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Our top choices for Duke Regional Hospital hotels

A breakfast area with a chalkboard menu, a sign indicating breakfast starts here, and a variety of food items like waffles, oatmeal, and fruits.
A Hampton Inn hotel with a modern facade, multiple floors, and a parking lot.
A large indoor swimming pool with clear blue water, surrounded by beige tiled flooring and walls, with large windows allowing natural light.
A hotel room with a bed, a desk with a chair, a flat-screen TV, a microwave, and a mirror.

1. Hampton Inn & Suites Durham/North I-85

Hampton Inn & Suites Durham/North I-85
2.2 km from Duke Regional Hospital
United States
Darrel
CA $175
CA $198 total
includes taxes & fees
Oct 18 - Oct 19
Hampton Inn & Suites Durham/North I-85
A hotel room with two beds, a flat-screen TV, a wooden headboard, and a carpeted floor.
A Holiday Inn Express hotel with a modern design, featuring a prominent sign, multiple windows, and a well-lit entrance.
A breakfast buffet with a bakery section, a coffee station, and a sign indicating the availability of breakfast.
A coffee station with two coffee machines, a coffee press, and various coffee-related items on a counter.

2. Holiday Inn Express Durham by IHG

Holiday Inn Express Durham by IHG
2.4 km from Duke Regional Hospital
United States
Kimberly R
CA $157
CA $178 total
includes taxes & fees
Nov 8 - Nov 9
Holiday Inn Express Durham by IHG
A hotel room with a television on a wooden cabinet, a desk with a chair, and a lamp.
A hotel room with a bed, bedside tables, a nightstand, a mirror, and a bathroom with a sink and mirror.
A Red Roof Cafe with a stone wall, a coffee machine, and two white chairs.
A Red Roof Inn with a modern architectural design, featuring a prominent red sign and a well-maintained lawn.

3. Red Roof Inn Durham - Duke Univ Medical Center

Red Roof Inn Durham - Duke Univ Medical Center
2.3 km from Duke Regional Hospital
United States
Luis
CA $89
CA $104 total
includes taxes & fees
Nov 1 - Nov 2
Red Roof Inn Durham - Duke Univ Medical Center
A stone fire pit surrounded by striped chairs and tables in an outdoor lounge area with a view of a building in the background.
An indoor swimming pool with clear blue water, surrounded by lounge chairs and a tiled floor.
A modern hotel lobby with a reception desk, seating area, and a cityscape mural on the wall.
A modern dining area with a long table, multiple chairs, and a sofa with red ottomans.

4. Hampton Inn & Suites Durham University Medical Center

Hampton Inn & Suites Durham University Medical Center
5 km from Duke Regional Hospital
United States
Nicole
CA $181
CA $205 total
includes taxes & fees
Oct 25 - Oct 26
Hampton Inn & Suites Durham University Medical Center
A bar area with wooden bar stools, pendant lighting, and a counter with a glass display. There are tables and chairs in the background, and the room has a wooden floor.
A bar area with wooden shelves, a chalkboard menu, and various bottles.
A colonial-style building with a covered porch, multiple windows, and outdoor seating.
A hotel room with two beds, a sofa, a TV, and a bathroom visible through a door.

5. The Colonial Inn, an Ascend Collection Hotel

The Colonial Inn, an Ascend Collection Hotel
18.6 km from Duke Regional Hospital
United States
Elizabeth
CA $155
CA $176 total
includes taxes & fees
Oct 25 - Oct 26
The Colonial Inn, an Ascend Collection Hotel
A stone fire pit surrounded by striped chairs and tables in an outdoor lounge area with a view of a building in the background.
A modern indoor space with multiple seating areas, including tables and chairs, a television, and decorative shelves.
A multi-story hotel with a prominent "HOME 2" sign, a brick facade, and a well-lit entrance.
An indoor swimming pool with clear blue water, surrounded by lounge chairs and a tiled floor.

6. Home2 Suites by Hilton Durham University Medical Center

Home2 Suites by Hilton Durham University Medical Center
5 km from Duke Regional Hospital
United States
katey
CA $199
CA $226 total
includes taxes & fees
Oct 18 - Oct 19
Home2 Suites by Hilton Durham University Medical Center
An outdoor patio area with round tables and chairs, large umbrellas, and a glass door entrance.
A modern living room with a fireplace, two sofas, a coffee table, and a TV mounted on the wall.
A multi-story hotel with a brick facade, large windows, and a well-lit entrance.
A hotel room with two beds, a desk, a chair, a sofa, and a TV.

7. Fairfield by Marriott Inn & Suites Durham

Fairfield by Marriott Inn & Suites Durham
18.2 km from Duke Regional Hospital
United States
Chip
CA $169
CA $192 total
includes taxes & fees
Oct 25 - Oct 26
Fairfield by Marriott Inn & Suites Durham
A modern lobby with a central seating area, a TV screen, and a patterned wall.
A reception area with a counter, a welcome sign, a digital screen, and a hallway leading to a dining area.
A modern kitchen with a built-in refrigerator, a gray sofa, and a gray armchair.
An indoor swimming pool with clear water, surrounded by lounge chairs and potted plants.

8. Hampton Inn & Suites Raleigh-Durham Airport-Brier Creek

Hampton Inn & Suites Raleigh-Durham Airport-Brier Creek
18.2 km from Duke Regional Hospital
United States
Maurice
CA $168
CA $191 total
includes taxes & fees
Oct 18 - Oct 19
Hampton Inn & Suites Raleigh-Durham Airport-Brier Creek
A brick pathway flanked by neatly trimmed hedges leading to a building with a red facade and a grey roof.
An outdoor dining area with tables set for four, surrounded by a brick pathway and lush greenery.
A spacious lobby with a long corridor, comfortable seating areas, and large windows providing natural light.
A modern living room with two sofas facing a glass coffee table, a large window with curtains, and a brick wall.

9. Rizzo Center, a Destination by Hyatt Hotel

Rizzo Center, a Destination by Hyatt Hotel
17 km from Duke Regional Hospital
United States
Dale
CA $254
CA $288 total
includes taxes & fees
Nov 1 - Nov 2
Rizzo Center, a Destination by Hyatt Hotel
A spacious lobby with high ceilings, a central fountain, and seating areas.
A bar area with multiple liquor cabinets and hanging pendant lights.
A spacious lobby with a curved seating area, large windows, and a modern chandelier.
An outdoor patio area with wicker furniture, stone pillars, and string lights.

10. Embassy Suites by Hilton Raleigh Durham Airport Brier Creek

Embassy Suites by Hilton Raleigh Durham Airport Brier Creek
18.2 km from Duke Regional Hospital
United States
Darren C.
CA $227
CA $257 total
includes taxes & fees
Oct 18 - Oct 19
Embassy Suites by Hilton Raleigh Durham Airport Brier Creek
Restaurant
A hotel room with two beds, a desk, a chair, a TV, and a bathroom.
A reception area with two wooden reception desks, a potted plant, and a computer on the wall.
An indoor swimming pool with clear water, a lifeguard chair, and a sign indicating no diving.

11. Courtyard Raleigh-Durham Airport/Brier Creek

Courtyard Raleigh-Durham Airport/Brier Creek
16.6 km from Duke Regional Hospital
United States
Sharon
CA $197
CA $223 total
includes taxes & fees
Oct 18 - Oct 19
Courtyard Raleigh-Durham Airport/Brier Creek
A hotel entrance with a stone facade, large wooden doors, and a view into the interior.
A person performing a yoga pose outdoors with trees and a golf course in the background.
An indoor swimming pool with clear blue water, surrounded by lounge chairs and potted plants.
A hotel with a stone lion statue, a covered entrance, and a landscaped garden.

12. Washington Duke Inn & Golf Club

Washington Duke Inn & Golf Club
6.6 km from Duke Regional Hospital
United States
Antonio
CA $342
CA $388 total
includes taxes & fees
Oct 25 - Oct 26
Washington Duke Inn & Golf Club
A swimming pool with lounge chairs and a wooden fence.
A modern bar area with a refrigerated display, wooden bar counter, and seating.
A multi-story hotel with a modern design, featuring a prominent entrance with a glass canopy and an American flag.
A spacious lobby with a reception desk, seating area, and artwork on the walls.

13. Hyatt Place Durham Southpoint

Hyatt Place Durham Southpoint
16.1 km from Duke Regional Hospital
United States
Jessica
CA $192
CA $218 total
includes taxes & fees
Oct 21 - Oct 22
Hyatt Place Durham Southpoint
An indoor swimming pool with clear water, a no diving sign, and a seating area with chairs and tables.
A modern hotel lobby with a long dining table, multiple chairs, a sofa, and a bar area.
A modern kitchen with built-in shelves, a glass backsplash, and a variety of kitchenware.
A modern hotel lobby with a sectional sofa, armchairs, and a coffee table.

14. Hyatt House Raleigh / RDU / Brier Creek

Hyatt House Raleigh / RDU / Brier Creek
17.8 km from Duke Regional Hospital
United States
Alton
CA $157
CA $178 total
includes taxes & fees
Nov 1 - Nov 2
Hyatt House Raleigh / RDU / Brier Creek
An outdoor seating area with wicker furniture and a stone fire pit.
A conference room with a long table, chairs, and a modern chandelier.
A modern hotel lobby with seating areas, large windows, and a dining section.
A hotel lobby with a sofa, chairs, a table, and a large window offering a view of the building.

15. Residence Inn Raleigh-Durham Airport/Brier Creek

Residence Inn Raleigh-Durham Airport/Brier Creek
16.6 km from Duke Regional Hospital
United States
Janet
CA $199
CA $225 total
includes taxes & fees
Oct 18 - Oct 19
Residence Inn Raleigh-Durham Airport/Brier Creek
An outdoor seating area with sofas, chairs, and a fire pit, adjacent to a modern building with large windows.
A modern living room with a fireplace, seating area, and a pool table.
A modern reception area with a marble counter, a wooden bench, and a unique chandelier.
A modern bar area with a long counter, multiple bar stools, and a large screen displaying a sports event.

16. JB Duke Hotel

JB Duke Hotel
6.2 km from Duke Regional Hospital
United States
samantha
CA $284
CA $322 total
includes taxes & fees
Oct 14 - Oct 15
JB Duke Hotel
An outdoor patio with a table set for a meal, surrounded by chairs and a red umbrella.
A compact hotel room with a kitchenette, including a microwave, coffee maker, and dishwasher.
A hotel room with two beds, a flat-screen TV, a desk, and a chair.
A tented outdoor dining area with round tables set for a meal, each with white chairs and yellow tablecloths.

17. DoubleTree Suites by Hilton Raleigh - Durham

DoubleTree Suites by Hilton Raleigh - Durham
14.2 km from Duke Regional Hospital
United States
Stephen
CA $147
CA $166 total
includes taxes & fees
Nov 5 - Nov 6
DoubleTree Suites by Hilton Raleigh - Durham
A modern hotel with a prominent entrance, multiple floors, and a balcony on the second floor.
A modern hotel room with a bed, a desk, a chair, a small seating area, and a kitchenette.
A modern hotel lobby with a reception desk, a beverage refrigerator, and a well-stocked snack bar.
A modern dining area with wooden tables and chairs, large windows, and geometric pendant lighting.

18. SpringHill Suites by Marriott Durham City View

SpringHill Suites by Marriott Durham City View
5.4 km from Duke Regional Hospital
United States
Taurean
CA $183
CA $208 total
includes taxes & fees
Nov 1 - Nov 2
SpringHill Suites by Marriott Durham City View
A spacious, elegantly decorated interior with a central round table, high ceilings, and classic architectural columns.
A banquet hall with round tables, chandeliers, and floral centerpieces.
A spacious living room with a sofa, armchairs, a coffee table, and a chandelier.
A well-lit living room with a sofa, armchairs, a coffee table, and a fireplace.

19. The Carolina Inn, a Destination by Hyatt Hotel

The Carolina Inn, a Destination by Hyatt Hotel
19.9 km from Duke Regional Hospital
United States
Stephanie Pauline
CA $523
CA $594 total
includes taxes & fees
Nov 1 - Nov 2
The Carolina Inn, a Destination by Hyatt Hotel
A lobby with a green sofa, yellow chairs, a coffee table with drinks, and a window with plants.
An indoor swimming pool with clear glass walls, a tiled floor, and a seating area with chairs and a table.
A business center with wooden paneling, multiple workstations, and framed artwork on the walls.
A bar area with a granite countertop, wooden chairs, and a large television screen.

20. Hilton Garden Inn Durham/University Medical Center

Hilton Garden Inn Durham/University Medical Center
9th Street District, 4 km from Duke Regional Hospital
United States
Michael
CA $187
CA $212 total
includes taxes & fees
Nov 9 - Nov 10
Hilton Garden Inn Durham/University Medical Center
View all properties

Compare popular hotels close to Duke Regional Hospital

Property
Star rating
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A breakfast area with a chalkboard menu, a sign indicating breakfast starts here, and a variety of food items like waffles, oatmeal, and fruits.
Hampton Inn & Suites Durham/North I-85
9.0
Wonderful
1,005 reviews
View
A hotel room with two beds, a flat-screen TV, a wooden headboard, and a carpeted floor.
Holiday Inn Express Durham by IHG
8.8
Excellent
1,003 reviews
View
A hotel room with a television on a wooden cabinet, a desk with a chair, and a lamp.
Red Roof Inn Durham - Duke Univ Medical Center
6.8
1,000 reviews
View
A stone fire pit surrounded by striped chairs and tables in an outdoor lounge area with a view of a building in the background.
Hampton Inn & Suites Durham University Medical Center
9.6
Exceptional
572 reviews
View
A bar area with wooden bar stools, pendant lighting, and a counter with a glass display. There are tables and chairs in the background, and the room has a wooden floor.
The Colonial Inn, an Ascend Collection Hotel
9.6
Exceptional
322 reviews
View

Top Duke Regional Hospital Hotel Reviews

Everything within 1 mile

Everything within 1 mile

10/10 Excellent
"This home is thoughtfully laid out and much more spacious than it looks in photos. Our kids enjoyed the snacks each night, and their grandma loved that the home is all one level with smooth floors and bright lighting. Location was perfect for attending events in Durham, Wake Forest and Raleigh. There's also a running path across the street."
Talita M. 3-night trip
Posted 4 hours ago
Everything within 1 mile
Comfort Inn & Suites Durham near Duke University

Comfort Inn & Suites Durham near Duke University

10/10 Excellent
"Arrived a little early and was accommodated by getting my room 30 minutes early. The room was very clean and comfy. The bed was firm but comfortable and the water pressure in the shower wasn’t great but was good enough. We never made it down for breakfast so I can’t comment on it. Also lots of good eating choices within a few minutes drive. I would recommend this property if you are wanting a good hotel for an affordable price."
David 2-night trip
Posted 5 hours ago
Comfort Inn & Suites Durham near Duke University
The Lodge at Duke Medical Center

The Lodge at Duke Medical Center

8/10 Good
"Very convenient to the medical center and university. The staff was very helpful. Good value. Very safe."
Malini 3-night trip
Posted 5 hours ago
The Lodge at Duke Medical Center
Millennium Hotel Durham

Millennium Hotel Durham

10/10 Excellent
"Very nice stay!"
Jeffrey 1-night trip
Posted 15 hours ago
Millennium Hotel Durham
Unscripted Durham, Part of JDV by Hyatt

Unscripted Durham, Part of JDV by Hyatt

8/10 Good
"The place was awesome! I'm not going into details....I came home with some bed bug bites......🤔"
Randell 1-night trip
Posted 1 day ago
Unscripted Durham, Part of JDV by Hyatt
Hilton Durham near Duke University

Hilton Durham near Duke University

10/10 Excellent
"We did not use the amenities, but the hotel was very clean. The bed was very comfortable, and the body wash in the room smelled AMAZING!"
Shaona 1-night trip
Posted 2 days ago
Hilton Durham near Duke University
21c Museum Hotel Durham

21c Museum Hotel Durham

10/10 Excellent
"Stellar customer service!! Look elsewhere for food."
James 3-night trip
Posted 3 days ago
21c Museum Hotel Durham
Curated & Caffeinated! Gem near Duke & Downtown • Espresso bar, Eco+, Fire Pit

Curated & Caffeinated! Gem near Duke & Downtown • Espresso bar, Eco+, Fire Pit

10/10 Excellent
"The house was absolutely immaculate and Kristin could not have nicer or more helpful. The location was just 25 minutes from RDU, 12 minutes from downtown Durham and about a half an hour from Chapel Hill. Comfortable living room for my small group, large screen TV with all the streaming channels and a very cool coffee grinder/maker for regular or espresso coffee. Highly recommend. John L"
John L. 3-night trip
Posted 7 days ago
Curated & Caffeinated! Gem near Duke & Downtown • Espresso bar, Eco+, Fire Pit
Cottage with Yard, Mins to Duke

Cottage with Yard, Mins to Duke

10/10 Excellent
"This was a cheerful home with comfortable beds and many thoughtful extras. We enjoyed our time here."
Mary and Richard D. 2-night trip
Posted 2 months ago
Cottage with Yard, Mins to Duke

Frequently asked questions

What's the area like around Duke Regional Hospital?
Duke Regional Hospital is located in an area of Durham known for its stunning cathedral. If you're looking for a convenient place to stay, check out the 10 hotels and other accommodations you'll find within a mile.
Where is the best place to stay close to Duke Regional Hospital?
Courtyard Durham Near Duke University/Downtown is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and free parking. It's located 2.2 mi (3.5 km) from Duke Regional Hospital. Other good choices within a few miles include Holiday Inn Express Durham by IHG and Red Roof Inn Durham - Duke Univ Medical Center.
How many hotels can I expect to find near Duke Regional Hospital?
Expedia has 10 hotels and other accommodations within a mile from Duke Regional Hospital.
If I need to cancel the hotel reservation for my stay near Duke Regional Hospital, will I receive a refund?
Yes! Most hotel room reservations are fully refundable provided that you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of your scheduled arrival. If you have a non-refundable reservation, you might be able to cancel it and be given a refund within 24 hours of booking. Add dates, click "Search", then you can filter by "fully refundable" to get the best deals near Duke Regional Hospital.
What can I see and do near Duke Regional Hospital?
You might want to spend some time browsing the exhibits at Museum of Life and Science, Nasher Museum of Art at Duke University, or Bennett Place. While you're exploring, swing by American Tobacco Campus, Cameron Indoor Stadium, and Wallace Wade Stadium to learn a bit about the area. You can enjoy live performances at Carolina Theatre and Common Ground Theatre.

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