Title: Luxury Vacations in Mesopotamia 2026 | Expedia.ca ![](https://images.trvl-media.com/place/6208836/ca0c6990-9932-4f38-bee6-e89ce7080803.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Mesopotamia Luxury Vacations ## Book a Hotel + Flight or Car together to unlock savings - ## Plan, book, travel with confidence - ### Better together Save up to CA $1,096 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Plan, book, and manage your trip all in one place ## Flight and Luxury hotel deals in Mesopotamia Price found within the past 48 hours. Click for updated prices. ![Hotel Saint George](https://images.trvl-media.com/lodging/4000000/3290000/3281500/3281425/260f31f1_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hotel Saint George CA $910 per person May 8 - May 12 found 9 hours ago Roundtrip non-stop flight included Santiago (SCL) to Iguazu (IGR) 8.8/10 Excellent! (1,015 reviews) Very nice hotel, clean room with nice bathroom shower. And close proximity to restaurants in the area. Excellent breakfast with a large variety and friendly staff. Enjoyed our stay there Reviewed on Mar 19, 2026 ![Gran Melia Iguazú](https://images.trvl-media.com/lodging/1000000/460000/454100/454059/c43a985d_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Gran Melia Iguazú CA $1,186 per person May 9 - May 12 found 9 hours ago Roundtrip non-stop flight included Santiago (SCL) to Iguazu (IGR) 9.2/10 Wonderful! (1,005 reviews) Stunning hotel!!! I wish I can back to this hotel again in the near future Reviewed on Mar 20, 2026 ![Loi Suites Iguazú Hotel](https://images.trvl-media.com/lodging/3000000/2460000/2450100/2450070/71380e56_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Loi Suites Iguazú Hotel CA $1,317 per person May 8 - May 12 found 9 hours ago Roundtrip non-stop flight included Santiago (SCL) to Iguazu (IGR) 9.2/10 Wonderful! (1,008 reviews) This hotel was perfection, from the moment we entered we were in paradise Reviewed on Mar 12, 2026 ![Hotel das Cataratas, A Belmond Hotel, Iguassu Falls](https://images.trvl-media.com/lodging/1000000/60000/53300/53288/3fe012c0_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hotel das Cataratas, A Belmond Hotel, Iguassu Falls CA $2,168 per person May 8 - May 12 found 9 hours ago Roundtrip non-stop flight included Santiago (SCL) to Iguassu Falls (IGU) 9.8/10 Exceptional! (1,006 reviews) You go here for the views of course. The common areas are beautiful. The rooms are 3 star - not 5\. They are worse than a premier inn or a Hampton room - small, shabby and dated. The amenities are not as you’d expect of a 5 star. Not even a plug socket on one side of the bed. The pictures are fixed in a haphazard way. Just awful for the price. Reviewed on Mar 13, 2026 ![Iguazu Grand Resort Spa & Casino](https://images.trvl-media.com/lodging/1000000/980000/979400/979370/afaaa032_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Iguazu Grand Resort Spa & Casino CA $1,102 per person May 8 - May 12 found 9 hours ago Roundtrip non-stop flight included Santiago (SCL) to Iguazu (IGR) 9/10 Wonderful! (626 reviews) We stayed here for only one night for our trip to Iguazu Falls. Room service was excellent, food was yummy. Staff were friendly and helpful. Room is top notch. Grounds were very clean and beautiful. Definitely recommend the hotel. Reviewed on Mar 18, 2026 Don't see what you're looking for? See all available trips from Columbus to Mesopotamia [View all trips](https://expedia.ca/go/package/search/FlightHotel/2026-04-21/2026-04-28/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=AOL&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ## 5\* Luxury holidays in Mesopotamia Price found within the past 48 hours. Click for updated prices. ![Gran Melia Iguazú](https://images.trvl-media.com/lodging/1000000/460000/454100/454059/c43a985d_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Gran Melia Iguazú CA $1,186 per person May 9 - May 12 found 9 hours ago Roundtrip non-stop flight included Santiago (SCL) to Iguazu (IGR) 9.2/10 Wonderful! (1,005 reviews) Stunning hotel!!! I wish I can back to this hotel again in the near future Reviewed on Mar 20, 2026 ![Loi Suites Iguazú Hotel](https://images.trvl-media.com/lodging/3000000/2460000/2450100/2450070/71380e56_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Loi Suites Iguazú Hotel CA $1,317 per person May 8 - May 12 found 9 hours ago Roundtrip non-stop flight included Santiago (SCL) to Iguazu (IGR) 9.2/10 Wonderful! (1,008 reviews) This hotel was perfection, from the moment we entered we were in paradise Reviewed on Mar 12, 2026 ![Hotel das Cataratas, A Belmond Hotel, Iguassu Falls](https://images.trvl-media.com/lodging/1000000/60000/53300/53288/3fe012c0_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hotel das Cataratas, A Belmond Hotel, Iguassu Falls CA $2,168 per person May 8 - May 12 found 9 hours ago Roundtrip non-stop flight included Santiago (SCL) to Iguassu Falls (IGU) 9.8/10 Exceptional! (1,006 reviews) You go here for the views of course. The common areas are beautiful. The rooms are 3 star - not 5\. They are worse than a premier inn or a Hampton room - small, shabby and dated. The amenities are not as you’d expect of a 5 star. Not even a plug socket on one side of the bed. The pictures are fixed in a haphazard way. Just awful for the price. Reviewed on Mar 13, 2026 Don't see what you're looking for? See all available trips from Columbus to Mesopotamia [View all trips](https://expedia.ca/go/package/search/FlightHotel/2026-04-21/2026-04-28/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=AOL&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ## 3 Night Luxury holidays in Mesopotamia Price found within the past 48 hours. Click for updated prices. ![Iguazu Grand Resort Spa & Casino](https://images.trvl-media.com/lodging/1000000/980000/979400/979370/afaaa032_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Iguazu Grand Resort Spa & Casino CA $764 per person May 9 - May 12 found 9 hours ago Roundtrip non-stop flight included Santiago (SCL) to Iguazu (IGR) 9/10 Wonderful! (626 reviews) We stayed here for only one night for our trip to Iguazu Falls. Room service was excellent, food was yummy. Staff were friendly and helpful. Room is top notch. Grounds were very clean and beautiful. Definitely recommend the hotel. Reviewed on Mar 18, 2026 ![Gran Melia Iguazú](https://images.trvl-media.com/lodging/1000000/460000/454100/454059/c43a985d_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Gran Melia Iguazú CA $1,186 per person May 9 - May 12 found 9 hours ago Roundtrip non-stop flight included Santiago (SCL) to Iguazu (IGR) 9.2/10 Wonderful! (1,005 reviews) Stunning hotel!!! I wish I can back to this hotel again in the near future Reviewed on Mar 20, 2026 ![Loi Suites Iguazú Hotel](https://images.trvl-media.com/lodging/3000000/2460000/2450100/2450070/71380e56_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Loi Suites Iguazú Hotel CA $930 per person May 9 - May 12 found 9 hours ago Roundtrip non-stop flight included Santiago (SCL) to Iguazu (IGR) 9.2/10 Wonderful! (1,008 reviews) This hotel was perfection, from the moment we entered we were in paradise Reviewed on Mar 12, 2026 Don't see what you're looking for? See all available trips from Columbus to Mesopotamia [View all trips](https://expedia.ca/go/package/search/FlightHotel/2026-04-21/2026-04-28/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=AOL&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ## 4 Night Luxury holidays in Mesopotamia Price found within the past 48 hours. Click for updated prices. ![Iguazú Jungle Lodge](https://images.trvl-media.com/lodging/5000000/4150000/4140600/4140549/4f23b6fd_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Iguazú Jungle Lodge CA $647 per person May 8 - May 12 found 2 hours ago Roundtrip non-stop flight included Santiago (SCL) to Iguazu (IGR) 9.4/10 Exceptional! (810 reviews) Spacious clean room at the hotel and great service from the staff in assisting with all the transport to and from the falls! Reviewed on Mar 18, 2026 ![Loi Suites Iguazú Hotel](https://images.trvl-media.com/lodging/3000000/2460000/2450100/2450070/71380e56_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Loi Suites Iguazú Hotel CA $1,317 per person May 8 - May 12 found 9 hours ago Roundtrip non-stop flight included Santiago (SCL) to Iguazu (IGR) 9.2/10 Wonderful! (1,008 reviews) This hotel was perfection, from the moment we entered we were in paradise Reviewed on Mar 12, 2026 ![Hotel das Cataratas, A Belmond Hotel, Iguassu Falls](https://images.trvl-media.com/lodging/1000000/60000/53300/53288/3fe012c0_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hotel das Cataratas, A Belmond Hotel, Iguassu Falls CA $2,168 per person May 8 - May 12 found 9 hours ago Roundtrip non-stop flight included Santiago (SCL) to Iguassu Falls (IGU) 9.8/10 Exceptional! (1,006 reviews) You go here for the views of course. The common areas are beautiful. The rooms are 3 star - not 5\. They are worse than a premier inn or a Hampton room - small, shabby and dated. The amenities are not as you’d expect of a 5 star. Not even a plug socket on one side of the bed. The pictures are fixed in a haphazard way. Just awful for the price. Reviewed on Mar 13, 2026 Don't see what you're looking for? See all available trips from Columbus to Mesopotamia [View all trips](https://expedia.ca/go/package/search/FlightHotel/2026-04-21/2026-04-28/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=AOL&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ## Plan the perfect luxury Mesopotamia vacation with Expedia #### What are some benefits when booking luxury Mesopotamia vacations? When you book a luxury Mesopotamia vacation, you get to enjoy some of the best amenities and special features available. Luxury vacation options often feature spa facilities right in your accommodation, along with room service and an on-site restaurant. The quality of the bedding and even the water pressure tends to be better, so it's the perfect solution for travellers looking to put their feet up and relax. #### How can I find all-inclusive luxury vacations in Mesopotamia? If you're looking for something luxurious in Mesopotamia, all you have to do is take advantage of our search filters. You can implement a filter to only show 5-star accommodations as well as some amenities you may be interested in, like spa facilities and hot tubs. When you opt for an all-inclusive package, you can enjoy luxury alongside a potential discount for booking your accommodation and flight together. #### Can I book a cheap luxury vacation? While luxury vacations tend to be on the more costly end of the spectrum, ranging from CA $647, there are a few methods you can try to lower the price as much as possible. When booking a flight and accommodation together, you can enjoy savings of up to 13\. After implementing filters for luxury features, you can also sort by price to list the cheapest luxury packages first. #### Are there luxury spa vacations? Yes, luxury spa vacations are available and quite popular in Mesopotamia. When you book one of these experiences, it's easier than ever to relax, unwind and recharge in between excursions. Either way, you can easily find spa vacations by implementing the spa filter in your search. #### What should I look for in a luxury family vacation in Mesopotamia? When booking something for the whole family, it's important to consider exactly what kind of experience your family will want.Luxury packages make it easy to keep everyone happy with creature comforts. Kids especially enjoy features like pools, a delicious breakfast and plenty of space. Suites tend to offer your family members a bit more privacy and comfort compared to simple rooms throughout Mesopotamia. #### Can I book last-minute luxury vacations? Yes, last-minute bookings are often available in Mesopotamia. All you have to do is enter your travel dates to see what's available. Sometimes, you'll even find additional discounts for booking last-minute, as accommodations are desperate to fill their last remaining spaces. #### What can help me find the best luxury vacation deals in Mesopotamia? You can use a few strategies to find the best deals on luxury vacation packages. Consider travelling during the off-season to take advantage of the typically lower overall prices. Additionally, staying in the less popular parts of Mesopotamia or travelling to more obscure destinations altogether can often lead to lower prices. #### Can I book a luxury vacation that is fully refundable? Yes, fully refundable reservations are sometimes available on luxury vacation packages in Mesopotamia. You can implement a filter for it specifically or check out the policy section on any one of your search results. It should clearly state what's necessary to qualify for a fully refundable booking. #### Why should I book my luxury vacation with Expedia? When you book with Expedia, you can enjoy a one-stop shop for all your travel planning needs. We offer accommodations as well as flights, and you may even be able to enjoy discounts by booking them together. Of course, Expedia Rewards members will find even more discounts and earn points that can be put toward discounts on future bookings. ## Luxury Hotels in Mesopotamia ![Hotel das Cataratas, A Belmond Hotel, Iguassu Falls](https://images.trvl-media.com/lodging/1000000/60000/53300/53288/3fe012c0_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hotel das Cataratas, A Belmond Hotel, Iguassu Falls Rodovia Br 469 Km 32 Foz do Iguaçu PR - 17 hours drive from Termas de Federacion Book a stay at this luxury hotel in Foz do Iguaçu. Enjoy free breakfast, free WiFi, and a full-service spa. Our guests praise the helpful staff and the property ... 9.8/10 Exceptional! (1,002 reviews) An amazing colonial style hotel - luxury from yester year Reviewed on Mar 20, 2026 [](https://expedia.ca/Foz-Do-Iguacu-Hotels-Hotel-Das-Cataratas.h53288.Hotel-Information) ![Iguazu Grand Resort Spa & Casino](https://images.trvl-media.com/lodging/1000000/980000/979400/979370/afaaa032_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Iguazu Grand Resort Spa & Casino Route 12 Km 1640 Puerto Iguazú Misiones - 17 hours drive from Termas de Federacion Book a stay at this luxury hotel in Puerto Iguazú. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular ... 9/10 Wonderful! (635 reviews) We stayed here for only one night for our trip to Iguazu Falls. Room service was excellent, food was yummy. Staff were friendly and helpful. Room is top notch. Grounds were very clean and beautiful. Definitely recommend the hotel. Reviewed on Mar 18, 2026 [](https://expedia.ca/Puerto-Iguazu-Hotels-Iguazu-Grand-Resort-Spa-Casino.h979370.Hotel-Information) ![Gran Melia Iguazú](https://images.trvl-media.com/lodging/1000000/460000/454100/454059/c43a985d_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Gran Melia Iguazú Parque Nacional Iguazu Puerto Iguazú Misiones - 17 hours drive from Termas de Federacion Book a stay at this luxury hotel in Puerto Iguazú. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular ... 9.2/10 Wonderful! (1,003 reviews) We, 4 friends had great time at Gran Melia hotel. The service was great and staff was very friendly. Ordered a half board package, which including dinner and breakfast. The food quality and service were great. Reviewed on Mar 20, 2026 [](https://expedia.ca/Puerto-Iguazu-Hotels-Gran-Melia-Iguazu.h454059.Hotel-Information) [See all 510 properties in Mesopotamia](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Package®ionId=6208836) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## More vacations you might like ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Vacations [](https://expedia.ca/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Vacations [](https://expedia.ca/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Family Vacations [](https://expedia.ca/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Family_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Golf Vacations [](https://expedia.ca/lp/theme-vacations/golf-vacations?rfrr=editorial.Golf_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Luxury Vacations [](https://expedia.ca/lp/theme-vacations/luxury-vacations?rfrr=editorial.Luxury_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Romantic Vacations [](https://expedia.ca/lp/theme-vacations/romantic-vacations?rfrr=editorial.Romantic_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Ski Vacations [](https://expedia.ca/lp/theme-vacations/ski-vacations?rfrr=editorial.Ski_Vacations.click) ### Top Luxury Vacation Destinations > - [Luxury vacations in India ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/80/India) > - [Luxury vacations in France ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/59/France) > - [Luxury vacations in Switzerland ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/174/Switzerland) > - [Luxury vacations in Canada ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/31/Canada) > - [Luxury vacations in Jamaica ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/88/Jamaica) > - [Luxury vacations in Italy ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/86/Italy) > - [Luxury vacations in New Zealand ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/133/New-Zealand) > - [Luxury vacations in the Maldives ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/109/Maldives) > - [Luxury vacations in Costa Rica ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/42/Costa-Rica) > - [Luxury vacations in Florida Keys ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/6023765/Florida-Keys) > - [Luxury vacations in Mexico ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/117/Mexico) > - [Luxury vacations in the Caribbean ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/6022969/Caribbean) > - [Luxury vacations in Zanzibar ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/4186/Zanzibar) > - [Luxury vacations in Cancun ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/179995/Cancun) > - [Luxury vacations in Kerala ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/602187/Kerala) > - [Luxury vacations in Australia ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/10/Australia) > - [Luxury vacations in Puglia ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/6048562/Puglia) > - [Luxury vacations in Cuba ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/44/Cuba) > - [Luxury vacations in Cyprus ](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/45/Cyprus) ## More Vacations Ideas [Flights to Mesopotamia ](https://expedia.ca/Cheap-Flights-To-Mesopotamia.d6208836.Travel-Guide-Flights)[ Mesopotamia Hotels ](https://expedia.ca/Mesopotamia-Hotels.d6208836.Travel-Guide-Hotels)[ Mesopotamia Vacation Rentals ](https://expedia.ca/Mesopotamia-Vacation-Rentals.d6208836.Travel-Guide-VacationRentals)[ Mesopotamia Car Rentals ](https://expedia.ca/Car-Rentals-In-Mesopotamia.d6208836.Car-Rental-Guide)[ Mesopotamia Vacations ](https://expedia.ca/Mesopotamia.d6208836.Destination-Travel-Guides) \* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels and earn double points when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app