Title: CA $327 Cheap American Airlines fights from Knoxville to Key West - Expedia.ca

  

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# CA $327 Cheap American Airlines fights from Knoxville (TYS) to Key West (EYW)

[View CA $327 flight on Mon, Nov 24, 2025](https://expedia.ca/Flights-Search?trip=oneway&leg1=from:TYS,to:EYW,departure:24/11/2025TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:326.60&airProductToken=AQpmCjEIwYIBEgQ1MTQ5GJOWASBDKMD2_QIwp_f9AjhCQABYAWoFQkFTSUNyCE83QVdaU0JaCjEIwYIBEgQzNzcxGEMghLYBKJv5_QIw1vr9AjhCQAFYAWoFQkFTSUNyCFE3QVdaU0JaEgoIARABGAEqAkFBGAEiBAgBEAEoAigDKAQwCw)

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## American Airlines flights from Knoxville to Key West (TYS→EYW)

Prices were available within the past 7 days and start at CA $327 for one-way flights and for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

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## Frequently asked questions

### How much is an American Airlines flight from McGhee Tyson Airport (TYS) to Key West Intl. Airport (EYW)?

> You can discover cheap return American Airlines flights from TYS to EYW by sorting your results from "Price (lowest to highest)" on Expedia. Or look for options from CA $327 for a one-way journey.\**\*These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.*

### What is the cheapest month to fly from TYS to EYW with American Airlines?

> American Airlines flights to Key West are typically cheaper in the off-peak months of September and August. Whether you're in search of a return or one-way ticket, you could score a better deal then.

### Does American Airlines fly nonstop from McGhee Tyson Airport (TYS) to Key West Intl. Airport (EYW)?

> Click on our "Nonstop" filter when looking for direct American Airlines flights from TYS to EYW. You'll also be able to compare other carriers offering the same direct route.

### What airports does American Airlines fly into in Key West?

> Key West Intl. Airport (EYW) is the primary Key West gateway for American Airlines flights from McGhee Tyson Airport (TYS).

### Can I change or cancel my American Airlines flight from McGhee Tyson Airport (TYS) to Key West Intl. Airport (EYW)?

> Changes are typically free within 24 hours of making your booking, but your airline may charge you after that. For more details about modifying your reservation, head to your "[Trips](https://www.expedia.ca/trips)," select your flight and click on "Manage Booking." If you'd like the flexibility to update your itinerary without extra charges, apply the "Changes included" and "No cancel fee" filters when planning your next escape.

## Travel information

| Origin airport | McGhee Tyson |
| --- | --- |
| Destination airport | Key West Intl. |
| Distance | 1261 km |

\*Available to Expedia members.