Title: Adults Only Vacations in Cayos Zapatilla 2026 | Expedia.ca ![](https://images.trvl-media.com/place/6286134/443bad9e-c57b-4b6d-aec8-29e5bf3e9898.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Cayos Zapatilla Adults Only Vacations ## Book a Hotel + Flight or Car together to unlock savings - ## Plan, book, travel with confidence - ### Better together Save up to CA $1,096 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Plan, book, and manage your trip all in one place ## Flight and Adults Only hotel deals in Cayos Zapatilla Price found within the past 48 hours. Click for updated prices. ![Hotel Riu Plaza Panama](https://images.trvl-media.com/lodging/4000000/3910000/3900400/3900395/1eaf88f5_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hotel Riu Plaza Panama Bella Vista CA $1,357 per person Mar 21 - Mar 26 found 1 day ago Roundtrip non-stop flight included Montreal (YMQ) to Panama City (PTY) 9/10 Wonderful! (4,515 reviews) Staff was super nice and helpful. The hotel was in a great location with lots of restaurants and bars within walking distance. Reviewed on Feb 15, 2026 ![Megapolis Hotel Panamá](https://images.trvl-media.com/lodging/92000000/92000000/91995600/91995575/4aee4896_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Megapolis Hotel Panamá San Francisco CA $1,740 per person May 5 - May 12 found 1 day ago Roundtrip non-stop flight included Toronto (YTO) to Panama City (PTY) 8.4/10 Very Good! (1,204 reviews) Nice hotel. Friendly staff Reviewed on Feb 9, 2026 ![Casa Mallet by Wynwood House](https://images.trvl-media.com/lodging/100000000/99780000/99778900/99778891/dfb3f761_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Casa Mallet by Wynwood House Casco Viejo CA $1,784 per person May 5 - May 12 found 1 day ago Roundtrip non-stop flight included Toronto (YTO) to Panama City (PTY) 9.8/10 Exceptional! (24 reviews) Beautiful apartment definitely recommend staying here if you are coming to Panama Reviewed on Nov 29, 2025 ![Casa Contemporanea by Wynwood House](https://images.trvl-media.com/lodging/100000000/99230000/99229300/99229225/64939a66_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Casa Contemporanea by Wynwood House Casco Viejo CA $1,488 per person Apr 18 - Apr 25 found 5 hours ago Roundtrip non-stop flight included Montreal (YMQ) to Panama City (PTY) 8.6/10 Excellent! (19 reviews) Great experience, beautiful apartment. Minor maintenance issues that were addressed in a timely fashion. Would definitely recommend and stay there again! Reviewed on Mar 28, 2025 Don't see what you're looking for? See all available trips from Columbus to Cayos Zapatilla [View all trips](https://expedia.ca/go/package/search/FlightHotel/2026-03-15/2026-03-22/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=PAC&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ## 5\* Adults Only holidays in Cayos Zapatilla Price found within the past 48 hours. Click for updated prices. ![Hotel Riu Plaza Panama](https://images.trvl-media.com/lodging/4000000/3910000/3900400/3900395/1eaf88f5_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hotel Riu Plaza Panama Bella Vista CA $1,199 per person Apr 22 - Apr 28 found 1 day ago Roundtrip non-stop flight included Montreal (YMQ) to Panama City (PTY) 9/10 Wonderful! (4,515 reviews) Staff was super nice and helpful. The hotel was in a great location with lots of restaurants and bars within walking distance. Reviewed on Feb 15, 2026 ![Waldorf Astoria Panama](https://images.trvl-media.com/lodging/5000000/4960000/4952100/4952056/e7e98c5e_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Waldorf Astoria Panama Bella Vista CA $1,708 per person Apr 18 - Apr 25 found 1 day ago Roundtrip non-stop flight included Montreal (YMQ) to Panama City (PTY) 9/10 Wonderful! (1,001 reviews) Clean, very polite and friendly staff. I loved the country. Reviewed on Feb 10, 2026 ![Hotel La Compania Del Valle](https://images.trvl-media.com/lodging/112000000/111210000/111207500/111207482/bd071da6_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hotel La Compania Del Valle CA $2,044 per person Mar 21 - Mar 26 found 1 day ago Roundtrip non-stop flight included Montreal (YMQ) to Panama City (PTY) 9.8/10 Exceptional! (54 reviews) Everything was perfect. Wonderful premises, wonderful staff and a great choice of food with 3 restaurants on site. Unbelievable set of statues all over the place. Highly recommend this gem in Anton Valley. Reviewed on Feb 11, 2026 Don't see what you're looking for? See all available trips from Columbus to Cayos Zapatilla [View all trips](https://expedia.ca/go/package/search/FlightHotel/2026-03-15/2026-03-22/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=PAC&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ## 3 Night Adults Only holidays in Cayos Zapatilla Price found within the past 48 hours. Click for updated prices. ![Megapolis Hotel Panamá](https://images.trvl-media.com/lodging/92000000/92000000/91995600/91995575/4aee4896_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Megapolis Hotel Panamá San Francisco CA $1,072 per person Apr 4 - Apr 6 found 1 day ago Roundtrip non-stop flight included Toronto (YTO) to Panama City (PTY) 8.4/10 Very Good! (1,204 reviews) Nice hotel. Friendly staff Reviewed on Feb 9, 2026 ![Central Hotel Panama Casco Viejo](https://images.trvl-media.com/lodging/16000000/15690000/15683600/15683502/3165768f_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Central Hotel Panama Casco Viejo Casco Viejo CA $1,238 per person Apr 4 - Apr 6 found 1 day ago Roundtrip non-stop flight included Toronto (YTO) to Panama City (PTY) 9/10 Wonderful! (1,002 reviews) Great room, central location, excellent breakfast and courteous staff. Highly recommended. Reviewed on Feb 15, 2026 ![Dreams Playa Bonita Panama - All Inclusive](https://images.trvl-media.com/lodging/13000000/12450000/12445600/12445554/7c338453_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Dreams Playa Bonita Panama - All Inclusive CA $1,302 per person Apr 4 - Apr 6 found 1 day ago Roundtrip non-stop flight included Toronto (YTO) to Panama City (PTY) 7.4/10 Good! (1,002 reviews) It was a wonderful stay with wonderful people Reviewed on Feb 7, 2026 Don't see what you're looking for? See all available trips from Columbus to Cayos Zapatilla [View all trips](https://expedia.ca/go/package/search/FlightHotel/2026-03-15/2026-03-22/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=PAC&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ## 4 Night Adults Only holidays in Cayos Zapatilla Price found within the past 48 hours. Click for updated prices. ![Mahogany Suites](https://images.trvl-media.com/lodging/119000000/118410000/118402400/118402387/179ad971_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Mahogany Suites CA $880 per person May 1 - May 5 found 1 day ago Roundtrip non-stop flight included Toronto (YYZ) to Panama City (PTY) 10/10 Exceptional! (1 review) Excellent apartment on a golf resort. 5 Star. Reviewed on Jan 28, 2026 ![Central Hotel Panama Casco Viejo](https://images.trvl-media.com/lodging/16000000/15690000/15683600/15683502/3165768f_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Central Hotel Panama Casco Viejo Casco Viejo CA $1,353 per person May 1 - May 5 found 1 day ago Roundtrip non-stop flight included Toronto (YYZ) to Panama City (PTY) 9/10 Wonderful! (1,002 reviews) Great room, central location, excellent breakfast and courteous staff. Highly recommended. Reviewed on Feb 15, 2026 ![Megapolis Hotel Panamá](https://images.trvl-media.com/lodging/92000000/92000000/91995600/91995575/4aee4896_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Megapolis Hotel Panamá San Francisco CA $1,310 per person May 1 - May 5 found 1 day ago Roundtrip non-stop flight included Toronto (YYZ) to Panama City (PTY) 8.4/10 Very Good! (1,204 reviews) Nice hotel. Friendly staff Reviewed on Feb 9, 2026 Don't see what you're looking for? See all available trips from Columbus to Cayos Zapatilla [View all trips](https://expedia.ca/go/package/search/FlightHotel/2026-03-15/2026-03-22/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=PAC&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ## More vacations you might like ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Vacations [](https://expedia.ca/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Vacations [](https://expedia.ca/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Family Vacations [](https://expedia.ca/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Family_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Golf Vacations [](https://expedia.ca/lp/theme-vacations/golf-vacations?rfrr=editorial.Golf_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Luxury Vacations [](https://expedia.ca/lp/theme-vacations/luxury-vacations?rfrr=editorial.Luxury_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Romantic Vacations [](https://expedia.ca/lp/theme-vacations/romantic-vacations?rfrr=editorial.Romantic_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Ski Vacations [](https://expedia.ca/lp/theme-vacations/ski-vacations?rfrr=editorial.Ski_Vacations.click) ## More Vacations Ideas [Flights to Cayos Zapatilla ](https://expedia.ca/Cheap-Flights-To-Cayos-Zapatilla.d6286134.Travel-Guide-Flights)[ Cayos Zapatilla Hotels ](https://expedia.ca/Cayos-Zapatilla-Hotels.d6286134.Travel-Guide-Hotels)[ Cayos Zapatilla Vacation Rentals ](https://expedia.ca/Cayos-Zapatilla-Vacation-Rentals.d6286134.Travel-Guide-VacationRentals)[ Cayos Zapatilla Car Rentals ](https://expedia.ca/Car-Rentals-In-Cayos-Zapatilla.d6286134.Car-Rental-Guide)[ Cayos Zapatilla Vacations ](https://expedia.ca/Cayos-Zapatilla.d6286134.Destination-Travel-Guides) \* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels and earn double points when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app