
Cayos Zapatilla Adults Only Vacations
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
Better together
Save up to CA $1,096 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place
Flight and Adults Only hotel deals in Cayos Zapatilla
Price found within the past 48 hours. Click for updated prices.

Summit Rainforest & Golf Resort
Price was CA $1,526, price is now CA $1,065 per person
CA $1,065
per person
Oct 17 - Oct 24
found 1 day ago
Roundtrip flight included
Montreal (YUL) to Panama City (PTY)
8.4/10 Very Good! (1,006 reviews)
Beautiful property, not must to see, don’t expect courteous service unless you speak fluent Spanish. People don’t seem to like Norte Americanos very much. Food is bountiful but pretty bland. Best pineapple I’ve ever tasted.
Reviewed on Sep. 2, 2025

Central Hotel Panama Casco Viejo
Casco Viejo
Price was CA $2,966, price is now CA $1,806 per person
CA $1,806
per person
Oct 11 - Oct 18
found 1 day ago
Roundtrip flight included
Toronto (YTO) to Panama City (PTY)
9/10 Wonderful! (986 reviews)
The hotel is so beautiful, the people are very friendly and helpful!
Reviewed on Sep. 2, 2025

NAYARA Bocas del Toro
Price was CA $8,025, price is now CA $5,529 per person
CA $5,529
per person
Nov 24 - Dec 1
found 9 hours ago
Roundtrip flight included
Toronto (YTO) to Panama City (PTY)
10/10 Exceptional! (54 reviews)
Amazing time across the board staying at both the Treehouse and the Ocean Villa for the week. The attention to the details made this an experience like no other. The treehouse created a one-of-a-kind experience especially with the views and birds around the island. Highly recommend doing both. The service staff were extremely kind and attentive to all needs with a caring spirit of service. The housekeeping staff kept the places immaculate each day. The food quality was exceptional, especially at dinner each night in the Elephant House. The focus and creativity of each meal along with the unique presentation each night really made it special. The soups and main course served each night were absoutely the best we have ever experienced. Our conpliments to the chefs. A special thanks to the staff that made us feel very special and exhibited the gift of hospitality. Outstanding service really shined through Gilberto, Andrea, Mikeal, Franco, Ruby, Carlos, Victor, Liz, Williams, Sherill, and so many others! If you desire an intimate, unique resort experience that you will never forget, this is your place!
Reviewed on Aug. 2, 2025


Red Frog Beach Island Resort
Price was CA $2,686, price is now CA $1,968 per person
CA $1,968
per person
Nov 24 - Dec 1
found 9 hours ago
Roundtrip flight included
Toronto (YTO) to Panama City (PTY)
8.8/10 Excellent! (81 reviews)
Red frog and the staff were excellent, we loved our stay and would be happy to come back. The only reason we give it 4 stars instead of 5 is because a good amount of amenities were closed : the pool, zipline, one of the restaurants, and the market. The staff did a good job making up for these closures, they were amazing! But if you’re booked for these you may want to be aware before you arrive.
Reviewed on Aug. 30, 2025
Don't see what you're looking for?
See all available trips from Columbus to Cayos Zapatilla
View all trips5* Adults Only holidays in Cayos Zapatilla
Price found within the past 48 hours. Click for updated prices.

Hotel La Compania Del Valle
Price was CA $1,907, price is now CA $1,525 per person
CA $1,525
per person
Oct 12 - Oct 17
found 6 hours ago
Roundtrip flight included
Toronto (YTO) to Panama City (PTY)
9.8/10 Exceptional! (37 reviews)
The hotel was clean and the room had a nice view. Dining options were far too expensive considering you are far from everywhere so you practically don’t have a chance to go anywhere else without driving. Also there were some very noisy children shouting outside in the garden very early in the morning. I know children are wonderful but someone should ask their parents to control their level of noisiness.
Reviewed on Sep. 5, 2025

Bristol Panama, a Registry Collection Hotel
Bella Vista
Price was CA $1,950, price is now CA $1,541 per person
CA $1,541
per person
Nov 20 - Nov 27
found 1 day ago
Roundtrip non-stop flight included
Edmonton (YEG) to Panama City (PTY)
9.2/10 Wonderful! (1,003 reviews)
A boutique hotel situated in an exceptional location, characterized by its immaculate cleanliness and a staff dedicated to ensuring the exceptional comfort and satisfaction of its guests. The receptionist, Danay, deserves our utmost gratitude for providing invaluable recommendations of places to visit and unique restaurants for my wife and me. Consequently, we wholeheartedly recommend this hotel.
Reviewed on Sep. 6, 2025

Hilton Panama
Bella Vista
Price was CA $2,475, price is now CA $1,990 per person
CA $1,990
per person
Oct 24 - Oct 31
found 22 hours ago
Roundtrip non-stop flight included
Toronto (YTO) to Panama City (PTY)
8.8/10 Excellent! (1,007 reviews)
The staff an the service is excellent. Everyone gives you personal attention
Reviewed on Sep. 8, 2025
Don't see what you're looking for?
See all available trips from Columbus to Cayos Zapatilla
View all trips3 Night Adults Only holidays in Cayos Zapatilla
Price found within the past 48 hours. Click for updated prices.

Central Hotel Panama Casco Viejo
Casco Viejo
Price was CA $1,683, price is now CA $1,139 per person
CA $1,139
per person
Nov 21 - Nov 24
found 1 day ago
Roundtrip flight included
Toronto (YYZ) to Panama City (PTY)
9/10 Wonderful! (986 reviews)
The hotel is so beautiful, the people are very friendly and helpful!
Reviewed on Sep. 2, 2025

NAYARA Bocas del Toro
Price was CA $3,896, price is now CA $2,731 per person
CA $2,731
per person
Nov 21 - Nov 24
found 1 day ago
Roundtrip flight included
Toronto (YYZ) to Panama City (PTY)
10/10 Exceptional! (54 reviews)
Amazing time across the board staying at both the Treehouse and the Ocean Villa for the week. The attention to the details made this an experience like no other. The treehouse created a one-of-a-kind experience especially with the views and birds around the island. Highly recommend doing both. The service staff were extremely kind and attentive to all needs with a caring spirit of service. The housekeeping staff kept the places immaculate each day. The food quality was exceptional, especially at dinner each night in the Elephant House. The focus and creativity of each meal along with the unique presentation each night really made it special. The soups and main course served each night were absoutely the best we have ever experienced. Our conpliments to the chefs. A special thanks to the staff that made us feel very special and exhibited the gift of hospitality. Outstanding service really shined through Gilberto, Andrea, Mikeal, Franco, Ruby, Carlos, Victor, Liz, Williams, Sherill, and so many others! If you desire an intimate, unique resort experience that you will never forget, this is your place!
Reviewed on Aug. 2, 2025

La Loma Jungle Lodge
Price was CA $2,115, price is now CA $1,639 per person
CA $1,639
per person
Nov 21 - Nov 24
found 1 day ago
Roundtrip flight included
Toronto (YYZ) to Panama City (PTY)
9/10 Wonderful! (16 reviews)
Absolutely stunning property. Serene and a great place to disconnect. Staff and owner were friendly and supportive. La Loma did a nice job accommodating dietary issues. I'd highly recommend a stay.
Tips for visitors:
Visitors should consider building in a contingency day in case an activity gets rained out.
One of our party had mobility issues. The family treetop I think would be a good choice. The stairs aren't as steep between the meal place and lodging. Hiking poles also helped with getting up and down the stairs to the dock.
I did the bat tour and bioluminescence tour through them, both super fun. I wore a rash guard top and swim pants for the bat tour and thought that was a good choice.
Suggestions for property:
Every meal is well done for the food that it is, but it would be a great to have a built in either/or choice for the meal so you don't feel like a burden if you'd prefer a different type of food.
The morning muffins are delicious. Consider giving each guest two :).
Reviewed on May 29, 2025
Don't see what you're looking for?
See all available trips from Columbus to Cayos Zapatilla
View all trips4 Night Adults Only holidays in Cayos Zapatilla
Price found within the past 48 hours. Click for updated prices.


Central Hotel Panama Casco Viejo
Casco Viejo
Price was CA $1,908, price is now CA $1,172 per person
CA $1,172
per person
Dec 4 - Dec 8
found 1 day ago
Roundtrip non-stop flight included
Toronto (YYZ) to Panama City (PTY)
9/10 Wonderful! (986 reviews)
The hotel is so beautiful, the people are very friendly and helpful!
Reviewed on Sep. 2, 2025

Megapolis Hotel Panamá
Punta Paitilla
Price was CA $1,216, price is now CA $914 per person
CA $914
per person
Dec 4 - Dec 8
found 1 day ago
Roundtrip non-stop flight included
Toronto (YYZ) to Panama City (PTY)
8.4/10 Very Good! (1,056 reviews)
I didn’t like the fees for additional guest.
Reviewed on Sep. 8, 2025
Don't see what you're looking for?
See all available trips from Columbus to Cayos Zapatilla
View all tripsMore vacations you might like
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.