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A forest trail with moss-covered rocks and dense green foliage.

Find hotels near Lewis and Clark Trail Trailhead, St. Louis from CA $111

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    Check prices for these dates, December 14–15, 2026

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    Our top choices for Lewis and Clark Trail Trailhead hotels

    1. Sleep Inn & Suites O'Fallon MO - Technology Drive

    A hotel room with a bed, a sofa, a coffee table, and wall art.

    2. Holiday Inn Express St. Louis West - O'Fallon by IHG

    A multi-story hotel with a mix of brick and siding exteriors, multiple windows, and a well-maintained lawn.

    3. Drury Plaza Hotel St. Louis Chesterfield

    A spacious lobby with a central round table, two sofas, and a chandelier.

    4. Hyatt Place St. Louis/Chesterfield

    A modern kitchen with a bar area, wooden cabinets, and pendant lighting.

    5. Drury Inn & Suites St. Louis St. Peters

    A spacious lobby with a high ceiling, a dining area, and a seating area with sofas and a coffee table.

    6. The Wildwood Hotel

    A hotel with a prominent tower, a fountain in the courtyard, and a well-maintained garden.

    7. Holiday Inn Express & Suites St Peters by IHG

    A spacious lobby with a high ceiling, a reception desk, seating areas, and a staircase leading to an upper level.

    8. DoubleTree by Hilton Hotel St. Louis - Chesterfield

    A spacious lobby with a brown leather sofa, multiple chairs, a coffee table with a skull decoration, and a large chandelier.

    9. Fairfield Inn & Suites by Marriott St. Louis Chesterfield

    A hotel with a modern design, featuring a brick facade and large windows.

    10. Courtyard by Marriott St. Louis Chesterfield

    An outdoor patio area with wicker furniture and a central fire feature.

    11. WoodSpring Suites St Peters-OFallon

    A multi-story hotel with a stone facade and a covered entrance.

    12. Residence Inn by Marriott St. Louis Chesterfield

    An outdoor patio with a built-in grill, seating area, and stone walls.

    13. AC Hotel by Marriott St. Louis Chesterfield

    A modern hotel with a prominent entrance, a landscaped courtyard, and a well-lit facade.

    14. Hampton Inn St. Louis/Chesterfield

    A modern kitchen area with a central island, bar stools, and a breakfast bar.

    15. Hilton Garden Inn St. Louis/O'Fallon MO

    A spacious lobby with a high ceiling, a central seating area with sofas and a coffee table, and a large window providing natural light.

    16. SpringHill Suites by Marriott St. Louis Chesterfield

    An outdoor seating area with a table and chairs, a fire feature, and a brick wall.

    17. Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

    A modern kitchen area with a breakfast bar, a coffee machine, and a refrigerator displaying menu options.

    18. TownePlace Suites by Marriott St. Louis Chesterfield

    An outdoor patio area with a stone fire pit, wicker furniture, and a covered seating area with a view of the building's interior.

    19. Hampton Inn St. Louis Wentzville

    A spacious hotel lobby with a long reception desk, multiple seating areas, and large windows allowing natural light.

    20. Courtyard by Marriott St. Louis St. Peters

    An outdoor patio area with wicker furniture, a stone fire pit, and a building in the background.

    Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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    Compare top hotels near Lewis and Clark Trail Trailhead

    A hotel room with a bed, a sofa, a coffee table, and wall art.

    Sleep Inn & Suites O'Fallon MO - Technology Drive

    3.2 km from Lewis and Clark Trail Trailhead View

    A multi-story hotel with a mix of brick and siding exteriors, multiple windows, and a well-maintained lawn.

    Holiday Inn Express St. Louis West - O'Fallon by IHG

    3.2 km from Lewis and Clark Trail Trailhead View

    A spacious lobby with a central round table, two sofas, and a chandelier.

    Drury Plaza Hotel St. Louis Chesterfield

    14.8 km from Lewis and Clark Trail Trailhead View

    A modern kitchen with a bar area, wooden cabinets, and pendant lighting.

    Hyatt Place St. Louis/Chesterfield

    14.9 km from Lewis and Clark Trail Trailhead View

    A spacious lobby with a high ceiling, a dining area, and a seating area with sofas and a coffee table.

    Drury Inn & Suites St. Louis St. Peters

    15 km from Lewis and Clark Trail Trailhead View
    9.0Wonderful1,164 reviews8.4Very good1,001 reviews9.6Exceptional1,325 reviews9.6Exceptional1,002 reviews9.6Exceptional1,000 reviews
    CA $115 CA $136 totalincludes taxes & feesDec 6 - Dec 7 CA $144 CA $170 totalincludes taxes & feesDec 1 - Dec 2 CA $185 CA $215 totalincludes taxes & feesDec 1 - Dec 2 CA $180 CA $209 totalincludes taxes & feesDec 2 - Dec 3 CA $157 CA $180 totalincludes taxes & feesDec 6 - Dec 7
    • Breakfast included
    • Pool
    • Spa
    • Pet-friendly
    • WiFi included
    • Parking
    • Breakfast included
    • Pool
    • Spa
    • Pet-friendly
    • WiFi included
    • Parking
    • Breakfast included
    • Pool
    • Spa
    • Pet-friendly
    • WiFi included
    • Parking
    • Breakfast included
    • Pool
    • Spa
    • Pet-friendly
    • WiFi included
    • Parking
    • Breakfast included
    • Pool
    • Spa
    • Pet-friendly
    • WiFi included
    • Parking

    Hotels recommended for families near Lewis and Clark Trail Trailhead

    Holiday Inn Express St. Louis West - O'Fallon by IHG

    A multi-story hotel with a mix of brick and siding exteriors, multiple windows, and a well-maintained lawn.

    Sleep Inn & Suites O'Fallon MO - Technology Drive

    A hotel room with a bed, a sofa, a coffee table, and wall art.

    Staybridge Suites O'Fallon Chesterfield by IHG

    A hotel entrance with a stone facade, a wooden archway, and a paved walkway.

    Residence Inn by Marriott O'Fallon

    A spacious lobby with a stone fireplace, seating area, and a bar with high stools.

    TownePlace Suites by Marriott St. Louis Chesterfield

    An outdoor patio area with a stone fire pit, wicker furniture, and a covered seating area with a view of the building's interior.

    Hilton Garden Inn St. Louis/O'Fallon MO

    A spacious lobby with a high ceiling, a central seating area with sofas and a coffee table, and a large window providing natural light.

    Free Breakfast. Pool & Gym. Near Progress West Hospital!

    A hotel entrance with a stone facade, a covered walkway, and a red car parked outside.

    Comfort Inn & Suites Chesterfield - St. Louis

    A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.

    Other attractions near Lewis and Clark Trail Trailhead

    A wooden dock extending into a pond with lily pads, surrounded by lush greenery and a clear blue sky.

    August A. Busch Memorial Conservation Area

    Rating: 8.6/10 (7 reviews)

    Explore the great outdoors at August A. Busch Memorial Conservation Area, a lovely green space in Defiance. While in this family-friendly area, you can savor the top-notch restaurants.

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    A chain-link fence with a red sign that reads "REMEMBRANCE DAY" and a date "09-11-01".

    9-11 Memorial

    Rating: 7.6/10 (44 reviews)

    Learn about the local history of O'Fallon when you spend time at 9-11 Memorial. While in this family-friendly area, you can savor the top-notch restaurants.

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    Weldon Spring Site Interpretive Center

    Rating: 8.2/10 (14 reviews)

    You can spend time browsing the exhibits at Weldon Spring Site Interpretive Center during your trip to Weldon Spring Heights. Attend a sporting event while in this family-friendly area or simply enjoy the top-notch restaurants.

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    Hamburg Trail Trailhead

    You can take time to visit Hamburg Trail Trailhead during your travels to Hamburg.

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    Missouri Bluffs Golf Course

    Rating: 7.6/10 (40 reviews)

    Enjoy a round of golf in Weldon Spring Heights at Missouri Bluffs Golf Course. Experience the great live music or attend a sporting event in this family-friendly area.

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    St. Louis Premium Outlets

    Rating: 8.8/10 (369 reviews)

    You can enjoy retail therapy at St. Louis Premium Outlets during your stay in Chesterfield. Discover the top-notch restaurants and great live music in this family-friendly area.

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    Golf Headquarters Family Golfplex

    You can take time to visit Golf Headquarters Family Golfplex during your travels to O'Fallon. Visit the shops in this family-friendly area, or simply enjoy its restaurants.

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    Babler State Park

    Rating: 8.6/10 (59 reviews)

    You can take time to visit Babler State Park during your travels to Chesterfield. Attend a sporting event while in this family-friendly area or simply enjoy the top-notch restaurants.

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    Top Lewis and Clark Trail Trailhead Hotel Reviews

    Sleep Inn & Suites O'Fallon MO - Technology Drive

    A hotel room with a bed, a sofa, a coffee table, and wall art.

    Drury Plaza Hotel St. Louis Chesterfield

    A spacious lobby with a central round table, two sofas, and a chandelier.

    Drury Inn & Suites St. Louis St. Peters

    A spacious lobby with a high ceiling, a dining area, and a seating area with sofas and a coffee table.

    Hyatt Place St. Louis/Chesterfield

    A modern kitchen with a bar area, wooden cabinets, and pendant lighting.

    Holiday Inn Express & Suites St Peters by IHG

    A spacious lobby with a high ceiling, a reception desk, seating areas, and a staircase leading to an upper level.

    TownePlace Suites by Marriott St. Louis Chesterfield

    An outdoor patio area with a stone fire pit, wicker furniture, and a covered seating area with a view of the building's interior.

    Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

    A modern kitchen area with a breakfast bar, a coffee machine, and a refrigerator displaying menu options.

    Holiday Inn Express & Suites Wentzville St Louis West by IHG

    A spacious lobby with a reception desk, seating area, and a conference room.

    Courtyard by Marriott St. Louis Chesterfield

    An outdoor patio area with wicker furniture and a central fire feature.

    Hilton Garden Inn St. Louis/O'Fallon MO

    A spacious lobby with a high ceiling, a central seating area with sofas and a coffee table, and a large window providing natural light.

    Drury Plaza Hotel St. Louis St. Charles

    A modern lobby with orange seating, a flat-screen TV, and a stone accent wall.

    Holiday Inn Express St. Louis West - O'Fallon by IHG

    A multi-story hotel with a mix of brick and siding exteriors, multiple windows, and a well-maintained lawn.

    Staybridge Suites O'Fallon Chesterfield by IHG

    A hotel entrance with a stone facade, a wooden archway, and a paved walkway.

    Residence Inn by Marriott O'Fallon

    A spacious lobby with a stone fireplace, seating area, and a bar with high stools.

    Frequently Asked Questions

    What's the area like around Lewis and Clark Trail Trailhead?

    Lewis and Clark Trail Trailhead is located in Weldon Spring Heights. You'll find 27 hotels and other accommodations within a few miles for a convenient home base.

    What's the best place to stay close to Lewis and Clark Trail Trailhead?

    Sleep Inn & Suites O'Fallon MO - Technology Drive is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an indoor pool. It's located 2 mi (3.2 km) from Lewis and Clark Trail Trailhead. Other good options around the area include Holiday Inn Express & Suites St. Louis - Chesterfield by IHG and Sonesta ES Suites St. Louis - Chesterfield.

    How many hotels can I expect to find near Lewis and Clark Trail Trailhead?

    Expedia has 27 hotels and other accommodations a few miles from Lewis and Clark Trail Trailhead.

    If I need to cancel the hotel reservation for my stay near Lewis and Clark Trail Trailhead, will I receive a refund?

    Yes, most room reservations are refundable if you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you have a non-refundable reservation, it might still be possible to cancel it and receive a refund within 24 hours of your booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to view the best options available near Lewis and Clark Trail Trailhead.

    Where can I learn more about changing or cancelling my trip in the area near Lewis and Clark Trail Trailhead?

    For more details about picking new dates or cancelling your stay near Lewis and Clark Trail Trailhead, click here.

    What can I see and do near Lewis and Clark Trail Trailhead?

    Explore nature at August A. Busch Memorial Conservation Area and Hamburg Trail Trailhead. Missouri Bluffs Golf Course, Babler State Park, and Golf Headquarters Family Golfplex are worth a stop while you're in the area. St. Louis Premium Outlets and 9-11 Memorial are both worth a visit while you're checking out the area.