Title: Book the Best BUSINESS Hotels in Southwest Illinois in 2026 | Expedia.ca

[Southwest Illinois Travel Guide](https://expedia.ca/Southwest-Illinois.dx6058943)[Hotels in Southwest Illinois](https://expedia.ca/Southwest-Illinois-Hotels.d6058943.Travel-Guide-Hotels)[Vacation Rentals in Southwest Illinois](https://expedia.ca/Southwest-Illinois-Vacation-Rentals.d6058943.Travel-Guide-VacationRentals)[Flights to Southwest Illinois](https://expedia.ca/Cheap-Flights-To-Southwest-Illinois.d6058943.Travel-Guide-Flights)[Southwest Illinois Car Rentals](https://expedia.ca/Car-Rentals-In-Southwest-Illinois.d6058943.Car-Rental-Guide)[Southwest Illinois Vacation Packages](https://expedia.ca/Southwest-Illinois.d6058943.Destination-Travel-Guides)

![One of the northermost cypress swamps in the States, the Cache River State Natural area is home to Cypress trees that are over 1000 years old. This is shot from the hiking trail (no boat), and was just a sampling of the scores of cypress trees all around. #treetrove](https://images.trvl-media.com/place/553248634983556233/b4c981e9-72cf-4dc0-8b97-270e21fe73c6.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

Photo by Carl Anderson

![](https://images.trvl-media.com/place/553248634983556233/b4c981e9-72cf-4dc0-8b97-270e21fe73c6.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Check availability on Southwest Illinois Business Hotels

Tonight

[Feb 5 - Feb 6](https://www.expedia.ca/Hotel-Search?regionId=6058943&startDate=2026-02-05&endDate=2026-02-06&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly)

Tomorrow

[Feb 6 - Feb 7](https://www.expedia.ca/Hotel-Search?regionId=6058943&startDate=2026-02-06&endDate=2026-02-07&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly)

This weekend

[Feb 6 - Feb 8](https://www.expedia.ca/Hotel-Search?regionId=6058943&startDate=2026-02-06&endDate=2026-02-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly)

Next weekend

[Feb 13 - Feb 15](https://www.expedia.ca/Hotel-Search?regionId=6058943&startDate=2026-02-13&endDate=2026-02-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly)

## Our top choices for Southwest Illinois business-friendly hotels

![Lobby](https://images.trvl-media.com/lodging/2000000/1390000/1387400/1387309/5b15716e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/2000000/1390000/1387400/1387309/6732cce6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free buffet breakfast](https://images.trvl-media.com/lodging/2000000/1390000/1387400/1387309/cd6d884a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/2000000/1390000/1387400/1387309/5c7b1e92.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Comfort Suites Mount Vernon

[](https://www.expedia.ca/Mount-Vernon-Hotels-Comfort-Suites-Mount-Vernon.h1387309.Hotel-Information)

Mount Vernon

9.0/10

Wonderful

(1,004 reviews)

"Very clean and safe stay!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Dale

CA $148

CA $167 total

includes taxes & fees

Feb 6 - Feb 7

[](https://www.expedia.ca/Mount-Vernon-Hotels-Comfort-Suites-Mount-Vernon.h1387309.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/17000000/16350000/16341900/16341844/80512ba4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/17000000/16350000/16341900/16341844/fcbb2184.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/17000000/16350000/16341900/16341844/df62cea8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room safe, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/17000000/16350000/16341900/16341844/7d4409d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Express & Suites Mount Vernon by IHG

[](https://www.expedia.ca/Mount-Vernon-Hotels-Holiday-Inn-Express-Suites-Mount-Vernon.h16341844.Hotel-Information)

Mount Vernon

9.0/10

Wonderful

(1,000 reviews)

"Breakfast very good staff excellent room clean and comfortable "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Scott

CA $150

CA $170 total

includes taxes & fees

Feb 8 - Feb 9

[](https://www.expedia.ca/Mount-Vernon-Hotels-Holiday-Inn-Express-Suites-Mount-Vernon.h16341844.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42100/42025/0b9bb173.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/1000000/50000/42100/42025/94013a8d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/50000/42100/42025/a8315e37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42100/42025/f5a8458f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Drury Inn & Suites Marion

[](https://www.expedia.ca/Carbondale-Hotels-Drury-Inn-Marion.h42025.Hotel-Information)

Marion

9.4/10

Exceptional

(1,002 reviews)

"Clean rooms, great food, friendly staff"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

John

CA $89

CA $106 total

includes taxes & fees

Feb 23 - Feb 24

[](https://www.expedia.ca/Carbondale-Hotels-Drury-Inn-Marion.h42025.Hotel-Information)

![Lobby lounge](https://images.trvl-media.com/lodging/1000000/50000/42100/42021/798d901b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/1000000/50000/42100/42021/24fa28eb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/50000/42100/42021/66dc4e91.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/50000/42100/42021/31850cab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Drury Plaza Hotel Mt. Vernon

[](https://www.expedia.ca/Mount-Vernon-Hotels-Drury-Inn-Suites-Mt-Vernon.h42021.Hotel-Information)

Mount Vernon

9.6/10

Exceptional

(1,655 reviews)

"Hotel is very clean, nicely furnished and the beds were so comfy!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Christina

CA $151

CA $171 total

includes taxes & fees

Feb 10 - Feb 11

[](https://www.expedia.ca/Mount-Vernon-Hotels-Drury-Inn-Suites-Mt-Vernon.h42021.Hotel-Information)

![Hiking](https://images.trvl-media.com/lodging/2000000/1490000/1489300/1489254/189476cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Breakfast meal](https://images.trvl-media.com/lodging/2000000/1490000/1489300/1489254/9e93654e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Point of interest](https://images.trvl-media.com/lodging/2000000/1490000/1489300/1489254/c949b501.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Breakfast meal](https://images.trvl-media.com/lodging/2000000/1490000/1489300/1489254/bc470bb1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Carbondale-Conference Center by IHG

[](https://www.expedia.ca/Carbondale-Hotels-Holiday-Inn-Carbondale-Conference-Center.h1489254.Hotel-Information)

Carbondale

8.8/10

Excellent

(652 reviews)

"nice stay! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

James

CA $146

CA $168 total

includes taxes & fees

Feb 11 - Feb 12

[](https://www.expedia.ca/Carbondale-Hotels-Holiday-Inn-Carbondale-Conference-Center.h1489254.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/8000000/7220000/7214300/7214281/1c773b5e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, pillowtop beds, individually decorated](https://images.trvl-media.com/lodging/8000000/7220000/7214300/7214281/89141360.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/8000000/7220000/7214300/7214281/1f46b3f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/8000000/7220000/7214300/7214281/2700f966.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### SureStay Hotel by Best Western Whittington Rend Lake

[](https://www.expedia.ca/Whittington-Hotels-SureStay-Hotel-By-Best-Western-Whittington-Rend-Lake.h7214281.Hotel-Information)

Whittington

8.8/10

Excellent

(928 reviews)

"Great place to stay."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Stephen

CA $98

CA $109 total

includes taxes & fees

Feb 11 - Feb 12

[](https://www.expedia.ca/Whittington-Hotels-SureStay-Hotel-By-Best-Western-Whittington-Rend-Lake.h7214281.Hotel-Information)

![Room, 1 Queen Bed, Accessible, Non Smoking](https://images.trvl-media.com/lodging/1000000/870000/861400/861371/04e0f544.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/870000/861400/861371/064919b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/870000/861400/861371/cb6402c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/870000/861400/861371/9818af49.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Super 8 by Wyndham Mt. Vernon IL

[](https://www.expedia.ca/Mount-Vernon-Hotels-Super-8-By-Wyndham-Mt-Vernon-IL.h861371.Hotel-Information)

Mount Vernon

7.8/10

Good

(1,002 reviews)

"Easy check-in. Good rate and dog friendly at a good fee"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Curt

CA $90

CA $102 total

includes taxes & fees

Feb 10 - Feb 11

[](https://www.expedia.ca/Mount-Vernon-Hotels-Super-8-By-Wyndham-Mt-Vernon-IL.h861371.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/3000000/2230000/2227000/2226989/242270a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 1 King Bed with Sofa bed, Accessible, Non Smoking](https://images.trvl-media.com/lodging/3000000/2230000/2227000/2226989/1dc4b266.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/3000000/2230000/2227000/2226989/eedc245f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/3000000/2230000/2227000/2226989/fb8eaf50.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Comfort Inn & Suites Greenville I-70

[](https://www.expedia.ca/Carlyle-Lake-Hotels-Comfort-Inn-Suites-Greenville-I-70.h2226989.Hotel-Information)

Greenville

8.4/10

Very good

(425 reviews)

"Great place to stay. Friendly front desk staff, comfortable rooms. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Douglas

CA $122

CA $135 total

includes taxes & fees

Feb 25 - Feb 26

[](https://www.expedia.ca/Carlyle-Lake-Hotels-Comfort-Inn-Suites-Greenville-I-70.h2226989.Hotel-Information)

![Desk, laptop workspace, blackout drapes, soundproofing](https://images.trvl-media.com/lodging/2000000/1090000/1088200/1088153/ba724154.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Business centre](https://images.trvl-media.com/lodging/2000000/1090000/1088200/1088153/e0cf975f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/2000000/1090000/1088200/1088153/71680cff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/2000000/1090000/1088200/1088153/add949db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Fairfield Inn and Suites by Marriott Marion

[](https://www.expedia.ca/Carbondale-Hotels-Fairfield-Inn-And-Suites-By-Marriott-Marion.h1088153.Hotel-Information)

Marion

8.4/10

Very good

(367 reviews)

"Nice room, good breakfast, and very easy to get to. Lots of options around, would stay here again "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Emily

CA $139

CA $167 total

includes taxes & fees

Feb 23 - Feb 24

[](https://www.expedia.ca/Carbondale-Hotels-Fairfield-Inn-And-Suites-By-Marriott-Marion.h1088153.Hotel-Information)

![Free daily full breakfast](https://images.trvl-media.com/lodging/1000000/100000/98000/97975/86964c5d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/100000/98000/97975/9cb51690.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/1000000/100000/98000/97975/39e99d4e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fitness facility](https://images.trvl-media.com/lodging/1000000/100000/98000/97975/853a6532.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Best Western Marion Hotel

[](https://www.expedia.ca/Carbondale-Hotels-Best-Western-Marion-Hotel.h97975.Hotel-Information)

Marion

8.2/10

Very good

(1,001 reviews)

"I was satisfied with my stay. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Frankie

CA $95

CA $114 total

includes taxes & fees

Feb 8 - Feb 9

[](https://www.expedia.ca/Carbondale-Hotels-Best-Western-Marion-Hotel.h97975.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-19&endDate=2026-02-20&regionId=6058943&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true)

## Top Southwest Illinois Hotel Reviews

![Drury Inn & Suites Marion](https://images.trvl-media.com/lodging/1000000/50000/42100/42025/a8315e37_y.jpg)

### Drury Inn & Suites Marion

10/10 Excellent

"Our room was clean and tidy. "

[](https://expedia.ca/Carbondale-Hotels-Drury-Inn-Marion.h42025.Hotel-Information)

![Holiday Inn Express & Suites - O'Fallon /Shiloh by IHG](https://images.trvl-media.com/lodging/2000000/1040000/1037700/1037681/d635442d_y.jpg)

### Holiday Inn Express & Suites - O'Fallon /Shiloh by IHG

10/10 Excellent

"always very consistent....young lady at check in was great and also the gentleman at check just as good....will use this property again... dc"

[](https://expedia.ca/Collinsville-Hotels-Holiday-Inn-Express-Suites-OFallon-Shiloh.h1037681.Hotel-Information)

![Drury Plaza Hotel Mt. Vernon](https://images.trvl-media.com/lodging/1000000/50000/42100/42021/f9296f7b_y.jpg)

### Drury Plaza Hotel Mt. Vernon

10/10 Excellent

"This place had free drinks, happy hour, great stay friendly staff great room , dog friendly.Beau"

[](https://expedia.ca/Mount-Vernon-Hotels-Drury-Inn-Suites-Mt-Vernon.h42021.Hotel-Information)

![Comfort Suites Mount Vernon](https://images.trvl-media.com/lodging/2000000/1390000/1387400/1387309/b34f836a_y.jpg)

### Comfort Suites Mount Vernon

10/10 Excellent

"Size and condition of room"

[](https://expedia.ca/Mount-Vernon-Hotels-Comfort-Suites-Mount-Vernon.h1387309.Hotel-Information)

![Red Lion Inn & Suites Pontoon Beach](https://images.trvl-media.com/lodging/1000000/20000/17400/17338/284b6d11_y.jpg)

### Red Lion Inn & Suites Pontoon Beach

10/10 Excellent

"Great breakfast! Staff was friendly. "

[](https://expedia.ca/St-Louis-Hotels-Red-Lion-Inn-Suites-Pontoon-Beach.h17338.Hotel-Information)

![Drury Inn & Suites St. Louis Fairview Heights](https://images.trvl-media.com/lodging/1000000/50000/41900/41802/c56c0460_y.jpg)

### Drury Inn & Suites St. Louis Fairview Heights

10/10 Excellent

"Clean room, comfortable bed, easy check in, friendly staff. "

[](https://expedia.ca/Collinsville-Hotels-Drury-Inn-Suites-St-Louis-Fairview-Heights.h41802.Hotel-Information)

![Drury Inn & Suites St. Louis O'Fallon, IL](https://images.trvl-media.com/lodging/2000000/1550000/1544100/1544028/d2bc121f_y.jpg)

### Drury Inn & Suites St. Louis O'Fallon, IL

10/10 Excellent

"Beautiful property, well managed. "

[](https://expedia.ca/Collinsville-Hotels-Drury-Inn-Suites-St-Louis-OFallon.h1544028.Hotel-Information)

![Holiday Inn Express & Suites Mount Vernon by IHG](https://images.trvl-media.com/lodging/17000000/16350000/16341900/16341844/20299fa2_y.jpg)

### Holiday Inn Express & Suites Mount Vernon by IHG

10/10 Excellent

"Staff (night front desk and breakfast) were excellent! The breakfast was really good. Our room was also big and clean"

[](https://expedia.ca/Mount-Vernon-Hotels-Holiday-Inn-Express-Suites-Mount-Vernon.h16341844.Hotel-Information)

![Baymont by Wyndham Marion](https://images.trvl-media.com/lodging/1000000/20000/19300/19275/7eb84743_y.jpg)

### Baymont by Wyndham Marion

10/10 Excellent

"Room was clean and shower was excellent. "

[](https://expedia.ca/Carbondale-Hotels-Baymont-By-Wyndham-Marion.h19275.Hotel-Information)

## Frequently asked questions

### How much do business-friendly hotels in Southwest Illinois cost?

### What are the best business-friendly hotels in Southwest Illinois?

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### What are the best cheap business-friendly hotels in Southwest Illinois?

### Are there any family-friendly hotels in Southwest Illinois that are also business friendly?

### Why book your business-friendly hotel in Southwest Illinois with Expedia?

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