Title: Book the Best Greenville SPA Resorts from CA $157 - Spa Hotels in Greenville, NC | Expedia.ca [Hotels in Greenville](https://expedia.ca/Greenville-Hotels.d2779.Travel-Guide-Hotels)[Vacation Rentals in Greenville](https://expedia.ca/Greenville-Vacation-Rentals.d2779.Travel-Guide-VacationRentals)[Flights to Greenville](https://expedia.ca/Cheap-Flights-To-Greenville.d2779.Travel-Guide-Flights)[Greenville Car Rentals](https://expedia.ca/Car-Rentals-In-Greenville.d2779.Car-Rental-Guide)[Greenville Vacation Packages](https://expedia.ca/Greenville.d2779.Destination-Travel-Guides) ![](https://images.trvl-media.com/place/2779/ca1ae87c-53ac-45e2-96aa-43cff9b357f8.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Spa Hotels in Greenville, NC from CA $157 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Greenville Spa Hotels Tonight [Nov 9 - Nov 10](https://www.expedia.ca/Hotel-Search?regionId=2779&startDate=2025-11-09&endDate=2025-11-10&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Nov 10 - Nov 11](https://www.expedia.ca/Hotel-Search?regionId=2779&startDate=2025-11-10&endDate=2025-11-11&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Nov 14 - Nov 16](https://www.expedia.ca/Hotel-Search?regionId=2779&startDate=2025-11-14&endDate=2025-11-16&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Nov 21 - Nov 23](https://www.expedia.ca/Hotel-Search?regionId=2779&startDate=2025-11-21&endDate=2025-11-23&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Greenville Spa Hotels No exact matches found, but these alternatives could be just right ## Recommended hotels in Greenville ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/123000000/122300000/122291800/122291718/83ded0fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/123000000/122300000/122291800/122291718/1624178a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/123000000/122300000/122291800/122291718/ba16bfba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/123000000/122300000/122291800/122291718/ae9f7353.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Retreat @ Brook Hollow Luxury 3BR/3BA • Garage • Patio & Backyard ECU Greenville CA $158 CA $385 total includes taxes & fees Nov 17 - Nov 18 [](https://www.expedia.ca/Greenville-Hotels-The-Retreat-Brook-Hollow-Luxury-3BR3BA-Garage-Patio-Backyard-ECU.h122291718.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/220000/217400/217352/5ca75dae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, pillowtop beds, desk, blackout drapes](https://images.trvl-media.com/lodging/1000000/220000/217400/217352/92dee2af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/220000/217400/217352/0acd51fa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Combined shower/tub, free toiletries, hair dryer, towels](https://images.trvl-media.com/lodging/1000000/220000/217400/217352/2a68663a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Greenville near East Carolina University Greenville 8.6/10 Excellent (377) "Love staying here. Rooms are was clean and accommodating. Staff super friendly. The kids and I loved it. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lisa CA $157 CA $177 total includes taxes & fees Nov 16 - Nov 17 [](https://www.expedia.ca/Greenville-Hotels-Wingate-By-Wyndham-Greenville.h217352.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/109000000/108400000/108395100/108395066/w3837h2557x3y3-9ca87b37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/109000000/108400000/108395100/108395066/w3837h2415x3y3-72322295.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/109000000/108400000/108395100/108395066/w3840h2556x0y4-0c33f88e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/109000000/108400000/108395100/108395066/w3837h2560x3y0-dfdc5921.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Garden INN Greenville University Uptown Greenville 9.4/10 Exceptional (86) "Excellent stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michael CA $179 CA $202 total includes taxes & fees Nov 16 - Nov 17 [](https://www.expedia.ca/Greenville-Hotels-Hilton-Garden-INN-Greenville-University.h108395066.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/105000000/104470000/104466400/104466390/356f6fc4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/105000000/104470000/104466400/104466390/fdf12260.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free WiFi](https://images.trvl-media.com/lodging/105000000/104470000/104466400/104466390/ce0cefde.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free WiFi](https://images.trvl-media.com/lodging/105000000/104470000/104466400/104466390/2692ddf2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Staybridge Suites Greenville Medical Center by IHG Greenville 9.4/10 Exceptional (194) "Always a great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) William CA $140 CA $159 total includes taxes & fees Nov 23 - Nov 24 [](https://www.expedia.ca/Greenville-Hotels-Staybridge-Suites-Greenville-Medical-Center.h104466390.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/91000000/90160000/90153300/90153266/36cd8e9e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee/tea maker](https://images.trvl-media.com/lodging/91000000/90160000/90153300/90153266/12a39e10.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/91000000/90160000/90153300/90153266/951ab926.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/91000000/90160000/90153300/90153266/90561384.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Homewood Suites By Hilton Greenville, NC Greenville 9.4/10 Exceptional (288) "Very clean property , good breakfast and very polite and helpful front desk " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ranganath CA $167 CA $189 total includes taxes & fees Nov 16 - Nov 17 [](https://www.expedia.ca/Greenville-Hotels-Homewood-Suites-By-Hilton-Greenville.h90153266.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/3000000/2600000/2593900/2593867/31fb46e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/3000000/2600000/2593900/2593867/c60c62e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/3000000/2600000/2593900/2593867/2c82a837.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/3000000/2600000/2593900/2593867/2da51b79.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Greenville Greenville 9.0/10 Wonderful (558) "Parking and check-in process was easy! Hotel was clean!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Klarissa CA $145 CA $164 total includes taxes & fees Nov 30 - Dec 1 [](https://www.expedia.ca/Greenville-Hotels-Hampton-Inn-Greenville.h2593867.Hotel-Information) ![In-room safe, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/300000/296600/296584/d19b7bd8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/300000/296600/296584/feceae8c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/300000/296600/296584/8fc50c3a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/300000/296600/296584/f93c58cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Suites-Greenville Greenville 9.0/10 Wonderful (1002) "Staff was friendly and accommodating. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) GENA CA $153 CA $173 total includes taxes & fees Nov 23 - Nov 24 [](https://www.expedia.ca/Greenville-Hotels-Best-Western-Plus-Suites-Greenville.h296584.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/7000000/6060000/6057700/6057673/f8514e6b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/7000000/6060000/6057700/6057673/3b2e3f70.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/7000000/6060000/6057700/6057673/ab4ea813.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Full-size fridge, microwave, stovetop, dishwasher](https://images.trvl-media.com/lodging/7000000/6060000/6057700/6057673/88403db4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Residence Inn by Marriott Greenville Greenville 8.6/10 Excellent (453) "I truly love stay at this property. It’s so convenient. Close to everything. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Janet CA $156 CA $176 total includes taxes & fees Nov 16 - Nov 17 [](https://www.expedia.ca/Greenville-Hotels-Residence-Inn-Greenville.h6057673.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/21000000/20400000/20392600/20392562/03136946.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free continental breakfast](https://images.trvl-media.com/lodging/21000000/20400000/20392600/20392562/d914847d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/21000000/20400000/20392600/20392562/c12cd9d8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/21000000/20400000/20392600/20392562/9a1f8379.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott Greenville Greenville 8.6/10 Excellent (448) "It was busy on Saturday during breakfast - the woman manning the area seemed like she could of really used someone else working with her to assist." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) carly CA $166 CA $187 total includes taxes & fees Nov 11 - Nov 12 [](https://www.expedia.ca/Greenville-Hotels-Fairfield-Inn-Suites-By-Marriott-Greenville.h20392562.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/110000/102500/102482/30d4a3d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, iron/ironing board, cribs/infant beds](https://images.trvl-media.com/lodging/1000000/110000/102500/102482/c98c2c60.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/110000/102500/102482/faaccec3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pool](https://images.trvl-media.com/lodging/1000000/110000/102500/102482/fdb16233.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Greenville by IHG Greenville 8.4/10 Very good (959) "Great location and breakfast menu " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Angela CA $139 CA $157 total includes taxes & fees Nov 16 - Nov 17 [](https://www.expedia.ca/Greenville-Hotels-Holiday-Inn-Express-Greenville.h102482.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-23&endDate=2025-11-24®ionId=2779&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ## Find out more about Greenville ### Top Greenville attractions for a relaxing vacation Greenville, North Carolina, offers an appealing blend of relaxation and adventure for travellers seeking spa hotels. Begin your journey at the serene River Park North, where you can stroll along scenic paths or kayak in tranquil waters, perfect for unwinding before or after a spa day. Next, immerse yourself in the vibrant local arts scene at the Greenville Museum of Art, showcasing impressive Southern artworks, followed by a leisurely afternoon at the nearby Uptown Greenville, known for its eclectic shops and inviting cafés. For those who enjoy outdoor activities, the nearby East Carolina University campus boasts beautiful gardens and walking trails that are ideal for a refreshing escape. Finally, the popular Greenville Town Common provides a picturesque setting for picnics and outdoor concerts, all while being a stone's throw from hotels that offer spa services. Staying in the heart of the city allows you to enjoy both comfort and convenience, with attentive service and pampering experiences readily available at your fingertips. ### Find the best hotels & resorts with spas in Greenville For travelers seeking relaxation and rejuvenation in Greenville, North Carolina, these hotels provide a perfect retreat with spa amenities to soothe the senses. [Microtel Inn & Suites by Wyndham Greenville/University Medic](https://www.expedia.ca/Greenville-Hotels-Microtel-Inn-Suites-By-Wyndham-GreenvilleUniversity-Medic.h2009531.Hotel-Information) - **Why it's great for tailored spa getaway:** The Microtel Inn & Suites by Wyndham Greenville/University Medic is an ideal choice for guests looking to unwind with spa services, featuring in-room massage options for a tranquil experience. With a solid guest review rating of 7.2, this hotel offers a comfortable and inviting atmosphere to relax after a long day of exploring or business meetings. - **Other amenities:** Guests can enjoy complimentary breakfast daily, including continental options on weekends, ensuring a delightful start to the day. The hotel also provides 24-hour fitness facilities, free self-parking, and early check-in/late check-out options to accommodate various schedules. With daily housekeeping and free toiletries, guests will find convenience and comfort throughout their stay. - **Nearby attractions:** Guy Smith Stadium - 0.5 km ## Top Greenville Hotel Reviews ![Hilton Greenville](//images.trvl-media.com/lodging/1000000/10000/1600/1575/39cdf1d9_y.jpg) ### Hilton Greenville 10/10 Excellent "Ok clean room " [](https://expedia.ca/Greenville-Hotels-Hilton-Greenville.h1575.Hotel-Information) ![Holiday Inn Express Greenville by IHG](//images.trvl-media.com/lodging/1000000/110000/102500/102482/30d4a3d9_y.jpg) ### Holiday Inn Express Greenville by IHG 10/10 Excellent "Staff was very kind and helpful." [](https://expedia.ca/Greenville-Hotels-Holiday-Inn-Express-Greenville.h102482.Hotel-Information) ![Microtel Inn & Suites by Wyndham Greenville/University Medic](//images.trvl-media.com/lodging/3000000/2010000/2009600/2009531/2e252281_y.jpg) ### Microtel Inn & Suites by Wyndham Greenville/University Medic 10/10 Excellent "Everything is perfect " [](https://expedia.ca/Greenville-Hotels-Microtel-Inn-Suites-By-Wyndham-GreenvilleUniversity-Medic.h2009531.Hotel-Information) ![Hampton Inn Greenville](//images.trvl-media.com/lodging/3000000/2600000/2593900/2593867/31fb46e7_y.jpg) ### Hampton Inn Greenville 10/10 Excellent "Great staff, good location, big, clean room. " [](https://expedia.ca/Greenville-Hotels-Hampton-Inn-Greenville.h2593867.Hotel-Information) ![Courtyard Marriott Greenville](//images.trvl-media.com/lodging/1000000/120000/119100/119042/1f6092e1_y.jpg) ### Courtyard Marriott Greenville 10/10 Excellent "Property has an updated fresh design. Rooms clean and comfortable. Liked the ambient lighting and big screen tv. Fresh coffee in the lobby in the morning plus complimentary donuts made it super special! Staff very nice. " [](https://expedia.ca/Greenville-Hotels-Courtyard-Marriott-Greenville.h119042.Hotel-Information) ## Frequently asked questions ### Looking to vacation at a spa hotel in Greenville? > Forget the stress of everyday life and book yourself a lush spa hotel. Travelers recommend the popular shops and gourmet restaurants in Greenville. Spa hotels are a great way to break away from your daily routine and add a layer of luxury to your weekend away. ### What's there to see and do in Greenville? > Enjoy all that Greenville has to offer when you visit Williams Arena at Minges Coliseum, Dowdy–Ficklen Stadium, and Bradford Creek Golf Club. If you have a bit of extra time while you're in the area, you might want to check out Rock Springs Center and Town Common. ### What is a Greenville spa hotel? > Spa hotels in Greenville have full on-site spas and offer services including massages and a selection of beauty treatments. Some also provide a selection of in-room treatments for the ultimate luxury. 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