Title: Book the Best BUSINESS Hotels in Southern Minnesota in 2026 | Expedia.ca [Southern Minnesota Travel Guide](https://expedia.ca/Southern-Minnesota.dx6059950)[Hotels in Southern Minnesota](https://expedia.ca/Southern-Minnesota-Hotels.d6059950.Travel-Guide-Hotels)[Vacation Rentals in Southern Minnesota](https://expedia.ca/Southern-Minnesota-Vacation-Rentals.d6059950.Travel-Guide-VacationRentals)[Flights to Southern Minnesota](https://expedia.ca/Cheap-Flights-To-Southern-Minnesota.d6059950.Travel-Guide-Flights)[Southern Minnesota Car Rentals](https://expedia.ca/Car-Rentals-In-Southern-Minnesota.d6059950.Car-Rental-Guide)[Southern Minnesota Vacation Packages](https://expedia.ca/Southern-Minnesota.d6059950.Destination-Travel-Guides) ![Lake Pepin & Mississippi River Scenic View](https://images.trvl-media.com/place/553248621532649642/b0facbcd-16cb-4461-946e-105f314f35fc.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/553248621532649642/b0facbcd-16cb-4461-946e-105f314f35fc.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Southern Minnesota Business Hotels Tonight [Feb 4 - Feb 5](https://www.expedia.ca/Hotel-Search?regionId=6059950&startDate=2026-02-04&endDate=2026-02-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [Feb 5 - Feb 6](https://www.expedia.ca/Hotel-Search?regionId=6059950&startDate=2026-02-05&endDate=2026-02-06&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) This weekend [Feb 6 - Feb 8](https://www.expedia.ca/Hotel-Search?regionId=6059950&startDate=2026-02-06&endDate=2026-02-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [Feb 13 - Feb 15](https://www.expedia.ca/Hotel-Search?regionId=6059950&startDate=2026-02-13&endDate=2026-02-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Our top choices for Southern Minnesota business-friendly hotels ![Lobby](https://images.trvl-media.com/lodging/1000000/860000/853500/853433/317c9900.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/860000/853500/853433/e2eff1d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, open 7:00 AM to 11:00 PM, sun loungers](https://images.trvl-media.com/lodging/1000000/860000/853500/853433/80430d2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/860000/853500/853433/6c566811.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Rochester South Mayo Clinic [](https://www.expedia.ca/Rochester-Hotels-AmericInn-By-Wyndham-Rochester-Airport.h853433.Hotel-Information) Rochester 8.8/10 Excellent (1,000 reviews) "Enjoyed our stay, rated breakfast as a erage as we did not try it." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) jeanne CA $103 CA $119 total includes taxes & fees Mar 5 - Mar 6 [](https://www.expedia.ca/Rochester-Hotels-AmericInn-By-Wyndham-Rochester-Airport.h853433.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/8900/8820/c90b9231.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cocktail bar](https://images.trvl-media.com/lodging/1000000/10000/8900/8820/40306b49.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/10000/8900/8820/dabc1b97.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Junior Suite Riverside](https://images.trvl-media.com/lodging/1000000/10000/8900/8820/caabe547.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### St James Hotel, a Historic Hotel of America [](https://www.expedia.ca/Red-Wing-Hotels-St-James-Hotel.h8820.Hotel-Information) Red Wing 9.2/10 Wonderful (1,002 reviews) "Alyssa, the front desk staff, was outstanding. She went above and beyond to make sure our stay was comfortable. We love the St. James Hotel for a weekend getaway!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Alysia CA $195 CA $224 total includes taxes & fees Feb 5 - Feb 6 [](https://www.expedia.ca/Red-Wing-Hotels-St-James-Hotel.h8820.Hotel-Information) ![Studio Suite, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/18000000/17870000/17860700/17860639/6c26280a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/18000000/17870000/17860700/17860639/db4e3d60.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, open 7:00 AM to midnight, sun loungers](https://images.trvl-media.com/lodging/18000000/17870000/17860700/17860639/0a91384a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/18000000/17870000/17860700/17860639/ed1e8ba3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### AmericInn by Wyndham Winona [](https://www.expedia.ca/Winona-Hotels-AmericInn-By-Wyndham-Winona.h17860639.Hotel-Information) Winona 9.0/10 Wonderful (906 reviews) "Nice location" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gina CA $141 CA $157 total includes taxes & fees Feb 15 - Feb 16 [](https://www.expedia.ca/Winona-Hotels-AmericInn-By-Wyndham-Winona.h17860639.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/12000000/11680000/11673200/11673145/c7dc0b32.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/12000000/11680000/11673200/11673145/34563649.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/12000000/11680000/11673200/11673145/00ce891c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio, 1 Queen Bed | Living area](https://images.trvl-media.com/lodging/12000000/11680000/11673200/11673145/5b3222d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Spark by Hilton Rochester South [](https://www.expedia.ca/Rochester-Hotels-Spark-By-Hilton-Rochester-South.h11673145.Hotel-Information) Rochester 9.4/10 Exceptional (368 reviews) "Clean, quiet and a really nice place to stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tony CA $100 CA $115 total includes taxes & fees Feb 12 - Feb 13 [](https://www.expedia.ca/Rochester-Hotels-Spark-By-Hilton-Rochester-South.h11673145.Hotel-Information) ![Double Room, 2 Double Beds](https://images.trvl-media.com/lodging/1000000/30000/25900/25829/4e0e5bca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/25900/25829/dc5d30b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/25900/25829/bc67da77.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/30000/25900/25829/15f1a178.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham Austin [](https://www.expedia.ca/Rochester-Hotels-Days-Inn-By-Wyndham-Austin.h25829.Hotel-Information) Austin 8.0/10 Very good (730 reviews) "Good " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) rama CA $95 CA $105 total includes taxes & fees Feb 26 - Feb 27 [](https://www.expedia.ca/Rochester-Hotels-Days-Inn-By-Wyndham-Austin.h25829.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/860000/855600/855537/73da9a49.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hair dryer, towels](https://images.trvl-media.com/lodging/1000000/860000/855600/855537/c84123be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free minibar, desk, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/860000/855600/855537/125b6ab7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/860000/855600/855537/8fcb95ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham St. James [](https://www.expedia.ca/Mankato-Hotels-Super-8-By-Wyndham-St-James.h855537.Hotel-Information) Saint James 8.2/10 Very good (434 reviews) "Breakfast and parking was great!! Light out in Bathroom but very clean room " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Deborah CA $112 CA $122 total includes taxes & fees Feb 6 - Feb 7 [](https://www.expedia.ca/Mankato-Hotels-Super-8-By-Wyndham-St-James.h855537.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/8000000/7780000/7772100/7772018/569eb353.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/8000000/7780000/7772100/7772018/76e5e57e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/8000000/7780000/7772100/7772018/dd818bd0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/8000000/7780000/7772100/7772018/1a6136b4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S [](https://www.expedia.ca/Rochester-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Rochester-Mayo-Clinic-S.h7772018.Hotel-Information) Rochester 7.2/10 Good (1,034 reviews) "Everything was excellent" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Barbara CA $98 CA $113 total includes taxes & fees Feb 7 - Feb 8 [](https://www.expedia.ca/Rochester-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Rochester-Mayo-Clinic-S.h7772018.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/1000000/540000/538500/538443/7134cbc0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/540000/538500/538443/fbd34e02.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/540000/538500/538443/b75bfa05.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/540000/538500/538443/b174610c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Country Inn & Suites by Radisson, Albert Lea - Austin [](https://www.expedia.ca/Owatonna-Hotels-Country-Inn-Suites-By-Radisson.h538443.Hotel-Information) Albert Lea 8.8/10 Excellent (1,004 reviews) "friendly staff good hotel breakfast" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Moss CA $115 CA $128 total includes taxes & fees Feb 27 - Feb 28 [](https://www.expedia.ca/Owatonna-Hotels-Country-Inn-Suites-By-Radisson.h538443.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1250000/1248300/1248233/c9770c0f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1250000/1248300/1248233/adf1570e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, individually decorated, individually furnished](https://images.trvl-media.com/lodging/2000000/1250000/1248300/1248233/25113234.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1250000/1248300/1248233/9e1366bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Nichols Inn of Red Wing [](https://www.expedia.ca/Red-Wing-Hotels-Nichols-Inn-Of-Red-Wing.h1248233.Hotel-Information) Red Wing 9.0/10 Wonderful (1,000 reviews) "Clean room, courteous staff, and a great location. All for a very reasonable price. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Joseph CA $109 CA $120 total includes taxes & fees Feb 5 - Feb 6 [](https://www.expedia.ca/Red-Wing-Hotels-Nichols-Inn-Of-Red-Wing.h1248233.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/4000000/3400000/3395700/3395689/05c87b51.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Handrails in stairways](https://images.trvl-media.com/lodging/4000000/3400000/3395700/3395689/be9b9262.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/4000000/3400000/3395700/3395689/5ef31f80.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/4000000/3400000/3395700/3395689/81bc0968.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### America's Stay Inn Stewartville [](https://www.expedia.ca/Rochester-Hotels-Americas-Stay-Inn-Stewartville.h3395689.Hotel-Information) Stewartville 8.0/10 Very good (424 reviews) "Good price, clean room." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Susan [](https://www.expedia.ca/Rochester-Hotels-Americas-Stay-Inn-Stewartville.h3395689.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-18&endDate=2026-02-19®ionId=6059950&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Southern Minnesota Hotel Reviews ![Kahler Grand Hotel](https://images.trvl-media.com/lodging/1000000/30000/25600/25516/a12994da_y.jpg) ### Kahler Grand Hotel 10/10 Excellent "Overall hospitality " [](https://expedia.ca/Rochester-Hotels-Kahler-Grand-Hotel.h25516.Hotel-Information) ![Hotel Indigo Rochester – Mayo Clinic Area by IHG](https://images.trvl-media.com/lodging/1000000/10000/5400/5327/48e45010_y.jpg) ### Hotel Indigo Rochester – Mayo Clinic Area by IHG 10/10 Excellent "Nice staff. The room is shaped a bit weird and cramped but it was clean and cozy. " [](https://expedia.ca/Rochester-Hotels-Hotel-Indigo-Rochester-Downtown.h5327.Hotel-Information) ![AmericInn by Wyndham Rochester Near Mayo Clinic](https://images.trvl-media.com/lodging/1000000/10000/8100/8008/71b6fb30_y.jpg) ### AmericInn by Wyndham Rochester Near Mayo Clinic 10/10 Excellent "The room was beautiful and spacious for my family and I. The staff I encountered was very friendly and helpful but a specific gentleman was especially helpful with every greeting, he had a smile and was extremely informational even with my kods Playstation! 5 stars and i would definitely stay here again as well as recommend others to stay here. 😃 ❤️ 💙 " [](https://expedia.ca/Rochester-Hotels-Ramada-By-Wyndham-Rochester-Mayo-Clinic-Area.h8008.Hotel-Information) ![Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area](https://images.trvl-media.com/lodging/1000000/10000/3600/3556/b33056f7_y.jpg) ### Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area 10/10 Excellent "The hotel was clean. I still do not like your small pillows, but the rest of the bedding were super comfortable. The staff were friendly and helpful. " [](https://expedia.ca/Rochester-Hotels-Centerstone-Plaza-Hotel-Soldiers-FieldMayo-Clinic-Area.h3556.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S](https://images.trvl-media.com/lodging/8000000/7780000/7772100/7772018/569eb353_y.jpg) ### La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S 10/10 Excellent "It was nice and clean. The halls was quiet " [](https://expedia.ca/Rochester-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Rochester-Mayo-Clinic-S.h7772018.Hotel-Information) ![Hampton Inn Rochester-South](https://images.trvl-media.com/lodging/1000000/20000/16600/16522/f90bd051_y.jpg) ### Hampton Inn Rochester-South 10/10 Excellent "We stayed for one night and everything was great. I especially like that the hot tub is open 24 hours!" [](https://expedia.ca/Rochester-Hotels-Hampton-Inn-Rochester.h16522.Hotel-Information) ![Spark by Hilton Rochester South](https://images.trvl-media.com/lodging/12000000/11680000/11673200/11673145/w3837h2557x3y3-c2ce9db3_y.jpg) ### Spark by Hilton Rochester South 10/10 Excellent "Comfy and Clean. " [](https://expedia.ca/Rochester-Hotels-Spark-By-Hilton-Rochester-South.h11673145.Hotel-Information) ![Kahler Inn and Suites - Mayo Clinic Area](https://images.trvl-media.com/lodging/1000000/180000/171600/171566/e56e7dae_y.jpg) ### Kahler Inn and Suites - Mayo Clinic Area 10/10 Excellent "Happy with the stay, great breakfast included. Happy with our room. No concerns, so continently located to Mayo. " [](https://expedia.ca/Rochester-Hotels-Kahler-Inn-And-Suites-Mayo-Clinic-Area.h171566.Hotel-Information) ![Brentwood Inn & Suites](https://images.trvl-media.com/lodging/11000000/10010000/10007700/10007613/d36e6ac3_y.jpg) ### Brentwood Inn & Suites 10/10 Excellent "Clean" [](https://expedia.ca/Rochester-Hotels-Brentwood-Inn-Suites.h10007613.Hotel-Information) ## Frequently asked questions ### How much do business-friendly hotels in Southern Minnesota cost? ### What are the best business-friendly hotels in Southern Minnesota? ### How many business-friendly hotels are there in Southern Minnesota? ### What are the best cheap business-friendly hotels in Southern Minnesota? ### What are the top business-friendly motels in Southern Minnesota? ### Are there any family-friendly hotels in Southern Minnesota that are also business friendly? ### Are there any 5-star business-friendly hotels in Southern Minnesota? ### Why book your business-friendly hotel in Southern Minnesota with Expedia? ### How can I find cheap business-friendly hotels in Southern Minnesota? ### What is there to do in Southern Minnesota near my business-friendly hotel? ## Explore a world of travel with Expedia - 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