Title: Lake City Vacation Home Rentals from CA $329: Search Top Private Vacation Homes for Rent | Expedia.ca [Hotels in Lake City](https://expedia.ca/Lake-City-Hotels.d8506.Travel-Guide-Hotels)[Vacation Rentals in Lake City](https://expedia.ca/Lake-City-Vacation-Rentals.d8506.Travel-Guide-VacationRentals)[Lake City Car Rentals](https://expedia.ca/Car-Rentals-In-Lake-City.d8506.Car-Rental-Guide)[Lake City Vacation Packages](https://expedia.ca/Lake-City.d8506.Destination-Travel-Guides) ![Default HTG hotel image](https://media.expedia.com/media/content/shared/images/travelguides/sem-hotels-tablet.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Lake City Vacation Rentals - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Next weekend [Nov 14 - Nov 16](https://www.expedia.ca/Hotel-Search?regionId=8506&startDate=2025-11-14&endDate=2025-11-16&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Nov 21 - Nov 23](https://www.expedia.ca/Hotel-Search?regionId=8506&startDate=2025-11-21&endDate=2025-11-23&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In one month [Dec 5 - Dec 7](https://www.expedia.ca/Hotel-Search?regionId=8506&startDate=2025-12-05&endDate=2025-12-07&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two months [Jan 2 - Jan 4](https://www.expedia.ca/Hotel-Search?regionId=8506&startDate=2026-01-02&endDate=2026-01-04&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Browse Select Lake City Vacation Homes ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/80000000/79670000/79668500/79668437/ad5ff8fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, books, printers](https://images.trvl-media.com/lodging/80000000/79670000/79668500/79668437/de0fb9af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, books, printers](https://images.trvl-media.com/lodging/80000000/79670000/79668500/79668437/ca6cd657.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/80000000/79670000/79668500/79668437/bd6a3dbb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Walking distance from one of South Carolina's top Medical centers. Florence 9.8/10 Exceptional (41) "The house was beautiful. We would stay there again!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Stephanie L. CA $188 CA $329 total includes taxes & fees Nov 13 - Nov 14 [](https://www.expedia.ca/Florence-Hotels-Walking-Distance-From-One-Of-South-Carolinas-Top-Medical-Centers.h79668437.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/104000000/103870000/103861800/103861731/d78ca460.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, iron/ironing board, travel crib, WiFi](https://images.trvl-media.com/lodging/104000000/103870000/103861800/103861731/de384ec0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace](https://images.trvl-media.com/lodging/104000000/103870000/103861800/103861731/23ea7b6f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/104000000/103870000/103861800/103861731/0a272051.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's Florence 10/10 Exceptional (32) "Very clean and comfortable.A perfect overnight stop on the way home from Florida." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Julie R. CA $294 CA $373 total includes taxes & fees Nov 6 - Nov 7 [](https://www.expedia.ca/Florence-Hotels-Take-A-Rest-In-Florence-Ideal-For-I95-Traveler-And-Florence-Center-And-Buc-Ees.h103861731.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-19&endDate=2025-11-20®ionId=8506&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FLake-City-Private-Vacation-Homes.d8506-aaPrivateVacationHomes.Travel-Guide-Accommodation)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FLake-City-Private-Vacation-Homes.d8506-aaPrivateVacationHomes.Travel-Guide-Accommodation) ## Top Lake City Hotel Reviews ![Comfort Inn & Suites](//images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/a0861bce_y.jpg) ### Comfort Inn & Suites 10/10 Excellent "Friendly staff, clean, great location near retail, restaurants and the highway." [](https://expedia.ca/Florence-Hotels-Comfort-Inn-Suites.h38336321.Hotel-Information) ![Staybridge Suites Florence - Civic Center by IHG](//images.trvl-media.com/lodging/22000000/21760000/21758600/21758593/5abcf1ed_y.jpg) ### Staybridge Suites Florence - Civic Center by IHG 10/10 Excellent "Staff was wonderful 😁 clean, quiet , great communication. " [](https://expedia.ca/Florence-Hotels-Staybridge-Suites-Florence-Civic-Center.h21758593.Hotel-Information) ![Home2 Suites by Hilton Florence, SC](//images.trvl-media.com/lodging/8000000/7280000/7271300/7271220/25ce2409_y.jpg) ### Home2 Suites by Hilton Florence, SC 10/10 Excellent "The front desk service was top notch as she assisted me with getting my reservation corrected that Hotel.com messed up." [](https://expedia.ca/Florence-Hotels-Home2-Suites-By-Hilton-Florence.h7271220.Hotel-Information) ![Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG](//images.trvl-media.com/lodging/2000000/1510000/1509700/1509674/17df73d5_y.jpg) ### Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG 10/10 Excellent "Bed had a dip in the middle but room was clean " [](https://expedia.ca/Florence-Hotels-Holiday-Inn-Ex-Hotel-Suites-Florence-I-95-I-20-Civic-Ctr.h1509674.Hotel-Information) ![TownePlace Suites by Marriott Florence](//images.trvl-media.com/lodging/11000000/10630000/10620800/10620701/4140d9d6_y.jpg) ### TownePlace Suites by Marriott Florence 10/10 Excellent "All was well " [](https://expedia.ca/Florence-Hotels-TownePlace-Suites-By-Marriott-Florence.h10620701.Hotel-Information) ![Fairfield Inn & Suites by Marriott Florence I-20](//images.trvl-media.com/lodging/18000000/17040000/17036000/17035960/5dc20640_y.jpg) ### Fairfield Inn & Suites by Marriott Florence I-20 10/10 Excellent "The room was super clean. The check-in staff were super efficient considering i arrived there late in the night (11 pm). There was hot tea available when i needed. " [](https://expedia.ca/Florence-Hotels-Fairfield-Inn-Suites-By-Marriott-Florence-I-20.h17035960.Hotel-Information) ![Hampton Inn & Suites Florence Center](//images.trvl-media.com/lodging/1000000/50000/42900/42876/e1b59003_y.jpg) ### Hampton Inn & Suites Florence Center 10/10 Excellent "Lovely receptionist, nice entrance hall " [](https://expedia.ca/Florence-Hotels-Hampton-Inn-Suites-Florence-Center.h42876.Hotel-Information) ![The Inn at the Crossroads](//images.trvl-media.com/lodging/10000000/9150000/9142300/9142228/06692e76_y.jpg) ### The Inn at the Crossroads 10/10 Excellent "Best hotel in Lake City " [](https://expedia.ca/Florence-Hotels-The-Inn-At-The-Crossroads.h9142228.Hotel-Information) ![Residence Inn Marriott Florence](//images.trvl-media.com/lodging/3000000/2480000/2478700/2478624/a45dedcb_y.jpg) ### Residence Inn Marriott Florence 10/10 Excellent "The in house breakfast was very good, the food tasted fresh, and the staff was very friendly and attentive. The kitchen was an unexpected pleasant surprise. We were able to cook food we had on hand for the rest of our trip instead of dining out." [](https://expedia.ca/Florence-Hotels-Residence-Inn-Marriott-Florence.h2478624.Hotel-Information) ## Find out more about Lake City ## Lake City Vacation Homes information | Number of reviews | 73 | | --- | --- | | Accommodation | 19 Vacation Homes | | Lowest Price | CA $329 | | Highest Price | CA $373 | ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Other - More ways to book - [5 Star Hotels in Florence](https://www.expedia.ca/5Star-Florence-Hotels.s50-0-d1221.Travel-Guide-Filter-Hotels) - [Apartments in Alcolu](https://www.expedia.ca/Alcolu-Apartments.d3000422483-aaApartments.Travel-Guide-Accommodation) - [Coward Hotels](https://www.expedia.ca/Coward-Hotels.d3000353109.Travel-Guide-Hotels) - [Farmstay in Florence](https://www.expedia.ca/Florence-Agritourism.d1221-aaAgritourism.Travel-Guide-Accommodation) - [Aparthotels in Florence](https://www.expedia.ca/Florence-Apart-Hotels.d1221-aaApartHotels.Travel-Guide-Accommodation) - [Apartments in Florence](https://www.expedia.ca/Florence-Apartments.d1221-aaApartments.Travel-Guide-Accommodation) - 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