Title: Best Panama City Luxury Spa Hotels in 2025 - Expedia.ca

  

# Book luxury spa hotels in Panama City

### Experience the ultimate relaxation at luxury spa retreats in Panama City

Luxury spa retreats in Panama City provide an extraordinary escape for travelers seeking rejuvenation and tranquility. With a stunning backdrop of vibrant city life and lush nature, these properties offer the perfect blend of relaxation and adventure. Families, couples, and solo travelers can indulge in upscale amenities, including world-class spa services, gourmet dining, and spacious accommodations designed for comfort. Whether you’re unwinding after a day of exploration or simply enjoying quality time with loved ones, Panama City’s luxury spa retreats promise an unforgettable experience filled with pampering and serenity.

## Our top choices for a great stay

![Hilton Panama](https://images.trvl-media.com/lodging/6000000/5940000/5938200/5938139/ae99e466_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### Hilton Panama

CA $326

CA $359 total

Oct 11 - Oct 12

includes taxes & fees

Stay at this 5-star luxury hotel in Panama City. Enjoy a full-service spa, 4 restaurants, and an attached winery. Our guests praise the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.

8.8/10 Excellent! (1,007 reviews)

[](https://expedia.ca/Panama-City-Hotels-Hilton-Panama.h5938139.Hotel-Information)

![Sortis Hotel, Spa & Casino, Autograph Collection by Marriott](https://images.trvl-media.com/lodging/9000000/8790000/8785100/8785045/486951c1_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### Sortis Hotel, Spa & Casino, Autograph Collection by Marriott

CA $222

CA $244 total

Oct 18 - Oct 19

includes taxes & fees

Stay at this 4.5-star luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and a casino. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Albrook Shopping Mall and Via Espana are located nearby.

8.6/10 Excellent! (991 reviews)

[](https://expedia.ca/Panama-City-Hotels-Sortis-Hotel.h8785045.Hotel-Information)

![Waldorf Astoria Panama](https://images.trvl-media.com/lodging/5000000/4960000/4952100/4952056/e7e98c5e_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### Waldorf Astoria Panama

CA $312

CA $344 total

Oct 25 - Oct 26

includes taxes & fees

Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Via Espana are located nearby.

8.8/10 Excellent! (1,008 reviews)

[](https://expedia.ca/Panama-City-Hotels-Waldorf-Astoria-Panama.h4952056.Hotel-Information)

![The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City](https://images.trvl-media.com/lodging/21000000/20960000/20958600/20958573/d80494b9_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

CA $307

CA $338 total

Oct 10 - Oct 11

includes taxes & fees

Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular attractions Multiplaza Pacific Mall and Avenida Balboa are located nearby.

9.6/10 Exceptional! (609 reviews)

[](https://expedia.ca/Panama-City-Hotels-The-Santa-Maria.h20958573.Hotel-Information)

![Sofitel Legend Casco Viejo, Panama City ](https://images.trvl-media.com/lodging/73000000/72990000/72981200/72981169/be6fe9a0_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### Sofitel Legend Casco Viejo, Panama City

CA $439

CA $483 total

Oct 14 - Oct 15

includes taxes & fees

Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff and the property condition in our reviews. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

9.8/10 Exceptional! (512 reviews)

[](https://expedia.ca/Panama-City-Hotels-Sofitel-Legend-Casco-Viejo.h72981169.Hotel-Information)

![Hotel La Compania, in the Unbound Collection by Hyatt](https://images.trvl-media.com/lodging/72000000/71140000/71136000/71135966/02cb9f51_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### Hotel La Compania, in the Unbound Collection by Hyatt

CA $390

CA $429 total

Oct 6 - Oct 7

includes taxes & fees

Stay at this 4.5-star luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 5 restaurants. Our guests praise the helpful staff and the property condition in our reviews. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

9.6/10 Exceptional! (235 reviews)

[](https://expedia.ca/Panama-City-Hotels-Hotel-La-Compania.h71135966.Hotel-Information)

![Bristol Panama, a Registry Collection Hotel](https://images.trvl-media.com/lodging/1000000/70000/69700/69638/1700edf5_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### Bristol Panama, a Registry Collection Hotel

CA $172

CA $189 total

Oct 3 - Oct 4

includes taxes & fees

Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and a full-service spa. Our guests praise the helpful staff and the property condition in our reviews. Popular attractions Albrook Shopping Mall and Via Espana are located nearby.

9.2/10 Wonderful! (1,013 reviews)

[](https://expedia.ca/Panama-City-Hotels-Bristol-Panama.h69638.Hotel-Information)

![Megapolis Hotel Panamá](https://images.trvl-media.com/lodging/92000000/92000000/91995600/91995575/4aee4896_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### Megapolis Hotel Panamá

CA $174

CA $192 total

Oct 3 - Oct 4

includes taxes & fees

Stay at this 4.5-star luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.

8.4/10 Very Good! (1,106 reviews)

[](https://expedia.ca/Panama-City-Hotels-Megapolis-Hotel-Panama.h91995575.Hotel-Information)

![Hyatt Regency Panama City](https://images.trvl-media.com/lodging/112000000/111850000/111843300/111843270/w3837h2557x3y3-241f7e7d_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### Hyatt Regency Panama City

CA $222

CA $244 total

Oct 17 - Oct 18

includes taxes & fees

Stay at this 4.5-star luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and a full-service spa. Popular attractions Albrook Shopping Mall and Via Espana are located nearby.

10/10 Exceptional! (75 reviews)

[](https://expedia.ca/Panama-City-Hotels-Hyatt-Regency-Panama-City.h111843270.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

### Why choose luxury spa hotels in Panama City for your romantic getaway or retreat?

Opting for luxury spa hotels in Panama City rather than standard hotels can significantly elevate your honeymoon or wellness retreat experience. These wellness-focused accommodations provide a unique atmosphere that fosters relaxation and intimacy, with exclusive spa services designed to pamper you and your partner. Enjoy high-end spa getaways where you can unwind together with couples massages, rejuvenating facials, and tranquil relaxation areas. Unlike traditional hotels, these luxurious retreats often feature serene surroundings, wellness programs, and personalized attention, allowing you to create lasting memories in a peaceful setting. The emphasis on holistic wellness means you can embrace a balanced lifestyle, making it easier to recharge your mind and body. Choosing a luxury spa hotel ensures that your stay is not just about a place to sleep, but a transformative experience dedicated to your well-being and connection.

### Top Destinations

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