Machu Picchu, an ancient Incan city, nestled in a mountainous valley with terraced fields and steep cliffs.

CA $478 Cheap Flights from Panama City (PTY) to Cusco (CUZ)

View CA $478 flight on Fri, Jul 24, 2026Opens in a new window

Popular airlines from Tocumen Intl. Airport (PTY) to Alejandro Velasco Astete Intl. Airport (CUZ)

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Cheap flights from Panama City (PTY) to Cusco (CUZ)

Prices were available within the past 7 days and start at CA $478 for one-way flights and CA $877 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

avianca
Mon, Feb 15 - Fri, Mar 5
PTY
Panama City
CUZ
Cusco
CA $877 Roundtrip, found 1 day ago
CA $877
Roundtrip
found 1 day ago
Select avianca flight, departing Mon, Feb 15 from Panama City to Cusco, returning Fri, Mar 5, priced at CA $877 found 1 day ago
avianca
Thu, Jul 16 - Tue, Aug 4
PTY
Panama City
CUZ
Cusco
CA $879 Roundtrip, found 7 hours ago
CA $879
Roundtrip
found 7 hours ago
Select avianca flight, departing Thu, Jul 16 from Panama City to Cusco, returning Tue, Aug 4, priced at CA $879 found 7 hours ago
avianca
Mon, Feb 15 - Fri, Mar 5
PTY
Panama City
CUZ
Cusco
CA $880 Roundtrip, found 1 day ago
CA $880
Roundtrip
found 1 day ago
Select avianca flight, departing Mon, Feb 15 from Panama City to Cusco, returning Fri, Mar 5, priced at CA $880 found 1 day ago
avianca
Mon, Feb 15 - Fri, Mar 5
PTY
Panama City
CUZ
Cusco
CA $883 Roundtrip, found 1 day ago
CA $883
Roundtrip
found 1 day ago
Select avianca flight, departing Mon, Feb 15 from Panama City to Cusco, returning Fri, Mar 5, priced at CA $883 found 1 day ago
avianca
Mon, Feb 15 - Fri, Mar 5
PTY
Panama City
CUZ
Cusco
CA $895 Roundtrip, found 1 day ago
CA $895
Roundtrip
found 1 day ago
Select avianca flight, departing Mon, Feb 15 from Panama City to Cusco, returning Fri, Mar 5, priced at CA $895 found 1 day ago
avianca
Fri, Jul 17 - Tue, Aug 4
PTY
Panama City
CUZ
Cusco
CA $901 Roundtrip, found 7 hours ago
CA $901
Roundtrip
found 7 hours ago
Select avianca flight, departing Fri, Jul 17 from Panama City to Cusco, returning Tue, Aug 4, priced at CA $901 found 7 hours ago
avianca
Thu, Jul 16 - Thu, Jul 30
PTY
Panama City
CUZ
Cusco
CA $1,046 Roundtrip, found 7 hours ago
CA $1,046
Roundtrip
found 7 hours ago
Select avianca flight, departing Thu, Jul 16 from Panama City to Cusco, returning Thu, Jul 30, priced at CA $1,046 found 7 hours ago
avianca
Fri, Jul 17 - Thu, Jul 30
PTY
Panama City
CUZ
Cusco
CA $1,068 Roundtrip, found 7 hours ago
CA $1,068
Roundtrip
found 7 hours ago
Select avianca flight, departing Fri, Jul 17 from Panama City to Cusco, returning Thu, Jul 30, priced at CA $1,068 found 7 hours ago
avianca
Mon, Feb 15 - Fri, Mar 5
PTY
Panama City
CUZ
Cusco
CA $1,089 Roundtrip, found 1 day ago
CA $1,089
Roundtrip
found 1 day ago
Select avianca flight, departing Mon, Feb 15 from Panama City to Cusco, returning Fri, Mar 5, priced at CA $1,089 found 1 day ago
Copa
Sat, Jul 18 - Sat, Aug 1
PTY
Panama City
CUZ
Cusco
CA $1,293 Roundtrip, found 7 hours ago
CA $1,293
Roundtrip
found 7 hours ago
Select Copa flight, departing Sat, Jul 18 from Panama City to Cusco, returning Sat, Aug 1, priced at CA $1,293 found 7 hours ago

Frequently asked questions

How much does a flight from Panama City (PTY-Tocumen Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.) cost?
You can find cheap one-way flights from CA $478 and cheap return flights from CA $877 PTY to CUZ with Expedia. One-way flights typically cost between CA$403 and CA$991, and return flights often range between CA$838 and CA$1443. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when PTY to CUZ ticket fares go up or down.
What is the cheapest month to fly from Panama City (PTY-Tocumen Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.)?
The cheapest months to fly from PTY to CUZ are typically during off-peak season when demand is low. Traveling in off-peak or shoulder months is usually a good way to secure cheap tickets, just remember to avoid flying during holidays if you are able to. Use the calendar view in your search to see which months have low fares on this route.
Which airlines fly direct from Panama City (PTY-Tocumen Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.)?
Enter PTY to CUZ and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
How do I find cheap flights from Panama City (PTY-Tocumen Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.)?
To find a cheap flight from Panama City (PTY-Tocumen Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Panama City (PTY-Tocumen Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
How many flights per day from Panama City (PTY-Tocumen Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.)?
There are approximately 7 connecting flights per day from Panama City (PTY-Tocumen Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.). Some common connection points include El Dorado Intl. (BOG), Jorge Chavez Intl. (LIM), and Hartsfield-Jackson Atlanta Intl. (ATL).
What is the earliest flight from Panama City (PTY-Tocumen Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.)?
The earliest flight from Panama City (PTY-Tocumen Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.) typically departs around 2:55 AM. This flight is operated by Avianca. This is a seasonal service active in January, February, October, and December. An early departure like this can help you make the most of your time at your destination. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What day of the week has the most flights from Panama City (PTY-Tocumen Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.)?
You'll typically find the most flights from Panama City (PTY-Tocumen Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.) on a Wednesday, with around 4 flights available. This gives you a good selection for your travel plans. Major airlines on this route include Avianca. Flight schedules are consistent throughout the week, so you'll have similar options on other days too.
What are the most popular departure times for flights from Panama City (PTY-Tocumen Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.)?
The most popular departure times for flights from Panama City (PTY-Tocumen Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.) are in the early morning, from 12am to 3am. Avianca offers flights during this window. Many travellers prefer these times as they allow for an early arrival at your destination, giving you more time to explore.
How long does it take to fly from Panama City (PTY-Tocumen Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.)?
A flight from PTY to CUZ with a layover takes around 17 hours 30 minutes, with the route covering approximately 2,644 kilometers. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Panama City (PTY-Tocumen Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.)?
You can fly business class between PTY and CUZ. Business class service on this route is offered by Avianca.
How do I earn miles on a Panama City (PTY) to Cusco (CUZ) flight with Expedia?
It's easy to earn miles on a Panama City (PTY) to Cusco (CUZ) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Cusco (CUZ) from Panama City (PTY)?
If you're planning to travel to Cusco from Tocumen Intl. (PTY), you can fly directly into Alejandro Velasco Astete Intl. (CUZ). Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Panama City (PTY) to Cusco (CUZ) at the last minute?
Typically, booking a last minute flight from Panama City (PTY) to Cusco (CUZ) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Panama City (PTY) to Cusco (CUZ) flight and hotel package?
Securing a Panama City (PTY) to Cusco (CUZ) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Panama City (PTY-Tocumen Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.)?
If you booked your Panama City (PTY-Tocumen Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Tocumen Intl.
Destination airport
Alejandro Velasco Astete Intl.
Airlines serving
avianca
Roundtrip price
CA $877
Distance
2629 km

Book with confidence

Tocumen to Cusco Flights

The easy way to book your flights from Panama City to Cusco 

With Expedia, it’s simple to find and book flights to Cusco from Panama City whether you’re traveling for business or pleasure. Enter your travel dates, hit search, and choose your flight from 20 airlines that cover this route. There are nonstop flights to Alejandro Velasco Astete Intl., too.  

Choose your preferred carrier and cabin class with the advanced search tool and select your ideal departure time. Then, if you want, you can see just nonstop or refundable flights. And if you’re traveling last minute, just enter the date to check out flights from Panama City to Cusco today, tomorrow, or this week.  

 

Save dollars with cheap flights from Tocumen Intl., PTY to Alejandro Velasco Astete Intl., CUZ 

Sort your search results by price to find great deals on your flight from Panama City to Cusco—you get all your cheapest options first. Grab yourself a bargain now—the lowest price on flights to Cusco from Panama City currently is just CA $877 rising to CA $1,293.  

Here are more money-saving tips: 

  • Fly in February when flight prices are normally at their lowest 
  • Book about a month to 6 weeks before you travel for the best prices to Cusco  
  • Avoid peak season and weekends when flights can cost more
  • Early morning and late-night flights are sometimes cheaper, so try varying your travel times 
  • One surefire way to save money on your flight is to book your flight and hotel together with Expedia. Sometimes, the savings are so large that the flight is basically free! 

 

Reasons to choose Expedia for your flight to Cusco from Panama City 

Whatever your destination, budget, or reason to travel, in just one quick search, you can choose from loads of flights, airlines, and cabin classes. The filters make it quick and easy to find your ideal flights, and if you choose one of the flexible options, you won’t be charged to change your flight. So book your flight to Cusco with Expedia today.

Tocumen to Cusco Flights

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