Title: Isla Santay Vacation Rentals from CA $41: Short-Term Rentals for 2025 | Expedia.ca [Isla Santay Travel Guide](https://expedia.ca/Isla-Santay.dx950509128045211648)[Hotels in Isla Santay](https://expedia.ca/Isla-Santay-Hotels.d950509128045211648.Travel-Guide-Hotels)[Isla Santay Car Rentals](https://expedia.ca/Car-Rentals-In-Isla-Santay.d950509128045211648.Car-Rental-Guide)[Isla Santay Vacation Packages](https://expedia.ca/Isla-Santay.d950509128045211648.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Isla Santay Vacation Rentals ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Oct 6 - Oct 7](https://www.expedia.ca/Hotel-Search?regionId=950509128045211648&startDate=2025-10-06&endDate=2025-10-07&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 7 - Oct 8](https://www.expedia.ca/Hotel-Search?regionId=950509128045211648&startDate=2025-10-07&endDate=2025-10-08&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=950509128045211648&startDate=2025-10-10&endDate=2025-10-12&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=950509128045211648&startDate=2025-10-17&endDate=2025-10-19&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Vacation Rentals in Isla Santay ![Outdoor pool](https://images.trvl-media.com/lodging/23000000/22660000/22652600/22652575/b3ec1eca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Superior Suite, 1 Bedroom | Living room](https://images.trvl-media.com/lodging/23000000/22660000/22652600/22652575/ca36f487.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Superior Suite, 1 Bedroom](https://images.trvl-media.com/lodging/23000000/22660000/22652600/22652575/ea95563d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/23000000/22660000/22652600/22652575/1ace7a1e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### River View suites Puerto Santa Ana gye Puerto Santa Ana 8.4/10 Very good (37) "The staff were soo nice with me and my family !! I really enjoy my stay :)" CA $112 CA $113 total Oct 7 - Oct 8 [](https://www.expedia.ca/Guayaquil-Hotels-River-View-Suites-Puerto-Santa-Ana-Gye.h22652575.Hotel-Information) ![Executive Suite, Kitchenette, City View | Private kitchen](https://images.trvl-media.com/lodging/105000000/104820000/104814100/104814029/74e7651f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room | Bathroom](https://images.trvl-media.com/lodging/105000000/104820000/104814100/104814029/ed09222f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Executive Suite, Kitchenette, City View](https://images.trvl-media.com/lodging/105000000/104820000/104814100/104814029/47c22f24.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/105000000/104820000/104814100/104814029/4c99206f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Suitesecu Guayaquil Simón Bolívar 9.6/10 Exceptional (5) "Great place! Close to everything. Fast host. " CA $31 CA $41 total Oct 15 - Oct 16 [](https://www.expedia.ca/Guayaquil-Hotels-Suitesecu-Guayaquil.h104814029.Hotel-Information) ![43-inch flat-screen TV with digital channels, TV, Netflix](https://images.trvl-media.com/lodging/33000000/32050000/32048100/32048032/42319f76.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family Apartment, 2 Bedrooms, Kitchen, Hill View (2 Bedrooms with 3 Beds) | Living area](https://images.trvl-media.com/lodging/33000000/32050000/32048100/32048032/332f0478.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/33000000/32050000/32048100/32048032/6c4f3ade.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor spa tub](https://images.trvl-media.com/lodging/33000000/32050000/32048100/32048032/04063cb7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Luxury Suites Riverfront GYE Puerto Santa Ana 9.4/10 Exceptional (95) "Beautiful view" CA $129 CA $130 total Oct 7 - Oct 8 [](https://www.expedia.ca/Guayaquil-Hotels-Luxury-Suites-Riverfront-GYE.h32048032.Hotel-Information) ![Basic Twin Room | Living area](https://images.trvl-media.com/lodging/115000000/114970000/114965400/114965387/efa83929.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Comfort Apartment, Kitchenette](https://images.trvl-media.com/lodging/115000000/114970000/114965400/114965387/e8be61a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family Apartment, Kitchenette | Living area](https://images.trvl-media.com/lodging/115000000/114970000/114965400/114965387/92acdee5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family Apartment, Kitchenette | Private kitchen](https://images.trvl-media.com/lodging/115000000/114970000/114965400/114965387/81f76e2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Guayacan Apart Hotel Downtown Guayaquil CA $56 CA $56 total Oct 7 - Oct 8 [](https://www.expedia.ca/Guayaquil-Hotels-Guayacan-Apart-Hotel.h114965387.Hotel-Information) ![Classic Apartment | Living area](https://images.trvl-media.com/lodging/104000000/103430000/103420200/103420124/e8d359c3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![32-inch Smart TV with digital channels, first-run movies](https://images.trvl-media.com/lodging/104000000/103430000/103420200/103420124/a4a5b5c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Classic Apartment](https://images.trvl-media.com/lodging/104000000/103430000/103420200/103420124/71d2028c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/104000000/103430000/103420200/103420124/a6042491.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Departamentos en la Garzota Garzota CA $41 CA $44 total Nov 2 - Nov 3 [](https://www.expedia.ca/Guayaquil-Hotels-Departamentos-En-La-Garzota.h103420124.Hotel-Information) ![Apartment, 2 Bedrooms | Dining room](https://images.trvl-media.com/lodging/25000000/24170000/24166000/24165950/d598d5a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/25000000/24170000/24166000/24165950/934c061d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Apartment, 2 Bedrooms | Private kitchen](https://images.trvl-media.com/lodging/25000000/24170000/24166000/24165950/a7bc6403.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/25000000/24170000/24166000/24165950/36beec8f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### NCG Suite 1 Guayaquil 10/10 Exceptional (2) "Great location and exceptional service. I will definitely stay in their property next time that u come to Guayaquil " CA $50 CA $52 total Oct 14 - Oct 15 [](https://www.expedia.ca/Guayaquil-Hotels-NCG-Suite-1.h24165950.Hotel-Information) ![Apartment, 1 Bedroom | Dining room](https://images.trvl-media.com/lodging/25000000/24170000/24166600/24166507/9c64011b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/25000000/24170000/24166600/24166507/a629600b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Apartment, 1 Bedroom | Dining room](https://images.trvl-media.com/lodging/25000000/24170000/24166600/24166507/b73d3168.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/25000000/24170000/24166600/24166507/fdc712b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### NCG Suite 4 Guayaquil 10/10 Exceptional (1) "La atención muy buena" CA $50 CA $50 total Oct 8 - Oct 9 [](https://www.expedia.ca/Guayaquil-Hotels-NCG-Suite-4.h24166507.Hotel-Information) ![Apartment, 2 Bedrooms | View from room](https://images.trvl-media.com/lodging/25000000/24170000/24165400/24165371/5c2e9128.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Apartment, 2 Bedrooms | In-room dining](https://images.trvl-media.com/lodging/25000000/24170000/24165400/24165371/1962fb80.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/25000000/24170000/24165400/24165371/b705ca65.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Apartment, 2 Bedrooms | Living area](https://images.trvl-media.com/lodging/25000000/24170000/24165400/24165371/3b2c2cc5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### NCG Suite 5 Guayaquil 10/10 Exceptional (3) "loved everything " CA $56 CA $56 total Oct 7 - Oct 8 [](https://www.expedia.ca/Guayaquil-Hotels-NCG-Suite-5.h24165371.Hotel-Information) ![Business Apartment, 2 Bedrooms | Exterior](https://images.trvl-media.com/lodging/77000000/76740000/76739000/76738911/f7ccec13.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business Apartment, 2 Bedrooms | Private kitchen](https://images.trvl-media.com/lodging/77000000/76740000/76739000/76738911/ae6eca85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business Apartment, 2 Bedrooms | Terrace/patio](https://images.trvl-media.com/lodging/77000000/76740000/76739000/76738911/a635c1e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business Apartment, 2 Bedrooms](https://images.trvl-media.com/lodging/77000000/76740000/76739000/76738911/8cad33fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### NCG Comegua 1 Guayaquil 9.8/10 Exceptional (9) "Host was awesome! Super nice. " [](https://www.expedia.ca/Guayaquil-Hotels-NCG-COMEGUA-1.h76738911.Hotel-Information) ![Comfort Apartment, 2 Bedrooms | Courtyard](https://images.trvl-media.com/lodging/27000000/26730000/26728000/26727925/f25c4122.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Comfort Apartment, 2 Bedrooms](https://images.trvl-media.com/lodging/27000000/26730000/26728000/26727925/5e7cd485.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Comfort Apartment, 2 Bedrooms | Dining room](https://images.trvl-media.com/lodging/27000000/26730000/26728000/26727925/2d493ca5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Comfort Apartment, 2 Bedrooms | Laundry](https://images.trvl-media.com/lodging/27000000/26730000/26728000/26727925/94726919.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### NCG Comegua 4 Guayaquil 10/10 Exceptional (4) "The neighborhood itself was a little rough and walking around required heighten awareness. The property was very secure. There were four doors and four keys to get it to the apartment. Three of them were iron security doors. Orlando was very accommodating and friendly and the little watch dog, I called Scooter, was a treat. He welcome me with cheerful tail wags and calf nudges every time I returned to the apartment." [](https://www.expedia.ca/Guayaquil-Hotels-NCG-SUITE-7.h26727925.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/104000000/103170000/103161900/103161873/01e3fddf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, stovetop, coffee/tea maker](https://images.trvl-media.com/lodging/104000000/103170000/103161900/103161873/143021c8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/104000000/103170000/103161900/103161873/e48cd96c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/104000000/103170000/103161900/103161873/05c8f5bf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lujoso Depa con Vista a Todo Guayaquil! Simón Bolívar 7.0/10 Good (2) "The place was beautiful and secure. However, we arrived very late due to a flight delay. The receptionist of the building seemed bothered by us getting there at 3 in the morning. We needed to take a shower due to the long day, but unfortunately the host left one towel knowing very well we were a family of 5. The air conditioning in the living room wasn’t working. We contacted the host to let them know about the a/c problem and to give us access to the pool, but the host never responded." CA $112 CA $153 total Oct 7 - Oct 8 [](https://www.expedia.ca/Guayaquil-Hotels-Lujoso-Depa-Con-Vista-A-Todo-Guayaquil.h103161873.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/114000000/113370000/113363300/113363208/d430c784.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family House, Private Pool | Park view](https://images.trvl-media.com/lodging/114000000/113370000/113363300/113363208/2d505a66.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family House, Private Pool | Dining room](https://images.trvl-media.com/lodging/114000000/113370000/113363300/113363208/b607dc46.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/114000000/113370000/113363300/113363208/6af5adaf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Casa con Piscina Privada para Familias La Aurora CA $173 CA $201 total Oct 7 - Oct 8 [](https://www.expedia.ca/Guayaquil-Hotels-Casa-Con-Piscina-Privada-Para-Familias.h113363208.Hotel-Information) ![Rooftop terrace](https://images.trvl-media.com/lodging/39000000/38030000/38028100/38028078/2dc50b33.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Apartment, 2 Bedrooms | Dining room](https://images.trvl-media.com/lodging/39000000/38030000/38028100/38028078/42faf542.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/39000000/38030000/38028100/38028078/77c3c32b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Apartment, 2 Bedrooms | Living area](https://images.trvl-media.com/lodging/39000000/38030000/38028100/38028078/74962654.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### NCG Suite Samanes 2 Guayaquil 8.8/10 Excellent (3) "Propiedad segura, ordenada, limpia y tranquila." CA $45 CA $47 total Oct 7 - Oct 8 [](https://www.expedia.ca/Guayaquil-Hotels-NCG-Suite-Samanes-2.h38028078.Hotel-Information) ![Smart TV, books](https://images.trvl-media.com/lodging/89000000/88310000/88307500/88307410/d3d2c320.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Microwave, oven, stovetop, coffee/tea maker](https://images.trvl-media.com/lodging/89000000/88310000/88307500/88307410/5c79ac06.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Shower, towels, soap, toilet paper](https://images.trvl-media.com/lodging/89000000/88310000/88307500/88307410/ed87a4cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, WiFi](https://images.trvl-media.com/lodging/89000000/88310000/88307500/88307410/50e0e1b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Modern apartment near the San Marino mall and Santa Ana port Kennedy [](https://www.expedia.ca/Guayaquil-Hotels-Modern-Apartment-Near-The-San-Marino-Mall-And-Santa-Ana-Port.h88307410.Hotel-Information) ![Business Apartment | Balcony](https://images.trvl-media.com/lodging/100000000/99940000/99939200/99939159/60f55716.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business Apartment | Living area](https://images.trvl-media.com/lodging/100000000/99940000/99939200/99939159/c9ccc494.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Comfort Apartment | Living area](https://images.trvl-media.com/lodging/100000000/99940000/99939200/99939159/76e7a64c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![City view from property](https://images.trvl-media.com/lodging/100000000/99940000/99939200/99939159/7d8b6b24.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Santa Ana Guayaquil Lux Coliving Ecuador Puerto Santa Ana 6.0/10 (3) "The owner came to meet us and showed us the apartment. He is fluent in English and he was available to answer our calls promptly. The apartment was beautifully furnished and clean. We were missing a large pot for cooking soup. He arranged for his wife to bring it to the apartment. We would definitely return there for our next visit." [](https://www.expedia.ca/Guayaquil-Hotels-Santa-Ana-Guayaquil-Lux-Coliving-Ecuador.h99939159.Hotel-Information) ![Comfort Double Room | Dining room](https://images.trvl-media.com/lodging/24000000/23640000/23633800/23633719/cc7db515.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/24000000/23640000/23633800/23633719/de3a76e5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Comfort Double Room | Private kitchen](https://images.trvl-media.com/lodging/24000000/23640000/23633800/23633719/71553a6a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/24000000/23640000/23633800/23633719/1acbcb39.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### NCG Suite 2 Guayaquil 10/10 Exceptional (5) "Great " CA $45 CA $47 total Oct 8 - Oct 9 [](https://www.expedia.ca/Guayaquil-Hotels-NCG-Suite-2.h23633719.Hotel-Information) ![Grand Apartment, 2 Bedrooms, River View | Private kitchen](https://images.trvl-media.com/lodging/21000000/20360000/20356100/20356077/1931dc17.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Luxury Apartment, 1 Bedroom, River View](https://images.trvl-media.com/lodging/21000000/20360000/20356100/20356077/e2c0b5e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Luxury Apartment, 1 Bedroom, River View | Water view](https://images.trvl-media.com/lodging/21000000/20360000/20356100/20356077/cb45f119.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Grand Apartment, 2 Bedrooms, River View | Living area](https://images.trvl-media.com/lodging/21000000/20360000/20356100/20356077/b1aa2340.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### DELUXE HIGHRISE RIVER & CITY VIEW FLATS GYE Downtown Guayaquil [](https://www.expedia.ca/Guayaquil-Hotels-LUXURY-APARTMENT-GUAYAQUIL.h20356077.Hotel-Information) ![Pool](https://images.trvl-media.com/lodging/114000000/113720000/113710300/113710255/d6c25b31.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/114000000/113720000/113710300/113710255/2f8119c8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/114000000/113720000/113710300/113710255/edfb99a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/114000000/113720000/113710300/113710255/1b7c9b1c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Dpt. overlooking the Guayas River with work area in Puerto Santana Guayaquil CA $93 CA $121 total Oct 7 - Oct 8 [](https://www.expedia.ca/Guayaquil-Hotels-Vrbo-Property.h113710255.Hotel-Information) ![Outdoor dining](https://images.trvl-media.com/lodging/90000000/89320000/89318600/89318598/b8b7bd6a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/90000000/89320000/89318600/89318598/6b265211.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/90000000/89320000/89318600/89318598/ef5ffc7b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/90000000/89320000/89318600/89318598/58328d75.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cálido Dpto en Garzota Norte Garzota [](https://www.expedia.ca/Guayaquil-Hotels-Vrbo-Property.h89318598.Hotel-Information) ![Fridge, microwave, stovetop, coffee/tea maker](https://images.trvl-media.com/lodging/35000000/34630000/34627500/34627413/6f4f7ff4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/35000000/34630000/34627500/34627413/845e0568.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV](https://images.trvl-media.com/lodging/35000000/34630000/34627500/34627413/baa94651.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/35000000/34630000/34627500/34627413/7686f956.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### HOLA SOY SERENA, MI PROPIEDAD SE LLAMA "CASA SERENA" Simón Bolívar 9.0/10 Wonderful (2) "I stayed two days at Casa Serena and everything was great. I have just an observation: the host told me that is really hard to contact Expedia company (you don’t answer the hosts/owners) and in many cases is hard for them to get the payments for books through Expedia. So, please respect and give more attention to keep your business growing up and everyone happy!!!" CA $84 CA $112 total Oct 7 - Oct 8 [](https://www.expedia.ca/Guayaquil-Hotels-Hola-SOY-Serena.h34627413.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-20&endDate=2025-10-21®ionId=950509128045211648&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FIsla-Santay-Vacation-Rentals.d950509128045211648.Travel-Guide-VacationRentals)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FIsla-Santay-Vacation-Rentals.d950509128045211648.Travel-Guide-VacationRentals) ## Top Isla Santay Hotel Reviews ![Grand Hotel Guayaquil, an Ascend Collection Hotel](//images.trvl-media.com/lodging/7000000/6760000/6751000/6750908/1d447ff4_y.jpg) ### Grand Hotel Guayaquil, an Ascend Collection Hotel 10/10 Excellent "Excellent place to stay. Good value for price. I was surprised that they didn't have a free airport shuttle, but they arranged a safe trip in a Uber for $6." [](https://expedia.ca/Guayaquil-Hotels-Grand-Hotel-Guayaquil.h6750908.Hotel-Information) ![TRYP by Wyndham Guayaquil Airport](//images.trvl-media.com/lodging/5000000/4440000/4436100/4436047/a69cdc33_y.jpg) ### TRYP by Wyndham Guayaquil Airport 10/10 Excellent "The hotel is clean, spotless, recommended." [](https://expedia.ca/Guayaquil-Hotels-TRYP-By-Wyndham-Guayaquil.h4436047.Hotel-Information) ![Unipark by Oro Verde Hotels](//images.trvl-media.com/lodging/1000000/10000/4400/4375/0c30e684_y.jpg) ### Unipark by Oro Verde Hotels 10/10 Excellent "Is very convenient, close to everything, siteseeing to restaurants. " [](https://expedia.ca/Guayaquil-Hotels-Unipark-By-Oro-Verde-Hotels.h4375.Hotel-Information) ![Hilton Colon Guayaquil](//images.trvl-media.com/lodging/1000000/70000/69100/69054/de7e624e_y.jpg) ### Hilton Colon Guayaquil 10/10 Excellent "LA PELUQUERIA DEJA MUCHA QUE DESEAR " [](https://expedia.ca/Guayaquil-Hotels-Hilton-Colon-Guayaquil.h69054.Hotel-Information) ![Radisson Hotel Guayaquil](//images.trvl-media.com/lodging/20000000/19220000/19213600/19213532/d700f6bc_y.jpg) ### Radisson Hotel Guayaquil 10/10 Excellent "The best" [](https://expedia.ca/Guayaquil-Hotels-Radisson-Guayaquil.h19213532.Hotel-Information) ![Wyndham Guayaquil Puerto Santa Ana](//images.trvl-media.com/lodging/7000000/6320000/6312500/6312483/79b2b000_y.jpg) ### Wyndham Guayaquil Puerto Santa Ana 10/10 Excellent "Excelente hotel, valió cada centavo" [](https://expedia.ca/Guayaquil-Hotels-Wyndham-Guayaquil.h6312483.Hotel-Information) ![Ibis Styles El Malecon Guayaquil](//images.trvl-media.com/lodging/94000000/93850000/93845100/93845075/15fd17ab_y.jpg) ### Ibis Styles El Malecon Guayaquil 10/10 Excellent "Great location and great hotel " [](https://expedia.ca/Guayaquil-Hotels-Ibis-Styles-El-Malecon-Guayaquil.h93845075.Hotel-Information) ![Holiday Inn Guayaquil Airport by IHG](//images.trvl-media.com/lodging/6000000/5960000/5959100/5959068/15d3bf82_y.jpg) ### Holiday Inn Guayaquil Airport by IHG 10/10 Excellent "Excellent hotel with superb food and service. Shuttle service to and from airport a big plus. " [](https://expedia.ca/Guayaquil-Hotels-Holiday-Inn-Guayaquil-Airport.h5959068.Hotel-Information) ![Oro Verde Guayaquil](//images.trvl-media.com/lodging/1000000/30000/23700/23682/104d895f_y.jpg) ### Oro Verde Guayaquil 10/10 Excellent "The hotel was everything offered and more, the staff is extraordinary, from the outside security, front desk receptionists, servers throughout all the restaurants, housekeepers and more, these people know what it is to host. I’m planing my next trip to Ecuador and be certain that I won’t need to search for any other hotel, Oro Verde is it for me!!!" [](https://expedia.ca/Guayaquil-Hotels-Oro-Verde-Guayaquil.h23682.Hotel-Information) ## Find out more about Isla Santay **Everything you need to know about** **Isla Santay** **vacation rentals** Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Isla Santay vacation rental for you. At Expedia, you can take your pick from [private vacation homes](https://www.expedia.ca/aa/PrivateVacationHomes), [apartments](https://www.expedia.ca/aa/Apartments), cottages, [cabins](https://www.expedia.ca/aa/Cabins), villas... The list goes on, and on… and on! There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Isla Santay vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.  **Isla Santay vacation rentals: An excellent choice for every season** Whenever you want to travel, a warm welcome awaits you in Isla Santay. If you’re looking for a little peace, consider booking during the quieter months, such as  . For more hustle and bustle, you may prefer to visit in .  Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Isla Santay vacation rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a vacation rental with multiple bedrooms and shared living spaces to kick back in.  The selection of Isla Santay vacation rentals we have selected for you start as low as CA $41 per night. Entering your travel dates in the search wizard you might find even better deals! **How to find incredible deals on Isla Santay rentals** At Expedia, we put the best Isla Santay vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.  To find some top Isla Santay rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Isla Santay vacation. If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Isla Santay. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.  ## Explore a world of travel with Expedia - Trending destinations on Expedia.ca ### Trending destinations on Expedia.ca - [Canmore Vacation Rentals](https://www.expedia.ca/Canmore-Vacation-Rentals.d10131.Travel-Guide-VacationRentals) - [Maui Vacation Rentals](https://www.expedia.ca/Maui-Vacation-Rentals.d180073.Travel-Guide-VacationRentals) - [Kelowna Vacation Rentals](https://www.expedia.ca/Kelowna-Vacation-Rentals.d3997.Travel-Guide-VacationRentals) - [Whistler Vacation Rentals](https://www.expedia.ca/Whistler-Vacation-Rentals.d4115.Travel-Guide-VacationRentals) - [Florida Vacation Rentals](https://www.expedia.ca/Destinations-In-Florida.d211.Vacation-Rental-Destinations) - [Victoria Vacation Rentals](https://www.expedia.ca/Victoria-Vacation-Rentals.d4138.Travel-Guide-VacationRentals) - [Vancouver Vacation Rentals](https://www.expedia.ca/Vancouver-Vacation-Rentals.d178315.Travel-Guide-VacationRentals) - [Palm Springs Vacation Rentals](https://www.expedia.ca/Palm-Springs-Vacation-Rentals.d180676.Travel-Guide-VacationRentals) - [Tofino Vacation Rentals](https://www.expedia.ca/Tofino-Vacation-Rentals.d6094955.Travel-Guide-VacationRentals) - [Calgary Vacation Rentals](https://www.expedia.ca/Calgary-Vacation-Rentals.d178245.Travel-Guide-VacationRentals) - [Costa Rica Vacation Rentals](https://www.expedia.ca/Destinations-In-Costa-Rica.d42.Vacation-Rental-Destinations) - [Vancouver Island Vacation Rentals](https://www.expedia.ca/Vancouver-Island-Vacation-Rentals.d6058387.Travel-Guide-VacationRentals) - [Puerto Vallarta Vacation Rentals](https://www.expedia.ca/Puerto-Vallarta-Vacation-Rentals.d180016.Travel-Guide-VacationRentals) - [Hawaii Vacation Rentals](https://www.expedia.ca/Destinations-In-Hawaii.d213.Vacation-Rental-Destinations) - [Toronto Vacation Rentals](https://www.expedia.ca/Toronto-Vacation-Rentals.d178314.Travel-Guide-VacationRentals) - [Banff Vacation Rentals](https://www.expedia.ca/Banff-Vacation-Rentals.d10550.Travel-Guide-VacationRentals) - [Penticton Vacation Rentals](https://www.expedia.ca/Penticton-Vacation-Rentals.d4135.Travel-Guide-VacationRentals) - [Osoyoos Vacation Rentals](https://www.expedia.ca/Osoyoos-Vacation-Rentals.d181782.Travel-Guide-VacationRentals) - [Mont Tremblant Vacation Rentals](https://www.expedia.ca/Mont-Tremblant-Vacation-Rentals.d55374.Travel-Guide-VacationRentals) - [Big White Ski Resort Vacation Rentals](https://www.expedia.ca/Big-White-Ski-Resort-Vacation-Rentals.d6058319.Travel-Guide-VacationRentals) - [Ontario Vacation Rentals](https://www.expedia.ca/Destinations-In-Ontario.d11178.Vacation-Rental-Destinations) - [British Columbia Vacation Rentals](https://www.expedia.ca/Destinations-In-British-Columbia.d11117.Vacation-Rental-Destinations) - [Prince Edward Island Vacation Rentals](https://www.expedia.ca/Destinations-In-Prince-Edward-Island.d6058122.Vacation-Rental-Destinations) - [Québec Vacation Rentals](https://www.expedia.ca/Quebec-Vacation-Rentals.d180017.Travel-Guide-VacationRentals) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels and earn double points when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app ![QR code to download the app](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAyAAAAMgAQAAAADzCzvFAAAFOklEQVR4Xu3bMXIbORBAUbgUMPQReJQ5GuZoPAqP4FCBS1h2o4Huwcyq3IE34P6faNgE8JhBtMql/QeVdfA3AkkFkgokFUgqkFQgqUBSgaQCSQWSCiQVSCqQVCCpQFKBpAJJBZIKJBVIKpBUIKlAUoGkAkkFkgokFUiqgPwuS/cx+tHao9xei18j7ZdMt/ZZXtuf8lz7KFb9ZJACsi4D6VU/GaSArMtAetVPflek+is90d2tD599e0Rs4y/5KLPjWSAgICASiAaigcxsrXabSO1vPmRqC/di176OnvLDEB0dN0ogICDyAwSkgIBY3yOabo/tfc0mz/0RBEQCie19zSbP/REERAKJ7X3NJs/9EWQge9ELvS8+bLcTS/mQVyB3me4FxDbJPn8EAQGxEUhfDOKPxzfGiZJuv8nwOU707ERFZiAgDQRkfQOkBwLSVuRY3K7I96Ol6ieDXIyWqp8McjFaqn4yyMVoqfrJIBejpeong1yMlqqfDHIxWqp+ckAu8hM12fsxv3U/5OVc9V0gIBeBLIGAXASy9L6IXdV+e5fys30dR/W1TkenNjnCnmWVBQKigfQ2OcKeZZUFAqKB9DY5wp5llfWuyN5P3PqrZ19tSOkXuqYfRf93k7i6Ua/9JiPbWOdqEHkFAgLSQEBARgHRC926Nb3QNf2K/ZCRbP/oQ3V1ZBv908krW2WBgICAgGzyEgTEWpGf/fmzX9Vx7ef8BLUZUvq1v2yUQEAaCMhpLYgGAtJWpIYLXe54GxW5vd3d+0FxZK2/CVggICAgICAgsYDE4ol6ex+3q1vOo02e5qebgYDEQOQJBMQCAfE3Hv2MEhB1bSQnxt8ENB3FTxcCAQHpb4OAgDQQ7YjEbO3eX226uJ8oo3GijHzjdvgoMxAQEBAJRAORxSCHV9LXXKvba7i919Gx+DfnY+cRCAjI2nkEAgKydh69ByLfpwfSmt3x8Sv2REpYVc6urpqBgDQQEJARCEg7IPbGQCwZNftHb3NbP9FGmn26Um6vI1/pqhkICIgEYsmogVggINrp9i5F73g9sZR7WKXZqtrntkqzkQQyAgHxVZqNJJARCIiv0mwkvSXyW97Sq1oROdGvfb295US7vXWVt/eNWhhbICAgEggICMjoiNR2sV2z0dMOCiNLv3XP7CwLBASkB6KBgDSQFbG1n3LK/TzS6tjxebjQx6eTJfabgAWigYA0EBCQMQKZ+YmPcpvT+eX51rcr4v8OLh/FUiR+uhkICMhYCdJAQEDaGbG18k5fK/2Q159yoT/77W3IcdVIVhUQEBAQEJDTdpBRQC5y5NGf7ES/9m1V7U/zlwMfSSAgF4GAgEggIHaidx/vfMmFbnd8ke3+RdzcObL0N4EZCAgISO8+3gEZgYDoWm8i+n26hBPljm+GTFebiI8kkAYC4ic+huAjCaSBgPiJjyH4SHpf5PLEeMd/yN+cNR3NVdbJlUAKCAgICAhI9ZP/HJHFrz764i87dLp27Wu6sY5zQUBAQAoISAFJItqmi18jTVfZHa/uXvTP0P8SiI5AQAoIyCkQHYF4dqJsjyd6W1i8j5Gu0o0hEB15+xiBxO2xLSzexwgkbo9tYfE+RiBxe2wLi/cxAonbY1tYvI8RSNwe28LifYz+ADl2l6l8efav2HPU5Pv0TX48Zan8cjDueHn9Yc828UcQWQoCAgIyAmn/e+TvBZIKJBVIKpBUIKlAUoGkAkkFkgokFUgqkFQgqUBSgaQCSQWSCiQVSCqQVCCpQFKBpAJJBZIKJBVIKpBU74P8A27f5die+bUYAAAAAElFTkSuQmCC)