Title: Sixt Car Rental in Southeast Missouri, MO - Expedia.ca ![](https://images.trvl-media.com/place/553248635976196024/558eb86b-b1ac-4ef2-8a0c-6bebbb1e2aae.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Sixt Car rental in Southeast Missouri Compare car suppliers to unlock big savings, and package your flight, hotel, and car to save even more. Members save 10% more on select hotels, cars, activities and vacation rentals. [Sign up.](https://www.expedia.ca/signup?enable_registration=true&rfrr=TG.CM) Enjoy maximum flexibility with penalty-free cancellation on most car rentals. ## Find Cheap Sixt Rental Deals in Southeast Missouri \* Price found within the past 6 days. Click for updated prices. ### Don't see what you're looking for? See all car rentals in Southeast Missouri [View all cars](https://expedia.ca/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Southeast%20Missouri,%20Missouri,%20United%20States%20of%20America&dpln=6058763&date1=26/09/2025&date2=28/09/2025&crfrr=defaultFlex&SearchType=Place&selVen=[%2235%22]) ## FAQs for Car Rentals in Southeast Missouri with Sixt ### What are the advantages of renting a car from Sixt in Southeast Missouri with Expedia.ca? In Southeast Missouri, Missouri, Sixt has some excellent deals on car rentals. They have multiple pick-up locations within the area and great customer service. Discover a large inventory of cars, many of which are available at an affordable price on Expedia.ca. ### How can I get the best deals from Sixt in Southeast Missouri? Compare the top deals from Sixt in Southeast Missouri. Prices vary depending on the type of car you choose, your travel dates, and the location. We recommend selecting an Economy or Compact vehicle for the lowest rate. You can check deals from all available providers on our [car rentals in Southeast Missouri](https://www.expedia.ca/Car-Rentals-In-Southeast Missouri.d6058763.Car-Rental-Guide) page. ### Where are the Sixt pick-up locations in Southeast Missouri? There are multiple options for Sixt locations in Southeast Missouri. Choose the most convenient one for you to save time during your trip. The largest selection of vehicles is usually at the airport or downtown location. Click around the page to see other options for branches in the area. ### Which types of cars can I rent from Sixt in Southeast Missouri? Sixt has a great selection of cars to choose from, many of which are available at a low price. While inventory varies between Southeast Missouri Sixt locations, you’re sure to find one that suits your needs and budget. Find options for luxury, compact, mid-range, SUVs, convertibles, hybrids, sports cars, sedans, and more. Wherever you’re going, Expedia.ca will help you get there. ### What is the cancellation policy? Sixt has a different cancellation policy for different types of deals. Some bookings are free to cancel, while others may be non-refundable. Be sure to understand the terms of your agreement before booking. We recommend filtering by “free cancellation” for the most amount of flexibility. ### Why is Expedia.ca the best place to book my car rental? Expedia.ca has a vast inventory and some of the best deals on all available cars in the area. Plus, you can get all your travel needs in one place. Book flights or [Southeast Missouri hotels](https://www.expedia.ca/Southeast Missouri-Hotels.d6058763.Travel-Guide-Hotels) with your car rental, and get a [vacation package in Southeast Missouri](https://www.expedia.ca/Southeast Missouri.d6058763.Destination-Travel-Guides) for less. We reward you with points back for every booking and make sure you get the perfect vehicle for the best price. ## Sixt Car Rental Information | Car Supplier: | Sixt | | --- | --- | | Price: | | | From the airport to your hotel: | [Airport Transportation](https://www.expedia.ca/ground-transfers?rfrr=car.table.AirportTransportation) | ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - [B&B in Annapolis](https://www.expedia.ca/Annapolis-Bed-And-Breakfast.d6282465-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Hotels with Balconies in Annapolis](https://www.expedia.ca/Annapolis-Hotels-Hotels-With-Balconies.0-0-d6282465-tHotelswithBalconies.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Annapolis](https://www.expedia.ca/Annapolis-Hotels-Luxury-Hotel.0-0-d6282465-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Spa Hotels in Annapolis](https://www.expedia.ca/Annapolis-Hotels-Spa-Hotel.0-0-d6282465-tSpaHotel.Travel-Guide-Filter-Hotels) - [Annapolis Hotels](https://www.expedia.ca/Annapolis-Hotels.d6282465.Travel-Guide-Hotels) - [Lodges in Annapolis](https://www.expedia.ca/Annapolis-Lodges.d6282465-aaLodges.Travel-Guide-Accommodation) - [Farmstay in Arcadia](https://www.expedia.ca/Arcadia-Agritourism.d6346857-aaAgritourism.Travel-Guide-Accommodation) - [B&B in Arcadia](https://www.expedia.ca/Arcadia-Bed-And-Breakfast.d6346857-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Cheap Hotels in Arcadia](https://www.expedia.ca/Arcadia-Hotels-Cheap-Hotels.0-0-d6346857-tCheapHotels.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Arcadia](https://www.expedia.ca/Arcadia-Hotels-Luxury-Hotel.0-0-d6346857-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Arcadia Hotels](https://www.expedia.ca/Arcadia-Hotels.d6346857.Travel-Guide-Hotels) - [Lodges in Arcadia](https://www.expedia.ca/Arcadia-Lodges.d6346857-aaLodges.Travel-Guide-Accommodation) - [B&B in Belleview](https://www.expedia.ca/Belleview-Bed-And-Breakfast.d3000444413-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Cabin Rentals in Belleview](https://www.expedia.ca/Belleview-Cabins.d3000444413-aaCabins.Travel-Guide-Accommodation) - [Belleview Hotels](https://www.expedia.ca/Belleview-Hotels.d3000444413.Travel-Guide-Hotels) - [Motels in Belleview](https://www.expedia.ca/Belleview-Motels.d3000444413-aaMotels.Travel-Guide-Accommodation) - [Luxury Hotels in Black](https://www.expedia.ca/Black-Hotels-Luxury-Hotel.0-0-d3000444470-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Black Hotels](https://www.expedia.ca/Black-Hotels.d3000444470.Travel-Guide-Hotels) - [Lodges in Black](https://www.expedia.ca/Black-Lodges.d3000444470-aaLodges.Travel-Guide-Accommodation) - [Apartments in Centerville](https://www.expedia.ca/Centerville-Apartments.d553248634983078632-aaApartments.Travel-Guide-Accommodation) - [Centerville Hotels](https://www.expedia.ca/Centerville-Hotels.d553248634983078632.Travel-Guide-Hotels) - [Motels in Centerville](https://www.expedia.ca/Centerville-Motels.d553248634983078632-aaMotels.Travel-Guide-Accommodation) - [Cobalt Hotels](https://www.expedia.ca/Cobalt-Hotels.d553248634983153223.Travel-Guide-Hotels) - [Cheap Hotels in Des Arc](https://www.expedia.ca/Des-Arc-Hotels-Cheap-Hotels.0-0-d553248634983251690-tCheapHotels.Travel-Guide-Filter-Hotels) - [Des Arc Hotels](https://www.expedia.ca/Des-Arc-Hotels.d553248634983251690.Travel-Guide-Hotels) - [Wayne County Hotels](https://www.expedia.ca/Destinations-In-Wayne-County.d553248635976433836.Hotel-Destinations) - [Cheap Hotels in Doe Run](https://www.expedia.ca/Doe-Run-Hotels-Cheap-Hotels.0-0-d3000349343-tCheapHotels.Travel-Guide-Filter-Hotels) - [Doe Run Hotels](https://www.expedia.ca/Doe-Run-Hotels.d3000349343.Travel-Guide-Hotels) - [Lodges in Doe Run](https://www.expedia.ca/Doe-Run-Lodges.d3000349343-aaLodges.Travel-Guide-Accommodation) - [Hotels near Elephant Rocks State Park](https://www.expedia.ca/Elephant-Rocks-State-Park-Hotels.0-l553248621532648464-0.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Fredericktown](https://www.expedia.ca/Fredericktown-Hotels-Cheap-Hotels.0-0-d55114-tCheapHotels.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Fredericktown](https://www.expedia.ca/Fredericktown-Hotels-Pet-Friendly-Hotel.0-0-d55114-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Fredericktown Hotels](https://www.expedia.ca/Fredericktown-Hotels.d55114.Travel-Guide-Hotels) - [Glen Allen Hotels](https://www.expedia.ca/Glen-Allen-Hotels.d553248634983455025.Travel-Guide-Hotels) - [Vacation Homes in Glen Allen](https://www.expedia.ca/Glen-Allen-Private-Vacation-Homes.d553248634983455025-aaPrivateVacationHomes.Travel-Guide-Accommodation) - [Greenville Hotels](https://www.expedia.ca/Greenville-Hotels.d553248634983564794.Travel-Guide-Hotels) - [Lodges in Greenville](https://www.expedia.ca/Greenville-Lodges.d553248634983564794-aaLodges.Travel-Guide-Accommodation) - [Resorts in Greenville](https://www.expedia.ca/Greenville-Resort-Hotels.d553248634983564794-aaResortHotels.Travel-Guide-Accommodation) - [Farmstay in Iron Mountain Lake](https://www.expedia.ca/Iron-Mountain-Lake-Agritourism.d553248634983534888-aaAgritourism.Travel-Guide-Accommodation) - [Ironton Hotels](https://www.expedia.ca/Ironton-Hotels.d6053585.Travel-Guide-Hotels) - [Hotels near Johnson's Shut-ins State Park](https://www.expedia.ca/Johnsons-Shut-Ins-State-Park-Hotels.0-l553248621555612544-0.Travel-Guide-Filter-Hotels) - [Lodges in Knob Lick](https://www.expedia.ca/Knob-Lick-Lodges.d553248635975872774-aaLodges.Travel-Guide-Accommodation) - [Cheap Hotels in Lesterville](https://www.expedia.ca/Lesterville-Hotels-Cheap-Hotels.0-0-d3000445174-tCheapHotels.Travel-Guide-Filter-Hotels) - [Lesterville Hotels](https://www.expedia.ca/Lesterville-Hotels.d3000445174.Travel-Guide-Hotels) - [Cheap Hotels in Marble Hill](https://www.expedia.ca/Marble-Hill-Hotels-Cheap-Hotels.0-0-d3000445212-tCheapHotels.Travel-Guide-Filter-Hotels) - [Marble Hill Hotels](https://www.expedia.ca/Marble-Hill-Hotels.d3000445212.Travel-Guide-Hotels) - [B&B in Middle Brook](https://www.expedia.ca/Middle-Brook-Bed-And-Breakfast.d3000445241-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Middle Brook Hotels](https://www.expedia.ca/Middle-Brook-Hotels.d3000445241.Travel-Guide-Hotels) - [Lodges in Middle Brook](https://www.expedia.ca/Middle-Brook-Lodges.d3000445241-aaLodges.Travel-Guide-Accommodation) - [Mill Spring Hotels](https://www.expedia.ca/Mill-Spring-Hotels.d553248634983294338.Travel-Guide-Hotels) - [Patterson Hotels](https://www.expedia.ca/Patterson-Hotels.d553248635975853657.Travel-Guide-Hotels) - [Lodges in Patterson](https://www.expedia.ca/Patterson-Lodges.d553248635975853657-aaLodges.Travel-Guide-Accommodation) - [Resorts in Patterson](https://www.expedia.ca/Patterson-Resort-Hotels.d553248635975853657-aaResortHotels.Travel-Guide-Accommodation) - [Cheap Hotels in Piedmont](https://www.expedia.ca/Piedmont-Hotels-Cheap-Hotels.0-0-d3000445413-tCheapHotels.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Piedmont](https://www.expedia.ca/Piedmont-Hotels-Luxury-Hotel.0-0-d3000445413-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Piedmont Hotels](https://www.expedia.ca/Piedmont-Hotels.d3000445413.Travel-Guide-Hotels) - [Motels in Piedmont](https://www.expedia.ca/Piedmont-Motels.d3000445413-aaMotels.Travel-Guide-Accommodation) - [Hotels with Wifi in Pilot Knob](https://www.expedia.ca/Pilot-Knob-Hotels-Hotel-With-Wifi.0-0-d3000008143-tHotelwithwifi.Travel-Guide-Filter-Hotels) - [Pilot Knob Hotels](https://www.expedia.ca/Pilot-Knob-Hotels.d3000008143.Travel-Guide-Hotels) - [Lodges in Pilot Knob](https://www.expedia.ca/Pilot-Knob-Lodges.d3000008143-aaLodges.Travel-Guide-Accommodation) - [Resorts in Wayne County](https://www.expedia.ca/Wayne-County-Resort-Hotels.d553248635976433836-aaResortHotels.Travel-Guide-Accommodation) - [Hotels with a Pool in Williamsville](https://www.expedia.ca/Williamsville-Hotels-Hotel-With-Pool.0-0-d553248634983506457-tHotelwithPool.Travel-Guide-Filter-Hotels) - [Flights to Fredericktown](https://www.expedia.ca/Cheap-Flights-To-Fredericktown.d55114.Travel-Guide-Flights) - [Flights to Ironton](https://www.expedia.ca/Cheap-Flights-To-Ironton.d6053585.Travel-Guide-Flights) - [Flights from Belleview](https://www.expedia.ca/lp/flights/3000444413/flights-from-belleview) - [Flights from Black](https://www.expedia.ca/lp/flights/3000444470/flights-from-black) - [Flights from Centerville](https://www.expedia.ca/lp/flights/553248634983078632/flights-from-centerville) - [Visit Fredericktown](https://www.expedia.ca/Fredericktown.dx55114) - [K Bridge Recreation Area](https://www.expedia.ca/K-Bridge-Recreation-Area-Annapolis.d6282501.Vacation-Attraction) - [Alamo Rent A Car Rental Cars in Downtown St. Louis](https://www.expedia.ca/Alamo-Rent-A-Car-Car-Rentals-In-Downtown-St-Louis.d800136-c6.Car-Rental-Guide-Suppliers) - [Alamo Rent A Car Rental Cars in Lambert-St. Louis Intl.](https://www.expedia.ca/Alamo-Rent-A-Car-Car-Rentals-In-Lambert-St-Louis-Intl.d5002323-c6.Car-Rental-Guide-Suppliers) - [Alamo Rent A Car Rental Cars in Poplar Bluff](https://www.expedia.ca/Alamo-Rent-A-Car-Car-Rentals-In-Poplar-Bluff.d9449-c6.Car-Rental-Guide-Suppliers) - [Alamo Rent A Car Rental Cars in St. James](https://www.expedia.ca/Alamo-Rent-A-Car-Car-Rentals-In-St-James.d7592-c6.Car-Rental-Guide-Suppliers) - [Avis Rental Cars in Arnold](https://www.expedia.ca/Avis-Car-Rentals-In-Arnold.d177608-c41.Car-Rental-Guide-Suppliers) - [Avis Rental Cars in Farmington](https://www.expedia.ca/Avis-Car-Rentals-In-Farmington.d6058764-c41.Car-Rental-Guide-Suppliers) - [Avis Rental Cars in Fort Leonard Wood](https://www.expedia.ca/Avis-Car-Rentals-In-Fort-Leonard-Wood.d3378-c41.Car-Rental-Guide-Suppliers) - [Avis Rental Cars in Lambert-St. Louis Intl.](https://www.expedia.ca/Avis-Car-Rentals-In-Lambert-St-Louis-Intl.d5002323-c41.Car-Rental-Guide-Suppliers) - [Avis Rental Cars in Sikeston](https://www.expedia.ca/Avis-Car-Rentals-In-Sikeston.d6058766-c41.Car-Rental-Guide-Suppliers) - [Budget Rental Cars in Fort Leonard Wood](https://www.expedia.ca/Budget-Car-Rentals-In-Fort-Leonard-Wood.d3378-c39.Car-Rental-Guide-Suppliers) - [Budget Rental Cars in Lambert-St. Louis Intl.](https://www.expedia.ca/Budget-Car-Rentals-In-Lambert-St-Louis-Intl.d5002323-c39.Car-Rental-Guide-Suppliers) - [Budget Rental Cars in Perryville](https://www.expedia.ca/Budget-Car-Rentals-In-Perryville.d6134448-c39.Car-Rental-Guide-Suppliers) - [Budget Rental Cars in St. Charles](https://www.expedia.ca/Budget-Car-Rentals-In-St-Charles.d9786-c39.Car-Rental-Guide-Suppliers) - [Enterprise Rental Cars in Downtown St. Louis](https://www.expedia.ca/Enterprise-Car-Rentals-In-Downtown-St-Louis.d800136-c15.Car-Rental-Guide-Suppliers) - [Enterprise Rental Cars in Ferguson](https://www.expedia.ca/Enterprise-Car-Rentals-In-Ferguson.d103805-c15.Car-Rental-Guide-Suppliers) - [Enterprise Rental Cars in Lambert-St. Louis Intl.](https://www.expedia.ca/Enterprise-Car-Rentals-In-Lambert-St-Louis-Intl.d5002323-c15.Car-Rental-Guide-Suppliers) - [Fox Rental Cars Rental Cars in St. Louis](https://www.expedia.ca/Fox-Rental-Cars-Car-Rentals-In-St-Louis.d178309-c19.Car-Rental-Guide-Suppliers) - [Hertz Rental Cars in Lambert-St. Louis Intl.](https://www.expedia.ca/Hertz-Car-Rentals-In-Lambert-St-Louis-Intl.d5002323-c40.Car-Rental-Guide-Suppliers) - [Hertz Rental Cars in Marble Hill](https://www.expedia.ca/Hertz-Car-Rentals-In-Marble-Hill.d3000445212-c40.Car-Rental-Guide-Suppliers) - [Hertz Rental Cars in Park Hills](https://www.expedia.ca/Hertz-Car-Rentals-In-Park-Hills.d183485-c40.Car-Rental-Guide-Suppliers) - [Hertz Rental Cars in Sikeston](https://www.expedia.ca/Hertz-Car-Rentals-In-Sikeston.d6058766-c40.Car-Rental-Guide-Suppliers) - [Hiper Rent a Car Rental Cars in Tiff](https://www.expedia.ca/Hiper-Rent-A-Car-Car-Rentals-In-Tiff.d3000349564-c1026.Car-Rental-Guide-Suppliers) - [National Car Rental Rental Cars in Fredericktown](https://www.expedia.ca/National-Car-Rental-Car-Rentals-In-Fredericktown.d55114-c42.Car-Rental-Guide-Suppliers) - [National Car Rental Rental Cars in Sikeston](https://www.expedia.ca/National-Car-Rental-Car-Rentals-In-Sikeston.d6058766-c42.Car-Rental-Guide-Suppliers) - [National Car Rental Rental Cars in Spirit of St. Louis](https://www.expedia.ca/National-Car-Rental-Car-Rentals-In-Spirit-Of-St-Louis.d6024951-c42.Car-Rental-Guide-Suppliers) - [National Car Rental Rental Cars in St. Louis](https://www.expedia.ca/National-Car-Rental-Car-Rentals-In-St-Louis.d178309-c42.Car-Rental-Guide-Suppliers) - [National Car Rental Rental Cars in Wesco](https://www.expedia.ca/National-Car-Rental-Car-Rentals-In-Wesco.d3000349585-c42.Car-Rental-Guide-Suppliers) - [Rent A Wreck Rental Cars in Berkeley](https://www.expedia.ca/Rent-A-Wreck-Car-Rentals-In-Berkeley.d6272-c33.Car-Rental-Guide-Suppliers) - [Sixt Rental Cars in Lambert-St. Louis Intl.](https://www.expedia.ca/Sixt-Car-Rentals-In-Lambert-St-Louis-Intl.d5002323-c35.Car-Rental-Guide-Suppliers) - [Sixt Rental Cars in St. Louis](https://www.expedia.ca/Sixt-Car-Rentals-In-St-Louis.d178309-c35.Car-Rental-Guide-Suppliers) - [Marble Hill Vacation Rentals](https://www.expedia.ca/Marble-Hill-Vacation-Rentals.d3000445212.Travel-Guide-VacationRentals) Heading to Southeast Missouri? Explore Southeast Missouri with Expedia's Travel Guides to find the best hotels, vacation packages, car rental deals and more! [Flights to Southeast Missouri](https://expedia.ca/Cheap-Flights-To-Southeast-Missouri.d6058763.Travel-Guide-Flights)[Southeast Missouri Hotels](https://expedia.ca/Southeast-Missouri-Hotels.d6058763.Travel-Guide-Hotels)[Southeast Missouri Vacation Rentals](https://expedia.ca/Southeast-Missouri-Vacation-Rentals.d6058763.Travel-Guide-VacationRentals)[Southeast Missouri Car Rentals](https://expedia.ca/Car-Rentals-In-Southeast-Missouri.d6058763.Car-Rental-Guide)[Southeast Missouri Vacations](https://expedia.ca/Southeast-Missouri.d6058763.Destination-Travel-Guides)[Things to do in Southeast Missouri](https://expedia.ca/Things-To-Do-In-Southeast-Missouri.d6058763.Travel-Guide-Activities)