Title: Book the Best BUSINESS Hotels in Durham in 2026 | Expedia.ca [Hotels in Durham](https://expedia.ca/Durham-Hotels.d7940.Travel-Guide-Hotels)[Vacation Rentals in Durham](https://expedia.ca/Durham-Vacation-Rentals.d7940.Travel-Guide-VacationRentals)[Flights to Durham](https://expedia.ca/Cheap-Flights-To-Durham.d7940.Travel-Guide-Flights)[Things to do in Durham](https://expedia.ca/Things-To-Do-In-Durham.d7940.Travel-Guide-Activities)[Durham Car Rentals](https://expedia.ca/Car-Rentals-In-Durham.d7940.Car-Rental-Guide)[Durham Vacation Packages](https://expedia.ca/Durham.d7940.Destination-Travel-Guides) ![College town in winter -Durham, New Hampshire ](https://images.trvl-media.com/place/7940/8b9c201d-fa97-4e76-888c-590d01f2d194.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Business Hotels in Durham, NH from CA $105 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Durham Business Hotels Tonight [Dec 22 - Dec 23](https://www.expedia.ca/Hotel-Search?regionId=7940&startDate=2025-12-22&endDate=2025-12-23&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [Dec 23 - Dec 24](https://www.expedia.ca/Hotel-Search?regionId=7940&startDate=2025-12-23&endDate=2025-12-24&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) This weekend [Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=7940&startDate=2025-12-26&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [Jan 2 - Jan 4](https://www.expedia.ca/Hotel-Search?regionId=7940&startDate=2026-01-02&endDate=2026-01-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Top Durham Hotel Reviews ![Hampton Inn & Suites Portsmouth Downtown](https://images.trvl-media.com/lodging/9000000/8270000/8268900/8268861/b0df55fb_y.jpg) ### Hampton Inn & Suites Portsmouth Downtown 10/10 Excellent "The staff was very helpful, professional and kind. All of those that we encountered! Would highly recommend for great breakfast, comfortable bedding, clean and great location! " [](https://expedia.ca/Portsmouth-Hotels-Hampton-Inn-Suites-Portsmouth-Downtown.h8268861.Hotel-Information) ![Fairfield Inn by Marriott Portsmouth-Seacoast](https://images.trvl-media.com/lodging/1000000/10000/6800/6779/017aeeb0_y.jpg) ### Fairfield Inn by Marriott Portsmouth-Seacoast 10/10 Excellent "It was lovely, clean, quiet. Easy parking good breakfast. I always choose Marriot when I am able because I am never disappointed. " [](https://expedia.ca/Portsmouth-Hotels-Fairfield-Inn-By-Marriott-Portsmouth-Seacoast.h6779.Hotel-Information) ![Hampton Inn & Suites Exeter](https://images.trvl-media.com/lodging/4000000/3820000/3814100/3814061/fea2754e_y.jpg) ### Hampton Inn & Suites Exeter 10/10 Excellent "Very friendly staff, clean hotel. I was surprised that breakfast ends at 9:00, thankfully I arrived to breakfast at 8:57." [](https://expedia.ca/Portsmouth-Hotels-Hampton-Inn-Suites-Exeter.h3814061.Hotel-Information) ![Garrison Hotel & Suites Dover-Portsmouth, an Ascend Collection Hotel](https://images.trvl-media.com/lodging/18000000/17930000/17924500/17924431/429c2f1e_y.jpg) ### Garrison Hotel & Suites Dover-Portsmouth, an Ascend Collection Hotel 10/10 Excellent "Griendly efficient staff. Nice room. Very good breakfast selection Gym ooen but pool being renovated" [](https://expedia.ca/Portsmouth-Hotels-The-Garrison-Hotel-Suites-Dover-Durham.h17924431.Hotel-Information) ![Hilton Garden Inn Portsmouth Downtown](https://images.trvl-media.com/lodging/2000000/1470000/1464400/1464340/7de77d01_y.jpg) ### Hilton Garden Inn Portsmouth Downtown 10/10 Excellent "Clean and great location " [](https://expedia.ca/Portsmouth-Hotels-Hilton-Garden-Inn-Portsmouth-Downtown.h1464340.Hotel-Information) ![Anchorage Inn and Resort](https://images.trvl-media.com/lodging/10000000/9320000/9317700/9317652/68fa4886_y.jpg) ### Anchorage Inn and Resort 10/10 Excellent "We stayed here during Christmas by the Sea. The inn was beautifully decorated for Christmas and the staff was very friendly. This is the second time I’ve stayed at this resort and I will stay again. " [](https://expedia.ca/York-Hotels-Anchorage-Inn-And-Resort.h9317652.Hotel-Information) ![Hampton Inn Portsmouth Central](https://images.trvl-media.com/lodging/1000000/60000/55600/55572/e343f353_y.jpg) ### Hampton Inn Portsmouth Central 10/10 Excellent "Great room & pool." [](https://expedia.ca/Portsmouth-Hotels-Hampton-Inn-Portsmouth-Central.h55572.Hotel-Information) ![Holiday Inn Portsmouth by IHG](https://images.trvl-media.com/lodging/1000000/10000/1900/1869/85d3558a_y.jpg) ### Holiday Inn Portsmouth by IHG 10/10 Excellent "It was great!" [](https://expedia.ca/Portsmouth-Hotels-Holiday-Inn-Portsmouth.h1869.Hotel-Information) ![Ashworth by the Sea](https://images.trvl-media.com/lodging/1000000/40000/37600/37503/82c149c5_y.jpg) ### Ashworth by the Sea 10/10 Excellent "The front desk staff were wonderful! Breakfast at the wharfside was was delicious. Room renovations were beautiful! The bed and pillows were very comfy. The fragrance in the lobby was great! Loved it!" [](https://expedia.ca/Portsmouth-Hotels-Ashworth-By-The-Sea.h37503.Hotel-Information) ## Frequently asked questions ### How much do business-friendly hotels in Durham cost? ### What are the best business-friendly hotels in Durham? ### How many business-friendly hotels are there in Durham? ### What are the best cheap business-friendly hotels in Durham? ### Are there any family-friendly hotels in Durham that are also business friendly? ### Why book your business-friendly hotel in Durham with Expedia? ### How can I find cheap business-friendly hotels in Durham? ### What is there to do in Durham near my business-friendly hotel? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - Other - More ways to book - [Beach Hotel Hotels in Barrington ](https://www.expedia.ca/Barrington-Hotels-Beach-Hotel.0-0-d6333108-tBeachHotel.Travel-Guide-Filter-Hotels) - [Boutique Hotels in Barrington ](https://www.expedia.ca/Barrington-Hotels-Boutique-Hotel.0-0-d6333108-tBoutiqueHotel.Travel-Guide-Filter-Hotels) - 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