Title: Hotels by La Quinta Inn & Suites in Southern Illinois from CA $114 | Expedia.ca [Southern Illinois Travel Guide](https://expedia.ca/Southern-Illinois.dx6233859)[Hotels in Southern Illinois](https://expedia.ca/Southern-Illinois-Hotels.d6233859.Travel-Guide-Hotels)[Vacation Rentals in Southern Illinois](https://expedia.ca/Southern-Illinois-Vacation-Rentals.d6233859.Travel-Guide-VacationRentals)[Flights to Southern Illinois](https://expedia.ca/Cheap-Flights-To-Southern-Illinois.d6233859.Travel-Guide-Flights)[Southern Illinois Car Rentals](https://expedia.ca/Car-Rentals-In-Southern-Illinois.d6233859.Car-Rental-Guide)[Southern Illinois Vacation Packages](https://expedia.ca/Southern-Illinois.d6233859.Destination-Travel-Guides) ![Southern Illinois featuring a sunset, forests and landscape views](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/208000/208725-Southern-Illinois.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Hotels by La Quinta Inn & Suites in Southern Illinois from CA $114 ### Change your mind Book hotels with free cancellation ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Oct 6 - Oct 7](https://www.expedia.ca/Hotel-Search?regionId=6233859&startDate=2025-10-06&endDate=2025-10-07&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 7 - Oct 8](https://www.expedia.ca/Hotel-Search?regionId=6233859&startDate=2025-10-07&endDate=2025-10-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=6233859&startDate=2025-10-10&endDate=2025-10-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=6233859&startDate=2025-10-17&endDate=2025-10-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Southern Illinois La Quinta Inn & Suites Hotels ![Lobby](https://images.trvl-media.com/lodging/1000000/60000/50100/50093/6cba26b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/60000/50100/50093/25e2a26d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, open 6:00 AM to 11:00 PM, sun loungers](https://images.trvl-media.com/lodging/1000000/60000/50100/50093/453e2ca5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 King Bed, Non Smoking, Jetted Tub](https://images.trvl-media.com/lodging/1000000/60000/50100/50093/140c98cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Effingham Effingham 9.2/10 Wonderful (1003) "Clean rooms, great staff." CA $135 CA $151 total includes taxes & fees Nov 6 - Nov 7 [](https://www.expedia.ca/Effingham-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Effingham.h50093.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/10000000/9650000/9642800/9642754/8a97f90e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/10000000/9650000/9642800/9642754/432f70f3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/10000000/9650000/9642800/9642754/54a98b82.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio Suite, Non Smoking (1 King Bed)](https://images.trvl-media.com/lodging/10000000/9650000/9642800/9642754/f9dcad0b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Collinsville - St. Louis Eastport 7.2/10 Good (1004) "We had a great experience here! " CA $115 CA $132 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Collinsville-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Collinsville-St-Louis.h9642754.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/210000/201300/201286/c5041840.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/210000/201300/201286/1a232cec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/210000/201300/201286/a9eaceec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/210000/201300/201286/079daa32.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis O'Fallon 6.0/10 (1002) "Enjoyed The Pool" CA $99 CA $114 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Collinsville-Hotels-La-Quinta-Inn-Suites-By-Wyndham-OFallon.h201286.Hotel-Information) ![Free daily self-serve breakfast](https://images.trvl-media.com/lodging/1000000/430000/424300/424254/dfd22323.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/430000/424300/424254/f969f8e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/430000/424300/424254/9075cfeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Accessible, Non Smoking (Mobility Accessible)](https://images.trvl-media.com/lodging/1000000/430000/424300/424254/7068f006.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Pontoon Beach Granite City 7.8/10 Good (498) "Great cheap stay" CA $131 CA $151 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/St-Louis-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Pontoon-Beach.h424254.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-20&endDate=2025-10-21®ionId=6233859&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSouthern-Illinois-Hotels-La-Quinta-Inn-Suites.0-0-d6233859--bLaQuintaInnSuites.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSouthern-Illinois-Hotels-La-Quinta-Inn-Suites.0-0-d6233859--bLaQuintaInnSuites.Travel-Guide-Filter-Hotels) ## Top Southern Illinois Hotel Reviews ![Drury Inn & Suites St. Louis O'Fallon, IL](//images.trvl-media.com/lodging/2000000/1550000/1544100/1544028/d2bc121f_y.jpg) ### Drury Inn & Suites St. Louis O'Fallon, IL 10/10 Excellent "Nice clean hotel. No complaints" [](https://expedia.ca/Collinsville-Hotels-Drury-Inn-Suites-St-Louis-OFallon.h1544028.Hotel-Information) ![Drury Plaza Hotel Mt. Vernon](//images.trvl-media.com/lodging/1000000/50000/42100/42021/f9296f7b_y.jpg) ### Drury Plaza Hotel Mt. Vernon 10/10 Excellent "Delighted dinner, breakfast and great beds " [](https://expedia.ca/Mount-Vernon-Hotels-Drury-Inn-Suites-Mt-Vernon.h42021.Hotel-Information) ![Drury Inn & Suites St. Louis Fairview Heights](//images.trvl-media.com/lodging/1000000/50000/41900/41802/c56c0460_y.jpg) ### Drury Inn & Suites St. Louis Fairview Heights 10/10 Excellent "The nigjt shift attendant was very thoughtful and helpful forn my LATE ( 2 am) arrival. Felt very safe with plenty of lightning in parking lot. Room was clean and bed/ pillows comfy " [](https://expedia.ca/Collinsville-Hotels-Drury-Inn-Suites-St-Louis-Fairview-Heights.h41802.Hotel-Information) ![Super 8 by Wyndham Troy IL/St. Louis Area](//images.trvl-media.com/lodging/2000000/1100000/1090700/1090603/6781e11c_y.jpg) ### Super 8 by Wyndham Troy IL/St. Louis Area 10/10 Excellent "Overall very nice" [](https://expedia.ca/St-Louis-Hotels-Super-8-By-Wyndham-Troy-ILSt-Louis-Area.h1090603.Hotel-Information) ![The Principal Hotel](//images.trvl-media.com/lodging/107000000/106860000/106856200/106856168/5d07ff1f_y.jpg) ### The Principal Hotel 10/10 Excellent "This is always a 10/10 for me!" [](https://expedia.ca/Columbia-Hotels-The-Principal-Hotel.h106856168.Hotel-Information) ![Comfort Suites Mount Vernon](//images.trvl-media.com/lodging/2000000/1390000/1387400/1387309/b34f836a_y.jpg) ### Comfort Suites Mount Vernon 10/10 Excellent "Kim was great" [](https://expedia.ca/Mount-Vernon-Hotels-Comfort-Suites-Mount-Vernon.h1387309.Hotel-Information) ![Country Inn & Suites by Radisson, Effingham, IL](//images.trvl-media.com/lodging/1000000/920000/914400/914400/f2163f3d_y.jpg) ### Country Inn & Suites by Radisson, Effingham, IL 10/10 Excellent "Very nice property. Close to a lot of restaurants and I70. The young lady at the front desk was very polite and helpful. " [](https://expedia.ca/Effingham-Hotels-Country-Inn-Suites-By-Radisson.h914400.Hotel-Information) ![Super 8 by Wyndham Fairview Heights-St. Louis](//images.trvl-media.com/lodging/1000000/440000/439700/439700/12639b39_y.jpg) ### Super 8 by Wyndham Fairview Heights-St. Louis 10/10 Excellent "The Super 8 Motel in Fairview Heights was a great stay for my wife and me. We had traveled to St.Louis for the General Conference of Seventh-day Adventists. The hotel is conveniently located near the bus routes that link with the metro rail. 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