/1730000/1723300/1723204/68a7ba44.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Las Cruces Las Cruces 9.4/10 Exceptional (1011) "Clean room, good breakfast, nice staff, and great pricing. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Shahzad CA $130 CA $151 total includes taxes & fees Dec 14 - Dec 15 [](https://www.expedia.ca/Las-Cruces-Hotels-Drury-Inn-Suites-Las-Cruces.h1723204.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/13000000/12820000/12817800/12817768/a6b6426a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/13000000/12820000/12817800/12817768/2816db98.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/13000000/12820000/12817800/12817768/f6627f8c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/13000000/12820000/12817800/12817768/6adba37c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Las Cruces I-10 Las Cruces 8.8/10 Excellent (1007) "I recommend Studio Suite; it's huge, very clean, has a very varied and delicious breakfast, and the staff is very friendly." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Nora CA $128 CA $149 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/Las-Cruces-Hotels-Hampton-Inn-Suites-Las-Cruces-I-10.h12817768.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15100/15035/4e26c2df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/15100/15035/89306788.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 KING BED – NON-SMOKING](https://images.trvl-media.com/lodging/1000000/20000/15100/15035/a0c41c28.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![BBQ/picnic area](https://images.trvl-media.com/lodging/1000000/20000/15100/15035/b4a415ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham Las Cruces Las Cruces 8.2/10 Very good (1277) "Friendly staff and spacious King room." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Donald CA $67 CA $79 total includes taxes & fees Dec 24 - Dec 25 [](https://www.expedia.ca/Las-Cruces-Hotels-Days-Inn-By-Wyndham-Las-Cruces.h15035.Hotel-Information) ![Business centre](https://images.trvl-media.com/lodging/1000000/30000/20600/20506/90d9a325.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds, Non Smoking, Refrigerator & Microwave](https://images.trvl-media.com/lodging/1000000/30000/20600/20506/c6ba58b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/20600/20506/89e377bc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/20600/20506/b11dfff8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Mission Inn Las Cruces 8.8/10 Excellent (1236) "Very comfortable place to stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Maryann CA $106 CA $123 total includes taxes & fees Dec 14 - Dec 15 [](https://www.expedia.ca/Las-Cruces-Hotels-Best-Western-Mission-Inn.h20506.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/3900/3871/b3828ca3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/3900/3871/1a82ee39.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/10000/3900/3871/d8a1d85a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio Suite, 1 King Bed, Non Smoking | Living area](https://images.trvl-media.com/lodging/1000000/10000/3900/3871/1d4ae1e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Ramada Hotel & Conference Center by Wyndham Las Cruces Las Cruces 8.0/10 Very good (1003) "Staff was friendly " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Timothy CA $93 CA $109 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/Las-Cruces-Hotels-Ramada-Hotel-Conference-Center-By-Wyndham-Las-Cruces.h3871.Hotel-Information) ![Outdoor pool, open 8:00 AM to 10:00 PM, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/30000/21300/21267/5b5c1a96.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor wedding area](https://images.trvl-media.com/lodging/1000000/30000/21300/21267/3f2542a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/30000/21300/21267/67719f59.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21300/21267/7f7a0786.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Encanto de Las Cruces Las Cruces 9.0/10 Wonderful (1590) "We had a wonderful stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Amber CA $148 CA $208 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/Las-Cruces-Hotels-Hotel-Encanto-De-Las-Cruces.h21267.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/3000000/2880000/2870400/2870330/a3f63928.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/3000000/2880000/2870400/2870330/21604ca5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/3000000/2880000/2870400/2870330/2718f0bf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Daily to-go breakfast (USD 13.95 per person)](https://images.trvl-media.com/lodging/3000000/2880000/2870400/2870330/dc8a7d85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Garden Inn Las Cruces Las Cruces 9.2/10 Wonderful (1005) "Great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Myles CA $111 CA $129 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/Las-Cruces-Hotels-Hilton-Garden-Inn-Las-Cruces.h2870330.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/11000000/10330000/10320300/10320201/c5bb6ea5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed with Sofa bed, Accessible, Non Smoking](https://images.trvl-media.com/lodging/11000000/10330000/10320300/10320201/bf4a0d2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/11000000/10330000/10320300/10320201/eae97133.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/11000000/10330000/10320300/10320201/a92d487e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Suites Las Cruces I-25 North Las Cruces 9.2/10 Wonderful (1004) "We stay here every time we are coming through Las Cruces. This hotel always meets our expectations. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) John CA $152 CA $180 total includes taxes & fees Dec 14 - Dec 15 [](https://www.expedia.ca/Las-Cruces-Hotels-Comfort-Suites-Las-Cruces-I-25-North.h10320201.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/2000000/1360000/1353900/1353805/518ac77c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/2000000/1360000/1353900/1353805/49939edf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/2000000/1360000/1353900/1353805/7f18df12.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Food and drink](https://images.trvl-media.com/lodging/2000000/1360000/1353900/1353805/8e674089.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Las Cruces Mesilla Las Cruces 8.8/10 Excellent (1004) "Nice place" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) chris CA $137 CA $159 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/Las-Cruces-Hotels-Comfort-Inn-Suites-Las-Cruces-Mesilla.h1353805.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-22&endDate=2025-12-23®ionId=132684&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Mesilla Hotel Reviews ![Hampton Inn & Suites Las Cruces I-25](https://images.trvl-media.com/lodging/2000000/1670000/1665200/1665185/b0473335_y.jpg) ### Hampton Inn & Suites Las Cruces I-25 10/10 Excellent "Room and service were great" [](https://expedia.ca/Las-Cruces-Hotels-Hampton-Inn-Suites-Las-Cruces-I-25.h1665185.Hotel-Information) ![Holiday Inn Express & Suites Las Cruces North by IHG](https://images.trvl-media.com/lodging/5000000/4670000/4663400/4663329/f4f7b494_y.jpg) ### Holiday Inn Express & Suites Las Cruces North by IHG 10/10 Excellent "It was nice stay " [](https://expedia.ca/Las-Cruces-Hotels-Holiday-Inn-Express-Suites-Las-Cruces-North.h4663329.Hotel-Information) ![Hotel Encanto de Las Cruces](https://images.trvl-media.com/lodging/1000000/30000/21300/21267/5b5c1a96_y.jpg) ### Hotel Encanto de Las Cruces 10/10 Excellent "Check in was fast and friendly as well as the checkout. One of the best place I have stayed. Everyone friendly cleans are very clean and easy to access" [](https://expedia.ca/Las-Cruces-Hotels-Hotel-Encanto-De-Las-Cruces.h21267.Hotel-Information) ![Hampton Inn & Suites Las Cruces I-10](https://images.trvl-media.com/lodging/13000000/12820000/12817800/12817768/a6b6426a_y.jpg) ### Hampton Inn & Suites Las Cruces I-10 10/10 Excellent "I recommend Studio Suite; it's huge, very clean, has a very varied and delicious breakfast, and the staff is very friendly." [](https://expedia.ca/Las-Cruces-Hotels-Hampton-Inn-Suites-Las-Cruces-I-10.h12817768.Hotel-Information) ![Hilton Garden Inn Las Cruces](https://images.trvl-media.com/lodging/3000000/2880000/2870400/2870330/a3f63928_y.jpg) ### Hilton Garden Inn Las Cruces 10/10 Excellent "everything was absolutely awesome!!" [](https://expedia.ca/Las-Cruces-Hotels-Hilton-Garden-Inn-Las-Cruces.h2870330.Hotel-Information) ![Days Inn by Wyndham Las Cruces](https://images.trvl-media.com/lodging/1000000/20000/15100/15035/4e26c2df_y.jpg) ### Days Inn by Wyndham Las Cruces 10/10 Excellent "Yes." [](https://expedia.ca/Las-Cruces-Hotels-Days-Inn-By-Wyndham-Las-Cruces.h15035.Hotel-Information) ![Comfort Suites University Las Cruces](https://images.trvl-media.com/lodging/1000000/50000/43200/43179/3f986bbe_y.jpg) ### Comfort Suites University Las Cruces 10/10 Excellent "Amazing staff, clean rooms, great breakfast " [](https://expedia.ca/Las-Cruces-Hotels-Comfort-Suites-University-Las-Cruces.h43179.Hotel-Information) ![Drury Inn & Suites Las Cruces](https://images.trvl-media.com/lodging/2000000/1730000/1723300/1723204/0bffe062_y.jpg) ### Drury Inn & Suites Las Cruces 10/10 Excellent "Excellent " [](https://expedia.ca/Las-Cruces-Hotels-Drury-Inn-Suites-Las-Cruces.h1723204.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Las Cruces Organ Mountain](https://images.trvl-media.com/lodging/1000000/80000/75400/75365/62ae9c45_y.jpg) ### La Quinta Inn & Suites by Wyndham Las Cruces Organ Mountain 10/10 Excellent "Clean room" [](https://expedia.ca/Las-Cruces-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Las-Cruces-Organ-Mountain.h75365.Hotel-Information) ## Frequently asked questions ### How much do business-friendly hotels in Mesilla cost? ### What are the best business-friendly hotels in Mesilla? ### How many business-friendly hotels are there in Mesilla? ### What are the best cheap business-friendly hotels in Mesilla? ### Are there any family-friendly hotels in Mesilla that are also business friendly? ### Why book your business-friendly hotel in Mesilla with Expedia? ### How can I find cheap business-friendly hotels in Mesilla? ### What is there to do in Mesilla near my business-friendly hotel? ## Explore a world of travel with Expedia - 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