Title: Book the Best BUSINESS Hotels in South San Diego in 2026 | Expedia.ca

[South San Diego Travel Guide](https://expedia.ca/South-San-Diego.dx553248632063518562)[Hotels in South San Diego](https://expedia.ca/South-San-Diego-Hotels.d553248632063518562.Travel-Guide-Hotels)[Vacation Rentals in South San Diego](https://expedia.ca/South-San-Diego-Vacation-Rentals.d553248632063518562.Travel-Guide-VacationRentals)[Flights to South San Diego](https://expedia.ca/Cheap-Flights-To-South-San-Diego.d553248632063518562.Travel-Guide-Flights)[Things to do in South San Diego](https://expedia.ca/Things-To-Do-In-South-San-Diego.d553248632063518562.Travel-Guide-Activities)[South San Diego Car Rentals](https://expedia.ca/Car-Rentals-In-South-San-Diego.d553248632063518562.Car-Rental-Guide)[South San Diego Vacation Packages](https://expedia.ca/South-San-Diego.d553248632063518562.Destination-Travel-Guides)

![Captured this guy doing a wheelie during a beautiful sunset! #imperialbeach #EndlessSummer #autographhotels #Marriott #piersouthresort](https://images.trvl-media.com/place/177683/d4a8a1a3-bd23-4c6a-826e-e0c1c12dddaa.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

Photo by Karen Leone

# Find Business Hotels in South San Diego, CA from CA $108

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## Check availability on South San Diego Business Hotels

Tonight

[Jan 5 - Jan 6](https://www.expedia.ca/Hotel-Search?regionId=553248632063518562&startDate=2026-01-05&endDate=2026-01-06&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly)

Tomorrow

[Jan 6 - Jan 7](https://www.expedia.ca/Hotel-Search?regionId=553248632063518562&startDate=2026-01-06&endDate=2026-01-07&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly)

This weekend

[Jan 9 - Jan 11](https://www.expedia.ca/Hotel-Search?regionId=553248632063518562&startDate=2026-01-09&endDate=2026-01-11&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly)

Next weekend

[Jan 16 - Jan 18](https://www.expedia.ca/Hotel-Search?regionId=553248632063518562&startDate=2026-01-16&endDate=2026-01-18&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly)

## Our top choices for South San Diego business-friendly hotels

![Terrace/patio](https://images.trvl-media.com/lodging/50000000/49290000/49284700/49284697/w3836h2556x3y3-467b2b48.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/50000000/49290000/49284700/49284697/w3839h2555x0y3-5f9fe6e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room safe, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/50000000/49290000/49284700/49284697/w3840h2558x0y3-98d4fb1d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/50000000/49290000/49284700/49284697/720d452f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hampton Inn & Suites Imperial Beach San Diego

[](https://www.expedia.ca/Imperial-Beach-Hotels-Hampton-Inn-Suites-Imperial-Beach-San-Diego.h49284697.Hotel-Information)

Imperial Beach

9.4/10

Exceptional

(968)

"It’s always a great place to stay. The staff are so nice and friendly, rooms are very nice."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Carolyn

CA $197

CA $224 total

includes taxes & fees

Jan 25 - Jan 26

[](https://www.expedia.ca/Imperial-Beach-Hotels-Hampton-Inn-Suites-Imperial-Beach-San-Diego.h49284697.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/2000000/1640000/1632400/1632358/eda7e8ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free buffet breakfast](https://images.trvl-media.com/lodging/2000000/1640000/1632400/1632358/c607b0c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free buffet breakfast](https://images.trvl-media.com/lodging/2000000/1640000/1632400/1632358/3f975189.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Room, 2 Queen Beds](https://images.trvl-media.com/lodging/2000000/1640000/1632400/1632358/6e94d1aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

[](https://www.expedia.ca/San-Diego-Hotels-Holiday-Inn-Express-Hotel-Suites-San-Diego-Otay-Mesa.h1632358.Hotel-Information)

Otay Mesa

8.0/10

Very good

(1581)

"Great place to stay. Really clean and helpful staff "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Zulma

CA $163

CA $186 total

includes taxes & fees

Jan 11 - Jan 12

[](https://www.expedia.ca/San-Diego-Hotels-Holiday-Inn-Express-Hotel-Suites-San-Diego-Otay-Mesa.h1632358.Hotel-Information)

![Meeting facility](https://images.trvl-media.com/lodging/1000000/580000/570900/570818/4cbc3cd6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby lounge](https://images.trvl-media.com/lodging/1000000/580000/570900/570818/743ac288.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Point of interest](https://images.trvl-media.com/lodging/1000000/580000/570900/570818/5d6482eb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby lounge](https://images.trvl-media.com/lodging/1000000/580000/570900/570818/e7aa7734.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Pier South Resort, Autograph Collection by Marriott

[](https://www.expedia.ca/Imperial-Beach-Hotels-Pier-South-Resort.h570818.Hotel-Information)

Imperial Beach

8.4/10

Very good

(1005)

"Room was beautiful, everything about my stay was perfect."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Victoria

CA $233

CA $297 total

includes taxes & fees

Jan 8 - Jan 9

[](https://www.expedia.ca/Imperial-Beach-Hotels-Pier-South-Resort.h570818.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/30000/22900/22810/bfd1ccfe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Deluxe Room, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/30000/22900/22810/b3ebadf5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/1000000/30000/22900/22810/83180011.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free continental breakfast](https://images.trvl-media.com/lodging/1000000/30000/22900/22810/84883664.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### La Quinta Inn by Wyndham San Diego Chula Vista

[](https://www.expedia.ca/Chula-Vista-Hotels-La-Quinta-Inn-By-Wyndham-San-Diego-Chula-Vista.h22810.Hotel-Information)

Chula Vista

8.6/10

Excellent

(1505)

"Everything was great, staff , Room , clean , great place to stay "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Luis

CA $127

CA $140 total

includes taxes & fees

Jan 15 - Jan 16

[](https://www.expedia.ca/Chula-Vista-Hotels-La-Quinta-Inn-By-Wyndham-San-Diego-Chula-Vista.h22810.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/2000000/1480000/1475800/1475800/57e60275.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Deluxe Room, 1 King Bed](https://images.trvl-media.com/lodging/2000000/1480000/1475800/1475800/2602a017.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Daily continental breakfast (USD 13.49 per person)](https://images.trvl-media.com/lodging/2000000/1480000/1475800/1475800/1303c0cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby lounge](https://images.trvl-media.com/lodging/2000000/1480000/1475800/1475800/fb95526d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hercor Hotel - Urban Boutique

[](https://www.expedia.ca/Chula-Vista-Hotels-Hercor-Hotel-Urban-Boutique.h1475800.Hotel-Information)

Chula Vista

8.6/10

Excellent

(1351)

"Clean room, friendly staff. Great breakfast. Many stores and food places near by. Highly recommended 👌 "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Daniel

CA $116

CA $127 total

includes taxes & fees

Jan 11 - Jan 12

[](https://www.expedia.ca/Chula-Vista-Hotels-Hercor-Hotel-Urban-Boutique.h1475800.Hotel-Information)

![View from room](https://images.trvl-media.com/lodging/1000000/20000/18300/18213/b70d99f9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Balcony](https://images.trvl-media.com/lodging/1000000/20000/18300/18213/28c3172b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Memory foam beds, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/1000000/20000/18300/18213/e0c0af28.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Business centre](https://images.trvl-media.com/lodging/1000000/20000/18300/18213/0df0eb3e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Rambler

[](https://www.expedia.ca/Chula-Vista-Hotels-The-Rambler-Motel.h18213.Hotel-Information)

Chula Vista

9.2/10

Wonderful

(2026)

"Absolutely amazing stay will def be coming back!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Victor

CA $125

CA $145 total

includes taxes & fees

Jan 12 - Jan 13

[](https://www.expedia.ca/Chula-Vista-Hotels-The-Rambler-Motel.h18213.Hotel-Information)

![Standard Room, 1 King Bed, Non Smoking, Refrigerator & Microwave](https://images.trvl-media.com/lodging/1000000/20000/12700/12645/cf5335af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/20000/12700/12645/a1205ac4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free continental breakfast](https://images.trvl-media.com/lodging/1000000/20000/12700/12645/bc7617fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/20000/12700/12645/6ca639f9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Best Western Chula Vista/Otay Valley Hotel

[](https://www.expedia.ca/Chula-Vista-Hotels-Best-Western-Chula-VistaOtay-Valley-Hotel.h12645.Hotel-Information)

Otay

7.8/10

Good

(1572)

"Great relaxing stay "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Gustavo

CA $139

CA $153 total

includes taxes & fees

Jan 18 - Jan 19

[](https://www.expedia.ca/Chula-Vista-Hotels-Best-Western-Chula-VistaOtay-Valley-Hotel.h12645.Hotel-Information)

![Coffee service](https://images.trvl-media.com/lodging/13000000/12500000/12496300/12496281/bc01198b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Room, 1 Queen Bed, Accessible, Bathtub](https://images.trvl-media.com/lodging/13000000/12500000/12496300/12496281/a3588783.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/13000000/12500000/12496300/12496281/62279bb2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Room, 1 Queen Bed, Accessible, Bathtub | Mini-refrigerator](https://images.trvl-media.com/lodging/13000000/12500000/12496300/12496281/17786c6f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Quality Inn San Diego South - Chula Vista

[](https://www.expedia.ca/Chula-Vista-Hotels-SureStay-Plus-Hotel-By-Best-Western-Chula-Vista-West.h12496281.Hotel-Information)

Chula Vista

7.8/10

Good

(1003)

"Staff was great!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

jennifer

CA $98

CA $108 total

includes taxes & fees

Jan 18 - Jan 19

[](https://www.expedia.ca/Chula-Vista-Hotels-SureStay-Plus-Hotel-By-Best-Western-Chula-Vista-West.h12496281.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/20000/18900/18870/36da2a73.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/20000/18900/18870/2e7509ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property entrance](https://images.trvl-media.com/lodging/1000000/20000/18900/18870/434ca240.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/20000/18900/18870/a48c362c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Comfort Inn Chula Vista San Diego South

[](https://www.expedia.ca/Chula-Vista-Hotels-Comfort-Inn-Chula-Vista-San-Diego-South.h18870.Hotel-Information)

Chula Vista

8.2/10

Very good

(1287)

"Excelente hotel "

![Mexico](https://a.travel-assets.com/egds/marks/flags/mx.svg)

ESTEBAN

CA $139

CA $154 total

includes taxes & fees

Jan 18 - Jan 19

[](https://www.expedia.ca/Chula-Vista-Hotels-Comfort-Inn-Chula-Vista-San-Diego-South.h18870.Hotel-Information)

![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/470000/461900/461837/673df2c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/470000/461900/461837/c6a042c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/470000/461900/461837/16237f85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/470000/461900/461837/d3d09d7e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Quality Suites San Diego Otay Mesa

[](https://www.expedia.ca/San-Diego-Hotels-Quality-Suites-San-Diego-Otay-Mesa.h461837.Hotel-Information)

Otay Mesa

7.2/10

Good

(1010)

"Clean, convenient location "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Mary

CA $136

CA $155 total

includes taxes & fees

Jan 11 - Jan 12

[](https://www.expedia.ca/San-Diego-Hotels-Quality-Suites-San-Diego-Otay-Mesa.h461837.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.ca/Hotel-Search?startDate=2026-01-20&endDate=2026-01-21&regionId=553248632063518562&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true)

## Top South San Diego Hotel Reviews

![Hard Rock Hotel San Diego](https://images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/fbbdfc57_y.jpg)

### Hard Rock Hotel San Diego

10/10 Excellent

"All good. "

[](https://expedia.ca/San-Diego-Hotels-Hard-Rock-Hotel-San-Diego.h1731557.Hotel-Information)

![Days Inn by Wyndham San Diego Hotel Circle](https://images.trvl-media.com/lodging/1000000/20000/19300/19220/3334d773_y.jpg)

### Days Inn by Wyndham San Diego Hotel Circle

10/10 Excellent

"Good and clean"

[](https://expedia.ca/San-Diego-Hotels-Days-Inn-By-Wyndham-San-Diego-Hotel-Circle.h19220.Hotel-Information)

![Marriott Marquis San Diego Marina](https://images.trvl-media.com/lodging/1000000/30000/24400/24394/9078a9ee_y.jpg)

### Marriott Marquis San Diego Marina

10/10 Excellent

"The room was great, great views of the city and marina. Location is great. Overall I’d recommend this hotel. Brought my girl for a weekend getaway and we both loved it. "

[](https://expedia.ca/San-Diego-Hotels-Marriott-Marquis-San-Diego-Marina.h24394.Hotel-Information)

![Best Western Plus Marina Gateway Hotel](https://images.trvl-media.com/lodging/3000000/2820000/2816700/2816688/f3777dfe_y.jpg)

### Best Western Plus Marina Gateway Hotel

10/10 Excellent

"Could have drain the tub better . But either then that I enjoy my stay. Always come back to this location. "

[](https://expedia.ca/National-City-Hotels-Best-Western-Plus-Marina-Gateway-Hotel.h2816688.Hotel-Information)

![San Diego Mission Bay Resort](https://images.trvl-media.com/lodging/1000000/30000/25600/25598/bbcdbd6d_y.jpg)

### San Diego Mission Bay Resort

10/10 Excellent

"Loved the bay front room with the large grass area right out the door!"

[](https://expedia.ca/San-Diego-Hotels-San-Diego-Mission-Bay-Resort.h25598.Hotel-Information)

![The DEXTRO Little Italy, BW Premier Collection](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/6fe441dd_y.jpg)

### The DEXTRO Little Italy, BW Premier Collection

10/10 Excellent

"Yes "

[](https://expedia.ca/San-Diego-Hotels-Four-Points-By-Sheraton-San-Diego-Downtown-Little-Italy.h170338.Hotel-Information)

![Sheraton San Diego Resort](https://images.trvl-media.com/lodging/1000000/20000/11200/11109/w4000h2662x0y0-91d299a1_y.jpg)

### Sheraton San Diego Resort

10/10 Excellent

"Great "

[](https://expedia.ca/San-Diego-Hotels-Sheraton-San-Diego-Resort.h11109.Hotel-Information)

![Hilton San Diego Mission Valley](https://images.trvl-media.com/lodging/1000000/20000/16100/16019/w5586h3835x5y5-2b129a15_y.jpg)

### Hilton San Diego Mission Valley

10/10 Excellent

"Very courteous lady at the front counter. Great beds. "

[](https://expedia.ca/San-Diego-Hotels-Hilton-San-Diego-Mission-Valley.h16019.Hotel-Information)

![Best Western Seven Seas](https://images.trvl-media.com/lodging/1000000/10000/1800/1734/w3837h2556x3y3-8b148daf_y.jpg)

### Best Western Seven Seas

10/10 Excellent

"Room was good and staff was very friendly and helpful."

[](https://expedia.ca/San-Diego-Hotels-Best-Western-Seven-Seas.h1734.Hotel-Information)

## Frequently asked questions

### How much do business-friendly hotels in South San Diego cost?

### How many business-friendly hotels are there in South San Diego?

### What are the best cheap business-friendly hotels in South San Diego?

### Are there any family-friendly hotels in South San Diego that are also business friendly?

### Are there any 5-star business-friendly hotels in South San Diego?

### Why book your business-friendly hotel in South San Diego with Expedia?

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