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Find hotels in Defiance, MO from CA $84

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Compare 826 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Hilton Garden Inn St. Louis/O'Fallon MO

3.0 star property
8.8 out of 10, Excellent, (695)
"Nice location, with a couple restaurants nearby. Quiet, clean, nice beds/pillows."
The price is CA $197
CA $233 total
includes taxes & fees
Sep 5 - Sep 6
Hilton Garden Inn St. Louis/O'Fallon MO

Drury Plaza Hotel St. Louis Chesterfield

3.0 star property
9.6 out of 10, Exceptional, (1012)
"Great place to stay! "
The price is CA $179
CA $207 total
includes taxes & fees
Sep 4 - Sep 5
Drury Plaza Hotel St. Louis Chesterfield

Comfort Inn & Suites St. Louis - O'Fallon

2.5 star property
7.6 out of 10, Good, (1003)
"And nice hotel at a nice price "
The price is CA $118
CA $139 total
includes taxes & fees
Sep 29 - Sep 30
Comfort Inn & Suites St. Louis - O'Fallon

Holiday Inn Express & Suites St Peters by IHG

2.5 star property
9.2 out of 10, Wonderful, (343)
"Very nice place. Clean... quiet and very friendly staff!! We will definitely stay here again!!"
The price is CA $128
CA $155 total
includes taxes & fees
Sep 28 - Sep 29
Holiday Inn Express & Suites St Peters by IHG

Baymont by Wyndham Warrenton

2.5 star property
7.4 out of 10, Good, (992)
"Very nice accommodations!"
The price is CA $124
CA $142 total
includes taxes & fees
Aug 31 - Sep 1
Baymont by Wyndham Warrenton

BEST WAY INN

2.5 star property
6.4 out of 10, (25)
"Dirty motel with cockroaches and prosistutes not a family friendly place at all "
The price is CA $90
CA $109 total
includes taxes & fees
Aug 31 - Sep 1
BEST WAY INN

Best Western Plus Washington Hotel

2.5 star property
9.0 out of 10, Wonderful, (588)
"Very nice place to stay"
The price is CA $177
CA $202 total
includes taxes & fees
Aug 31 - Sep 1
Best Western Plus Washington Hotel

Hampton Inn & Suites St. Louis/Chesterfield

3.5 star property
8.8 out of 10, Excellent, (806)
"Everything was wonderful!"
The price is CA $151
CA $175 total
includes taxes & fees
Sep 21 - Sep 22
Hampton Inn & Suites St. Louis/Chesterfield

Fairfield Inn & Suites Wentzville

2.5 star property
9.0 out of 10, Wonderful, (601)
"Wonderful place to stay."
The price is CA $188
CA $216 total
includes taxes & fees
Sep 4 - Sep 5
Fairfield Inn & Suites Wentzville

Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

2.5 star property
9.0 out of 10, Wonderful, (958)
"Comfortable beds, good breakfast, and great hotel!"
The price is CA $162
CA $189 total
includes taxes & fees
Sep 6 - Sep 7
Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

Best Western Plus Fenton

2.5 star property
9.2 out of 10, Wonderful, (107)
"Great stay! "
The price is CA $143
CA $165 total
includes taxes & fees
Sep 2 - Sep 3
Best Western Plus Fenton

Holiday Inn Express & Suites Wentzville St Louis West by IHG

2.5 star property
9.4 out of 10, Exceptional, (794)
"Very clean and nice hotel overall"
The price is CA $186
CA $221 total
includes taxes & fees
Sep 7 - Sep 8
Holiday Inn Express & Suites Wentzville St Louis West by IHG

Holiday Inn Express St. Louis West - O'Fallon by IHG

2.5 star property
8.6 out of 10, Excellent, (772)
"Friendly staff and clean, fresh smelling rooms."
The price is CA $139
CA $164 total
includes taxes & fees
Sep 1 - Sep 2
Holiday Inn Express St. Louis West - O'Fallon by IHG

Fairfield Inn & Suites St Louis Westport

2.5 star property
9.2 out of 10, Wonderful, (789)
"Great place to stay. Friendly staff. Spacious room and hearty yummy breakfast. "
The price is CA $168
CA $195 total
includes taxes & fees
Sep 4 - Sep 5
Fairfield Inn & Suites St Louis Westport

Quality Inn Near Six Flags St. Louis

2.5 star property
8.4 out of 10, Very good, (334)
"Pool was small. Staff was great. Room was very clean and well maintained. Overall very nice stay. "
The price is CA $136
CA $156 total
includes taxes & fees
Sep 1 - Sep 2
Quality Inn Near Six Flags St. Louis

Courtyard by Marriott St. Louis West County

3.0 star property
9.0 out of 10, Wonderful, (443)
"The staff were very friendly. "
The price is CA $204
CA $235 total
includes taxes & fees
Sep 6 - Sep 7
Courtyard by Marriott St. Louis West County

Wingate by Wyndham St. Louis/Fenton Route 66

3.0 star property
8.2 out of 10, Very good, (1011)
"Good hotel! "
The price is CA $116
CA $134 total
includes taxes & fees
Aug 31 - Sep 1
Wingate by Wyndham St. Louis/Fenton Route 66

Hampton Inn St. Louis/Chesterfield

3.5 star property
8.6 out of 10, Excellent, (1007)
"Clean motel. "
The price is CA $141
CA $164 total
includes taxes & fees
Sep 25 - Sep 26
Hampton Inn St. Louis/Chesterfield

The Wildwood Hotel

3.5 star property
9.2 out of 10, Wonderful, (1568)
"Great place to stay."
The price is CA $121
CA $147 total
includes taxes & fees
Sep 2 - Sep 3
The Wildwood Hotel

Super 8 by Wyndham Washington

2.0 star property
8.4 out of 10, Very good, (667)
"It was clean and quaint for the price and was also close to where I was going the next morning. "
The price is CA $121
CA $138 total
includes taxes & fees
Sep 7 - Sep 8
Super 8 by Wyndham Washington
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

Stay near popular Defiance attractions

More cheap stays in Defiance

More cheap stays in Defiance

Hotels in Defiance with star-rating

Hotels in Defiance with star-rating

Explore a world of travel with Expedia

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Frequently asked questions

When is the best time to go to Defiance?
The most popular time to visit Defiance is during the summer months, particularly in July, when the weather is warm and inviting. With average temperatures ranging from 22 to 28°C, it's the superb backdrop for outdoor adventures, whether you're exploring the scenic Maumee River or enjoying local events in the parks.

During the peak season from July to September, Defiance buzzes with activity. Festivals and community gatherings take place, providing visitors with a delightful opportunity to immerse themselves in the local culture. The vibrant atmosphere makes it ideal for families and couples alike, as there are plenty of outdoor activities, such as hiking, biking, and picnicking, in the surrounding nature.

If you're looking for a more budget-friendly time to visit, consider late September or early October. While the weather may start to cool slightly, with temperatures around 15 to 20°C, the autumn foliage offers a beautiful setting for sightseeing. This time of year also means fewer crowds, allowing you to enjoy the attractions at a more leisurely pace.
Can I cancel my hotel reservation on Expedia?
Many Expedia hotel reservations are refundable, provided that you cancel before the hotel's cancellation deadline – this is often within 24-48 hours of your scheduled arrival. If you have a non-refundable booking, it might still be possible to receive a refund if you cancel it within 24 hours of booking. Be sure to check your booking confirmation for the exact cancellation policy. For maximum flexibility, use our "Fully refundable property" filter during your search to find the right Defiance hotel for you.
How can I save on a Defiance hotel booking with Expedia?
Members always get our best prices. Find our best Defiance hotel deals by joining Expedia's free travel rewards program today. As a member, you can unlock instant savings and member perks when you're logged in to your account. Another tip is to book your hotel and flights together on Expedia, where bundling can result in significant savings.
How much is the nightly rate at a Defiance hotel?
Prices for hotels in Defiance often vary, but you can find a great deal from CA $84 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.