Title: 10 Best Hotels in South Main, Houston for 2025 | Expedia.ca [Vacation Rentals in Houston](https://expedia.ca/Houston-Vacation-Rentals.d178265.Travel-Guide-VacationRentals)[Flights to Houston](https://expedia.ca/Cheap-Flights-To-Houston.d178265.Travel-Guide-Flights)[Things to do in Houston](https://expedia.ca/Things-To-Do-In-Houston.d178265.Travel-Guide-Activities)[South Main Car Rentals](https://expedia.ca/Car-Rentals-In-South-Main.d553248635976386992.Car-Rental-Guide)[South Main Vacations](https://expedia.ca/South-Main.d553248635976386992.Destination-Travel-Guides) ![Aerial view of Hermann park in Houston with Japanese Garden, zoo, Space Adventure playground](https://images.trvl-media.com/place/553248635976386992/633bd53d-8369-45ed-9507-93d6ecf02186.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Hotels in South Main, Houston ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in South Main Apart hotel [](https://www.expedia.ca/Hotel-Search?destination=South+Main%2C+Houston%2C+Texas%2C+United+States+of+America®ionId=553248635976386992&latLong=29.67287%2C-95.418071&adults=2&startDate=2025-10-15&d1=2025-10-15&endDate=2025-10-17&d2=2025-10-17&lodging=APART_HOTEL) Apart­ment [](https://www.expedia.ca/Hotel-Search?destination=South+Main%2C+Houston%2C+Texas%2C+United+States+of+America®ionId=553248635976386992&latLong=29.67287%2C-95.418071&adults=2&startDate=2025-10-15&d1=2025-10-15&endDate=2025-10-17&d2=2025-10-17&lodging=APARTMENT) Family friendly [](https://www.expedia.ca/Hotel-Search?destination=South+Main%2C+Houston%2C+Texas%2C+United+States+of+America®ionId=553248635976386992&latLong=29.67287%2C-95.418071&adults=2&startDate=2025-10-15&d1=2025-10-15&endDate=2025-10-17&d2=2025-10-17&travelerType=family_friendly) Condo [](https://www.expedia.ca/Hotel-Search?destination=South+Main%2C+Houston%2C+Texas%2C+United+States+of+America®ionId=553248635976386992&latLong=29.67287%2C-95.418071&adults=2&startDate=2025-10-15&d1=2025-10-15&endDate=2025-10-17&d2=2025-10-17&lodging=CONDO) Pet friendly [](https://www.expedia.ca/Hotel-Search?destination=South+Main%2C+Houston%2C+Texas%2C+United+States+of+America®ionId=553248635976386992&latLong=29.67287%2C-95.418071&adults=2&startDate=2025-10-15&d1=2025-10-15&endDate=2025-10-17&d2=2025-10-17&amenities=PETS) Hot tub [](https://www.expedia.ca/Hotel-Search?destination=South+Main%2C+Houston%2C+Texas%2C+United+States+of+America®ionId=553248635976386992&latLong=29.67287%2C-95.418071&adults=2&startDate=2025-10-15&d1=2025-10-15&endDate=2025-10-17&d2=2025-10-17&amenities=HOT_TUB) Pool [](https://www.expedia.ca/Hotel-Search?destination=South+Main%2C+Houston%2C+Texas%2C+United+States+of+America®ionId=553248635976386992&latLong=29.67287%2C-95.418071&adults=2&startDate=2025-10-15&d1=2025-10-15&endDate=2025-10-17&d2=2025-10-17&amenities=POOL) Waterpark [](https://www.expedia.ca/Hotel-Search?destination=South+Main%2C+Houston%2C+Texas%2C+United+States+of+America®ionId=553248635976386992&latLong=29.67287%2C-95.418071&adults=2&startDate=2025-10-15&d1=2025-10-15&endDate=2025-10-17&d2=2025-10-17&amenities=WATER_PARK) Villa [](https://www.expedia.ca/Hotel-Search?destination=South+Main%2C+Houston%2C+Texas%2C+United+States+of+America®ionId=553248635976386992&latLong=29.67287%2C-95.418071&adults=2&startDate=2025-10-15&d1=2025-10-15&endDate=2025-10-17&d2=2025-10-17&lodging=VILLA) Cottage [](https://www.expedia.ca/Hotel-Search?destination=South+Main%2C+Houston%2C+Texas%2C+United+States+of+America®ionId=553248635976386992&latLong=29.67287%2C-95.418071&adults=2&startDate=2025-10-15&d1=2025-10-15&endDate=2025-10-17&d2=2025-10-17&lodging=COTTAGE) Spa [](https://www.expedia.ca/Hotel-Search?destination=South+Main%2C+Houston%2C+Texas%2C+United+States+of+America®ionId=553248635976386992&latLong=29.67287%2C-95.418071&adults=2&startDate=2025-10-15&d1=2025-10-15&endDate=2025-10-17&d2=2025-10-17&amenities=SPA_ON_SITE) ## Check prices for these dates Tonight [Oct 1 - Oct 2](https://www.expedia.ca/Hotel-Search?regionId=553248635976386992&startDate=2025-10-01&endDate=2025-10-02&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 2 - Oct 3](https://www.expedia.ca/Hotel-Search?regionId=553248635976386992&startDate=2025-10-02&endDate=2025-10-03&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 3 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=553248635976386992&startDate=2025-10-03&endDate=2025-10-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=553248635976386992&startDate=2025-10-10&endDate=2025-10-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Recommended Price (low to high) Distance Star rating ## South Main hotels and places to stay ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21300/21297/w2558h1440x0y0-44773629.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pet-friendly](https://images.trvl-media.com/lodging/1000000/30000/21300/21297/982edefb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Food and drink](https://images.trvl-media.com/lodging/1000000/30000/21300/21297/83265e97.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Ballroom](https://images.trvl-media.com/lodging/1000000/30000/21300/21297/63833027.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Wyndham Houston near NRG Park/Medical Center South Main 7.2/10 Good (1169) "Everyone was very pleasant, I will be returning." CA $138 CA $161 total includes taxes & fees Oct 2 - Oct 3 [](https://www.expedia.ca/Houston-Hotels-Wyndham-Houston-Near-NRG-ParkMedical-Center.h21297.Hotel-Information) ![Gazebo](https://images.trvl-media.com/lodging/67000000/66030000/66022900/66022895/ab4b9445.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/67000000/66030000/66022900/66022895/98547457.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/67000000/66030000/66022900/66022895/6b2e094a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Double Beds, Non Smoking](https://images.trvl-media.com/lodging/67000000/66030000/66022900/66022895/bdf24163.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Wingate Houston near NRG Park/Medical Center South Main 6.6/10 (941) "Walking distance to NRG Stadium " CA $110 CA $129 total includes taxes & fees Oct 2 - Oct 3 [](https://www.expedia.ca/Houston-Hotels-Wingate-By-Wyndham-Houston-Reliant-Medical-Center.h66022895.Hotel-Information) ![1 bedroom, hypo-allergenic bedding, in-room safe, individually decorated](https://images.trvl-media.com/lodging/1000000/20000/17600/17531/3135be14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/20000/17600/17531/b55cbe72.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/17600/17531/1e7f9dd7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/17600/17531/c101e36a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn & Suites NRG Park - Medical Center South Main 6.6/10 (1000) "The rooms were clean, the beds were soft, the staff was friendly. The breakfast wasnt bad either. It was literally the best bang for our buck. " CA $82 CA $96 total includes taxes & fees Oct 30 - Oct 31 [](https://www.expedia.ca/Houston-Hotels-Quality-Inn-Suites-NRG-Park-Medical-Center.h17531.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/3000000/2230000/2227000/2227000/168bdeac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/3000000/2230000/2227000/2227000/b0f701b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/3000000/2230000/2227000/2227000/27e929b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Full-size fridge, microwave, stovetop, dishwasher](https://images.trvl-media.com/lodging/3000000/2230000/2227000/2227000/14da1a00.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Candlewood Suites Houston Medical Center by IHG South Main 7.4/10 Good (799) "The staff is great. The area is questionable due to homeless population." CA $109 CA $127 total includes taxes & fees Oct 5 - Oct 6 [](https://www.expedia.ca/Houston-Hotels-Candlewood-Suites-Houston-Medical-Center.h2227000.Hotel-Information) ![Outdoor pool, open 6:00 AM to 10:00 PM, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/11000000/10630000/10620700/10620692/9a708987.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, hypo-allergenic bedding, in-room safe, desk](https://images.trvl-media.com/lodging/11000000/10630000/10620700/10620692/e4ab6d84.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bars/lounges, poolside bar](https://images.trvl-media.com/lodging/11000000/10630000/10620700/10620692/5138e12a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/11000000/10630000/10620700/10620692/b1e04b0e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Regency Houston/Galleria The Galleria, 8.7 km from South Main 9.0/10 Wonderful (1075) " Good hotel" CA $232 CA $274 total includes taxes & fees Oct 23 - Oct 24 [](https://www.expedia.ca/Houston-Hotels-Hyatt-Regency-HoustonGalleria.h10620692.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/89000000/88140000/88130500/88130440/6621e9bb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/89000000/88140000/88130500/88130440/fe601f8c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/89000000/88140000/88130500/88130440/da865e41.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/89000000/88140000/88130500/88130440/6cb181db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Place Houston Medical Center Texas Medical Center, 3.1 km from South Main 9.2/10 Wonderful (2003) "Great place to stay!" CA $194 CA $228 total includes taxes & fees Oct 3 - Oct 4 [](https://www.expedia.ca/Houston-Hotels-Hyatt-Place-Houston-Medical-Center.h88130440.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/59000000/58990000/58985900/58985846/dc9d050c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, premium bedding, minibar, in-room safe](https://images.trvl-media.com/lodging/59000000/58990000/58985900/58985846/40a5bc26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![City view](https://images.trvl-media.com/lodging/59000000/58990000/58985900/58985846/e0a5cc4a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/59000000/58990000/58985900/58985846/a130d0da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Blossom Hotel Houston, Curio Collection by Hilton Texas Medical Center, 3.5 km from South Main 9.0/10 Wonderful (3561) "Great stay " [](https://www.expedia.ca/Houston-Hotels-Blossom-Houston-Hotel.h58985846.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/13300/13295/c40a6103.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite (Composer) | Dining room](https://images.trvl-media.com/lodging/1000000/20000/13300/13295/f9f8ae11.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, free minibar, in-room safe](https://images.trvl-media.com/lodging/1000000/20000/13300/13295/a617bbb9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/1000000/20000/13300/13295/dd9a3669.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Lancaster Hotel Downtown Houston, 11.1 km from South Main 9.8/10 Exceptional (1000) "Great place... lots of nice people and nice rooms." CA $275 CA $322 total includes taxes & fees Oct 25 - Oct 26 [](https://www.expedia.ca/Houston-Hotels-The-Lancaster-Hotel.h13295.Hotel-Information) ![City view from property](https://images.trvl-media.com/lodging/1000000/700000/693700/693655/f1d85056.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/700000/693700/693655/ebaa4874.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/700000/693700/693655/e16d70bb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/700000/693700/693655/31209257.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Whitehall Houston Houston Central Business District, 10 km from South Main 8.6/10 Excellent (1775) "Great staff nice rooms" CA $221 CA $259 total includes taxes & fees Oct 9 - Oct 10 [](https://www.expedia.ca/Houston-Hotels-The-Whitehall-Houston.h693655.Hotel-Information) ![Exterior detail](https://images.trvl-media.com/lodging/1000000/30000/20200/20116/555244ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/30000/20200/20116/ec3f4d74.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, down comforters, in-room safe, blackout drapes](https://images.trvl-media.com/lodging/1000000/30000/20200/20116/d7c28c50.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/20200/20116/109ddc6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### DoubleTree by Hilton Hotel & Suites Houston by the Galleria 8.9 km from South Main 8.2/10 Very good (2608) "Great stay!!!" CA $176 CA $207 total includes taxes & fees Oct 31 - Nov 1 [](https://www.expedia.ca/Houston-Hotels-DoubleTree-By-Hilton-Hotel-Suites-Houston-By-The-Galleria.h20116.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/1000000/20000/17800/17746/37423ee4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bars/lounges, lobby lounge](https://images.trvl-media.com/lodging/1000000/20000/17800/17746/1b15f0cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Nightclub](https://images.trvl-media.com/lodging/1000000/20000/17800/17746/w6992h4673x0y8-ea923e10.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/20000/17800/17746/516b3f9c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Omni Houston Hotel 10.6 km from South Main 9.0/10 Wonderful (1003) "Really enjoyed my stay. " CA $244 CA $290 total includes taxes & fees Oct 17 - Oct 18 [](https://www.expedia.ca/Houston-Hotels-Omni-Houston-Hotel.h17746.Hotel-Information) ![Breakfast, lunch, brunch served; American cuisine, garden views ](https://images.trvl-media.com/lodging/1000000/20000/12400/12378/7e4ad465.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/12400/12378/06b8ac16.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/12400/12378/880627d4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/12400/12378/729ec87e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Regency Houston West 23.2 km from South Main 8.6/10 Excellent (1175) "Great stay for work trips." CA $153 CA $179 total includes taxes & fees Oct 10 - Oct 11 [](https://www.expedia.ca/Houston-Hotels-Hyatt-Regency-Houston-West.h12378.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/84000000/83760000/83751000/83750993/baae5025.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/84000000/83760000/83751000/83750993/82145210.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, premium bedding, in-room safe, laptop workspace](https://images.trvl-media.com/lodging/84000000/83760000/83751000/83750993/7a919d78.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/84000000/83760000/83751000/83750993/81d3670a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt House Houston Medical Center Texas Medical Center, 3.1 km from South Main 9.2/10 Wonderful (1118) "Have stayed there many times" CA $194 CA $228 total includes taxes & fees Oct 4 - Oct 5 [](https://www.expedia.ca/Houston-Hotels-Hyatt-House-Houston-Medical-Center.h83750993.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/70000/67600/67561/875dd499.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/70000/67600/67561/e45aa8e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/70000/67600/67561/0c819a97.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Double Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/70000/67600/67561/6a5f2f0e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Houston Southwest 9.4 km from South Main 7.0/10 Good (1029) "Great stay. " CA $95 CA $111 total includes taxes & fees Oct 5 - Oct 6 [](https://www.expedia.ca/Houston-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Houston-Southwest.h67561.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/73000000/72510000/72510000/72509948/02126088.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/73000000/72510000/72510000/72509948/0f298d6d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, in-room safe, desk, soundproofing](https://images.trvl-media.com/lodging/73000000/72510000/72510000/72509948/a772e6cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/73000000/72510000/72510000/72509948/7f2b0483.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Houston – Downtown North by IHG Northside, 13.7 km from South Main 9.2/10 Wonderful (587) "Staff was friendly, room was clean, and quiet area!" CA $161 CA $189 total includes taxes & fees Oct 5 - Oct 6 [](https://www.expedia.ca/Houston-Hotels-Holiday-Inn-Express-Suites-Houston-N-Downtown.h72509948.Hotel-Information) ![Premium bedding, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/19000000/18130000/18122200/18122141/e02c73c3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/19000000/18130000/18122200/18122141/18c0750c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily full breakfast](https://images.trvl-media.com/lodging/19000000/18130000/18122200/18122141/be7d736f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Garden](https://images.trvl-media.com/lodging/19000000/18130000/18122200/18122141/a514112d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Haven Inn & Suites Downtown Houston North Houston, 18.8 km from South Main 9.4/10 Exceptional (1000) "Was great stay." CA $90 CA $106 total includes taxes & fees Oct 2 - Oct 3 [](https://www.expedia.ca/Houston-Hotels-Haven-Inn-Suites-Downtown-Houston.h18122141.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1160000/1157000/1156923/44a9a3fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/2000000/1160000/1157000/1156923/76e7278c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1160000/1157000/1156923/aa7fafd4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 Queen Bed](https://images.trvl-media.com/lodging/2000000/1160000/1157000/1156923/c91eaea0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Club Quarters Hotel Downtown, Houston Houston Central Business District, 10.9 km from South Main 8.4/10 Very good (3723) "Overall great property to stay at. " CA $128 CA $150 total includes taxes & fees Oct 17 - Oct 18 [](https://www.expedia.ca/Houston-Hotels-Club-Quarters-Hotel-In-Houston.h1156923.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/880000/878700/878652/9874e960.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Staircase](https://images.trvl-media.com/lodging/1000000/880000/878700/878652/5506d9bf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, Egyptian cotton sheets, premium bedding, pillowtop beds](https://images.trvl-media.com/lodging/1000000/880000/878700/878652/w3836h2556x4y4-d736e03c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/880000/878700/878652/b032cc4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Royal Sonesta Houston Galleria The Galleria, 8.8 km from South Main 8.4/10 Very good (1281) "Great hotel " CA $190 CA $223 total includes taxes & fees Oct 10 - Oct 11 [](https://www.expedia.ca/Houston-Hotels-Royal-Sonesta-Houston-Galleria.h878652.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/450000/447900/447810/5002086e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/450000/447900/447810/4732a92f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![BBQ/picnic area](https://images.trvl-media.com/lodging/1000000/450000/447900/447810/b3ca5c88.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/450000/447900/447810/41c29f8d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sonesta ES Suites Houston Galleria The Galleria, 8.4 km from South Main 8.2/10 Very good (1117) "This hotel was great, lovely & convenience is a double plus! My family and I enjoyed our stay." CA $153 CA $179 total includes taxes & fees Oct 3 - Oct 4 [](https://www.expedia.ca/Houston-Hotels-Sonesta-ES-Suites-Houston-Galleria.h447810.Hotel-Information) ![View from room](https://images.trvl-media.com/lodging/51000000/50570000/50569300/50569221/ae2459a3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Accessible, Non Smoking](https://images.trvl-media.com/lodging/51000000/50570000/50569300/50569221/19a77f29.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pool views, open daily](https://images.trvl-media.com/lodging/51000000/50570000/50569300/50569221/c64947fb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/51000000/50570000/50569300/50569221/5827cd11.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Heights House Hotel - Houston Heights Downtown, an Ascend Collection Hotel 15.2 km from South Main 7.8/10 Good (1022) "Loved the commons/patio area " CA $135 CA $158 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/Houston-Hotels-Heights-House-Hotel.h50569221.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-15&endDate=2025-10-16®ionId=553248635976386992&adults=2&sort=RECOMMENDED&openPlayBack=true) ## Where to stay in South Main Find the best South Main areas and neighborhoods for the activities you enjoy most. - Downtown Houston - The Galleria - Texas Medical Center - Montrose - Houston Central Business District ![Discovery Green which includes city views, a square or plaza and a skyscraper](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/23000/23540-Discovery-Green.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Discovery Green showing a park, a skyscraper and street scenes](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/34000/34453-Discovery-Green.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/507000/507468-downtown-houston.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/507000/507497-downtown-houston.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Discovery Green showing a statue or sculpture, a high-rise building and modern architecture](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/34000/34451-Discovery-Green.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) [](https://www.expedia.ca/Hotel-Search?pwaOverlay=map®ionId=800037) ![Downtown Houston map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:q%7CrtDz%7BbeQkQ_%40eEcBgCkDuQ%7D_%40m%5EeQ%7EMi%5DoAePiLi%60%40m%40%7DTlCul%40pNj%5CxW%7CUxS%60Bv%7CAhmAcg%40ncAuI%60DkZx%40&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=1QgAgrTvk7PkY13c5YaLrvezhfU=) ### Downtown Houston Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines. [See properties](https://www.expedia.ca/Hotel-Search?regionId=800037) ![](https://mediaim.expedia.com/destination/1/733d46a93b53c864b5c00945f6416b51.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://mediaim.expedia.com/destination/1/d7dc12b9d267be169566d38db8ea7eac.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://mediaim.expedia.com/destination/7/01538c9f6eb646ea96e3df2059618b27.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://mediaim.expedia.com/destination/7/374a9a687602bd093583e97522a04bc6.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://mediaim.expedia.com/destination/9/aadfd687906d99829a520409ec046d47.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) [](https://www.expedia.ca/Hotel-Search?pwaOverlay=map®ionId=501263) ![The Galleria map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:%7DxptDn%7DteQ_AcXqKr%40mHsB%7BXT%5DgYeZY%3F_a%40jGg%40rA_HxCyFTuIpzAsBbBt%7D%40fw%40%60NdA%7Ce%40szAdB&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=eLyvWjet6omo-XVzVSkCj7zXPog=) ### The Galleria Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower. [See properties](https://www.expedia.ca/Hotel-Search?regionId=501263) ![](https://mediaim.expedia.com/destination/1/f4655cac96c82fca6c00f4ab3162178c.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://mediaim.expedia.com/destination/7/29187be13ac57fa24b0f672247c7afbc.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://mediaim.expedia.com/destination/7/52a59f2a0bfb2cf153bbc44f917f7275.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) [](https://www.expedia.ca/Hotel-Search?pwaOverlay=map®ionId=6143504) ![Texas Medical Center map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:wbftD%7C%60keQwBu%40w%5DkXgZySqC%7EG%7DEnG%7DQrDyAw%60%40aa%40gYrCsKe%5BcW%7CM_UbGi%40%60LmLjQmE%5DmPvB%60%40vEoQhGyJnDgKjKlC%7DDbTqAUq%40lDrYtHbGdd%40nKsDlOe%40bW%60Oj%40d_%40%7BFd%40%3FdRkCpAAdAtC%7CDL%60_%40eF%3F%7B%40uFiDf%40AsAwBD%7BC%60Ae%40yCm%40OlBhOjId%60%40hAnC&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=clfGppypW4bREcqpe6GxdaNdBv0=) ### Texas Medical Center Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience. [See properties](https://www.expedia.ca/Hotel-Search?regionId=6143504) ![Menil Collection which includes interior views and art](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/23000/23619-Menil-Collection.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Menil Collection featuring interior views](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/23000/23623-Menil-Collection.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Menil Collection showing interior views](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/34000/34667-Menil-Collection.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Menil Collection featuring a garden](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/34000/34665-Menil-Collection.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/34000/34668-Menil-Collection.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) [](https://www.expedia.ca/Hotel-Search?pwaOverlay=map®ionId=3000663145) ![Montrose map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:wiptDf%7CieQmBWy%7E%40R%7BAe%40qByG_CiCwQJiG%60%40X%7BBoAyGIeOwDsLe%40qDh%40uJ%7D%40sCSsDuCkJJyE%60AsGLaMnD%7DQBcLreAQGwItTKI_MxFA%60%40a%40rNdApW%40nf%40l%5D%60BlBnFpdBf%40tTElUyoA%5C&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=yYef0qnrIjIE5eFLQJoXDdAkgXk=) ### Montrose Unique features of Montrose include the theaters and museums. Make a stop by Menil Collection or Houston Center for Photography while you're exploring the area. [See properties](https://www.expedia.ca/Hotel-Search?regionId=3000663145) ![Houston featuring a city and a skyscraper](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/34000/34818-Houston.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Houston showing night scenes and a sporting event](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/21000/21517-Houston.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) Photo by Greater Houston Convention and Visitors Bureau ![Space Center Houston which includes aircraft](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/34000/34685-Space-Center-Houston.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Houston featuring skyline, a city and modern architecture](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/21000/21508-Houston.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) Photo by Greater Houston Convention and Visitors Bureau ![Houston featuring a garden](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/21000/21512-Houston-Museum-Of-Fine-Arts.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) Photo by Greater Houston Convention and Visitors Bureau (photographer: Rick Gardner) [](https://www.expedia.ca/Hotel-Search?pwaOverlay=map®ionId=553248635976473213) ![Houston Central Business District map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:wfqtD%7EuceQsXeRk%60Ayr%40x%7E%40_jBp%7D%40zp%40qMrVh%5BfUcp%40fqA&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=l24t0KYtEnk7l4YWZTxkpNv3bu8=) ### Houston Central Business District If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Main Street Square Station. [See properties](https://www.expedia.ca/Hotel-Search?regionId=553248635976473213) ## Top South Main Hotel Reviews ![Hyatt Place Houston/Galleria](//images.trvl-media.com/lodging/13000000/12300000/12294900/12294828/36442d5d_y.jpg) ### Hyatt Place Houston/Galleria 10/10 Excellent "Great hotel! Great location! I would stay here again! " [](https://expedia.ca/Houston-Hotels-Hyatt-Place-HoustonGalleria.h12294828.Hotel-Information) ![Magnolia Hotel Houston, A Tribute Portfolio Hotel](//images.trvl-media.com/lodging/1000000/910000/907500/907459/0b2adb37_y.jpg) ### Magnolia Hotel Houston, A Tribute Portfolio Hotel 10/10 Excellent "We stayed here with kids for Astros game. Loved the convenience to walk to Astros games, park downtown and metro! Lived the nightly complimentary milk and cookies. Also, loved the rooftop pool and the gym " [](https://expedia.ca/Houston-Hotels-Magnolia-Hotel-Houston.h907459.Hotel-Information) ![The Royal Sonesta Houston Galleria](//images.trvl-media.com/lodging/1000000/880000/878700/878652/9874e960_y.jpg) ### The Royal Sonesta Houston Galleria 10/10 Excellent "I always have a wonderful day at this hotel" [](https://expedia.ca/Houston-Hotels-Royal-Sonesta-Houston-Galleria.h878652.Hotel-Information) ![Cambria Hotel Houston Downtown Convention Center](//images.trvl-media.com/lodging/36000000/35560000/35559700/35559679/82e8dff0_y.jpg) ### Cambria Hotel Houston Downtown Convention Center 10/10 Excellent "Property was nice no soap dispenser in the shower area. " [](https://expedia.ca/Houston-Hotels-Cambria-Hotel-Houston-Downtown-Convention-Center.h35559679.Hotel-Information) ![Omni Houston Hotel](//images.trvl-media.com/lodging/1000000/20000/17800/17746/37423ee4_y.jpg) ### Omni Houston Hotel 10/10 Excellent "Really enjoyed my stay. " [](https://expedia.ca/Houston-Hotels-Omni-Houston-Hotel.h17746.Hotel-Information) ![DoubleTree by Hilton Hotel & Suites Houston by the Galleria](//images.trvl-media.com/lodging/1000000/30000/20200/20116/555244ce_y.jpg) ### DoubleTree by Hilton Hotel & Suites Houston by the Galleria 10/10 Excellent "The staff is very friendly and took care of all my requests. The room is very clean, the hotel in general has a good atmosphere. " [](https://expedia.ca/Houston-Hotels-DoubleTree-By-Hilton-Hotel-Suites-Houston-By-The-Galleria.h20116.Hotel-Information) ![DoubleTree by Hilton Hotel Houston - Greenway Plaza](//images.trvl-media.com/lodging/1000000/30000/20200/20177/682ca680_y.jpg) ### DoubleTree by Hilton Hotel Houston - Greenway Plaza 10/10 Excellent "Stay was great" [](https://expedia.ca/Houston-Hotels-DoubleTree-By-Hilton-Hotel-Houston-Greenway-Plaza.h20177.Hotel-Information) ![Blossom Hotel Houston](//images.trvl-media.com/lodging/59000000/58990000/58985900/58985846/dc9d050c_y.jpg) ### Blossom Hotel Houston 10/10 Excellent "Hotel was amazing, staff were excellent and very friendly, and the facilities were outstanding. Only issue was some gym equipment wasn’t operational with no signage indicating this " [](https://expedia.ca/Houston-Hotels-Blossom-Houston-Hotel.h58985846.Hotel-Information) ![Hyatt Place Houston Medical Center](//images.trvl-media.com/lodging/89000000/88140000/88130500/88130440/6621e9bb_y.jpg) ### Hyatt Place Houston Medical Center 10/10 Excellent "The breakfast is really healthy " [](https://expedia.ca/Houston-Hotels-Hyatt-Place-Houston-Medical-Center.h88130440.Hotel-Information) ## Frequently asked questions ### What are the best hotels in South Main that travellers recommend? > [Wyndham Houston near NRG Park/Medical Center](https://www.expedia.ca/Houston-Hotels-Wyndham-Houston-Near-NRG-ParkMedical-Center.h21297.Hotel-Information) is a solid choice for travellers seeking comfort and convenience, earning a customer review rating of 7.2. This hotel features an inviting outdoor pool, superb for unwinding after a day of adventure, along with kitchenettes in the rooms—ideal for families wanting to prepare snacks or meals. The combination of free WiFi and a 24-hour business centre makes it suitable for both leisure and business travellers, ensuring a straightforward stay. > > > > For families, [Wingate Houston near NRG Park/Medical Center](https://www.expedia.ca/Houston-Hotels-Wingate-By-Wyndham-Houston-Reliant-Medical-Center.h66022895.Hotel-Information) is another great option. With a complimentary continental breakfast to fuel your adventures and a refreshing outdoor pool, it caters superbly to parents and kids alike. The accessible fitness centre allows for some family fun, while the hotel's pet-friendly policies make it a fantastic choice for those traveling with furry companions. With a focus on convenience and value, this hotel provides excellent amenities while keeping everyone comfortable. ### What are the best family hotels in South Main? > When it comes to family-friendly hotels in South Main, the [Comfort Suites near Texas Medical Center - NRG Stadium](https://www.expedia.ca/Houston-Hotels-Comfort-Suites-Near-Texas-Medical-Center-NRG-Stadium.h904192.Hotel-Information) shines brightly with a solid traveller review rating of 8.6. This hotel offers daily housekeeping to ensure your family's stay is comfortable and straightforward. > > > > Another excellent option is the [Candlewood Suites Houston Medical Center by IHG](https://www.expedia.ca/Houston-Hotels-Candlewood-Suites-Houston-Medical-Center.h2227000.Hotel-Information), which boasts a family-friendly atmosphere with its free cribs, connecting rooms, and a sofa bed, making it great for families needing extra space. Guests appreciate the convenience of in-room kitchen amenities like a microwave and dishwasher, allowing for easy meal prep during your stay. It has a review score of 7.6, reflecting its appeal to families on the go. > > > > For those seeking a place with a pool, the [Quality Inn & Suites NRG Park - Medical Center](https://www.expedia.ca/Houston-Hotels-Quality-Inn-Suites-NRG-Park-Medical-Center.h17531.Hotel-Information) is a great choice. With its inviting pool area, free meals for children, and options for rollaway beds at no extra charge, families can enjoy a splash-filled vacation while also benefiting from daily housekeeping and snack options. > > > > Lastly, the [Wyndham Houston near NRG Park/Medical Center](https://www.expedia.ca/Houston-Hotels-Wyndham-Houston-Near-NRG-ParkMedical-Center.h21297.Hotel-Information) features child-friendly window designs and connecting rooms, catering specifically to families' needs. The presence of kitchenettes adds to the convenience, allowing families to prepare snacks or meals together. This property has a traveller rating of 7.2, making it a reliable choice for family stays. > > > > These hotels exemplify quality and convenience, ensuring that your family's adventure in South Main is both enjoyable and comfortable. ### What hotels in South Main offer free breakfast? > [Comfort Suites near Texas Medical Center - NRG Stadium](https://www.expedia.ca/Houston-Hotels-Comfort-Suites-Near-Texas-Medical-Center-NRG-Stadium.h904192.Hotel-Information) is a fantastic option for travellers seeking comfort and convenience in South Main. With a traveller review rating of 8.6, this hotel offers a delightful free full breakfast to start your day right. Families will appreciate the seasonal outdoor pool, superb for a refreshing dip after a day of exploring. Additionally, the property features complimentary WiFi and self-parking, making it easy to stay connected and save on travel expenses. > > > > Another great choice is [Quality Inn & Suites NRG Park - Medical Center](https://www.expedia.ca/Houston-Hotels-Quality-Inn-Suites-NRG-Park-Medical-Center.h17531.Hotel-Information), which also provides a free breakfast, including options for those on the go. This family-friendly hotel offers spacious suites with balconies and patios, allowing families to unwind outdoors. The outdoor pool invites guests to relax and enjoy the Texas sunshine, while the complimentary area shuttle makes it simple to explore the attractions nearby. > > > > For those traveling without children, the [Wingate Houston near NRG Park/Medical Center](https://www.expedia.ca/Houston-Hotels-Wingate-By-Wyndham-Houston-Reliant-Medical-Center.h66022895.Hotel-Information) presents a delightful blend of comfort and accessibility. With an outdoor pool and fitness centre, it caters to adults looking for a rejuvenating getaway. The hotel's continental breakfast is another perk that guarantees a satisfying start to your morning adventures. ### What are the best budget hotels in South Main? > [Comfort Suites near Texas Medical Center - NRG Stadium](https://www.expedia.ca/Houston-Hotels-Comfort-Suites-Near-Texas-Medical-Center-NRG-Stadium.h904192.Hotel-Information) is a fantastic budget-friendly option for travellers seeking convenience and quality in South Main. With an excellent review score of 8.6, this hotel offers a range of family-friendly amenities, including a seasonal outdoor pool, free breakfast, and complimentary WiFi. Families will appreciate the spacious rooms and the convenience of free self-parking, making it easy to explore the area together. > > > > For another appealing choice, [Candlewood Suites Houston Medical Center by IHG](https://www.expedia.ca/Houston-Hotels-Candlewood-Suites-Houston-Medical-Center.h2227000.Hotel-Information) stands out with a review score of 7.6. This property is superb for families, as it features kitchenettes in the rooms, allowing for meal preparation and snacks on the go. Kids can also enjoy the complimentary cribs and sofa beds, making it a comfortable stay for everyone. Additionally, the hotel offers a free area shuttle, which is great for exploring local attractions without the hassle of driving. > > > > If you're traveling with your partner or friends, the [Wyndham Houston near NRG Park/Medical Center](https://www.expedia.ca/Houston-Hotels-Wyndham-Houston-Near-NRG-ParkMedical-Center.h21297.Hotel-Information) offers a more relaxed atmosphere with a lower review score of 7.2. This hotel features outdoor pool access and convenient amenities, including a kitchenette in some rooms, which can appeal to those looking for a home-like experience while away. > > > > No matter your travel group, these options in South Main cater to various needs while ensuring a comfortable and enjoyable stay. ### Can I cancel my hotel reservation on Expedia? > You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in South Main. ### How can I save on a South Main hotel booking with Expedia? > Members always get our best prices. Find our best South Main hotel deals by joining Expedia's free travel rewards program today. As a member, you can unlock instant savings and member perks when you're logged in to your account. Another tip is to book your hotel and flights together on Expedia, where bundling can result in significant savings. ### How much is the nightly rate at a South Main hotel? > Hotel prices in South Main often vary, but you can find a great deal on Expedia. Different factors affect nightly hotel rates, such as the time of year or the days of the week you want to book. 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Brown Convention Center](https://expedia.ca/George-R-Brown-Convention-Center-Hotels.0-l501247-0.Travel-Guide-Filter-Hotels) - [Hotels near Daikin Park](https://expedia.ca/Daikin-Park-Hotels.0-l6034772-0.Travel-Guide-Filter-Hotels) - [Hotels near Toyota Center](https://expedia.ca/Toyota-Center-Hotels.0-l6082241-0.Travel-Guide-Filter-Hotels) - [Hotels near Rice University](https://expedia.ca/Rice-University-Hotels.0-l501268-0.Travel-Guide-Filter-Hotels) - [Hotels near University of Houston](https://expedia.ca/University-Of-Houston-Hotels.0-l501270-0.Travel-Guide-Filter-Hotels) - [Hotels near Houston Zoo](https://expedia.ca/Houston-Zoo-Hotels.0-l6082223-0.Travel-Guide-Filter-Hotels) - [Hotels near Westheimer Road](https://expedia.ca/Westheimer-Road-Hotels.0-l553248633938962786-0.Travel-Guide-Filter-Hotels) - [Hotels near Memorial City Mall](https://expedia.ca/Memorial-City-Mall-Hotels.0-l6178075-0.Travel-Guide-Filter-Hotels) ### More Accommodation Types in South Main - [Vacation Homes in Houston](https://expedia.ca/Houston-Private-Vacation-Homes.d178265-aaPrivateVacationHomes.Travel-Guide-Accommodation) - [Apartments in Houston](https://expedia.ca/Houston-Apartments.d178265-aaApartments.Travel-Guide-Accommodation) - [Condo Rentals in Houston](https://expedia.ca/Houston-Condos.d178265-aaCondos.Travel-Guide-Accommodation) - [Motels in Houston](https://expedia.ca/Houston-Motels.d178265-aaMotels.Travel-Guide-Accommodation) - [Cottages in Houston](https://expedia.ca/Houston-Cottages.d178265-aaCottages.Travel-Guide-Accommodation) - [Aparthotels in Houston](https://expedia.ca/Houston-Apart-Hotels.d178265-aaApartHotels.Travel-Guide-Accommodation) - [Villas in Houston](https://expedia.ca/Houston-Villas.d178265-aaVillas.Travel-Guide-Accommodation) - [Guest Houses in Houston](https://expedia.ca/Houston-Guest-Houses.d178265-aaGuestHouses.Travel-Guide-Accommodation) - [B&B in Houston](https://expedia.ca/Houston-Bed-And-Breakfast.d178265-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Hostels in Houston](https://expedia.ca/Houston-Hostels.d178265-aaHostels.Travel-Guide-Accommodation) - [Farmstay in Houston](https://expedia.ca/Houston-Agritourism.d178265-aaAgritourism.Travel-Guide-Accommodation) - [Cabin Rentals in Houston](https://expedia.ca/Houston-Cabins.d178265-aaCabins.Travel-Guide-Accommodation) - [Resorts in Houston](https://expedia.ca/Houston-Resort-Hotels.d178265-aaResortHotels.Travel-Guide-Accommodation) - [Townhomes in Houston](https://expedia.ca/Houston-Townhomes.d178265-aaTownhomes.Travel-Guide-Accommodation) - [Inns in Houston](https://expedia.ca/Houston-Inns.d178265-aaInns.Travel-Guide-Accommodation) - [Residences in Houston](https://expedia.ca/Houston-Residences.d178265-aaResidences.Travel-Guide-Accommodation) ### Hotels Close to Nearby Airports - [Hotels near George Bush Intercontinental Airport](https://expedia.ca/George-Bush-Intercontinental-Airport-Hotels.0-aIAH-0.Travel-Guide-Filter-Hotels) - [Hotels near William P. Hobby Airport](https://expedia.ca/William-P-Hobby-Airport-Hotels.0-aHOU-0.Travel-Guide-Filter-Hotels) - [Hotels near Sugar Land Regional Airport](https://expedia.ca/Sugar-Land-Regional-Airport-Hotels.0-aSGR-0.Travel-Guide-Filter-Hotels) - [Hotels near Ellington Field Airport](https://expedia.ca/Ellington-Field-Airport-Hotels.0-aEFD-0.Travel-Guide-Filter-Hotels) - [Hotels near Westchase Helipad Airport](https://expedia.ca/Westchase-Helipad-Airport-Hotels.0-aJWH-0.Travel-Guide-Filter-Hotels) ### South Main Hotels by Star Rating - [2 Star Hotels in South Main](https://expedia.ca/2Star-South-Main-Houston-Hotels.s20-n553248635976386992-0.Travel-Guide-Filter-Hotels) - [3 Star Hotels in South Main](https://expedia.ca/3Star-South-Main-Houston-Hotels.s30-n553248635976386992-0.Travel-Guide-Filter-Hotels) - [4 Star Hotels in South Main](https://expedia.ca/4Star-South-Main-Houston-Hotels.s40-n553248635976386992-0.Travel-Guide-Filter-Hotels) - [5 Star Hotels in South Main](https://expedia.ca/5Star-South-Main-Houston-Hotels.s50-n553248635976386992-0.Travel-Guide-Filter-Hotels) ### South Main Hotels by Brand - [Best Western Hotels](https://expedia.ca/South-Main-Houston-Hotels-Best-Western.0-n553248635976386992-0--bBestWestern.Travel-Guide-Filter-Hotels) - [Budget Host Hotels](https://expedia.ca/South-Main-Houston-Hotels-Budget-Host.0-n553248635976386992-0--bBudgetHost.Travel-Guide-Filter-Hotels) - [Club Quarters Hotels](https://expedia.ca/South-Main-Houston-Hotels-Club-Quarters.0-n553248635976386992-0--bClubQuarters.Travel-Guide-Filter-Hotels) - [Hilton Hotels Hotels](https://expedia.ca/South-Main-Houston-Hotels-Hilton-Hotels.0-n553248635976386992-0--bHiltonHotels.Travel-Guide-Filter-Hotels) - [Independent Hotels](https://expedia.ca/South-Main-Houston-Hotels-Independent.0-n553248635976386992-0--bIndependent.Travel-Guide-Filter-Hotels) - [La Quinta Inn & Suites Hotels](https://expedia.ca/South-Main-Houston-Hotels-La-Quinta-Inn-Suites.0-n553248635976386992-0--bLaQuintaInnSuites.Travel-Guide-Filter-Hotels) - [Marriott Hotels & Resorts Hotels](https://expedia.ca/South-Main-Houston-Hotels-Marriott-Hotels-Resorts.0-n553248635976386992-0--bMarriottHotelsResorts.Travel-Guide-Filter-Hotels) - [Motel 6 Hotels](https://expedia.ca/South-Main-Houston-Hotels-Motel-6.0-n553248635976386992-0--bMotel6.Travel-Guide-Filter-Hotels) - [Red Lion Hotels](https://expedia.ca/South-Main-Houston-Hotels-Red-Lion.0-n553248635976386992-0--bRedLion.Travel-Guide-Filter-Hotels) - [Red Roof Inn Hotels](https://expedia.ca/South-Main-Houston-Hotels-Red-Roof-Inn.0-n553248635976386992-0--bRedRoofInn.Travel-Guide-Filter-Hotels) - [Scottish Inn Hotels](https://expedia.ca/South-Main-Houston-Hotels-Scottish-Inn.0-n553248635976386992-0--bScottishInn.Travel-Guide-Filter-Hotels) - [Sonesta Hotel Hotels](https://expedia.ca/South-Main-Houston-Hotels-Sonesta-Hotel.0-n553248635976386992-0--bSonestaHotel.Travel-Guide-Filter-Hotels) - [Wyndham Hotels Hotels](https://expedia.ca/South-Main-Houston-Hotels-Wyndham-Hotels.0-n553248635976386992-0--bWyndhamHotels.Travel-Guide-Filter-Hotels) ### Explore more hotels - [The Royal Sonesta Houston Galleria](https://expedia.ca/Houston-Hotels-Royal-Sonesta-Houston-Galleria.h878652.Hotel-Information) - [Cambria Hotel Houston Downtown Convention Center](https://expedia.ca/Houston-Hotels-Cambria-Hotel-Houston-Downtown-Convention-Center.h35559679.Hotel-Information) - [C. Baldwin, Curio Collection by Hilton](https://expedia.ca/Houston-Hotels-C-Baldwin.h24968.Hotel-Information) - [Hyatt Regency Houston/Galleria](https://expedia.ca/Houston-Hotels-Hyatt-Regency-HoustonGalleria.h10620692.Hotel-Information) - [Hyatt Place Houston Downtown](https://expedia.ca/Houston-Hotels-Hyatt-Place-Houston-Downtown.h44399547.Hotel-Information) - [Marriott Marquis Houston](https://expedia.ca/Houston-Hotels-Marriott-Marquis-Houston.h14986044.Hotel-Information) - [Hyatt Place Houston Medical Center](https://expedia.ca/Houston-Hotels-Hyatt-Place-Houston-Medical-Center.h88130440.Hotel-Information) - [Omni Houston Hotel](https://expedia.ca/Houston-Hotels-Omni-Houston-Hotel.h17746.Hotel-Information) - [Hyatt Regency Houston Downtown](https://expedia.ca/Houston-Hotels-Hyatt-Regency-Houston.h20005.Hotel-Information) - [Hampton Inn & Suites Houston Heights I-10](https://expedia.ca/Houston-Hotels-Hampton-Inn-Suites-Houston-Heights-I-10.h490.Hotel-Information) - [SpringHill Suites by Marriott Houston Intercontinental Arprt](https://expedia.ca/Houston-Hotels-SpringHill-Suites-By-Marriott-Houston-Intercontinental-Arprt.h2964240.Hotel-Information) - [Heritage Place Houston Brookhollow](https://expedia.ca/Houston-Hotels-Heritage-Place-Houston-Brookhollow.h6298.Hotel-Information) [See a list of all hotels in Houston](https://expedia.ca/All-Houston-Hotels.d178265.Travel-Guide-City-All-Hotels) ### More ways to book - [Book Hotels in South Main on Expedia.com](https://www.expedia.com/South-Main-Houston-Hotels.0-n553248635976386992-0.Travel-Guide-Filter-Hotels) ### Expedia's Latest Trends Hotels - [Hotels in Jasper](https://expedia.ca/Jasper-Hotels.d10578.Travel-Guide-Hotels) - [Downtown Dallas hotels](https://expedia.ca/Downtown-Dallas-Dallas-Hotels.0-n800026-0.Travel-Guide-Filter-Hotels) - [Hotels in St. John's](https://expedia.ca/St-Johns-Hotels.d181832.Travel-Guide-Hotels) - [Comfort Suites Paradise Island](https://expedia.ca/Nassau-Hotels-Comfort-Suites-Paradise-Island.h13636.Hotel-Information) - [Hotels near Banff National Park](https://expedia.ca/Banff-National-Park-Hotels.0-l602291-0.Travel-Guide-Filter-Hotels) - [Hotels in Lincoln City](https://expedia.ca/Lincoln-City-Hotels.d8438.Travel-Guide-Hotels) - [Downtown Austin hotels](https://expedia.ca/Downtown-Austin-Austin-Hotels.0-n6059085-0.Travel-Guide-Filter-Hotels) - [Hotels near Rogers Centre](https://expedia.ca/Rogers-Centre-Hotels.0-l503145-0.Travel-Guide-Filter-Hotels) - [Stay Inn](https://expedia.ca/Toronto-Hotels-Stay-Inn.h918836.Hotel-Information) - [Cheap Hotels in Downtown Austin](https://expedia.ca/Downtown-Austin-Austin-Hotels-Cheap-Hotels.0-n6059085-0-tCheapHotels.Travel-Guide-Filter-Hotels) - [Hotels in Salaberry-de-Valleyfield](https://expedia.ca/Salaberry-De-Valleyfield-Hotels.d181966.Travel-Guide-Hotels) - [Downtown Houston hotels](https://expedia.ca/Downtown-Houston-Houston-Hotels.0-n800037-0.Travel-Guide-Filter-Hotels) - [All Inclusive Resorts and Hotels in Turks and Caicos](https://expedia.ca/Destinations-In-Turks-And-Caicos-All-Inclusive-Hotel.0-0-d184-tAllInclusiveHotel.Hotel-Filter-Destinations) - [Fort Worth Stockyards hotels](https://expedia.ca/Fort-Worth-Stockyards-Fort-Worth-Hotels.0-n6190845-0.Travel-Guide-Filter-Hotels) Flights - [Cheap Flights from Ottawa (YOW) to Orlando (MCO)](https://expedia.ca/lp/flights/yow/mco/ottawa-to-orlando) - [Flights from Watertown Intl. Airport](https://expedia.ca/lp/airports/art/flights-from-watertown-intl-airport) - [Cheap Flights to Cochrane](https://expedia.ca/Cheap-Flights-To-Cochrane.d3913.Travel-Guide-Flights) - [Cheap Flights from Winnipeg (YWG) to Toronto (YYZ)](https://expedia.ca/lp/flights/ywg/yyz/winnipeg-to-toronto) Packages - [Caribbean Vacations](https://expedia.ca/Caribbean.d6022969.Destination-Travel-Guides) - [Cancun Vacations](https://expedia.ca/Cancun.d179995.Destination-Travel-Guides) General - [Visit Downtown Dallas](https://expedia.ca/Dallas-Downtown-Dallas.dx800026) - [Visit Downtown Houston](https://expedia.ca/Houston-Downtown-Houston.dx800037) - [Visit Fort Worth Stockyards](https://expedia.ca/Fort-Worth-Fort-Worth-Stockyards.dx6190845) - [Visit Bhutan](https://expedia.ca/Bhutan.dx11400) - [Visit Downtown San Antonio](https://expedia.ca/San-Antonio-Downtown-San-Antonio.dx800120) - [Visit Tiki Island](https://expedia.ca/Galveston-Tiki-Island.dx3000398918) - [Visit Crystal Beach](https://expedia.ca/Port-Bolivar-Crystal-Beach.dx94245) - [Visit Downtown Austin](https://expedia.ca/Austin-Downtown-Austin.dx6059085) - [Visit Deep Ellum](https://expedia.ca/Dallas-Deep-Ellum.dx6190847)