Title: Book the Best BUSINESS Hotels in Southeast Missouri in 2025 | Expedia.ca

 

[Southeast Missouri Travel Guide](https://expedia.ca/Southeast-Missouri.dx6058763)[Hotels in Southeast Missouri](https://expedia.ca/Southeast-Missouri-Hotels.d6058763.Travel-Guide-Hotels)[Vacation Rentals in Southeast Missouri](https://expedia.ca/Southeast-Missouri-Vacation-Rentals.d6058763.Travel-Guide-VacationRentals)[Flights to Southeast Missouri](https://expedia.ca/Cheap-Flights-To-Southeast-Missouri.d6058763.Travel-Guide-Flights)[Things to do in Southeast Missouri](https://expedia.ca/Things-To-Do-In-Southeast-Missouri.d6058763.Travel-Guide-Activities)[Southeast Missouri Car Rentals](https://expedia.ca/Car-Rentals-In-Southeast-Missouri.d6058763.Car-Rental-Guide)[Southeast Missouri Vacation Packages](https://expedia.ca/Southeast-Missouri.d6058763.Destination-Travel-Guides)

![Mini Takes the States 2014 Road Rally Memphis to St.Louis Leg:
Moark Regional Railroad Museum
HOURS: Saturdays 1 p.m. - 4 p.m.
It was not open when I stopped by but there are a few rail cars outside. Poplar has a train rich history.
This was a cool little town to stop in and take pictures. Lot's of wall murals for some reason, and some very cool architecture. Worth the stop and be sure and enjoy a lunch at Hayden's Drive-In ! 
#MTTS2014 #minitakesthestates #go11
#train](https://images.trvl-media.com/place/9449/f87e8b74-cb32-40ea-afa8-0f245bfdc84b.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

Photo by Bill Dillard

# Find Business Hotels in Southeast Missouri, MO from CA $85

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## Check availability on Southeast Missouri Business Hotels

Tonight

[Nov 26 - Nov 27](https://www.expedia.ca/Hotel-Search?regionId=6058763&startDate=2025-11-26&endDate=2025-11-27&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly)

Tomorrow

[Nov 27 - Nov 28](https://www.expedia.ca/Hotel-Search?regionId=6058763&startDate=2025-11-27&endDate=2025-11-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly)

This weekend

[Nov 28 - Nov 30](https://www.expedia.ca/Hotel-Search?regionId=6058763&startDate=2025-11-28&endDate=2025-11-30&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly)

Next weekend

[Dec 5 - Dec 7](https://www.expedia.ca/Hotel-Search?regionId=6058763&startDate=2025-12-05&endDate=2025-12-07&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly)

## Top Southeast Missouri Business Hotels

![Property amenity](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/f737107e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/ea01e15a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Deluxe Room, 2 Queen Beds, Accessible, Refrigerator & Microwave (Tub)](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/0941dc05.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Drury Inn & Suites Sikeston, MO

Sikeston

9.4/10

Exceptional

(1004)

"Clean room, great location and friendly staff"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Mark

CA $127

CA $146 total

includes taxes & fees

Dec 1 - Dec 2

[](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information)

![Ballroom](https://images.trvl-media.com/lodging/2000000/1770000/1768200/1768149/800a6847.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property entrance](https://images.trvl-media.com/lodging/2000000/1770000/1768200/1768149/035dee6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 1 King Bed, Jetted Tub | Jetted tub](https://images.trvl-media.com/lodging/2000000/1770000/1768200/1768149/66ab3de8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby sitting area](https://images.trvl-media.com/lodging/2000000/1770000/1768200/1768149/9fbd251c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Wildwood Hotel

Wildwood

9.2/10

Wonderful

(1607)

"Great hotel in a great neighborhood "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Linda

[](https://www.expedia.ca/St-Louis-Hotels-The-Wildwood-Hotel.h1768149.Hotel-Information)

![Suite, Non Smoking](https://images.trvl-media.com/lodging/3000000/2230000/2221500/2221409/8d032822.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free buffet breakfast](https://images.trvl-media.com/lodging/3000000/2230000/2221500/2221409/ab276100.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, iron/ironing board, free cribs/infant beds, rollaway beds](https://images.trvl-media.com/lodging/3000000/2230000/2221500/2221409/b0c2bdb7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/3000000/2230000/2221500/2221409/fd79dc35.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Comfort Inn Willow Springs US 60 and US 63

Willow Springs

9.2/10

Wonderful

(543)

"Nice hotel, clean, comfortable beds, convenient location."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jeff

CA $155

CA $167 total

includes taxes & fees

Dec 7 - Dec 8

[](https://www.expedia.ca/West-Plains-Hotels-Comfort-Inn-Willow-Springs.h2221409.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/742aaf1e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/2d914387.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/c279dc08.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/6f9bce18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

9.6/10

Exceptional

(1003)

"Very nice stay."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Charity

CA $127

CA $143 total

includes taxes & fees

Dec 2 - Dec 3

[](https://www.expedia.ca/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information)

![Free daily self-serve breakfast](https://images.trvl-media.com/lodging/64000000/63310000/63308800/63308723/2785ae14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/64000000/63310000/63308800/63308723/f0e5a143.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Room, 1 King Bed](https://images.trvl-media.com/lodging/64000000/63310000/63308800/63308723/f803d387.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fitness facility](https://images.trvl-media.com/lodging/64000000/63310000/63308800/63308723/c3df7346.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

Murphysboro

9.4/10

Exceptional

(505)

"great property, great breakfast, friendly and knowledgable staff."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Ronald

CA $146

CA $162 total

includes taxes & fees

Nov 28 - Nov 29

[](https://www.expedia.ca/Carbondale-Hotels-Holiday-Inn-Express-Suites-Murphysboro-Carbondale.h63308723.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/b034b164.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/b2d719b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/239bd50a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 2 Queen Beds, Accessible, Refrigerator & Microwave (Sofabed, 2 Rooms, Tub)](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/83931306.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Drury Inn & Suites Poplar Bluff

Poplar Bluff

9.2/10

Wonderful

(952)

"Delicious, well-ran breakfast and quiet peaceful hotel. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Janene

CA $133

CA $150 total

includes taxes & fees

Dec 4 - Dec 5

[](https://www.expedia.ca/Poplar-Bluff-Hotels-Drury-Inn-Suites-Poplar-Bluff.h41515.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/8996a36d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/fbb12bb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/132cb18c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fitness facility](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/66c21f7d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Drury Inn & Suites Jackson MO

Jackson

9.6/10

Exceptional

(1009)

"This was a wonderful stay. We will definitely stay again when we are in town!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Trista

CA $117

CA $124 total

includes taxes & fees

Dec 1 - Dec 2

[](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information)

![Front of property](https://images.trvl-media.com/lodging/16000000/15490000/15487700/15487684/4071c448.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/16000000/15490000/15487700/15487684/0c1d1e5e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Point of interest](https://images.trvl-media.com/lodging/16000000/15490000/15487700/15487684/db5aadc3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/16000000/15490000/15487700/15487684/136440e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Echo Bluff State Park

Eminence

9.6/10

Exceptional

(215)

"Beautiful location…excellent service and facilities / grounds were clean and well kept."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

William

CA $209

CA $221 total

includes taxes & fees

Dec 9 - Dec 10

[](https://www.expedia.ca/Rolla-Hotels-Echo-Bluff-State-Park.h15487684.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/fe49057f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool, open 8 AM to 11 PM, sun loungers](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/64fb9857.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, down comforters, pillowtop beds, in-room safe](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/eb2507f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free breakfast](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/5fa70c20.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Cape Girardeau

9.4/10

Exceptional

(1003)

"It was right off the interstate with lots of restaurant options "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Kelly

CA $134

CA $151 total

includes taxes & fees

Dec 4 - Dec 5

[](https://www.expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information)

![Business centre](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/02759b26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Building design](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/f4d876e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/7e9b49ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/c41116cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Baymont Inn and Suites by Wyndham Farmington, MO

Farmington

8.0/10

Very good

(1003)

"The room was clean and the staff, as always were very courteous!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Steven

CA $75

CA $85 total

includes taxes & fees

Dec 6 - Dec 7

[](https://www.expedia.ca/Farmington-Hotels-Baymont-Inn-And-Suites-By-Wyndham-Farmington.h16153.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-10&endDate=2025-12-11&regionId=6058763&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true)

![](https://forever.travel-assets.com/flex/flexmanager/images/2025/11/05/BEX-BF-25_CA_1_Desktop.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh)

## 

Black Friday Sale

Limited-time deals: save up to 50% on select hotels

[Book now](https://expedia.ca/deals?rfrr=AFFINITY_BF_PROMO_6058763)

## Top Southeast Missouri Hotel Reviews

![Pear Tree Inn Cape Girardeau West](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/3a7dec89_y.jpg)

### Pear Tree Inn Cape Girardeau West

10/10 Excellent

"Clean room. Clean well stocked bathroom. Nice big bathroom. Very courteous check in attendent. And sweet lady serving breakfast. "

[](https://expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information)

![Drury Plaza Hotel Cape Girardeau Conference Center](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/742aaf1e_y.jpg)

### Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent

"Breakfast and super Kickoff was AWESOME? love this hotel!!!"

[](https://expedia.ca/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information)

![Drury Inn & Suites Jackson MO](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/8996a36d_y.jpg)

### Drury Inn & Suites Jackson MO

10/10 Excellent

"I did not stay for breakfast, but I did have a hot dinner that was excellent. I will recommend and stay at Drury Inn's the next time I travel."

[](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information)

![Holiday Inn Poplar Bluff by IHG](https://images.trvl-media.com/lodging/2000000/1230000/1222200/1222183/e91b57a7_y.jpg)

### Holiday Inn Poplar Bluff by IHG

10/10 Excellent

"Very spacious suite, awesome staff! "

[](https://expedia.ca/Poplar-Bluff-Hotels-Holiday-Inn-Poplar-Bluff.h1222183.Hotel-Information)

![Days Inn and Suites by Wyndham Sikeston](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/e12b74a2_y.jpg)

### Days Inn and Suites by Wyndham Sikeston

10/10 Excellent

"This was a really great stay, which was part of my long roadtrip. The hotel was right off the interstate & wasn't too noisy. My room was pretty big which I really enjoyed! The bed was super comfy. The front desk woman was super friendly and welcoming. I was able to get Door Dash to deliver to the location so that was a plus! They had quite a lot of items for breakfast, so I was surprised about that for a Days Inn. Only thing I didn't like was lack of parking, but overall, I would definitely stay here again if I come back to the area."

[](https://expedia.ca/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information)

![Drury Inn & Suites Sikeston, MO](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67_y.jpg)

### Drury Inn & Suites Sikeston, MO

10/10 Excellent

"Staff are wonderful, kind and welcoming! The happy hour is a great way to get out of your room and socialize. Lots of yummy food and drinks. "

[](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information)

![Drury Inn & Suites Cape Girardeau](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/4b521966_y.jpg)

### Drury Inn & Suites Cape Girardeau

10/10 Excellent

"Great rooms, super friendly staff!"

[](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Cape-Girardeau.h40831.Hotel-Information)

![La Quinta Inn & Suites by Wyndham Festus - St. Louis South](https://images.trvl-media.com/lodging/1000000/50000/42200/42120/1887aa70_y.jpg)

### La Quinta Inn & Suites by Wyndham Festus - St. Louis South

10/10 Excellent

"Staff was very nice ans helpful. Our room was clean and pleasant. "

[](https://expedia.ca/Farmington-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Festus-St-Louis-South.h42120.Hotel-Information)

![Candlewood Suites Cape Girardeau by IHG](https://images.trvl-media.com/lodging/4000000/3540000/3530400/3530303/6afa6c85_y.jpg)

### Candlewood Suites Cape Girardeau by IHG

10/10 Excellent

"Great room"

[](https://expedia.ca/Sikeston-Hotels-Candlewood-Suites-Cape-Girardeau.h3530303.Hotel-Information)

## Frequently asked questions

### How much do business-friendly hotels in Southeast Missouri cost?

> Rates for business hotels in Southeast Missouri range between CA $85 and CA $221 per night. No matter your budget, Expedia is here to help you find the perfect place to get the job done. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.

### What are the best business-friendly hotels in Southeast Missouri?

> Southeast Missouri has multiple business-friendly hotels with a total average guest review rating of 9.2. Attending a work-related event in Cape Girardeau? [Hampton Inn Cape Girardeau I 55 East](https://www.expedia.ca/Sikeston-Hotels-Hampton-Inn-Cape-Girardeau-I-55-East.h12786627.Hotel-Information) is a 2.5-stars stay that comes highly recommended by corporate travellers and includes a dining venue and a terrace. Another excellent choice for a business trip is [Drury Plaza Hotel Cape Girardeau Conference Centre](https://www.expedia.ca/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information). Also in Cape Girardeau, it has a 3-stars rating and amenities such as a swimming pool and a restaurant.

### How many business-friendly hotels are there in Southeast Missouri?

> Southeast Missouri has 50 business-friendly hotels to pick from. Whether you're meeting with new clients or working remotely, these stays come with the services and amenities you need to be productive.

### What are the best cheap business-friendly hotels in Southeast Missouri?

> When you're on the road for work in Southeast Missouri, Expedia will help you find the ideal business-friendly hotel. [Hampton Inn Cape Girardeau I 55 East](https://www.expedia.ca/Sikeston-Hotels-Hampton-Inn-Cape-Girardeau-I-55-East.h12786627.Hotel-Information) is a budget pick in Cape Girardeau. A dining venue and a swimming pool are some of its many amenities. Seeking affordable stays in Sikeston? [Pear Tree Inn Sikeston](https://www.expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Sikeston.h19205.Hotel-Information) is recommended by many corporate travellers. It offers conveniences that make it easy to both work and play, such as a swimming pool and a spa tub. Business-friendly hotels in Southeast Missouri start at just CA $85 a night. You'll find tons of fabulous and free attractions wherever you're off to in Southeast Missouri. If you're meeting with clients in Cape Girardeau, try to make time in your schedule for [Hunter Valley Winery](https://www.expedia.ca/Hunter-Valley-Winery-Cape-Girardeau.d553248621532655783.Vacation-Attraction). You can also see the sights without spending a penny in Sikeston. [Sikeston Depot Museum](https://www.expedia.ca/Sikeston-Depot-Museum-Sikeston.d6305602.Vacation-Attraction) is one of the most popular free things to do here. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.

### Are there any family-friendly hotels in Southeast Missouri that are also business friendly?

> There sure are. Whether you're searching for a stay in Southeast Missouri with a conference room or a quiet space to work alone, con espacio para trabajar Expedia's got you sorted. [Drury Plaza Hotel Cape Girardeau Conference Centre](https://www.expedia.ca/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information) in Cape Girardeau is a fantastic choice. This 3-stars business and family-friendly option comes with all the necessary conveniences, like complimentary breakfast and housekeeping services. [Pear Tree Inn Cape Girardeau West](https://www.expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information) is another option in Cape Girardeau where corporate travellers can get some work done with the family in tow. Complimentary breakfast and a laundry service are among the many amenities at this 2.5-stars hotel. When you've finished work, it's time to discover Cape Girardeau with the kids. Popular family-friendly attractions include [Cape Splash Family Aquatic Centre](https://www.expedia.ca/Cape-Splash-Family-Aquatic-Center-Cape-Girardeau.d553248621532655772.Vacation-Attraction) and [Lazy L Safari Park](https://www.expedia.ca/Lazy-L-Safari-Park-Cape-Girardeau.d553248621532655782.Vacation-Attraction).

### Why book your business-friendly hotel in Southeast Missouri with Expedia?

> Expedia is here to help you find an ideal business-friendly hotel when work takes you away from home. From meeting rooms and conference spaces to gyms and on-site restaurants, our stays have all the amenities you'll need to settle that big contract.

### How can I find cheap business-friendly hotels in Southeast Missouri?

> Select the "business friendly" filter, located under the "traveller experience" heading, to find cheap business-friendly hotels in Southeast Missouri. Then fine-tune your search by your per-night budget. Basing yourself outside the city centre is another easy way to save.

### What is there to do in Southeast Missouri near my business-friendly hotel?

> The most important accessory for your Southeast Missouri work visit is an epic itinerary for your downtime! [Isle Casino Cape Girardeau](https://www.expedia.ca/Isle-Casino-Cape-Girardeau-Cape-Girardeau.d553248621532655780.Vacation-Attraction), [Show Me Centre](https://www.expedia.ca/Show-Me-Center-Sikeston.d693562494384107520.Vacation-Attraction) and [Riverfront Park](https://www.expedia.ca/Riverfront-Park-Cape-Girardeau.d740677735274594304.Vacation-Attraction) are among the top sights if you're headed to Cape Girardeau. Sikeston is also home to terrific attractions, such as [Sikeston Depot Museum](https://www.expedia.ca/Sikeston-Depot-Museum-Sikeston.d6305602.Vacation-Attraction), [Central Park](https://www.expedia.ca/Central-Park-Sikeston.d6305608.Vacation-Attraction) and [The Book Bug](https://www.expedia.ca/The-Book-Bug-Sikeston.d553248621532655751.Vacation-Attraction).

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-   [Flights to Farmington](https://www.expedia.ca/Cheap-Flights-To-Farmington.d6058764.Travel-Guide-Flights)
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-   [Visit Fredericktown](https://www.expedia.ca/Fredericktown.dx55114)
-   [K Bridge Recreation Area](https://www.expedia.ca/K-Bridge-Recreation-Area-Annapolis.d6282501.Vacation-Attraction)

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-   [Marble Hill Vacation Rentals](https://www.expedia.ca/Marble-Hill-Vacation-Rentals.d3000445212.Travel-Guide-VacationRentals)

-   [Book Business Hotels in Southeast Missouri on Expedia.com](https://www.expedia.com/Southeast-Missouri-Hotels-Business-Hotel.0-0-d6058763-tBusinessHotel.Travel-Guide-Filter-Hotels)