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Holiday Inn Express & Suites St. Louis South - I-55 by IHG

2.5 star property
Travelers can start their day with a complimentary breakfast buffet before heading to the 24-hour fitness center for a morning workout session

Choose dates to view prices

Located in the business district, Holiday Inn Express & Suites St. Louis South - I-55 offers practical comforts for busy travelers. Enjoy a hearty breakfast buffet, reliable in-room WiFi, an indoor pool for relaxation, and a 24-hour gym.

Reviews

9.6 out of 10
Exceptional

Popular amenities

  • Free WiFi
  • Air conditioning

Room options

Available filters for rooms
Showing 10 of 10 rooms

View all photos for Standard Room, 2 Queen Beds, Accessible (Comm, Bath Shwr Combo)

Room amenity

Standard Room, 2 Queen Beds, Accessible (Comm, Bath Shwr Combo)

9.4 out of 10
Exceptional
(13 reviews)

Highlights

Air conditioning
Heating
Connecting rooms available
Free cribs/infant beds
Refrigerator
Flat-screen TV
Blackout drapes/curtains
Separate bedroom
  • 300 sq ft
  • 1 bedroom
  • Sleeps 4
  • 2 Queen Beds

View all photos for Standard Room, 2 Queen Beds, Accessible (Mobil Tub)

Standard Room, 2 Queen Beds, Accessible (Mobil Tub)

Standard Room, 2 Queen Beds, Accessible (Mobil Tub)

9.6 out of 10
Exceptional
(4 reviews)

Highlights

Air conditioning
Heating
Connecting rooms available
Free cribs/infant beds
Refrigerator
Flat-screen TV
Blackout drapes/curtains
Separate bedroom
  • 300 sq ft
  • 1 bedroom
  • Sleeps 4
  • 2 Queen Beds

View all photos for Suite, 1 Bedroom (2 Queen, Extra Living Area)

Room amenity

Suite, 1 Bedroom (2 Queen, Extra Living Area)

9.4 out of 10
Exceptional
(28 reviews)

Highlights

Air conditioning
Heating
Connecting rooms available
Free rollaway/extra beds
Free cribs/infant beds
Refrigerator
Flat-screen TV
Blackout drapes/curtains
  • 300 sq ft
  • 1 bedroom
  • Sleeps 6
  • 2 Queen Beds

View all photos for Standard Room, 1 King Bed, Accessible (Comm, Bath Shower Combo)

Room amenity

Standard Room, 1 King Bed, Accessible (Comm, Bath Shower Combo)

9.0 out of 10
Wonderful
(7 reviews)

Highlights

Air conditioning
Heating
Connecting rooms available
Free cribs/infant beds
Refrigerator
Flat-screen TV
Blackout drapes/curtains
Separate bedroom
  • 300 sq ft
  • 1 bedroom
  • Sleeps 4
  • 1 King Bed

View all photos for Standard Room, 1 King Bed, Accessible (Mobil Roll In Shwr)

Free toiletries, hair dryer, towels, soap

Standard Room, 1 King Bed, Accessible (Mobil Roll In Shwr)

10.0 out of 10
Exceptional
(2 reviews)

Highlights

Air conditioning
Heating
Connecting rooms available
Free cribs/infant beds
Refrigerator
Flat-screen TV
Blackout drapes/curtains
Separate bedroom
  • 300 sq ft
  • 1 bedroom
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed (Extra Living, Walk in Shwr)

Suite, 1 King Bed (Extra Living, Walk in Shwr)

Suite, 1 King Bed (Extra Living, Walk in Shwr)

9.0 out of 10
Wonderful
(4 reviews)

Highlights

Air conditioning
Heating
Connecting rooms available
Free rollaway/extra beds
Free cribs/infant beds
Refrigerator
Flat-screen TV
Blackout drapes/curtains
  • 300 sq ft
  • 1 bedroom
  • Sleeps 4
  • 1 King Bed

View all photos for Standard Room, 1 King Bed (Bath Shwr Combo)

Room amenity

Standard Room, 1 King Bed (Bath Shwr Combo)

9.8 out of 10
Exceptional
(16 reviews)

Highlights

Air conditioning
Heating
Connecting rooms available
Free cribs/infant beds
Refrigerator
Flat-screen TV
Blackout drapes/curtains
Separate bedroom
  • 300 sq ft
  • 1 bedroom
  • Sleeps 4
  • 1 King Bed

View all photos for Standard Room

Standard Room

Standard Room

Highlights

Air conditioning
Heating
Connecting rooms available
Free cribs/infant beds
Refrigerator
Flat-screen TV
Blackout drapes/curtains
Separate bedroom
  • 300 sq ft
  • 1 bedroom
  • Sleeps 2
  • 1 Twin Bed

View all photos for Suite, 1 King Bed, Accessible (Mobil Tub, Extra Living)

Suite, 1 King Bed, Accessible (Mobil Tub, Extra Living)

Suite, 1 King Bed, Accessible (Mobil Tub, Extra Living)

Highlights

Air conditioning
Heating
Connecting rooms available
Free rollaway/extra beds
Free cribs/infant beds
Refrigerator
Flat-screen TV
Blackout drapes/curtains
  • 300 sq ft
  • 1 bedroom
  • Sleeps 4
  • 1 King Bed

View all photos for Standard Room, 2 Queen Beds

Room amenity

Standard Room, 2 Queen Beds

9.4 out of 10
Exceptional
(74 reviews)

Highlights

Air conditioning
Heating
Connecting rooms available
Free cribs/infant beds
Refrigerator
Flat-screen TV
Blackout drapes/curtains
Separate bedroom
  • 300 sq ft
  • 1 bedroom
  • Sleeps 4
  • 2 Queen Beds

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About the area

Located in St. Louis, Holiday Inn Express & Suites St. Louis South - I-55 by IHG is in the business district. Arnold Historical Society & Museum and Jefferson Barracks Historic Park are cultural highlights, and some of the area's landmarks include Missouri Civil War Museum and Ulysses S. Grant National Historic Site. Looking to enjoy an event or a game while in town? See what's happening at Kennedy Rink or Shaw Park Tennis Center. Visit our St. Louis travel guide
Map
4250 Midamerica Lane, St. Louis, MO, 63129

What's nearby

  • St. Louis Cardinals Baseball.
    Busch Stadium
    16 min drive - 27.2 km
  • Gateway Arch featuring a monument, night scenes and a park
    Gateway Arch
    17 min drive - 27.8 km
  • Aerial view of vibrant downtown St. Louis with Enterprise Center and St. Louis Wheel, St. Louis, Missouri, United States.
    Enterprise Center
    17 min drive - 26.8 km
  • Union Station, St. Louis, MO
    St. Louis Union Station
    18 min drive - 27.2 km
  • Barnes Jewish South Campus
    5 min walk - 0.4 km

Getting around

  • Kirkwood Station
    17 min drive
  • St. Louis Lambert Intl. Airport (STL)
    32 min drive

Restaurants

  • Burger King
    10 min walk
  • McDonald's
    5 min drive
  • Popeyes Louisiana Kitchen
    4 min walk
  • Hardee's / Red Burrito
    11 min walk
  • Rich & Charlie's Italian Restaurant
    3 min drive

About this property

Holiday Inn Express & Suites St. Louis South - I-55 by IHG

Hotel in the business district
A free breakfast buffet, a 24-hour gym, and a business center are just a few of the amenities provided at Holiday Inn Express & Suites St. Louis South - I-55 by IHG. Stay connected with free in-room WiFi.
You'll also enjoy perks such as:
  • An indoor pool along with sun loungers
  • Free self parking
  • An elevator, a vending machine, and a front-desk safe
  • A banquet hall, smoke-free premises, and a 24-hour front desk
  • Guest reviews say great things about the breakfast and helpful staff
Room features
All 99 rooms offer comforts such as laptop-friendly workspaces and air conditioning, as well as thoughtful touches like free WiFi and safes. Guest reviews highly rate the clean rooms at the property.
More amenities include:
  • Bathrooms with free toiletries and hair dryers
  • 49-inch flat-screen TVs with cable channels
  • Wardrobes/closets, refrigerators, and microwaves

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Property amenities

Internet

  • Available in all rooms: Free WiFi and wired internet
  • Available in some public areas: Free WiFi

Parking and transportation

  • Free self parking on site
  • Wheelchair-accessible parking and van parking available

Food and drink

  • Free buffet breakfast available daily 6:00 AM to 9:30 AM

Things to do

  • 24-hour gym
  • Indoor pool

Family friendly

  • In-room crib
  • In-room microwave
  • In-room refrigerator
  • Indoor pool

Conveniences

  • 24-hour front desk
  • Safe at front desk
  • Vending machine

Guest services

  • Change of bedsheets (on request)
  • Change of towels on request
  • Housekeeping (daily)

Business services

  • Business center
  • Meeting rooms

Outdoors

  • Pool loungers

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Elevator
  • Stair-free path to entrance
  • Visual alarms in hallways
  • Well-lit path to entrance
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible concierge desk
  • Wheelchair-accessible gym
  • Wheelchair-accessible lounge
  • Wheelchair-accessible parking
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible path to elevator
  • Wheelchair-accessible pool
  • Wheelchair-accessible public washroom
  • Wheelchair-accessible van parking

More

  • 4 floors
  • At least 10% of profits reinvested in community and sustainability
  • Banquet hall
  • No plastic drinking straws
  • Smoking not allowed

Room amenities

Bedroom

  • Bedsheets provided
  • Blackout drapes
  • Free crib

Bathroom

  • Free toiletries
  • Hair dryer
  • Private bathroom
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Entertainment

  • 49-inch flat-screen TV with cable channels

Food and drink

  • Coffee/tea maker
  • Microwave
  • Refrigerator

More

  • Air conditioning (climate-controlled)
  • Connecting rooms available
  • Desk
  • Free local calls
  • Heating
  • Iron/ironing board
  • Laptop workspace
  • Phone
  • Safe

Policies

Check-in

Check-in start time: 3:00 PM; Check-in end time: 2:30 AM
Minimum check-in age: 21

Check-out

Check-out before 11 AM
Contactless check-out available

Special check-in instructions

Front desk staff will greet guests on arrival at the property
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

Pets not allowed (service animals are welcome, and are exempt from fees)

Children and extra beds

Children are welcome
Free cribs are available on request at the property

Property payment types

Important information

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Safety features at this property include a fire extinguisher
This property affirms that it follows the cleaning and disinfection practices of Clean Promise (IHG)

We should mention

Pool access available from 8 AM to 10 PM
The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation
This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly)

Property is also known as

Holiday Inn Express St. Louis South I-55 Hotel
Holiday Inn Express St. Louis South I-55
Inn Express St Louis I55
Holiday Inn Express Suites St. Louis South I 55
Holiday Inn Express Suites St. Louis South I 55 by IHG
Holiday Inn Express Suites St. Louis South I 55 an IHG Hotel
Holiday Inn Express & Suites St. Louis South - I-55 by IHG Hotel

Frequently asked questions

Does Holiday Inn Express & Suites St. Louis South - I-55 by IHG have a pool?

Yes, this property has an indoor pool. Pool access is from 8 AM–10 PM.

How much does it cost to stay at Holiday Inn Express & Suites St. Louis South - I-55 by IHG?

As of Mar 8, 2026, prices found for a 1-night stay for 2 adults at Holiday Inn Express & Suites St. Louis South - I-55 by IHG on Apr 5, 2026 start from CA $179, excluding taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

Is Holiday Inn Express & Suites St. Louis South - I-55 by IHG pet-friendly?

No, only service animals are welcome at the property.

How much is parking?

Self parking is free at this property.

What time is check-in at Holiday Inn Express & Suites St. Louis South - I-55 by IHG?

Check-in start time: 3:00 PM; Check-in end time: 2:30 AM.

What time is check-out at Holiday Inn Express & Suites St. Louis South - I-55 by IHG?

Check-out is at 11 AM.

Where is Holiday Inn Express & Suites St. Louis South - I-55 by IHG located?

Situated in the business district, this hotel is 0.3 mi (0.6 km) from Barnes Jewish South Campus and within 3 mi (5 km) of BounceU of St. Louis and St Anthony's. Kindred Hospital St. Louis South and Kennedy Rink are also within 3 mi (5 km).

Can I cancel my reservation for free and receive a full refund?

Yes, this property offers free cancellation on select room rates, because flexibility matters! Please refer to the property cancellation policy on our site for more details about any exclusions or requirements.

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Reviews

Holiday Inn Express & Suites St. Louis South - I-55 by IHG Reviews

9.6

Exceptional

9.6

Cleanliness

9.4

Location

9.6

Staff & service

9.6

Property conditions & facilities
Rating 10 - Excellent. 803 out of 1006 reviews
Rating 8 - Good. 146 out of 1006 reviews
Rating 6 - Okay. 35 out of 1006 reviews
Rating 4 - Poor. 15 out of 1006 reviews
Rating 2 - Terrible. 7 out of 1006 reviews

Reviews

10/10 Excellent

Anita

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Room was clean and staff was friendly.
Stayed 2 nights in Nov 2025

10/10 Excellent

Pamela

Liked: Cleanliness, amenities, property conditions & facilities
Staff is very nice! The rooms are clean and comfortable.
Stayed 1 night in Jan 2026

10/10 Excellent

Brandy

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Friendly staff clean rooms
Stayed 1 night in Jan 2026

10/10 Excellent

Zackariah

Liked: Cleanliness, amenities, property conditions & facilities
The breakfast was very great! They also served cookies and milk during the evening in the lobby. The gym and swimming pool were very nice and conveniently located near the elevators and outside doorway with two bathrooms nearby.
Stayed 1 night in Dec 2025

10/10 Excellent

tiffany

Liked: Cleanliness, amenities, property conditions & facilities
Room was very clean! enjoyed the amenities!
Stayed 1 night in Dec 2025

10/10 Excellent

Melissa

Liked: Cleanliness
Staff was welcoming and helpful at check in. Offered cookies and milk. The room was clean and the breakfast was good too. I would stay again.
Stayed 1 night in Dec 2025

10/10 Excellent

Kalina

Staff was extremely helpful
Stayed 1 night in Nov 2025

8/10 Good

Ruth

Liked: Cleanliness, staff & service, property conditions & facilities
cleaning staff was very helpful and I loved the cookies at night
Stayed 4 nights in Oct 2025

10/10 Excellent

Jessica

Great breakfast, great rooms and comfy beds.
Stayed 1 night in May 2025

10/10 Excellent

James

Very nice new hotel and even the breakfast was great.
Stayed 2 nights in Jul 2025

10/10 Excellent

Kevan

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Good clean hotel.
Stayed 1 night in Jun 2025

10/10 Excellent

Mark

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
The breakfast was good and the hotel staff was the best made it worth the trip
Stayed 2 nights in Jun 2025

10/10 Excellent

Danielle

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

Best Hotel Ever

My stay was awesome! Everything was great! Staff so awesome! Friendliest hotel I’ve ever stayed at! A+
Stayed 1 night in Sep 2025

10/10 Excellent

sonia

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Great location and service
Stayed 1 night in Jul 2025

10/10 Excellent

James

Liked: Cleanliness, staff & service, property conditions & facilities
Friendly staff, great location!
Stayed 1 night in Apr 2025

10/10 Excellent

Marilyn

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

Clean, fast, & friendly!

We are currently still checked in and had the most delicious & well presented breakfast. Coffee is excellent, and breakfast area is cleaned. The breakfast server was very friendly & respectful.
Stayed 1 night in Aug 2025

10/10 Excellent

Charles

Liked: Cleanliness, staff & service, property conditions & facilities
Staff was very friendly and breakfast options were hot and tasty!
Stayed 1 night in Apr 2025

10/10 Excellent

Susan

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Great location, wonderful staff, very clean
Stayed 1 night in Mar 2025

8/10 Good

Laura

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

Great place!

Hotel is always super clean, staff is very friendly and breakfast buffet is awesome. We stayed on the first floor in a standard room, but will book a suite next time. They were all booked up.
Stayed 2 nights in Aug 2025

10/10 Excellent

Berta

Liked: Cleanliness, amenities, property conditions & facilities
I was in a convention in St Louis, I stayed at this hotel and it was so convenient going in hwy. The place is clean and upgraded front desk vey helpful.
Stayed 2 nights in Jul 2025

10/10 Excellent

Marilyn

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

Comfortable & Relaxing

My family and I were in transit to a family reunion in Wisconsin. We had double reservations here and back. Both times were very satisfying and great. Amazing breakfast and love cookie hour.
Stayed 1 night in Sep 2025

10/10 Excellent

Porsha

Liked: Cleanliness, amenities, property conditions & facilities
Room was clean. People were very friendly. Would stay here again.
Stayed 2 nights in Jun 2025

10/10 Excellent

Nancy

Liked: Cleanliness, staff & service, property conditions & facilities
Great breakfast and staff.
Stayed 1 night in Sep 2024

10/10 Excellent

Joan

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
The staff was excellent. Our room was clean and comfortable. The couch as a bit dated But are stay was good
Stayed 1 night in Jun 2025

10/10 Excellent

Gurpreet

Liked: Cleanliness, amenities, property conditions & facilities
Property looks and feels brand new. Staff is extremely nice.
Stayed 1 night in May 2025