Title: Lake City Vacation Home Rentals from CA $330: Search Top Private Vacation Homes for Rent | Expedia.ca [Hotels in Lake City](https://expedia.ca/Lake-City-Hotels.d8506.Travel-Guide-Hotels)[Vacation Rentals in Lake City](https://expedia.ca/Lake-City-Vacation-Rentals.d8506.Travel-Guide-VacationRentals)[Lake City Car Rentals](https://expedia.ca/Car-Rentals-In-Lake-City.d8506.Car-Rental-Guide)[Lake City Vacation Packages](https://expedia.ca/Lake-City.d8506.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Lake City Vacation Rentals ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates In two weeks [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=8506&startDate=2025-10-24&endDate=2025-10-26&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In one month [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=8506&startDate=2025-11-07&endDate=2025-11-09&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two months [Dec 5 - Dec 7](https://www.expedia.ca/Hotel-Search?regionId=8506&startDate=2025-12-05&endDate=2025-12-07&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In three months [Jan 2 - Jan 4](https://www.expedia.ca/Hotel-Search?regionId=8506&startDate=2026-01-02&endDate=2026-01-04&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Browse Select Lake City Vacation Homes ![Interior](https://images.trvl-media.com/lodging/121000000/120270000/120261400/120261310/ab0517c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Private kitchen](https://images.trvl-media.com/lodging/121000000/120270000/120261400/120261310/72c688f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/121000000/120270000/120261400/120261310/835fe193.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/121000000/120270000/120261400/120261310/89486a6e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Charming 1-bedroom cabin in welcoming Florence with AC and heating Florence CA $123 CA $209 total includes taxes & fees Oct 20 - Oct 21 [](https://www.expedia.ca/Florence-Hotels-Charming-1-Bedroom-Cabin-In-Welcoming-Florence-With-AC-And-Heating.h120261310.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/80000000/79670000/79668500/79668437/ad5ff8fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, books, printers](https://images.trvl-media.com/lodging/80000000/79670000/79668500/79668437/de0fb9af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/80000000/79670000/79668500/79668437/bd6a3dbb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, books, printers](https://images.trvl-media.com/lodging/80000000/79670000/79668500/79668437/ca6cd657.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Walking distance from one of South Carolina's top Medical centers. Florence 9.8/10 Exceptional (41) "Clean, well stocked and very comfortable. I would definitely stay again if I am in the area." CA $188 CA $330 total includes taxes & fees Oct 20 - Oct 21 [](https://www.expedia.ca/Florence-Hotels-Walking-Distance-From-One-Of-South-Carolinas-Top-Medical-Centers.h79668437.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/104000000/103870000/103861800/103861731/d78ca460.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/104000000/103870000/103861800/103861731/0a272051.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/104000000/103870000/103861800/103861731/e85ce030.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, iron/ironing board, travel crib, WiFi](https://images.trvl-media.com/lodging/104000000/103870000/103861800/103861731/de384ec0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's Florence 10/10 Exceptional (29) "Property had everything we needed for a weekend stay for a wedding. " CA $290 CA $372 total includes taxes & fees Oct 13 - Oct 14 [](https://www.expedia.ca/Florence-Hotels-Take-A-Rest-In-Florence-Ideal-For-I95-Traveler-And-Florence-Center-And-Buc-Ees.h103861731.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-25&endDate=2025-10-26®ionId=8506&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FLake-City-Private-Vacation-Homes.d8506-aaPrivateVacationHomes.Travel-Guide-Accommodation)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FLake-City-Private-Vacation-Homes.d8506-aaPrivateVacationHomes.Travel-Guide-Accommodation) ## Top Lake City Hotel Reviews ![Comfort Inn & Suites](//images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/a0861bce_y.jpg) ### Comfort Inn & Suites 10/10 Excellent "Friendly staff, clean rooms, comfortable beds, nice breakfast. Just a very nice hotel experience. Will definitely stay here again. " [](https://expedia.ca/Florence-Hotels-Comfort-Inn-Suites.h38336321.Hotel-Information) ![Aloft Florence](//images.trvl-media.com/lodging/77000000/76030000/76026200/76026194/0724af0f_y.jpg) ### Aloft Florence 10/10 Excellent "I have to say this was the best hotel I ever stayed in‼️ the staff wonderful all of them they go above and beyond ‼️" [](https://expedia.ca/Florence-Hotels-Aloft-Florence.h76026194.Hotel-Information) ![Quality Inn & Suites Florence Civic Center](//images.trvl-media.com/lodging/1000000/20000/11600/11535/74f401dc_y.jpg) ### Quality Inn & Suites Florence Civic Center 10/10 Excellent "Bueno" [](https://expedia.ca/Florence-Hotels-Quality-Inn-And-Suites-Civic.h11535.Hotel-Information) ![TownePlace Suites by Marriott Florence](//images.trvl-media.com/lodging/11000000/10630000/10620800/10620701/4140d9d6_y.jpg) ### TownePlace Suites by Marriott Florence 10/10 Excellent "Staff super friendly " [](https://expedia.ca/Florence-Hotels-TownePlace-Suites-By-Marriott-Florence.h10620701.Hotel-Information) ![The Inn at the Crossroads](//images.trvl-media.com/lodging/10000000/9150000/9142300/9142228/06692e76_y.jpg) ### The Inn at the Crossroads 10/10 Excellent "A" [](https://expedia.ca/Florence-Hotels-The-Inn-At-The-Crossroads.h9142228.Hotel-Information) ![Home2 Suites by Hilton Florence, SC](//images.trvl-media.com/lodging/8000000/7280000/7271300/7271220/25ce2409_y.jpg) ### Home2 Suites by Hilton Florence, SC 10/10 Excellent "Clean and spacious room. " [](https://expedia.ca/Florence-Hotels-Home2-Suites-By-Hilton-Florence.h7271220.Hotel-Information) ![Residence Inn Marriott Florence](//images.trvl-media.com/lodging/3000000/2480000/2478700/2478624/a45dedcb_y.jpg) ### Residence Inn Marriott Florence 10/10 Excellent "Everything was very nice and the staff was very friendly. " [](https://expedia.ca/Florence-Hotels-Residence-Inn-Marriott-Florence.h2478624.Hotel-Information) ![Hampton Inn & Suites Florence Center](//images.trvl-media.com/lodging/1000000/50000/42900/42876/e1b59003_y.jpg) ### Hampton Inn & Suites Florence Center 10/10 Excellent "Front desk clerk STACY gave excellent service. All other staff and house keepers were very friendly and nice. Definitely will stay again." [](https://expedia.ca/Florence-Hotels-Hampton-Inn-Suites-Florence-Center.h42876.Hotel-Information) ![Fairfield Inn & Suites by Marriott Florence I-20](//images.trvl-media.com/lodging/18000000/17040000/17036000/17035960/5dc20640_y.jpg) ### Fairfield Inn & Suites by Marriott Florence I-20 10/10 Excellent "Nice, clean room!" [](https://expedia.ca/Florence-Hotels-Fairfield-Inn-Suites-By-Marriott-Florence-I-20.h17035960.Hotel-Information) ## Find out more about Lake City ## Lake City Vacation Homes information | Number of reviews | 68 | | --- | --- | | Accommodation | 19 Vacation Homes | | Lowest Price | CA $330 | | Highest Price | CA $372 | ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Other - More ways to book - [5 Star Hotels in Florence](https://www.expedia.ca/5Star-Florence-Hotels.s50-0-d1221.Travel-Guide-Filter-Hotels) - [Apartments in Alcolu](https://www.expedia.ca/Alcolu-Apartments.d3000422483-aaApartments.Travel-Guide-Accommodation) - [Coward Hotels](https://www.expedia.ca/Coward-Hotels.d3000353109.Travel-Guide-Hotels) - [Farmstay in Florence](https://www.expedia.ca/Florence-Agritourism.d1221-aaAgritourism.Travel-Guide-Accommodation) - [Aparthotels in Florence](https://www.expedia.ca/Florence-Apart-Hotels.d1221-aaApartHotels.Travel-Guide-Accommodation) - [Apartments in Florence](https://www.expedia.ca/Florence-Apartments.d1221-aaApartments.Travel-Guide-Accommodation) - 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