Title: Visit Mesopotamia: Best of Mesopotamia Tourism | Expedia Travel Guide - Expedia.ca [Hotels in Mesopotamia](https://expedia.ca/Mesopotamia-Hotels.d6208836.Travel-Guide-Hotels)[Vacation Rentals in Mesopotamia](https://expedia.ca/Mesopotamia-Vacation-Rentals.d6208836.Travel-Guide-VacationRentals)[Flights to Mesopotamia](https://expedia.ca/Cheap-Flights-To-Mesopotamia.d6208836.Travel-Guide-Flights)[Mesopotamia Car Rentals](https://expedia.ca/Car-Rentals-In-Mesopotamia.d6208836.Car-Rental-Guide)[Mesopotamia Vacation Packages](https://expedia.ca/Mesopotamia.d6208836.Destination-Travel-Guides) # Mesopotamia ## Travel Guide ![Mesopotamia showing a river or creek and forests](https://images.trvl-media.com/place/6208836/ca0c6990-9932-4f38-bee6-e89ce7080803.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Mesopotamia showing a river or creek and forests](https://images.trvl-media.com/place/6208836/ca0c6990-9932-4f38-bee6-e89ce7080803.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Mesopotamia which includes forests](https://images.trvl-media.com/place/180997/7a653d94-20a1-43a0-b303-6577a8217222.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Foz do Iguaçu which includes bird life](https://images.trvl-media.com/place/180997/ae7673a2-dfbe-430a-b060-de1d51d3af44.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Mesopotamia showing forest scenes and a river or creek](https://images.trvl-media.com/place/6208836/589ecd67-e516-45e9-9448-7351cf47baac.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ## Visit Mesopotamia Things to do #### The awe-inspiring Iguazú Falls is the centerpiece attraction of this northeastern Argentine region, which also hosts the country’s biggest carnival celebration. A heady mix of ancient history, natural beauty and flamboyant festivals features in Argentina’s hot and humid Mesopotamia region. Be inspired by thundering waterfalls, spot exotic wildlife, experience indigenous traditions and relax at sleepy riverside resorts. Mesopotamia sits sandwiched between two mighty rivers, the Río Paraná and Rió Uruguay, and is covered with subtropical rainforests and wetlands. It includes the provinces of Misiones, Corrientes and Entre Ríos. Straddling the Río Iguazú in Misiones province, and shared between Argentina and Brazil, is the UNESCO-protected Iguazú National Park. Come here to admire the 275 individual waterfalls that make up the Iguazú Falls. Follow trails to panoramic lookouts, ride on a speedboat beneath a cascade and see wildlife such as toucans and monkeys. Access the Brazilian side of the park via a short drive from the town of Puerto Iguazú. Tour the towns of Misiones to appreciate the province’s diversity. Find a gemstone mine in Wanda, flower-filled gardens in Montecarlo and colonial architecture in Oberá. Visit 17th-century Jesuit ruins at San Ignacio. Saltos del Moconá, in Parque Provincial Moconá, is another waterfall worth visiting. Discover a breezy esplanade, graceful architecture and artisan markets, which showcase Guarani culture, in Corrientes city. Spend some time at easy-going river towns, including Itati and Ituzaingó. Be amazed by the craggy, granite ravine of Barrancas del Empedrado and hike amid thick forest in Mburucuya National Park. Go in search of some 350 bird species and the rare maned wolf at Esteros del Iberá wetlands reserve. Hot springs, fishing trips, pristine reserves and boisterous carnival parties await in Entre Ríos province. Gualeguaychú explodes into color in February with arguably Argentina’s most famous carnival. The powdery, white sand at nearby Ñandubaysal evokes images of a tropical island paradise. Fish for huge dorado in Santa Elena and enjoy the charm of riverfront Colón. Don’t miss the enormous yatay palm trees in El Palmar National Park. The southern area of Mesopotamia is just a short bus ride from Buenos Aires. You can also fly to Corrientes and Puerto Iguazú and then get around the region via public buses and organized tours. - Mesopotamia Hotel Deals - Vacation Rentals in Mesopotamia ![O2 Hotel Gualeguaychú](https://images.trvl-media.com/lodging/77000000/76460000/76459400/76459363/759ad5d8_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### O2 Hotel Gualeguaychú 115 3 de Febrero Gualeguaychú Entre Ríos CA $59 CA $59 total Feb 2 - Feb 3 Stay at this hotel in Gualeguaychú. Enjoy free WiFi, a 24-hour front desk, and a business center. Popular attractions Gualeguaychú Cathedral and San Martin Square ... 7.6/10 Good! (68 reviews) La limpieza de los cuartos necesita mejorar. También agregar servicios básicos como TV y teléfono en los cuartos Reviewed on Mar 12, 2025 [](https://expedia.ca/Hotel-Search?startDate=02%2F02%2F2026&endDate=03%2F02%2F2026&selected=76459363&PinnedHotelID=76459363&HadPinnedHotel=true®ionId=6208836) ![Marriott Corrientes Hotel](https://images.trvl-media.com/lodging/118000000/117160000/117154200/117154160/45830686_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Marriott Corrientes Hotel Av Costanera Juan Pablo II y Lavalle Corrientes CA $184 CA $184 total Feb 3 - Feb 4 Book a stay at this luxury hotel in Corrientes. Popular attractions Costanera de Corrientes and Cumba Cua Park are located nearby. 9.8/10 Exceptional! (20 reviews) Excelente Reviewed on Jan 21, 2026 [](https://expedia.ca/Hotel-Search?startDate=03%2F02%2F2026&endDate=04%2F02%2F2026&selected=117154160&PinnedHotelID=117154160&HadPinnedHotel=true®ionId=6208836) ![Hathor Concordia](https://images.trvl-media.com/lodging/5000000/4670000/4668300/4668235/cc821f0d_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hathor Concordia Ruta Nacional 14-km 264.5 Concordia Entre Rios Book a stay at this business-friendly hotel in Concordia. Enjoy free breakfast, free WiFi, and room service. Popular attractions Concordia Golf Course and Castillo ... 8.6/10 Excellent! (363 reviews) The hotel staff is very polite Service: "Friendly and efficient," "helpful," "attentive," "welcoming smile," "professional". Reviewed on Dec 5, 2025 [Get rates](https://expedia.ca/Hotel-Search?startDate=11%2F02%2F2026&endDate=12%2F02%2F2026&selected=4668235&PinnedHotelID=4668235&HadPinnedHotel=true®ionId=6208836) [](https://expedia.ca/Hotel-Search?startDate=11%2F02%2F2026&endDate=12%2F02%2F2026&selected=4668235&PinnedHotelID=4668235&HadPinnedHotel=true®ionId=6208836) [See all 496 properties in Mesopotamia](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=29%2F01%2F2026&endDate=30%2F01%2F2026®ionId=6208836) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![Complejo La Loma](https://images.trvl-media.com/lodging/89000000/88090000/88087500/88087470/11027249_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Complejo La Loma Santa Catalina entre Calle 40 y Tonello Federacion Entre Ríos Stay at this aparthotel in Federacion. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Termas Federacion Water Park and Termas de Federacion ... Great self-contained suite! Had a very good experience here. Hosts do not speak English, but were very patient with me as I used Google Translate to communicate. Woman at the desk was very kind. I had arrived late and was able to check in without issue. The suite is great - there is a full bathroom, bedroom and kitchen / dining ... Reviewed on Sep 9, 2023 [](https://expedia.ca/Federacion-Hotels-Complejo-La-Loma.h88087470.Hotel-Information) ![Agustín 1 Apart](https://images.trvl-media.com/lodging/100000000/99270000/99269400/99269311/9cad496d_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Agustín 1 Apart 130 Gral. Pedro Ferré Parana Entre Ríos Stay at this aparthotel in Parana. Enjoy free WiFi, parking (surcharge), and onsite spa services. Popular attractions Plaza de Mayo and Museu De Sitio are located ... 9/10 Wonderful! (4 reviews) Indico Meu problema foi só a garagem, o apartamento é ótimo, limpeza estava impecável. Reviewed on Jan 25, 2025 [](https://expedia.ca/Parana-Hotels-Agustin-1-Apart.h99269311.Hotel-Information) ![Totoras Apart Federacion](https://images.trvl-media.com/lodging/34000000/33350000/33341500/33341429/13800447_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Totoras Apart Federacion Ñandubay (ex Hermanas Betancourt) 2610 Federacion Entre Rios Stay at this aparthotel in Federacion. Enjoy free WiFi, free parking, and room service. Popular attractions Termas de Federacion and Termas Federacion Water ... 7.4/10 Good! (27 reviews) Nada en particular, es buena la relación precio prestación. Reviewed on Jan 3, 2026 [](https://expedia.ca/Federacion-Hotels-Totoras-Apart-Federacion.h33341429.Hotel-Information) [See all properties in Mesopotamia](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience®ionId=6208836&sort=VACATION_RENTAL) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Check Mesopotamia hotel availability [Tonight ](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=2026-01-28&endDate=2026-01-29)[Jan 28 - Jan 29](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=2026-01-28&endDate=2026-01-29) [Tomorrow night ](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=2026-01-29&endDate=2026-01-30)[Jan 29 - Jan 30](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=2026-01-29&endDate=2026-01-30) [This weekend ](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=30%2F01%2F2026&endDate=01%2F02%2F2026)[Jan 30 - Feb 1](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=30%2F01%2F2026&endDate=01%2F02%2F2026) [Next weekend ](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=06%2F02%2F2026&endDate=08%2F02%2F2026)[Feb 6 - Feb 8](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=06%2F02%2F2026&endDate=08%2F02%2F2026) ### Popular places to visit ![Parque Nacional El Palmar, Entre Rios, Argentina.](https://images.trvl-media.com/place/6096826/3ac30eef-b699-482d-95ce-e991c872d599.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### El Palmar National Park Explore the great outdoors at El Palmar National Park, a lovely green space in Ubajay. [](https://expedia.ca/El-Palmar-National-Park-Ubajay.d6096826.Vacation-Attraction) ![Punta San Sebastian, Corrientes, Costanera Corrientes](https://images.trvl-media.com/place/553248621532463961/5eccf4f4-bdb0-4368-8beb-0fffd1c8eab0.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Costanera de Corrientes Enjoy an outing to Costanera de Corrientes during your stay in Corrientes. You can enjoy the restaurants while in the area. [](https://expedia.ca/Costanera-De-Corrientes-Corrientes.d553248621532463961.Vacation-Attraction) ![Parroquia Nuestra Señora de Itati](https://images.trvl-media.com/place/553248621532463967/dcc3f703-5a3b-46d8-99a7-83b2e87b8ea0.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Basilica Nuestra Senora De Itati Learn about the local history of Municipo de Itatí when you take a trip to Basilica Nuestra Senora De Itati. [](https://expedia.ca/Basilica-Nuestra-Senora-De-Itati-Municipo-de-Itati.d553248621532463967.Vacation-Attraction) #### Termas de Federacion Bring your family to Termas de Federacion and have a fun-filled day at this amusement park in Federacion. Stroll along the beaches or discover the area's waterfalls. [](https://expedia.ca/Termas-De-Federacion-Federacion.d553248621532463682.Vacation-Attraction) #### Isla Cambacua Beach Why not spend a lazy afternoon at Isla Cambacua Beach during your trip to Concepción del Uruguay? Experience the area's art scene and museums. [](https://expedia.ca/Isla-Cambacua-Beach-Concepcion-del-Uruguay.d553248635974793609.Vacation-Attraction) #### Corsódromo You can find out about the history of Gualeguaychú when you stop by Corsódromo. Discover the area's museums and spas. [](https://expedia.ca/Corsodromo-Gualeguaychu.d553248621532374259.Vacation-Attraction) ## Cities near Mesopotamia ![Adobe](https://images.trvl-media.com/place/3026/594454f8-3526-4642-9a20-13c59381f9fd.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Rosario ![Vue panoramique de Rosario en Argentine](https://images.trvl-media.com/place/3131/e0ac3a1c-95fd-4135-bd90-83e37e933cc2.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Santa Fe ![A view of the Uruguay river with high water level in Uruguaiana, Brazil](https://images.trvl-media.com/place/3648/cfffca8d-e72d-49ff-a6ca-794810ccaee5.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Uruguaiana !['Go riding At sunset. For two or three hours. The dust, the wild parrots, and the gaucho hats of the guides will add a certain je-ne-sais-quoi to your experience. Argentina has a great tradition in horses and in horseback riding and exploring the wetlands on top of a beautiful animal should not be missed.'](https://images.trvl-media.com/place/6343234/cbd59132-18ef-4760-aebb-1bfcdc8e15bf.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Colonia Carlos Pellegrini - Cities near Mesopotamia - Places of interest [Paysandu](https://expedia.ca/Paysandu.dx2758)[Rosario](https://expedia.ca/Rosario.dx3026)[Santa Fe](https://expedia.ca/Santa-Fe.dx3131)[Uruguaiana](https://expedia.ca/Uruguaiana.dx3648)[Paso de la Patria](https://expedia.ca/Paso-De-La-Patria.dx6050259)[Gualeguay](https://expedia.ca/Gualeguay.dx6323676)[Colonia Carlos Pellegrini](https://expedia.ca/Colonia-Carlos-Pellegrini.dx6343234)[São Borja](https://expedia.ca/Sao-Borja.dx6352007) - [El Palmar National Park ](https://expedia.ca/El-Palmar-National-Park-Ubajay.d6096826.Vacation-Attraction) - [Bodega Vulliez Sermet ](https://expedia.ca/Bodega-Vulliez-Sermet-Colon.d553248621532463666.Vacation-Attraction) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels and earn double points when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. 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