Title: Adults Only Vacations in Eastern Panama 2026/2026 | Expedia.ca ![](https://images.trvl-media.com/place/6246376/42fe0cae-c805-47d5-a705-ee119c68d58c.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Eastern Panama Adults Only Vacations ## Book a Hotel + Flight or Car together to unlock savings Photo by Nico Barner - ## Plan, book, travel with confidence - ### Better together Save up to CA $1,096 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Plan, book, and manage your trip all in one place ## Flight and Adults Only hotel deals in Eastern Panama Price found within the past 48 hours. Click for updated prices. ![Yoo by Wynwood House](https://images.trvl-media.com/lodging/104000000/103610000/103606300/103606257/f526e4da_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Yoo by Wynwood House Calidonia CA $1,686 per person Feb 9 - Feb 15 found 1 day ago Roundtrip non-stop flight included Toronto (YTO) to Panama City (PTY) 9.2/10 Wonderful! (5 reviews) Unfortunately the name of the property was not Yoo by Wynwood. It is P. H. Yoo Panama & Arts Tower. This detail that was incorrect cost us time, money and stress at the beginning of our trip. We weren't able to get in touch with anyone at the property or at expedia and we ended up having to cross reference google photos to figure out the correct name and address of the location. This took us about an hour to do in a Country that we had never been to. We are very displeased with Expedia about this. We still have not been contacted by anyone. Reviewed on Jul 26, 2025 ![Central Hotel Panama Casco Viejo](https://images.trvl-media.com/lodging/16000000/15690000/15683600/15683502/3165768f_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Central Hotel Panama Casco Viejo Casco Viejo CA $2,107 per person Feb 12 - Feb 19 found 1 day ago Roundtrip non-stop flight included Toronto (YTO) to Panama City (PTY) 9/10 Wonderful! (1,002 reviews) Great staff, perfect location, and delicious breakfast. Reviewed on Dec 4, 2025 ![La Concordia Boutique Hotel](https://images.trvl-media.com/lodging/18000000/17390000/17380200/17380132/3645c5b6_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### La Concordia Boutique Hotel Casco Viejo CA $1,924 per person Feb 14 - Feb 18 found 1 day ago Roundtrip non-stop flight included Toronto (YTO) to Panama City (PTY) 9.6/10 Exceptional! (191 reviews) Beautiful room Good location Reviewed on Nov 29, 2025 ![Casa Contemporanea by Wynwood House](https://images.trvl-media.com/lodging/100000000/99230000/99229300/99229225/64939a66_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Casa Contemporanea by Wynwood House Casco Viejo CA $1,916 per person Feb 12 - Feb 19 found 1 day ago Roundtrip non-stop flight included Toronto (YTO) to Panama City (PTY) 8.6/10 Excellent! (19 reviews) Great experience, beautiful apartment. Minor maintenance issues that were addressed in a timely fashion. Would definitely recommend and stay there again! Reviewed on Mar 28, 2025 ![Dreams Playa Bonita Panama - All Inclusive](https://images.trvl-media.com/lodging/13000000/12450000/12445600/12445554/7c338453_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Dreams Playa Bonita Panama - All Inclusive CA $3,041 per person Feb 12 - Feb 19 found 1 day ago Roundtrip non-stop flight included Toronto (YTO) to Panama City (PTY) 7.4/10 Good! (1,002 reviews) This one of the best vacation I ever had. Reviewed on Dec 4, 2025 Don't see what you're looking for? See all available trips from Columbus to Eastern Panama [View all trips](https://expedia.ca/go/package/search/FlightHotel/2026-01-05/2026-01-12/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=PAC&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ## 5\* Adults Only holidays in Eastern Panama Price found within the past 48 hours. Click for updated prices. ![The Westin Playa Bonita Panama](https://images.trvl-media.com/lodging/5000000/4670000/4668700/4668643/6d441b5e_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### The Westin Playa Bonita Panama CA $1,724 per person Feb 12 - Feb 19 found 1 day ago Roundtrip non-stop flight included Toronto (YTO) to Panama City (PTY) 8/10 Very Good! (1,000 reviews) Nice enough place. Westin is always reliable. Reviewed on Dec 3, 2025 ![The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City](https://images.trvl-media.com/lodging/21000000/20960000/20958600/20958573/d80494b9_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City Juan Diaz CA $2,189 per person Feb 12 - Feb 19 found 1 day ago Roundtrip non-stop flight included Toronto (YTO) to Panama City (PTY) 9.6/10 Exceptional! (627 reviews) As usual the stay was amazing in this hotel Reviewed on Dec 3, 2025 ![Waldorf Astoria Panama](https://images.trvl-media.com/lodging/5000000/4960000/4952100/4952056/e7e98c5e_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Waldorf Astoria Panama Bella Vista CA $1,818 per person Jan 28 - Feb 4 found 1 hour ago Roundtrip non-stop flight included Toronto (YTO) to Panama City (PTY) 9/10 Wonderful! (1,001 reviews) I loved everything about my stay Reviewed on Nov 29, 2025 Don't see what you're looking for? See all available trips from Columbus to Eastern Panama [View all trips](https://expedia.ca/go/package/search/FlightHotel/2026-01-05/2026-01-12/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=PAC&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ## 3 Night Adults Only holidays in Eastern Panama Price found within the past 48 hours. Click for updated prices. ![Central Hotel Panama Casco Viejo](https://images.trvl-media.com/lodging/16000000/15690000/15683600/15683502/3165768f_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Central Hotel Panama Casco Viejo Casco Viejo CA $1,300 per person Jan 9 - Jan 12 found 1 day ago Roundtrip non-stop flight included Toronto (YYZ) to Panama City (PTY) 9/10 Wonderful! (1,002 reviews) Great staff, perfect location, and delicious breakfast. Reviewed on Dec 4, 2025 ![La Concordia Boutique Hotel](https://images.trvl-media.com/lodging/18000000/17390000/17380200/17380132/3645c5b6_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### La Concordia Boutique Hotel Casco Viejo CA $1,421 per person Jan 9 - Jan 12 found 1 day ago Roundtrip non-stop flight included Toronto (YYZ) to Panama City (PTY) 9.6/10 Exceptional! (191 reviews) Beautiful room Good location Reviewed on Nov 29, 2025 ![Dreams Playa Bonita Panama - All Inclusive](https://images.trvl-media.com/lodging/13000000/12450000/12445600/12445554/7c338453_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Dreams Playa Bonita Panama - All Inclusive CA $1,591 per person Feb 18 - Feb 21 found 17 hours ago Roundtrip non-stop flight included Toronto (YYZ) to Panama City (PTY) 7.4/10 Good! (1,002 reviews) This one of the best vacation I ever had. Reviewed on Dec 4, 2025 Don't see what you're looking for? See all available trips from Columbus to Eastern Panama [View all trips](https://expedia.ca/go/package/search/FlightHotel/2026-01-05/2026-01-12/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=PAC&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ## 4 Night Adults Only holidays in Eastern Panama Price found within the past 48 hours. Click for updated prices. ![Mahogany Suites](https://images.trvl-media.com/lodging/119000000/118410000/118402400/118402387/179ad971_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Mahogany Suites CA $942 per person Feb 14 - Feb 18 found 1 day ago Roundtrip non-stop flight included Toronto (YTO) to Panama City (PTY) 10/10 Exceptional! (1 review) ![Central Hotel Panama Casco Viejo](https://images.trvl-media.com/lodging/16000000/15690000/15683600/15683502/3165768f_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Central Hotel Panama Casco Viejo Casco Viejo CA $1,567 per person Feb 14 - Feb 18 found 1 day ago Roundtrip non-stop flight included Toronto (YTO) to Panama City (PTY) 9/10 Wonderful! (1,002 reviews) Great staff, perfect location, and delicious breakfast. Reviewed on Dec 4, 2025 ![La Concordia Boutique Hotel](https://images.trvl-media.com/lodging/18000000/17390000/17380200/17380132/3645c5b6_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### La Concordia Boutique Hotel Casco Viejo CA $1,924 per person Feb 14 - Feb 18 found 1 day ago Roundtrip non-stop flight included Toronto (YTO) to Panama City (PTY) 9.6/10 Exceptional! (191 reviews) Beautiful room Good location Reviewed on Nov 29, 2025 Don't see what you're looking for? See all available trips from Columbus to Eastern Panama [View all trips](https://expedia.ca/go/package/search/FlightHotel/2026-01-05/2026-01-12/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=PAC&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ## More vacations you might like ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Vacations [](https://expedia.ca/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Vacations [](https://expedia.ca/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Family Vacations [](https://expedia.ca/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Family_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Golf Vacations [](https://expedia.ca/lp/theme-vacations/golf-vacations?rfrr=editorial.Golf_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Luxury Vacations [](https://expedia.ca/lp/theme-vacations/luxury-vacations?rfrr=editorial.Luxury_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Romantic Vacations [](https://expedia.ca/lp/theme-vacations/romantic-vacations?rfrr=editorial.Romantic_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Ski Vacations [](https://expedia.ca/lp/theme-vacations/ski-vacations?rfrr=editorial.Ski_Vacations.click) ## More Vacations Ideas [Flights to Eastern Panama ](https://expedia.ca/Cheap-Flights-To-Eastern-Panama.d6246114.Travel-Guide-Flights)[ Eastern Panama Hotels ](https://expedia.ca/Eastern-Panama-Hotels.d6246114.Travel-Guide-Hotels)[ Eastern Panama Vacation Rentals ](https://expedia.ca/Eastern-Panama-Vacation-Rentals.d6246114.Travel-Guide-VacationRentals)[ Eastern Panama Car Rentals ](https://expedia.ca/Car-Rentals-In-Eastern-Panama.d6246114.Car-Rental-Guide)[ Eastern Panama Vacations ](https://expedia.ca/Eastern-Panama.d6246114.Destination-Travel-Guides)[ Things to do in Eastern Panama ](https://expedia.ca/Things-To-Do-In-Eastern-Panama.d6246114.Travel-Guide-Activities) \* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels and earn double points when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app