Title: Book the Best Sikeston SPA Resorts from CA $149 - Spa Hotels in Sikeston, MO | Expedia.ca

  

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# Find Spa Hotels in Sikeston, MO from CA $149

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## Check availability on Sikeston Spa Hotels

Tonight

[Oct 7 - Oct 8](https://www.expedia.ca/Hotel-Search?regionId=6058766&startDate=2025-10-07&endDate=2025-10-08&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Oct 8 - Oct 9](https://www.expedia.ca/Hotel-Search?regionId=6058766&startDate=2025-10-08&endDate=2025-10-09&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=6058766&startDate=2025-10-10&endDate=2025-10-12&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=6058766&startDate=2025-10-17&endDate=2025-10-19&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Top Sikeston Spa Hotels

![Exterior](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/fe49057f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free breakfast](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/5fa70c20.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool, open 8 AM to 11 PM, sun loungers](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/64fb9857.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/479dc559.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Cape Girardeau

9.4/10

Exceptional

(1003)

"It was right off the interstate with lots of restaurant options "

CA $132

CA $149 total

includes taxes & fees

Oct 19 - Oct 20

[](https://www.expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-21&endDate=2025-10-22&regionId=6058766&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true)

## Top Sikeston Hotel Reviews

![Drury Plaza Hotel Cape Girardeau Conference Center](//images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/742aaf1e_y.jpg)

### Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent

"This is the best hotel experience for the price that I’ve ever had, and I travel a lot. Very generous social time with three free drinks and lots of complementary food. Everyone was lovely, bed comfortable, perfect temperature and no stale smell. Very clean. And so well priced! I wish all hotels were like this one!"

[](https://expedia.ca/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information)

![Drury Inn & Suites Jackson MO](//images.trvl-media.com/lodging/1000000/50000/41100/41077/8996a36d_y.jpg)

### Drury Inn & Suites Jackson MO

10/10 Excellent

"We just came in for one night to see our grandson play football. We come to Jackson often and always stay here. It is consistently excellent. Clean, friendly, staff is great. "

[](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information)

## Frequently asked questions

### Looking for a spa hotel in Sikeston?

> Book one of our lush spa hotels and pamper yourself from the moment you arrive. Travelers like the gourmet restaurants and popular shops in Sikeston. Enjoy the museums and riverfront during your vacation. Hotels with spas are the perfect way to break out of your daily routine and add a layer of luxury to your holiday.

### What's there to see and do in Sikeston?

> Experience Sikeston and visit Sikeston Depot Museum, Central Park, and Front Street Studio & Art Gallery. If you have a little extra time during your trip, you might want to make a stop at Stoddard County Civil War Memorial Cemetery and Hunter-Dawson State Historic Site.

### What is a Sikeston spa hotel?

> Spa hotels in Sikeston provide lodging and have an on-site spa offering services including therapies and beauty treatments. Some also offer in-room treatments. Spa hotels are ideal if you are looking for some R&R during your vacation.

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