Title: Book the Best Southern Illinois LUXURY Hotels - Upscale Hotels in Southern Illinois, IL | Expedia.ca

[Southern Illinois Travel Guide](https://expedia.ca/Southern-Illinois.dx6233859)[Hotels in Southern Illinois](https://expedia.ca/Southern-Illinois-Hotels.d6233859.Travel-Guide-Hotels)[Vacation Rentals in Southern Illinois](https://expedia.ca/Southern-Illinois-Vacation-Rentals.d6233859.Travel-Guide-VacationRentals)[Flights to Southern Illinois](https://expedia.ca/Cheap-Flights-To-Southern-Illinois.d6233859.Travel-Guide-Flights)[Southern Illinois Car Rentals](https://expedia.ca/Car-Rentals-In-Southern-Illinois.d6233859.Car-Rental-Guide)[Southern Illinois Vacation Packages](https://expedia.ca/Southern-Illinois.d6233859.Destination-Travel-Guides)

![Southern Illinois featuring a sunset, forests and landscape views](https://images.trvl-media.com/place/553248635944113522/0e29d2f8-2d58-457a-908d-4b89b13776d9.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

Photo by Southernmost Illinois Tourism Bureau

![](https://images.trvl-media.com/place/553248635944113522/0e29d2f8-2d58-457a-908d-4b89b13776d9.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Check availability on Southern Illinois Luxury Hotels

Tonight

[Jan 26 - Jan 27](https://www.expedia.ca/Hotel-Search?regionId=6233859&startDate=2026-01-26&endDate=2026-01-27&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property)

Tomorrow

[Jan 27 - Jan 28](https://www.expedia.ca/Hotel-Search?regionId=6233859&startDate=2026-01-27&endDate=2026-01-28&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property)

This weekend

[Jan 30 - Feb 1](https://www.expedia.ca/Hotel-Search?regionId=6233859&startDate=2026-01-30&endDate=2026-02-01&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property)

Next weekend

[Feb 6 - Feb 8](https://www.expedia.ca/Hotel-Search?regionId=6233859&startDate=2026-02-06&endDate=2026-02-08&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property)

## Our top choices for Southern Illinois luxury hotels

![Indoor pool, sun loungers](https://images.trvl-media.com/lodging/1000000/10000/5600/5553/5af8e624.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Pillowtop beds, in-room safe, desk, iron/ironing board](https://images.trvl-media.com/lodging/1000000/10000/5600/5553/ec25eb2d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/1000000/10000/5600/5553/86d47a64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/10000/5600/5553/7cac1c62.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### DoubleTree by Hilton Mt. Vernon

[](https://www.expedia.ca/Mount-Vernon-Hotels-DoubleTree-By-Hilton-Mt-Vernon.h5553.Hotel-Information)

Mount Vernon

8.4/10

Very good

(773 reviews)

"What stood out for us were the amenities. This hotel has amazing spaces for meetings or conversation groups. The breakfast buffet was amazing. And there were the cookies!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Glenn

CA $175

CA $197 total

includes taxes & fees

Jan 29 - Jan 30

[](https://www.expedia.ca/Mount-Vernon-Hotels-DoubleTree-By-Hilton-Mt-Vernon.h5553.Hotel-Information)

![Sauna, hot tub, body treatments, hot stone massages](https://images.trvl-media.com/lodging/98000000/97070000/97064800/97064786/8fcd4708.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 restaurants, breakfast, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/98000000/97070000/97064800/97064786/3a123ac6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Casino](https://images.trvl-media.com/lodging/98000000/97070000/97064800/97064786/2902012c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 restaurants, breakfast, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/98000000/97070000/97064800/97064786/84958281.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Walker's Bluff Casino Resort

[](https://www.expedia.ca/Carterville-Hotels-Walkers-Bluff-Casino-Resort.h97064786.Hotel-Information)

Carterville

9.4/10

Exceptional

(403 reviews)

"Clean & friendly place "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Beverly

CA $171

CA $190 total

includes taxes & fees

Jan 27 - Jan 28

[](https://www.expedia.ca/Carterville-Hotels-Walkers-Bluff-Casino-Resort.h97064786.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/27100/27006/579b996f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/1000000/30000/27100/27006/5581a60c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/1000000/30000/27100/27006/35f1a1de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/1000000/30000/27100/27006/a497be51.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### DoubleTree by Hilton Collinsville - St. Louis

[](https://www.expedia.ca/Collinsville-Hotels-DoubleTree-By-Hilton-Collinsville-St-Louis.h27006.Hotel-Information)

Eastport

8.2/10

Very good

(1,001 reviews)

"Great stay"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Patrina

CA $167

CA $192 total

includes taxes & fees

Feb 26 - Feb 27

[](https://www.expedia.ca/Collinsville-Hotels-DoubleTree-By-Hilton-Collinsville-St-Louis.h27006.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/124000000/123050000/123048300/123048290/0b27031e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/124000000/123050000/123048300/123048290/f98ba8d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/124000000/123050000/123048300/123048290/a9cf7169.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Classic Suite](https://images.trvl-media.com/lodging/124000000/123050000/123048300/123048290/aef8249a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Charleston House Bed & Breakfast Inn

[](https://www.expedia.ca/Charleston-Hotels-Charleston-House-Bed-Breakfast-Inn.h123048290.Hotel-Information)

Charleston

CA $143

CA $159 total

includes taxes & fees

Feb 22 - Feb 23

[](https://www.expedia.ca/Charleston-Hotels-Charleston-House-Bed-Breakfast-Inn.h123048290.Hotel-Information)

![Seasonal outdoor pool](https://images.trvl-media.com/lodging/2000000/1880000/1873300/1873292/70b128db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/2000000/1880000/1873300/1873292/502ee41b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Casino](https://images.trvl-media.com/lodging/2000000/1880000/1873300/1873292/w2880h1936x0y0-34b8c827.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Nightclub](https://images.trvl-media.com/lodging/2000000/1880000/1873300/1873292/4519749c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Ameristar Casino Resort and Spa

[](https://www.expedia.ca/St-Louis-Hotels-Ameristar-Casino-Resort-And-Spa.h1873292.Hotel-Information)

St. Charles

8.4/10

Very good

(1,007 reviews)

"Excellent staff"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Cheri

CA $218

CA $278 total

includes taxes & fees

Feb 1 - Feb 2

[](https://www.expedia.ca/St-Louis-Hotels-Ameristar-Casino-Resort-And-Spa.h1873292.Hotel-Information)

![Property amenity](https://images.trvl-media.com/lodging/3000000/2300000/2292900/2292856/w2897h2195x0y8-cdf51e05.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior detail](https://images.trvl-media.com/lodging/3000000/2300000/2292900/2292856/1004381f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby sitting area](https://images.trvl-media.com/lodging/3000000/2300000/2292900/2292856/150f8d2c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bars/lounges, rooftop bar](https://images.trvl-media.com/lodging/3000000/2300000/2292900/2292856/996a216e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Moonrise Hotel

[](https://www.expedia.ca/St-Louis-Hotels-Moonrise-Hotel.h2292856.Hotel-Information)

Delmar Loop

9.0/10

Wonderful

(1,929 reviews)

"The staff was wonderful. Very unique hotel it was awesome."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jaden

CA $170

CA $203 total

includes taxes & fees

Jan 27 - Jan 28

[](https://www.expedia.ca/St-Louis-Hotels-Moonrise-Hotel.h2292856.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/20000/14900/14877/335a172e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Meeting facility](https://images.trvl-media.com/lodging/1000000/20000/14900/14877/e4de4f95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/20000/14900/14877/3721d666.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/20000/14900/14877/65a6e602.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hyatt Regency St. Louis at The Arch

[](https://www.expedia.ca/St-Louis-Hotels-Hyatt-Regency-St-Louis-At-The-Arch.h14877.Hotel-Information)

Downtown St. Louis

8.4/10

Very good

(4,037 reviews)

"Great location and vibe. I will definitely return "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Cassey

CA $218

CA $257 total

includes taxes & fees

Jan 30 - Jan 31

[](https://www.expedia.ca/St-Louis-Hotels-Hyatt-Regency-St-Louis-At-The-Arch.h14877.Hotel-Information)

![5 restaurants, breakfast, dinner served; American cuisine](https://images.trvl-media.com/lodging/102000000/101750000/101749800/101749750/2fa826c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![6 bars/lounges, poolside bar](https://images.trvl-media.com/lodging/102000000/101750000/101749800/101749750/11323991.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![5 restaurants, breakfast, dinner served; American cuisine](https://images.trvl-media.com/lodging/102000000/101750000/101749800/101749750/31f323b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/102000000/101750000/101749800/101749750/573bb871.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Terre Haute Casino Resort

[](https://www.expedia.ca/Terre-Haute-Hotels-Terre-Haute-Casino-Resort.h101749750.Hotel-Information)

Terre Haute

9.2/10

Wonderful

(774 reviews)

"Very clean, good location and excellent value for money"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

George

CA $165

CA $190 total

includes taxes & fees

Jan 27 - Jan 28

[](https://www.expedia.ca/Terre-Haute-Hotels-Terre-Haute-Casino-Resort.h101749750.Hotel-Information)

![Oven, stovetop, dishwasher, espresso maker](https://images.trvl-media.com/lodging/104000000/103360000/103357800/103357795/becf52a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Coffee and/or coffee maker](https://images.trvl-media.com/lodging/104000000/103360000/103357800/103357795/f7d784c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/104000000/103360000/103357800/103357795/ab0818b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Coffee service](https://images.trvl-media.com/lodging/104000000/103360000/103357800/103357795/ca731d53.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Arbor Rose Boutique Hotel

[](https://www.expedia.ca/Arcola-Hotels-Joyful-Life.h103357795.Hotel-Information)

Arcola

9.6/10

Exceptional

(36 reviews)

"Great place! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Connie

CA $204

CA $227 total

includes taxes & fees

Feb 26 - Feb 27

[](https://www.expedia.ca/Arcola-Hotels-Joyful-Life.h103357795.Hotel-Information)

![Meeting facility](https://images.trvl-media.com/lodging/45000000/44460000/44452500/44452446/bfa9a7c8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Garden](https://images.trvl-media.com/lodging/45000000/44460000/44452500/44452446/f4a93dba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Elevator](https://images.trvl-media.com/lodging/45000000/44460000/44452500/44452446/46465b3e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/45000000/44460000/44452500/44452446/d41f9415.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Respite Bed and Breakfast

[](https://www.expedia.ca/Paducah-Hotels-The-Respite-Bed-And-Breakfast.h44452446.Hotel-Information)

Paducah

9.8/10

Exceptional

(289 reviews)

"Very clean room and staff was very courteous and hospitable. Enjoyed our stay very much. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Damon

[](https://www.expedia.ca/Paducah-Hotels-The-Respite-Bed-And-Breakfast.h44452446.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-09&endDate=2026-02-10&regionId=6233859&adults=2&sort=LUXURY&star=40,50&openPlayBack=true)

## Find out more about Southern Illinois

### Southern Illinoisand its attractions for luxury travelers

Southern Illinois offers an intriguing blend of natural beauty and cultural experiences, making it a unique spot for the discerning traveller. Begin your exploration in the Shawnee National Forest, where you can hike the stunning trails, marvel at the towering rock formations of Giant City State Park, or even try your hand at horseback riding through picturesque landscapes. For a more leisurely pace, indulge in wine tasting at the numerous vineyards along the Shawnee Hills Wine Trail, where you can savour exquisite local wines paired with gourmet dining options. Don't miss the captivating Cache River State Natural Area, home to ancient cypress swamps and rich biodiversity, ideal for birdwatching and serene canoeing adventures. For a touch of history and culture, visit the charming town of Carbondale, where you can enjoy fine dining at upscale restaurants and explore local art galleries. For your luxurious stay, consider the exclusive accommodations in the heart of this region, such as the beautiful Stone Creek Lodge, which offers a rustic yet refined atmosphere complete with modern amenities and attentive service that caters to your every need. Here, you can unwind in style after a day of exploration, enjoying the comfort and convenience that make your stay utterly relaxing.

## Top Southern Illinois Hotel Reviews

![Comfort Suites Mount Vernon](https://images.trvl-media.com/lodging/2000000/1390000/1387400/1387309/b34f836a_y.jpg)

### Comfort Suites Mount Vernon

10/10 Excellent

"Staff was so nice room clean"

[](https://expedia.ca/Mount-Vernon-Hotels-Comfort-Suites-Mount-Vernon.h1387309.Hotel-Information)

![Super 8 by Wyndham O'Fallon](https://images.trvl-media.com/lodging/1000000/20000/11100/11071/055d0e3b_y.jpg)

### Super 8 by Wyndham O'Fallon

10/10 Excellent

"Yes "

[](https://expedia.ca/Collinsville-Hotels-Super-8-By-Wyndham-OFallon.h11071.Hotel-Information)

![Sleep Inn O'Fallon near I-64](https://images.trvl-media.com/lodging/1000000/170000/168400/168383/8c254240_y.jpg)

### Sleep Inn O'Fallon near I-64

10/10 Excellent

"Clean and quiet. Slept well."

[](https://expedia.ca/Collinsville-Hotels-Sleep-Inn.h168383.Hotel-Information)

![Red Lion Inn & Suites Pontoon Beach](https://images.trvl-media.com/lodging/1000000/20000/17400/17338/284b6d11_y.jpg)

### Red Lion Inn & Suites Pontoon Beach

10/10 Excellent

"Clean room, friendly staff, good breakfast "

[](https://expedia.ca/St-Louis-Hotels-Red-Lion-Inn-Suites-Pontoon-Beach.h17338.Hotel-Information)

![Drury Inn & Suites St. Louis Fairview Heights](https://images.trvl-media.com/lodging/1000000/50000/41900/41802/c56c0460_y.jpg)

### Drury Inn & Suites St. Louis Fairview Heights

10/10 Excellent

"Very clean "

[](https://expedia.ca/Collinsville-Hotels-Drury-Inn-Suites-St-Louis-Fairview-Heights.h41802.Hotel-Information)

![Drury Plaza Hotel Mt. Vernon](https://images.trvl-media.com/lodging/1000000/50000/42100/42021/f9296f7b_y.jpg)

### Drury Plaza Hotel Mt. Vernon

10/10 Excellent

"Hotel is very clean, nicely furnished and the beds were so comfy!"

[](https://expedia.ca/Mount-Vernon-Hotels-Drury-Inn-Suites-Mt-Vernon.h42021.Hotel-Information)

![Red Roof Inn St Louis - Troy, IL](https://images.trvl-media.com/lodging/1000000/490000/482700/482646/05c66ebb_y.jpg)

### Red Roof Inn St Louis - Troy, IL

10/10 Excellent

"Would stay ahain"

[](https://expedia.ca/St-Louis-Hotels-Red-Roof-Inn-St-Louis-Troy.h482646.Hotel-Information)

![La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis](https://images.trvl-media.com/lodging/1000000/210000/201300/201286/c5041840_y.jpg)

### La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis

10/10 Excellent

"Everything was really good."

[](https://expedia.ca/Collinsville-Hotels-La-Quinta-Inn-Suites-By-Wyndham-OFallon.h201286.Hotel-Information)

![Quality Inn O'Fallon IL - St. Louis](https://images.trvl-media.com/lodging/1000000/70000/64700/64675/8890354b_y.jpg)

### Quality Inn O'Fallon IL - St. Louis

10/10 Excellent

"Great place to stay, very helpful ataff!"

[](https://expedia.ca/Collinsville-Hotels-Quality-Inn-OFallon-I-64.h64675.Hotel-Information)

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