Title: Southeastern Indiana Vacation Packages & Trips 2026 | Expedia.ca [Southeastern Indiana Travel Guide](https://expedia.ca/Southeastern-Indiana.dx6233889)[Hotels in Southeastern Indiana](https://expedia.ca/Southeastern-Indiana-Hotels.d6233889.Travel-Guide-Hotels)[Vacation Rentals in Southeastern Indiana](https://expedia.ca/Southeastern-Indiana-Vacation-Rentals.d6233889.Travel-Guide-VacationRentals)[Flights to Southeastern Indiana](https://expedia.ca/Cheap-Flights-To-Southeastern-Indiana.d6233889.Travel-Guide-Flights)[Southeastern Indiana Car Rentals](https://expedia.ca/Car-Rentals-In-Southeastern-Indiana.d6233889.Car-Rental-Guide) ![](https://images.trvl-media.com/place/553248635989202622/88a60920-d501-4b4d-b386-caf78a7f4191.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Southeastern Indiana Vacation Packages ## Book a Hotel + Flight or Car together to unlock savings Photo by Serendipity Trip - ## Plan, book, travel with confidence - ### Better together Save up to CA $1,096 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Plan, book, and manage your trip all in one place ## Where to stay in Southeastern Indiana Find the best Southeastern Indiana areas and neighborhoods for the activities you enjoy most. [Learn more about Southeastern Indiana](https://expedia.ca/Southeastern-Indiana.dx6233889) ![Louisville Science Center which includes outdoor art](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/297000/297336-Louisville-Science-Center.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### West Main Historic District Boasting the largest collection of cast iron façades outside New York's SoHo district, this historic area features "Museum Row" with attractions like the Louisville Slugger Museum and Muhammad Ali Center. [Find hotel + flight trips in West Main Historic District](https://expedia.ca/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=West%20Main%20Historic%20District&DestID=6338837&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods) ![Default Image](https://images.trvl-media.com/media/content/expus/graphics/deals/TE_Clouds_card_r1.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Portland While visiting Portland, you might make a stop by sights like Portland Museum and Lannan Park Trailhead. [Find hotel + flight trips in Portland](https://expedia.ca/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Portland&DestID=553248635976395733&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods) ![Default Image](https://images.trvl-media.com/media/content/expus/graphics/deals/TE_Clouds_card_r1.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### California If you're spending some time in California, Ohio River Valley and Union Station are top sights worth seeing. [Find hotel + flight trips in California](https://expedia.ca/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=California&DestID=553248635976386133&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods) ![Default Image](https://images.trvl-media.com/media/content/expus/graphics/deals/TE_Clouds_card_r1.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Shawnee Though Shawnee might not have many top sights, you can venture to the surrounding area to see attractions like Frazier International History Museum and Louisville Slugger Museum. [Find hotel + flight trips in Shawnee](https://expedia.ca/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Shawnee&DestID=553248635976394486&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods) ![Default Image](https://images.trvl-media.com/media/content/expus/graphics/deals/TE_Clouds_card_r1.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Russell If you're spending some time in Russell, Ohio River Valley and I. Willis Cole Residence are top sights worth seeing. [Find hotel + flight trips in Russell](https://expedia.ca/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Russell&DestID=553248635976387155&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods) ## Ready to book your vacation to Southeastern Indiana? Choose your dates ## Southeastern Indiana Hotel Deals ![Radisson Hotel Louisville North](https://images.trvl-media.com/lodging/1000000/30000/26400/26306/50b82654_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Radisson Hotel Louisville North 505 Marriott Drive Clarksville IN Fully refundableReserve now, pay when you stay CA $87 CA $98 total Jan 21 - Jan 22, 2026 includes taxes & fees 6.8/10 (2,625 reviews) it was clean and nice Reviewed on Dec 15, 2025 [](https://expedia.ca/Hotel-Search?startDate=21%2F01%2F2026&endDate=22%2F01%2F2026&selected=26306&PinnedHotelID=26306&HadPinnedHotel=true®ionId=6233889) ![Hilton Garden Inn Jeffersonville Louisville North](https://images.trvl-media.com/lodging/77000000/76420000/76418000/76417931/a3e348c4_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hilton Garden Inn Jeffersonville Louisville North 4900 Water Tower Road Jeffersonville IN Fully refundableReserve now, pay when you stay CA $146 CA $165 total Dec 25 - Dec 26 includes taxes & fees 9.4/10 Exceptional! (406 reviews) The room was spotless and the staff was great. Reviewed on Dec 15, 2025 [](https://expedia.ca/Hotel-Search?startDate=25%2F12%2F2025&endDate=26%2F12%2F2025&selected=76417931&PinnedHotelID=76417931&HadPinnedHotel=true®ionId=6233889) ![Comfort Inn & Suites Clarksville - Louisville North](https://images.trvl-media.com/lodging/65000000/64420000/64410900/64410808/254e595c_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Comfort Inn & Suites Clarksville - Louisville North 1485 Broadway St Clarksville IN Fully refundableReserve now, pay when you stay CA $120 CA $135 total Dec 27 - Dec 28 includes taxes & fees 8.8/10 Excellent! (1,003 reviews) Everything was fine it the bed was way to soft Reviewed on Dec 17, 2025 [](https://expedia.ca/Hotel-Search?startDate=27%2F12%2F2025&endDate=28%2F12%2F2025&selected=64410808&PinnedHotelID=64410808&HadPinnedHotel=true®ionId=6233889) [See all 1,145 properties in Southeastern Indiana](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=22%2F12%2F2025&endDate=23%2F12%2F2025®ionId=6233889) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Vacations [](https://expedia.ca/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Vacations [](https://expedia.ca/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Family Vacations [](https://expedia.ca/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Family_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Golf Vacations [](https://expedia.ca/lp/theme-vacations/golf-vacations?rfrr=editorial.Golf_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Luxury Vacations [](https://expedia.ca/lp/theme-vacations/luxury-vacations?rfrr=editorial.Luxury_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Romantic Vacations [](https://expedia.ca/lp/theme-vacations/romantic-vacations?rfrr=editorial.Romantic_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Ski Vacations [](https://expedia.ca/lp/theme-vacations/ski-vacations?rfrr=editorial.Ski_Vacations.click) ### Discover the most popular places to visit in Southeastern Indiana ![Louisville Slugger Museum featuring interior views](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/297000/297317-Louisville-Slugger-Museum.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Louisville Slugger Museum Baseball is part of the American fabric. See where one important tool for this sport is produced in the factory that makes ball games possible. [](https://expedia.ca/Louisville-Slugger-Museum-Downtown-Louisville.d6062643.Vacation-Attraction) ![Muhammad Ali Center showing night scenes and modern architecture](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/297000/297213-Kentucky.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Muhammad Ali Center One of the world’s greatest boxers continues providing inspiration beyond the world of sport. Understand this superstar by visiting this center honoring him. [](https://expedia.ca/Muhammad-Ali-Center-Downtown-Louisville.d6062649.Vacation-Attraction) ![Louisville Waterfront Park](https://mediaim.expedia.com/destination/2/7a5014b6075e13c5abf94b893ec11f7a.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Louisville Waterfront Park After visiting Louisville Waterfront Park, make a plan to see the other sights and activities in Louisville. Stroll along the area's riverfront or experience its lively festivals. [](https://expedia.ca/Louisville-Waterfront-Park-Butchertown.d6062681.Vacation-Attraction) ## Frequently asked questions ### Can I cancel my flight booking to Southeastern Indiana due to COVID-19? ### What's the best way to find cheap flights to Southeastern Indiana that have flexible change policies? ### What are some of the general tips for travelers to Southeastern Indiana during the COVID-19 outbreak? > - Research if any travel restrictions apply to your origin and destination before locking in a flight. Also check if there are any conditions you'll have to follow on arrival, such as proof of a negative COVID-19 test. > - You must wear a face mask at the airport, including at security checkpoints. You should be prepared to lower your mask for identification purposes when asked by a TSA employee. > - To minimize the risk of cross-contamination, place your boarding pass on the reader yourself and then hold it up for inspection. Do not hand your pass directly to a TSA officer. > - TSA now allows passengers to take one container of hand sanitizer, up to 12 oz (350 ml) in size, in carry-on bags. This will need to be removed from your bag at the X-ray machine for screening. > - Place any personal items (e.g, keys, phone and wallet) in your carry-on instead of a bin to minimize handling during screening. > - Transport all food items in a clear plastic bag and also place them in a screening bin. Keeping food separate from your carry-on makes it less likely that a TSA officer will need to touch and open your bag for inspection. ### Which airlines fly to Southeastern Indiana? ### How can I find cheap tickets to Southeastern Indiana? ### How much is a flight to Southeastern Indiana? ### What are the most popular airports to fly into in Southeastern Indiana? ### When is the cheapest time to fly to Southeastern Indiana? ### How much is a plane ticket to Southeastern Indiana? ### Which airlines with flights to Southeastern Indiana employ COVID-19 cleanliness policies? > - United Airlines - this airline is known for providing passenger masks and cleaning with disinfectant. > - American Airlines - this airline is known for providing passenger masks and cleaning with disinfectant. > - Delta - this airline is known for electrostatic cleaning and cleaning with disinfectant. ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Other - [Hotels near Cumberland River ](https://www.expedia.ca/Cumberland-River-Hotels.0-l681609143447191552-0.Travel-Guide-Filter-Hotels) - 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[Resorts in Southwestern Indiana ](https://www.expedia.ca/Southwestern-Indiana-Resort-Hotels.d6233876-aaResortHotels.Travel-Guide-Accommodation) - [Flights to Ohio River Valley ](https://www.expedia.ca/Cheap-Flights-To-Ohio-River-Valley.d6233674.Travel-Guide-Flights) - [Flights to Southern Indiana ](https://www.expedia.ca/Cheap-Flights-To-Southern-Indiana.d6059635.Travel-Guide-Flights) - [Flights to Southwestern Indiana ](https://www.expedia.ca/Cheap-Flights-To-Southwestern-Indiana.d6233876.Travel-Guide-Flights) - [Flights from Atlanta to Southern Indiana ](https://www.expedia.ca/lp/flights/178232/6059635/atlanta-to-southern-indiana) - [Flights from Calgary to Ohio River Valley ](https://www.expedia.ca/lp/flights/178245/6233674/calgary-to-ohio-river-valley) - [Flights from Dallas to Ohio River Valley ](https://www.expedia.ca/lp/flights/178253/6233674/dallas-to-ohio-river-valley) - [Flights from Miami to Ohio River Valley ](https://www.expedia.ca/lp/flights/178286/6233674/miami-to-ohio-river-valley) - 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