Title: Book the Best Jeffersonville SPA Resorts from CA $220 - Spa Hotels in Jeffersonville, IN | Expedia.ca [Hotels in Jeffersonville](https://expedia.ca/Jeffersonville-Hotels.d8031.Travel-Guide-Hotels)[Vacation Rentals in Jeffersonville](https://expedia.ca/Jeffersonville-Vacation-Rentals.d8031.Travel-Guide-VacationRentals)[Flights to Jeffersonville](https://expedia.ca/Cheap-Flights-To-Jeffersonville.d8031.Travel-Guide-Flights)[Jeffersonville Car Rentals](https://expedia.ca/Car-Rentals-In-Jeffersonville.d8031.Car-Rental-Guide)[Jeffersonville Vacation Packages](https://expedia.ca/Jeffersonville.d8031.Destination-Travel-Guides) # Find Spa Hotels in Jeffersonville, IN from CA $220 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Jeffersonville Spa Hotels Tonight [Nov 1 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=8031&startDate=2025-11-01&endDate=2025-11-02&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Nov 2 - Nov 3](https://www.expedia.ca/Hotel-Search?regionId=8031&startDate=2025-11-02&endDate=2025-11-03&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=8031&startDate=2025-11-07&endDate=2025-11-09&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Nov 14 - Nov 16](https://www.expedia.ca/Hotel-Search?regionId=8031&startDate=2025-11-14&endDate=2025-11-16&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Jeffersonville Spa Hotels ![Indoor pool](https://images.trvl-media.com/lodging/1000000/800000/795900/795844/80fbdedc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/800000/795900/795844/2339d325.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Casino](https://images.trvl-media.com/lodging/1000000/800000/795900/795844/bea44cd2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Casino](https://images.trvl-media.com/lodging/1000000/800000/795900/795844/a36c57b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Caesars Southern Indiana - A Caesars Rewards Destination Elizabeth 8.2/10 Very good (1034) "Beautiful property. Perfect stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Karen [](https://www.expedia.ca/Elizabeth-Hotels-Caesars-Southern-Indiana.h795844.Hotel-Information) ![32-inch Smart TV with cable channels](https://images.trvl-media.com/lodging/122000000/121880000/121877400/121877336/a0c5fbcf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/122000000/121880000/121877400/121877336/43341613.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/122000000/121880000/121877400/121877336/eec2d0c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Full-size fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/122000000/121880000/121877400/121877336/51cddfa7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Reserve on Main Downtown Louisville CA $195 CA $227 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Louisville-Hotels-The-Reserve-On-Main.h121877336.Hotel-Information) ![4 restaurants, breakfast, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/b5c46c3f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/9c82234b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![4 restaurants, breakfast, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/ab0af7cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/594caae3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Galt House Hotel Trademark Collection by Wyndham Downtown Louisville 9.0/10 Wonderful (3714) "Great place to stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tia CA $187 CA $220 total includes taxes & fees Nov 25 - Nov 26 [](https://www.expedia.ca/Louisville-Hotels-Galt-House-Hotel-Trademark-Collection-By-Wyndham.h191434.Hotel-Information) ![Bar (on property)](https://images.trvl-media.com/lodging/12000000/11690000/11688300/11688222/9cc68008.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family Apartment, Multiple Beds, Kitchenette, Garden View | Living area](https://images.trvl-media.com/lodging/12000000/11690000/11688300/11688222/3fd39b2e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Signature Apartment, 1 King Bed with Sofa bed, Kitchenette, Garden View | Terrace/patio](https://images.trvl-media.com/lodging/12000000/11690000/11688300/11688222/46f16aa2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Porch](https://images.trvl-media.com/lodging/12000000/11690000/11688300/11688222/f227b8bf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Pillow and Paddock B&B La Grange 10/10 Exceptional (51) "This has been our second time staying here and we will continue to come back. Beautiful home, amazing breakfasts, and wonderful hosts, not much else we could ask for. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rachel CA $424 CA $468 total includes taxes & fees Nov 11 - Nov 12 [](https://www.expedia.ca/Louisville-Hotels-Pillow-And-Paddock-BB.h11688222.Hotel-Information) ![Sauna, body treatments, aromatherapy, hot stone massages](https://images.trvl-media.com/lodging/22000000/21110000/21106200/21106192/4c7c479b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillowtop beds, minibar, in-room safe, desk](https://images.trvl-media.com/lodging/22000000/21110000/21106200/21106192/e108d0ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bars/lounges, cocktail bar, lobby lounge](https://images.trvl-media.com/lodging/22000000/21110000/21106200/21106192/547de83e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 restaurants, breakfast served](https://images.trvl-media.com/lodging/22000000/21110000/21106200/21106192/w5757h3840x3y0-b0a2f211.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Omni Louisville Hotel Downtown Louisville 9.2/10 Wonderful (1662) "Room was very clean and relaxing, we loved how the hotel had a lot of dining options and the drinks were amazing. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lauren CA $279 CA $328 total includes taxes & fees Nov 21 - Nov 22 [](https://www.expedia.ca/Louisville-Hotels-Omni-Louisville-Hotel.h21106192.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/a9b7038a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/22b7d23e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fountain](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/864ff441.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/cef338e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 21c Museum Hotel Louisville Downtown Louisville 9.2/10 Wonderful (1001) "Room was very clean and staff were very friendly. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jennifer CA $225 CA $272 total includes taxes & fees Nov 28 - Nov 29 [](https://www.expedia.ca/Louisville-Hotels-21c-Museum-Hotel-Louisville.h1413350.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-15&endDate=2025-11-16®ionId=8031&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ## Top Jeffersonville Hotel Reviews ![Galt House Hotel Trademark Collection by Wyndham](//images.trvl-media.com/lodging/1000000/200000/191500/191434/b5c46c3f_y.jpg) ### Galt House Hotel Trademark Collection by Wyndham 10/10 Excellent "We enjoyed our stay" [](https://expedia.ca/Louisville-Hotels-Galt-House-Hotel-Trademark-Collection-By-Wyndham.h191434.Hotel-Information) ![Courtyard by Marriott Louisville Airport](//images.trvl-media.com/lodging/1000000/880000/874400/874388/9148c40a_y.jpg) ### Courtyard by Marriott Louisville Airport 10/10 Excellent "Got take out from the restaurant-grilled chicken sandwich was excellent as were the chicken wings. Arugula salad would have been better with a little iceberg and shreded carrots mixed in! Tv going off every 3 or 4 hours was annoying. I had made reservation for a king but room had 2 queens and was told it was last room available. Overall room was nice but king would have been much better!" [](https://expedia.ca/Louisville-Hotels-Courtyard-By-Marriott-Louisville-Airport.h874388.Hotel-Information) ## Frequently asked questions ### How much does a spa hotel in Jeffersonville cost? > Enjoy staying in a spa hotel in Jeffersonville, with plenty of hotels from CA $220 offering incredible amenities. If you're leaning toward a little luxury, prices can rise, and may vary depending on the location, season, and hotel amenities. Be sure to book in advance to enjoy more options and potentially better rates, especially if you're planning a trip during the weekend or around public holidays. ### Is it cheaper to book a spa hotel in Jeffersonville with flights as part of a package deal? > Booking a hotel and flight package on Expedia can be cheaper than booking flights and hotels separately. Bundling can lead to significant savings, especially for international travel or when booking well in advance. However, savings vary depending on factors like destination, travel dates, and availability, so it's wise to compare options. With access to over 300,000 hotels worldwide, Expedia makes it easy to build the perfect [travel package](https://www.expedia.ca/Jeffersonville.d8031.Destination-Travel-Guides). ### Are there any unique spa experiences available in Jeffersonville? > Yes, Jeffersonville, Indiana offers several unique spa experiences that go beyond typical massages and facials. > > > > ZEN Massage Studio provides customizable full-body and chair massages with enhancements tailored for stress relief, pain management, or relaxation, creating a personalised escape for clients. > > > > Simply You Aesthetics & Wellness offers a medical spa experience, including functional medicine, IV hydration, wrinkle-smoothing injectables, permanent makeup, and medical weight loss. They also provide specialised head spa services focused on scalp health and deep relaxation, which is a distinctive wellness offering in the area. > > > > CMC MediSpa features advanced medical aesthetic procedures such as injectables and fillers performed by physicians, emphasising natural beauty enhancement without pressure to upsell. > > > > Perfect Ten Rejuvenation Salon & Spa combines cosmetic treatments like tattoo removal, laser hair removal, Lipo Laser, and Ice Sculpting with rejuvenating facials and body treatments aimed at maintaining natural beauty and youthful skin. ### How can I save on a spa hotel in Jeffersonville with Expedia? > Members always get our best prices. Find our best Jeffersonville spa hotel deals by joining Expedia's free travel rewards program—[One Key™](https://www.expedia.ca/welcome-one-key). As a member, you can unlock instant savings and member perks when you're logged in to your account. For a spontaneous weekend retreat, discover last-minute offers. ### Can I cancel my spa hotel reservation on Expedia? > Many Expedia hotel reservations are refundable, provided that you cancel before the hotel's cancellation deadline. This is often within 24-48 hours of your scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. For maximum flexibility, use Expedia's "Fully refundable property" filter during your search to find the right spa hotel in Jeffersonville for you. ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - Other - More ways to book - [5 Star Hotels in Duncan](https://www.expedia.ca/5Star-Duncan-Georgetown-Hotels.s50-n553248635975849362-0.Travel-Guide-Filter-Hotels) - [Hotels near Atlantis Waterpark](https://www.expedia.ca/Atlantis-Waterpark-Hotels.0-l553248621532656248-0.Travel-Guide-Filter-Hotels) - [Farmstay in Charlestown](https://www.expedia.ca/Charlestown-Agritourism.d7184-aaAgritourism.Travel-Guide-Accommodation) - [Aparthotels in Charlestown](https://www.expedia.ca/Charlestown-Apart-Hotels.d7184-aaApartHotels.Travel-Guide-Accommodation) - [Guest Houses in Charlestown](https://www.expedia.ca/Charlestown-Guest-Houses.d7184-aaGuestHouses.Travel-Guide-Accommodation) - [Charlestown Hotels](https://www.expedia.ca/Charlestown-Hotels.d7184.Travel-Guide-Hotels) - 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