Title: Book the Best Southern Minnesota LUXURY Hotels - Upscale Hotels in Southern Minnesota, MN | Expedia.ca [Southern Minnesota Travel Guide](https://expedia.ca/Southern-Minnesota.dx6059950)[Hotels in Southern Minnesota](https://expedia.ca/Southern-Minnesota-Hotels.d6059950.Travel-Guide-Hotels)[Vacation Rentals in Southern Minnesota](https://expedia.ca/Southern-Minnesota-Vacation-Rentals.d6059950.Travel-Guide-VacationRentals)[Flights to Southern Minnesota](https://expedia.ca/Cheap-Flights-To-Southern-Minnesota.d6059950.Travel-Guide-Flights)[Southern Minnesota Car Rentals](https://expedia.ca/Car-Rentals-In-Southern-Minnesota.d6059950.Car-Rental-Guide)[Southern Minnesota Vacation Packages](https://expedia.ca/Southern-Minnesota.d6059950.Destination-Travel-Guides) ![Lake Pepin & Mississippi River Scenic View](https://images.trvl-media.com/place/553248621532649642/b0facbcd-16cb-4461-946e-105f314f35fc.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find luxury hotels in Southern Minnesota, MN - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Southern Minnesota Luxury Hotels Tonight [Nov 30 - Dec 1](https://www.expedia.ca/Hotel-Search?regionId=6059950&startDate=2025-11-30&endDate=2025-12-01&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [Dec 1 - Dec 2](https://www.expedia.ca/Hotel-Search?regionId=6059950&startDate=2025-12-01&endDate=2025-12-02&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [Dec 5 - Dec 7](https://www.expedia.ca/Hotel-Search?regionId=6059950&startDate=2025-12-05&endDate=2025-12-07&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) In two weeks [Dec 12 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=6059950&startDate=2025-12-12&endDate=2025-12-14&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Top Southern Minnesota Luxury Hotels ![Front of property - evening/night](https://images.trvl-media.com/lodging/1000000/30000/25600/25516/a12994da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Ballroom](https://images.trvl-media.com/lodging/1000000/30000/25600/25516/86c17899.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/30000/25600/25516/ecda08e8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Bedrooms | Living area](https://images.trvl-media.com/lodging/1000000/30000/25600/25516/45535621.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Kahler Grand Hotel Downtown Rochester 8.2/10 Very good (1795) "Great hotel close to everything convenient location " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Marta CA $156 CA $179 total includes taxes & fees Dec 11 - Dec 12 [](https://www.expedia.ca/Rochester-Hotels-Kahler-Grand-Hotel.h25516.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/1000000/480000/471600/471550/c539222f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily full breakfast](https://images.trvl-media.com/lodging/1000000/480000/471600/471550/0fa2acf1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/480000/471600/471550/13696772.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/480000/471600/471550/39a14f28.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### AmericInn by Wyndham Blue Earth Blue Earth 7.8/10 Good (458) "Clean room, comfortable bed, great staff friendly & accomodating" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Nancy CA $105 CA $116 total includes taxes & fees Dec 7 - Dec 8 [](https://www.expedia.ca/Fairmont-Hotels-AmericInn-By-Wyndham-Blue-Earth.h471550.Hotel-Information) ![2 indoor pools](https://images.trvl-media.com/lodging/1000000/10000/4200/4106/821fc05d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/10000/4200/4106/4b21fb74.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/10000/4200/4106/f78e7c09.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Arcade](https://images.trvl-media.com/lodging/1000000/10000/4200/4106/ced48756.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Med City Inn & Suites - Mayo Clinic Area Kutzky Park 7.8/10 Good (1017) "Great staff, room was clean and location was great for our needs." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tim CA $101 CA $116 total includes taxes & fees Dec 7 - Dec 8 [](https://www.expedia.ca/Rochester-Hotels-GuestHouse-Rochester.h4106.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/9000000/8150000/8145400/8145327/f7403b77.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/9000000/8150000/8145400/8145327/9f9116a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/9000000/8150000/8145400/8145327/90ab369f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/9000000/8150000/8145400/8145327/416983a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### AmericInn by Wyndham Northfield Northfield 8.2/10 Very good (620) "Loved the lobby area and the staff were very kind and friendly. Breakfast was good with a variety of choices. The pool and hot tub were also a welcome addition! I will definitely be staying here again. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lighann CA $137 CA $151 total includes taxes & fees Dec 2 - Dec 3 [](https://www.expedia.ca/Owatonna-Hotels-AmericInn-By-Wyndham-Northfield.h8145327.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/860000/855300/855258/71230855.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Non Smoking, Kitchenette](https://images.trvl-media.com/lodging/1000000/860000/855300/855258/eb63d9ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/860000/855300/855258/5b2b2f4d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/860000/855300/855258/2ce5782f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Jackson MN Jackson 8.0/10 Very good (601) "The staff was very helpful, the building is well kept, rooms were clean and spacious. I would stay there again " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Daniel CA $95 CA $105 total includes taxes & fees Dec 5 - Dec 6 [](https://www.expedia.ca/Worthington-Hotels-Super-8-By-Wyndham-Jackson-MN.h855258.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/1000000/460000/459800/459757/f9d660c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Combined shower/tub, designer toiletries, hair dryer, towels](https://images.trvl-media.com/lodging/1000000/460000/459800/459757/c00e3044.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Egyptian cotton sheets, premium bedding, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/460000/459800/459757/70737bed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/460000/459800/459757/39bea812.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Coratel Inn & Suites By Jasper Northfield Northfield 6.2/10 (653) "Clean room comfortable stay and comfortable bed" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Karla CA $82 CA $91 total includes taxes & fees Dec 9 - Dec 10 [](https://www.expedia.ca/Owatonna-Hotels-Coratel-Inn-Suites-Northfield.h459757.Hotel-Information) ![Room, 2 Queen Beds](https://images.trvl-media.com/lodging/1000000/180000/171600/171566/e56e7dae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/180000/171600/171566/053999c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/180000/171600/171566/5e158908.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, open 7:00 AM to 10:00 PM, sun loungers](https://images.trvl-media.com/lodging/1000000/180000/171600/171566/41a1c74b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Kahler Inn and Suites - Mayo Clinic Area Downtown Rochester 8.0/10 Very good (1521) "Staff at check in was friendly and efficient!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Heidi CA $152 CA $175 total includes taxes & fees Dec 2 - Dec 3 [](https://www.expedia.ca/Rochester-Hotels-Kahler-Inn-And-Suites-Mayo-Clinic-Area.h171566.Hotel-Information) ![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/11000000/10010000/10007700/10007613/d36e6ac3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/11000000/10010000/10007700/10007613/a518fccf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/11000000/10010000/10007700/10007613/10fbc765.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/11000000/10010000/10007700/10007613/f77375e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Brentwood Inn & Suites Downtown Rochester 8.8/10 Excellent (1004) "Room was clean breakfast was good everybody was helpful " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) james CA $157 CA $181 total includes taxes & fees Dec 3 - Dec 4 [](https://www.expedia.ca/Rochester-Hotels-Brentwood-Inn-Suites.h10007613.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/25400/25338/046c7ce7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/25400/25338/ceaab958.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/30000/25400/25338/95539a8f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/30000/25400/25338/71dead3d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham Winona Winona 7.8/10 Good (1012) "Clean rooms, friendly staff!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michele CA $77 CA $86 total includes taxes & fees Dec 2 - Dec 3 [](https://www.expedia.ca/Winona-Hotels-Days-Inn-By-Wyndham-Winona.h25338.Hotel-Information) ![Standard Room, 1 Queen Bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/50000/43500/43416/c82aecae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/43500/43416/2bd6f3e5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/50000/43500/43416/32e69416.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/1000000/50000/43500/43416/90117589.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Regency Inn & Suites Faribault 7.4/10 Good (626) " Always a good stop" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michael CA $89 CA $116 total includes taxes & fees Dec 4 - Dec 5 [](https://www.expedia.ca/Owatonna-Hotels-Regency-Inn-Suites.h43416.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-15&endDate=2025-12-16®ionId=6059950&adults=2&star=50&sort=RECOMMENDED&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2025/11/05/BEX-BF-25_CA_1_Desktop.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## Black Friday Sale Limited-time deals: save up to 50% on select hotels [Book now](https://expedia.ca/deals?rfrr=AFFINITY_BF_PROMO_6059950) ## Top Southern Minnesota Hotel Reviews ![Kahler Grand Hotel](https://images.trvl-media.com/lodging/1000000/30000/25600/25516/a12994da_y.jpg) ### Kahler Grand Hotel 10/10 Excellent "Construction " [](https://expedia.ca/Rochester-Hotels-Kahler-Grand-Hotel.h25516.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S](https://images.trvl-media.com/lodging/8000000/7780000/7772100/7772018/569eb353_y.jpg) ### La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S 10/10 Excellent "Clean and quiet. Great breakfast" [](https://expedia.ca/Rochester-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Rochester-Mayo-Clinic-S.h7772018.Hotel-Information) ![Kahler Inn and Suites - Mayo Clinic Area](https://images.trvl-media.com/lodging/1000000/180000/171600/171566/e56e7dae_y.jpg) ### Kahler Inn and Suites - Mayo Clinic Area 10/10 Excellent "We were able to use the subway system to the Mayo Clinic and back to the hotel without going outside. This was a plus since it was cold and rainy weather. Our room was clean. Breakfast gave a good variety of choices." [](https://expedia.ca/Rochester-Hotels-Kahler-Inn-And-Suites-Mayo-Clinic-Area.h171566.Hotel-Information) ![Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area](https://images.trvl-media.com/lodging/1000000/10000/3600/3556/b33056f7_y.jpg) ### Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area 10/10 Excellent "The staff here were the most kind, caring, efficient and joyful staff that we've encountered. The hotel was immaculate, but a bit dated. Twigs Restaurant, in the hotel, had amazing food! We highly recommend it for any meal. Breakfast had a large variety of foods, drinks, etc. and was well maintained. We were only blocks away from the Mayo Clinic for appointments, tours, and could easily walk and enjoy all the architecture in the neighborhood! The shuttle service was quick, efficient and clean, and a nice, comfortable ride. There are plenty of stores & restaurants nearby." [](https://expedia.ca/Rochester-Hotels-Centerstone-Plaza-Hotel-Soldiers-FieldMayo-Clinic-Area.h3556.Hotel-Information) ![AmericInn by Wyndham Rochester Near Mayo Clinic](https://images.trvl-media.com/lodging/1000000/10000/8100/8008/71b6fb30_y.jpg) ### AmericInn by Wyndham Rochester Near Mayo Clinic 10/10 Excellent "Heat was good need a darker shade on window " [](https://expedia.ca/Rochester-Hotels-Ramada-By-Wyndham-Rochester-Mayo-Clinic-Area.h8008.Hotel-Information) ![Med City Inn & Suites - Mayo Clinic Area](https://images.trvl-media.com/lodging/1000000/10000/4200/4106/821fc05d_y.jpg) ### Med City Inn & Suites - Mayo Clinic Area 10/10 Excellent "Staff was super helpful, great breakfast, shirt drive to Mayo" [](https://expedia.ca/Rochester-Hotels-GuestHouse-Rochester.h4106.Hotel-Information) ![Hilton Garden Inn Rochester Downtown, MN](https://images.trvl-media.com/lodging/1000000/220000/214700/214679/67ee8968_y.jpg) ### Hilton Garden Inn Rochester Downtown, MN 10/10 Excellent "Breakfast cost extra" [](https://expedia.ca/Rochester-Hotels-Hilton-Garden-Inn-Rochester-Downtown.h214679.Hotel-Information) ![SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys](https://images.trvl-media.com/lodging/1000000/110000/102000/101902/39da8a7c_y.jpg) ### SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys 10/10 Excellent "Check in was easy. Room was great for me & my sister. All the staff was friendly and helpful. Had a great breakfast buffet. Clean room and great hotel. I would recommend to anyone. You can’t beat the location." [](https://expedia.ca/Rochester-Hotels-SpringHill-Suites-By-Marriott-Rochester-Mayo-ClinicSt-Marys.h101902.Hotel-Information) ![Brentwood Inn & Suites](https://images.trvl-media.com/lodging/11000000/10010000/10007700/10007613/d36e6ac3_y.jpg) ### Brentwood Inn & Suites 10/10 Excellent "Very nice." 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