Title: Adults Only Vacations in Eastern Panama 2026 | Expedia.ca ![](https://images.trvl-media.com/place/6246376/42fe0cae-c805-47d5-a705-ee119c68d58c.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Eastern Panama Adults Only Vacations ## Book a Hotel + Flight or Car together to unlock savings Photo by Nico Barner - ## Plan, book, travel with confidence - ### Better together Save up to CA $1,096 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Plan, book, and manage your trip all in one place ## Flight and Adults Only hotel deals in Eastern Panama Price found within the past 48 hours. Click for updated prices. ![Hotel Riu Plaza Panama](https://images.trvl-media.com/lodging/4000000/3910000/3900400/3900395/6f5f0f4f_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hotel Riu Plaza Panama Bella Vista CA $1,437 per person May 9 - May 16 found 1 day ago Roundtrip non-stop flight included Edmonton (YEG) to Panama City (PTY) 9/10 Wonderful! (5,100 reviews) Amazing breakfast selection a large variety very friendly and pleasant staff Reviewed on Mar 27, 2026 ![Central Hotel Panama Casco Viejo](https://images.trvl-media.com/lodging/16000000/15690000/15683600/15683502/786350eb_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Central Hotel Panama Casco Viejo Casco Viejo CA $2,025 per person May 9 - May 16 found 1 day ago Roundtrip non-stop flight included Edmonton (YEG) to Panama City (PTY) 9/10 Wonderful! (1,000 reviews) Such a beautiful hotel!!! I chose it because of the stair case but was floored when I saw it in person. Gorgeous, peaceful.It was a dream fantasy come to fruition!!! The location perfect. Few feet away from the presidential plaza. There was something happening everyday right outside the hotel all the time. The staff so welcoming, breakfast was delicious. The city the people. I cannot say enough Panama and its people. So welcoming. I will definitely stay there again and longer. It was like staying in a movie. I see why our people move there and why citizens rarely move out this country Reviewed on Mar 20, 2026 ![Megapolis Hotel Panamá](https://images.trvl-media.com/lodging/92000000/92000000/91995600/91995575/4aee4896_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Megapolis Hotel Panamá San Francisco CA $1,741 per person May 9 - May 16 found 1 day ago Roundtrip non-stop flight included Edmonton (YEG) to Panama City (PTY) 8.4/10 Very Good! (1,448 reviews) Breakfast was great everything was very clean lots of restaurants near by Reviewed on Mar 27, 2026 ![Las Americas Golden Tower Panama](https://images.trvl-media.com/lodging/10000000/9680000/9675300/9675263/83f7ceed_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Las Americas Golden Tower Panama San Francisco CA $1,511 per person May 9 - May 16 found 1 day ago Roundtrip non-stop flight included Edmonton (YEG) to Panama City (PTY) 9/10 Wonderful! (1,017 reviews) Great hotel , great location Reviewed on Mar 27, 2026 Don't see what you're looking for? See all available trips from Columbus to Eastern Panama [View all trips](https://expedia.ca/go/package/search/FlightHotel/2026-04-28/2026-05-05/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=PAC&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ## 5\* Adults Only holidays in Eastern Panama Price found within the past 48 hours. Click for updated prices. ![Hotel Riu Plaza Panama](https://images.trvl-media.com/lodging/4000000/3910000/3900400/3900395/6f5f0f4f_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hotel Riu Plaza Panama Bella Vista CA $1,437 per person May 9 - May 16 found 1 day ago Roundtrip non-stop flight included Edmonton (YEG) to Panama City (PTY) 9/10 Wonderful! (5,100 reviews) Amazing breakfast selection a large variety very friendly and pleasant staff Reviewed on Mar 27, 2026 ![W Panama](https://images.trvl-media.com/lodging/22000000/21320000/21314100/21314035/5dc0b3d1_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### W Panama Bella Vista CA $1,882 per person May 9 - May 16 found 1 hour ago Roundtrip non-stop flight included Edmonton (YEG) to Panama City (PTY) 9/10 Wonderful! (1,019 reviews) Great location and friendly staff. Housekeeping could have been better. Reviewed on Mar 24, 2026 Don't see what you're looking for? See all available trips from Columbus to Eastern Panama [View all trips](https://expedia.ca/go/package/search/FlightHotel/2026-04-28/2026-05-05/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=PAC&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ## 3 Night Adults Only holidays in Eastern Panama Price found within the past 48 hours. Click for updated prices. ![Hotel Riu Plaza Panama](https://images.trvl-media.com/lodging/4000000/3910000/3900400/3900395/6f5f0f4f_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hotel Riu Plaza Panama Bella Vista CA $1,197 per person Jun 10 - Jun 13 found 6 hours ago Roundtrip non-stop flight included Toronto (YYZ) to Panama City (PTY) 9/10 Wonderful! (5,100 reviews) Amazing breakfast selection a large variety very friendly and pleasant staff Reviewed on Mar 27, 2026 ![Megapolis Hotel Panamá](https://images.trvl-media.com/lodging/92000000/92000000/91995600/91995575/4aee4896_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Megapolis Hotel Panamá San Francisco CA $1,295 per person Jun 10 - Jun 13 found 6 hours ago Roundtrip non-stop flight included Toronto (YYZ) to Panama City (PTY) 8.4/10 Very Good! (1,448 reviews) Breakfast was great everything was very clean lots of restaurants near by Reviewed on Mar 27, 2026 Don't see what you're looking for? See all available trips from Columbus to Eastern Panama [View all trips](https://expedia.ca/go/package/search/FlightHotel/2026-04-28/2026-05-05/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=PAC&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ## 4 Night Adults Only holidays in Eastern Panama Price found within the past 48 hours. Click for updated prices. ![Hotel Riu Plaza Panama](https://images.trvl-media.com/lodging/4000000/3910000/3900400/3900395/6f5f0f4f_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hotel Riu Plaza Panama Bella Vista CA $1,132 per person May 6 - May 10 found 11 hours ago Roundtrip non-stop flight included Toronto (YTO) to Panama City (PTY) 9/10 Wonderful! (5,100 reviews) Amazing breakfast selection a large variety very friendly and pleasant staff Reviewed on Mar 27, 2026 ![Central Hotel Panama Casco Viejo](https://images.trvl-media.com/lodging/16000000/15690000/15683600/15683502/786350eb_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Central Hotel Panama Casco Viejo Casco Viejo CA $1,612 per person May 13 - May 17 found 9 hours ago Roundtrip non-stop flight included Toronto (YTO) to Panama City (PTY) 9/10 Wonderful! (1,000 reviews) Such a beautiful hotel!!! I chose it because of the stair case but was floored when I saw it in person. Gorgeous, peaceful.It was a dream fantasy come to fruition!!! The location perfect. Few feet away from the presidential plaza. There was something happening everyday right outside the hotel all the time. The staff so welcoming, breakfast was delicious. The city the people. I cannot say enough Panama and its people. So welcoming. I will definitely stay there again and longer. It was like staying in a movie. I see why our people move there and why citizens rarely move out this country Reviewed on Mar 20, 2026 ![Megapolis Hotel Panamá](https://images.trvl-media.com/lodging/92000000/92000000/91995600/91995575/4aee4896_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Megapolis Hotel Panamá San Francisco CA $1,314 per person May 6 - May 10 found 11 hours ago Roundtrip non-stop flight included Toronto (YTO) to Panama City (PTY) 8.4/10 Very Good! (1,448 reviews) Breakfast was great everything was very clean lots of restaurants near by Reviewed on Mar 27, 2026 Don't see what you're looking for? See all available trips from Columbus to Eastern Panama [View all trips](https://expedia.ca/go/package/search/FlightHotel/2026-04-28/2026-05-05/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=PAC&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ## More vacations you might like ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Vacations [](https://expedia.ca/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Vacations [](https://expedia.ca/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Family Vacations [](https://expedia.ca/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Family_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Golf Vacations [](https://expedia.ca/lp/theme-vacations/golf-vacations?rfrr=editorial.Golf_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Luxury Vacations [](https://expedia.ca/lp/theme-vacations/luxury-vacations?rfrr=editorial.Luxury_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Romantic Vacations [](https://expedia.ca/lp/theme-vacations/romantic-vacations?rfrr=editorial.Romantic_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Ski Vacations [](https://expedia.ca/lp/theme-vacations/ski-vacations?rfrr=editorial.Ski_Vacations.click) ## More Vacations Ideas [Flights to Eastern Panama ](https://expedia.ca/Cheap-Flights-To-Eastern-Panama.d6246114.Travel-Guide-Flights)[ Eastern Panama Hotels ](https://expedia.ca/Eastern-Panama-Hotels.d6246114.Travel-Guide-Hotels)[ Eastern Panama Vacation Rentals ](https://expedia.ca/Eastern-Panama-Vacation-Rentals.d6246114.Travel-Guide-VacationRentals)[ Eastern Panama Car Rentals ](https://expedia.ca/Car-Rentals-In-Eastern-Panama.d6246114.Car-Rental-Guide)[ Eastern Panama Vacations ](https://expedia.ca/Eastern-Panama.d6246114.Destination-Travel-Guides) \* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels and earn double points when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app