Title: Book the Best Greenville LUXURY Hotels - Upscale Hotels in Greenville, MO | Expedia.ca [Greenville Travel Guide](https://expedia.ca/Greenville.dx553248634983564794)[Hotels in Greenville](https://expedia.ca/Greenville-Hotels.d553248634983564794.Travel-Guide-Hotels)[Vacation Rentals in Greenville](https://expedia.ca/Greenville-Vacation-Rentals.d553248634983564794.Travel-Guide-VacationRentals)[Greenville Car Rentals](https://expedia.ca/Car-Rentals-In-Greenville.d553248634983564794.Car-Rental-Guide)[Greenville Vacation Packages](https://expedia.ca/Greenville.d553248634983564794.Destination-Travel-Guides) ![Default HTG hotel image](https://media.expedia.com/media/content/shared/images/travelguides/sem-hotels-tablet.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find luxury hotels in Greenville, MO ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Greenville Luxury Hotels Tonight [Oct 19 - Oct 20](https://www.expedia.ca/Hotel-Search?regionId=553248634983564794&startDate=2025-10-19&endDate=2025-10-20&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [Oct 20 - Oct 21](https://www.expedia.ca/Hotel-Search?regionId=553248634983564794&startDate=2025-10-20&endDate=2025-10-21&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=553248634983564794&startDate=2025-10-24&endDate=2025-10-26&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) In two weeks [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=553248634983564794&startDate=2025-10-31&endDate=2025-11-02&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Top Greenville Luxury Hotels ## Find out more about Greenville ### Greenvilleand its attractions for luxury travelers In the heart of Greenville, Missouri, luxury travellers can indulge in a variety of unique experiences that make for an unforgettable getaway. Begin your journey at the stunning Lake Wappapello State Park, where you can enjoy boating, fishing, or simply relaxing on the lakeshore, surrounded by lush greenery and picturesque views. For a taste of local history, visit the nearby town of Piedmont, where the charming antique shops and quaint cafes offer a glimpse into the region's rich heritage. Thrill-seekers can explore the scenic hiking trails in the Mark Twain National Forest, which provide breathtaking vistas and the chance to spot local wildlife. In the evenings, unwind at the luxurious accommodations in the downtown area, where upscale hotels offer elegant suites with modern amenities and attentive service, ensuring your every need is met. Enjoy fine dining options featuring locally-sourced cuisine that reflects the flavour of the Ozarks, making your stay in Greenville a perfect blend of relaxation and adventure. ## Top Greenville Hotel Reviews ## Frequently asked questions ### Are you looking for a luxury hotel for your stay in Greenville? > Amenities are an important consideration when you plan a vacation, so we make it easy to get what you'd like to make your stay special. If you want a posh hotel that has fine dining, a spa, or several swimming pools, Expedia can help you find the best luxury hotel experience that Greenville has to offer. Greenville has some interesting things to see and do including Mark Twain National Forest, so you might want to take in the local sights during your visit. ### When can I expect good weather in Greenville? > Planning for the weather is a good way to make your trip to Greenville relaxing and enjoyable, especially when you're splurging. The hottest months are usually July and August with an average temp of 77°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Greenville is 59 inches. ### What's there to see and do in Greenville? > Experience Greenville with a stop at Mark Twain National Forest, Lake Wappapello, and Lake Wappapello State Park. If you have a bit of extra time while you're in the area, you might want to check out Sam A. 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