Title: CA $292 Cheap American Airlines fights from Knoxville to San Diego - Expedia.ca ![](https://images.trvl-media.com/place/3073/476a7863-1b66-47b5-9758-1dc7b3787493.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_flights_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # CA $292 Cheap American Airlines fights from Knoxville (TYS) to San Diego (SAN) [View CA $292 flight on Sat, Nov 8, 2025](https://expedia.ca/Flights-Search?trip=oneway&leg1=from:TYS,to:SAN,departure:08/11/2025TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:291.70&airProductToken=AQqcAQoyCMGCARIENDM1NhiTlgEgjAIoxMf8AjDIyPwCOEJAAFgBagVCQVNJQ3IIUVZBWlVTQlgKMgjBggESBDIyMzEYjAIg77kBKNbJ_AIwicz8AjhCQAFYAWoFQkFTSUNyCFFWQVpVU0JYCjIIwYIBEgQyMDU3GO-5ASCSaCjiz_wCMK_Q_AI4QkABWAFqBUJBU0lDcghPVkFLWlNCWBIKCAEQARgBKgJBQRgBIgQIARABKAIoAygEMAs) - [Roundtrip](?flightType=roundtrip) - [One-way](?flightType=oneway) - [Multi-city](?flightType=multicity) ### Travellers Adults ChildrenAges 2 to 17 InfantsYounger than 2 EconomyPremium economyBusiness classFirst class Leaving from Going to Departing Returning Add a place to stay Add a car Direct flights only ![notification illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__notification.svg) ### Be in the know Get alerts if flight prices drop or rise\* ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Book smarter Save up to 30% on select hotels after you book a flight\* ![trophy illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__trophy.svg) ### Earn twice Earn your airline miles on top of our rewards [Sign in](https://www.expedia.ca/login) ## American Airlines flights from Knoxville to San Diego (TYS→SAN) Prices were available within the past 7 days and start at CA $292 for one-way flights and for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply. All deals One way Roundtrip ## Frequently asked questions ### How much is an American Airlines flight from McGhee Tyson Airport (TYS) to San Diego Intl. Airport (SAN)? > You can discover budget-friendly return American Airlines flights from TYS to SAN by sorting your results from "Price (lowest to highest)" on Expedia. Or look for deals from CA $292 for a one-way journey.\**\*These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.* ### What is the cheapest month to fly from TYS to SAN with American Airlines? > American Airlines flights to San Diego are typically more affordable in the quieter months of January and November. Whether you're in search of a one-way or round-trip ticket, you could find a better deal then. ### Does American Airlines fly nonstop from McGhee Tyson Airport (TYS) to San Diego Intl. Airport (SAN)? > Use the "Nonstop" filter when browsing for direct American Airlines flights from TYS to SAN. It's also a great way to compare other airlines servicing the same nonstop trip. ### What airports does American Airlines fly into in San Diego? > San Diego Intl. Airport (SAN) is the main San Diego hub for American Airlines flights from McGhee Tyson Airport (TYS). ### Can I change or cancel my American Airlines flight from McGhee Tyson Airport (TYS) to San Diego Intl. Airport (SAN)? > Changes are often free within 24 hours of making a booking, but your airline may charge you after that. For further information about modifying your flights, check out your "[Trips](https://www.expedia.ca/trips)," select your flight and click on "Manage Booking." If you want the freedom to make changes without being charged, apply the "Changes included" or "No cancel fee" filter when planning your next getaway. ## Travel information | Origin airport | McGhee Tyson | | --- | --- | | Destination airport | San Diego Intl. | | Distance | 3038 km | ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Other - [Beach Hotel Hotels in San Diego County](https://www.expedia.ca/Destinations-In-San-Diego-County-Beach-Hotel.0-0-d178304-tBeachHotel.Hotel-Filter-Destinations) - [San Diego County Hotels](https://www.expedia.ca/Destinations-In-San-Diego-County.d178304.Hotel-Destinations) - [Downtown San Diego Hotels](https://www.expedia.ca/Downtown-San-Diego-San-Diego-Hotels.0-n800123-0.Travel-Guide-Filter-Hotels) - [Beach Hotel Hotels in Harbor Island](https://www.expedia.ca/Harbor-Island-San-Diego-Hotels-Beach-Hotel.0-n6193750-0-tBeachHotel.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Harbor Island](https://www.expedia.ca/Harbor-Island-San-Diego-Hotels-Cheap-Hotels.0-n6193750-0-tCheapHotels.Travel-Guide-Filter-Hotels) - 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