Find Historic Hotels in Southeast Missouri, MO from CA $117
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Top Southeast Missouri Historic Hotels
Our top choices for Southeast Missouri historic hotels

⚜️Rivertown Retreat⚜️ Lewis & Clark: King Bed Sleeps 4
⚜️Rivertown Retreat⚜️ Lewis & Clark: King Bed Sleeps 4
9.8 out of 10, Exceptional, (8)
The price is CA $155
CA $279 total
includes taxes & fees
Sep 2 - Sep 3

Beautiful Modern Loft In Wine Country!
Beautiful Modern Loft In Wine Country!
10.0 out of 10, Exceptional, (261)
The price is CA $204
CA $248 total
includes taxes & fees
Aug 25 - Aug 26

Cozy Haven Little Hidden Gem Sleeps 4
Cozy Haven Little Hidden Gem Sleeps 4
9.8 out of 10, Exceptional, (46)
The price is CA $140
CA $290 total
includes taxes & fees
Aug 21 - Aug 22

"Little Brick House on Main (1865)”
"Little Brick House on Main (1865)”
10.0 out of 10, Exceptional, (51)
The price is CA $164
CA $219 total
includes taxes & fees
Aug 31 - Sep 1

The Weber Farm - Enjoy a beautiful 100 acre farm!
The Weber Farm - Enjoy a beautiful 100 acre farm!
10.0 out of 10, Exceptional, (30)
The price is CA $155
CA $254 total
includes taxes & fees
Aug 26 - Aug 27

Doves Nest Guest House<br> Tranquil & Relaxing
Doves Nest Guest House<br> Tranquil & Relaxing
10.0 out of 10, Exceptional, (43)
The price is CA $171
CA $305 total
includes taxes & fees
Sep 3 - Sep 4

Serenity South -- Gardens, River-Views, and Refreshing Space
Serenity South -- Gardens, River-Views, and Refreshing Space
10.0 out of 10, Exceptional, (139)
The price is CA $207
CA $338 total
includes taxes & fees
Aug 26 - Aug 27

Rest, Relax and Renew. Our log cabin experience awaits your arrival.
Rest, Relax and Renew. Our log cabin experience awaits your arrival.
10.0 out of 10, Exceptional, (390)
The price is CA $161
CA $274 total
includes taxes & fees
Sep 18 - Sep 19
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Southeast Missouri Hotel Reviews

Baymont Inn and Suites by Wyndham Farmington, MO
10/10 Excellent
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Hotels near popular Southeast Missouri Attractions
- Hotels near Mark Twain National Forest
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Southeast Missouri Hotels by Star Rating
Explore more hotels
- Comfort Inn Festus - St Louis South
- Best Western Plus Sikeston
- Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
- Drury Inn & Suites Sikeston, MO
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- Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
- Days Inn and Suites by Wyndham Sikeston
- Silo Farm Haus- located in the heart of wine country!
- Pear Tree Inn Sikeston
- Postcard Cabins St. Francois
- Candlewood Suites Cape Girardeau by IHG
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- Hampton Inn Poplar Bluff
- Super 8 by Wyndham Farmington
- Holiday Inn Poplar Bluff by IHG
- Quality Inn
- Super 8 by Wyndham Perryville
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- Fairfield Inn & Suites by Marriott Cape Girardeau
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