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Honeymoon Hotels in Southeast Minnesota

Alexander Mansion Bed and Breakfast

274 East Broadway Winona MN

2 hours drive from Mayo Clinic

Stay at this B&B in Winona. Enjoy free parking, a business center, and daily housekeeping. Popular attractions Winona Arts Center and Watkins Heritage Museum ...

9.8/10 Exceptional! (510 reviews)

"Best Overnight Stay I Have Ever Had. Book it!"

Reviewed on Jun 4, 2026

Residence Inn by Marriott Rochester Mayo Clinic Area

441 W Center St Nw Rochester MN

4 min walk from Mayo Clinic

Stay at this hotel in Rochester. Enjoy free breakfast, free WiFi, and a rooftop terrace. Our guests praise the helpful staff in our reviews. Popular attractions ...

8.6/10 Excellent! (209 reviews)

"Mayo Clinic in Rochester Minnesota is impressive. We were able to walk from our hotel through a pedestrian tunnel system to get to the hospital with access to other clinic buildings, restaurants and shopping. Very convenient for patients and families during the harsh Minnesota winters.I’m"

Reviewed on May 26, 2026

St James Hotel, a Historic Hotel of America

406 Main St. Red Wing MN

2 hours drive from Mayo Clinic

Book a stay at this spa hotel in Red Wing. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff and the comfy rooms in ...

9.2/10 Wonderful! (1,007 reviews)

"Lovely old hotel with lots of amenities. Located along the Mississippi River in downtown Red Wing, a walkable town with a nice 19th century feel to it."

Reviewed on Jun 5, 2026

See all 932 properties in Southeast Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.