Title: Book the Best BUSINESS Hotels in Southern Indiana in 2026 | Expedia.ca [Southern Indiana Travel Guide](https://expedia.ca/Southern-Indiana.dx6059635)[Hotels in Southern Indiana](https://expedia.ca/Southern-Indiana-Hotels.d6059635.Travel-Guide-Hotels)[Vacation Rentals in Southern Indiana](https://expedia.ca/Southern-Indiana-Vacation-Rentals.d6059635.Travel-Guide-VacationRentals)[Flights to Southern Indiana](https://expedia.ca/Cheap-Flights-To-Southern-Indiana.d6059635.Travel-Guide-Flights)[Southern Indiana Car Rentals](https://expedia.ca/Car-Rentals-In-Southern-Indiana.d6059635.Car-Rental-Guide)[Southern Indiana Vacation Packages](https://expedia.ca/Southern-Indiana.d6059635.Destination-Travel-Guides) ![Belle of Louisville which includes a bay or harbour and a ferry as well as a small group of people](https://images.trvl-media.com/place/6062661/de2e6e20-7fec-4f19-8f1c-b6f175615380.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Business Hotels in Southern Indiana from CA $112 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Southern Indiana Business Hotels Tonight [Dec 27 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=6059635&startDate=2025-12-27&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [Dec 28 - Dec 29](https://www.expedia.ca/Hotel-Search?regionId=6059635&startDate=2025-12-28&endDate=2025-12-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [Jan 2 - Jan 4](https://www.expedia.ca/Hotel-Search?regionId=6059635&startDate=2026-01-02&endDate=2026-01-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) In two weeks [Jan 9 - Jan 11](https://www.expedia.ca/Hotel-Search?regionId=6059635&startDate=2026-01-09&endDate=2026-01-11&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Top Southern Indiana Hotel Reviews ![Hampton Inn New Albany Louisville West](https://images.trvl-media.com/lodging/1000000/30000/25400/25301/eb53eba8_y.jpg) ### Hampton Inn New Albany Louisville West 10/10 Excellent "yes, room was ok. staff good. the next mornings was a problem was the shower curtain. it was not tall enough to stop the water from flooding down to the toilet. this room 218 is a wheel chair room. I cleaned up the water as best I could. the shower curtain was not tall enough to touch the small roll over barirer for a wheelchair person. I reported tjis to the front desk. the stay is always good." [](https://expedia.ca/Louisville-Hotels-Hampton-Inn-New-Albany-Louisville-West.h25301.Hotel-Information) ![Bally’s Evansville Casino & Hotel](https://images.trvl-media.com/lodging/1000000/70000/67500/67414/a8c75042_y.jpg) ### Bally’s Evansville Casino & Hotel 10/10 Excellent "Clean updated room" [](https://expedia.ca/Evansville-Hotels-Tropicana-Evansville-Hotel.h67414.Hotel-Information) ![Radisson Hotel Louisville North](https://images.trvl-media.com/lodging/1000000/30000/26400/26306/50b82654_y.jpg) ### Radisson Hotel Louisville North 10/10 Excellent "Friendly staff. Great amenities. Easy access from Louisville via 2nd Street bridge. Nice clean rooms with plenty of pillows for maximum comfort. Even though I didn’t use the pool it is a nice size pool with plenty of room to just sit and relax. " [](https://expedia.ca/Louisville-Hotels-Radisson-Hotel-Louisville-North.h26306.Hotel-Information) ![Ramada by Wyndham Sellersburg/Louisville North](https://images.trvl-media.com/lodging/1000000/660000/659000/658960/dbc92ac1_y.jpg) ### Ramada by Wyndham Sellersburg/Louisville North 10/10 Excellent "Friendly service, clean rooms, comfortable beds, " [](https://expedia.ca/Sellersburg-Hotels-Ramada-By-Wyndham-SellersburgLouisville-North.h658960.Hotel-Information) ![DoubleTree by Hilton Evansville](https://images.trvl-media.com/lodging/16000000/15410000/15401700/15401694/b1976648_y.jpg) ### DoubleTree by Hilton Evansville 10/10 Excellent "Didnt eat breakfast. " [](https://expedia.ca/Evansville-Hotels-DoubleTree-By-Hilton-Evansville.h15401694.Hotel-Information) ![Hampton Inn Evansville](https://images.trvl-media.com/lodging/1000000/20000/15400/15372/6afca36a_y.jpg) ### Hampton Inn Evansville 10/10 Excellent "Loved the bottles of bath wash,shampoo,conditioner and lotion in the big bottles verses the small bottles " [](https://expedia.ca/Evansville-Hotels-Hampton-Inn-Evansville.h15372.Hotel-Information) ![Hampton Inn Louisville-North/Clarksville](https://images.trvl-media.com/lodging/1000000/90000/85100/85064/2cfb06f6_y.jpg) ### Hampton Inn Louisville-North/Clarksville 10/10 Excellent "Quiet location. Comfortable bed. Hot breakfast! Loved the strawberries, almonds, & whip cream for the waffles." [](https://expedia.ca/Louisville-Hotels-Hampton-Inn-Louisville-NorthClarksville.h85064.Hotel-Information) ![Drury Inn & Suites Evansville East](https://images.trvl-media.com/lodging/1000000/120000/116600/116545/2ba5f829_y.jpg) ### Drury Inn & Suites Evansville East 10/10 Excellent "Good selection of hot food options at breakfast. " [](https://expedia.ca/Evansville-Hotels-Drury-Inn-Suites-Evansville-East.h116545.Hotel-Information) ![Best Western Green Tree Inn](https://images.trvl-media.com/lodging/1000000/30000/21100/21059/80ec0958_y.jpg) ### Best Western Green Tree Inn 10/10 Excellent "Yes " [](https://expedia.ca/Louisville-Hotels-Best-Western-Green-Tree-Inn.h21059.Hotel-Information) ## Frequently asked questions ### How much do business-friendly hotels in Southern Indiana cost? ### What are the best business-friendly hotels in Southern Indiana? ### How many business-friendly hotels are there in Southern Indiana? ### What are the best cheap business-friendly hotels in Southern Indiana? ### What are the top business-friendly motels in Southern Indiana? ### Are there any family-friendly hotels in Southern Indiana that are also business friendly? ### Are there any 5-star business-friendly hotels in Southern Indiana? ### Why book your business-friendly hotel in Southern Indiana with Expedia? ### How can I find cheap business-friendly hotels in Southern Indiana? ### What is there to do in Southern Indiana near my business-friendly hotel? ## Explore a world of travel with Expedia - 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