A calm lake with mountains in the background.

Seneca Vacation Rentals

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Check prices for these dates

In two weeks
Nov 6 - Nov 8
In two months
Dec 18 - Dec 20
In three months
Jan 15 - Jan 17
In four months
Feb 12 - Feb 14

Our top choices for Seneca vacation homes

A bedroom with a bed, a nightstand, a lamp, a window with blinds, a ceiling fan, and a painting on the wall.

1. Peaceful 3-bedroom home 4 miles from Clemson.

Peaceful 3-bedroom home 4 miles from Clemson.
Seneca
The price is CA $152
CA $405 total
includes taxes & fees
Nov 17 - Nov 18
Peaceful 3-bedroom home 4 miles from Clemson.
A bedroom with two beds, a ceiling fan, a large mirror, and a window with curtains.

2. Walk to Boat Ramp Lake Keowee w/ Parking + Firepit

Walk to Boat Ramp Lake Keowee w/ Parking + Firepit
Seneca
2.0 out of 10, (1 review)
The price is CA $179
CA $603 total
includes taxes & fees
Oct 28 - Oct 29
Walk to Boat Ramp Lake Keowee w/ Parking + Firepit
A bedroom with a bed, a dresser, a nightstand, a lamp, and a painting on the wall.

3. Renovated 3BR near Lake Keowee & Clemson

Renovated 3BR near Lake Keowee & Clemson
Seneca
10.0 out of 10, Exceptional, (2 reviews)
"Fantastic location and really nicely done home. It was a perfect touch having a desk in one of the rooms to be able to get work done."
United States
Brenda B.
The price is CA $243
CA $517 total
includes taxes & fees
Oct 28 - Oct 29
Renovated 3BR near Lake Keowee & Clemson
A living room with a large tiger mural, a fireplace, a sofa, and a coffee table.

4. Renovated Bungalow 1 Block from Downtown Seneca! 7 miles from Clemson!

Renovated Bungalow 1 Block from Downtown Seneca! 7 miles from Clemson!
Downtown
10.0 out of 10, Exceptional, (23 reviews)
"Great host! We had a great experience during our stay. "
United States
David E.
The price is CA $226
CA $517 total
includes taxes & fees
Oct 28 - Oct 29
Renovated Bungalow 1 Block from Downtown Seneca! 7 miles from Clemson!
A modern kitchen with a central island, wooden cabinets, and a built-in refrigerator.

5. 3 bedroom 2 bath home located minutes from Keowee Mariana, shopping and Clemson

3 bedroom 2 bath home located minutes from Keowee Mariana, shopping and Clemson
Seneca
9.8 out of 10, Exceptional, (13 reviews)
"Easy check in, pet-friendly, great location!!"
United States
Jason M.
The price is CA $317
CA $542 total
includes taxes & fees
Oct 22 - Oct 23
3 bedroom 2 bath home located minutes from Keowee Mariana, shopping and Clemson
A spacious living room with a sofa, chairs, a wooden coffee table, and a fireplace.

6. Lake Retreat- Mins to CU- Kayaks, Fire Pit, Dock

Lake Retreat- Mins to CU- Kayaks, Fire Pit, Dock
Seneca
8.0 out of 10, Very good, (7 reviews)
"Adorable and clean house! The yard is beautiful "
United States
Diana H.
Lake Retreat- Mins to CU- Kayaks, Fire Pit, Dock
A modern kitchen with white cabinetry, a central island, and a large window.

7. The Big Golf House- 10 miles to Clemson

The Big Golf House- 10 miles to Clemson
Seneca
10.0 out of 10, Exceptional, (4 reviews)
"Great house and host!"
United States
David E.
The price is CA $357
CA $854 total
includes taxes & fees
Oct 25 - Oct 26
The Big Golf House- 10 miles to Clemson
A wooden deck with a railing overlooking a forested area during sunset.

8. Waterfront 3br home on Lake Hartwell near Clemson

Waterfront 3br home on Lake Hartwell near Clemson
Seneca
9.8 out of 10, Exceptional, (19 reviews)
"Planning was super simple and the host is very responsive!"
United States
Trevor&Shaya Z.
The price is CA $361
CA $764 total
includes taxes & fees
Oct 28 - Oct 29
Waterfront 3br home on Lake Hartwell near Clemson
A covered porch with wicker furniture, a wooden table, and a ceiling fan.

9. Beautiful Updated Clemson Lake House - 4 Miles from Downtown Clemson and the Stadium

Beautiful Updated Clemson Lake House - 4 Miles from Downtown Clemson and the Stadium
Seneca
9.6 out of 10, Exceptional, (13 reviews)
"Everything was lovely."
United States
Allison C.
The price is CA $459
CA $977 total
includes taxes & fees
Oct 28 - Oct 29
Beautiful Updated Clemson Lake House - 4 Miles from Downtown Clemson and the Stadium
A cozy living room with a fireplace, a dining area with a table and chairs, and a kitchen in the background.

10. Clemson Memorabilia House Frank Howard III’s Home

Clemson Memorabilia House Frank Howard III’s Home
Clemson
8.4 out of 10, Very good, (20 reviews)
"Great location!"
United States
Libby S.
The price is CA $118
CA $373 total
includes taxes & fees
Nov 1 - Nov 2
Clemson Memorabilia House Frank Howard III’s Home
A church interior with pews, a cross, and a view of a landscape through a large window.

11. The Rustic Rectangle

The Rustic Rectangle
Pendleton
10.0 out of 10, Exceptional, (13 reviews)
"Cozy, clean and quiet! Loved that we could have our dogs stay with us! "
United States
Jennifer T.
The price is CA $122
CA $323 total
includes taxes & fees
Oct 27 - Oct 28
The Rustic Rectangle
A modern kitchen with a dining area, wooden flooring, and a ceiling fan.

12. Our Nest, a well loved quiet retreat in Foxwood Hills Resort near Lake Hartwell.

Our Nest, a well loved quiet retreat in Foxwood Hills Resort near Lake Hartwell.
Westminster
9.8 out of 10, Exceptional, (10 reviews)
"Outstanding place and host. Will definitely stay here again. "
United States
William H. J.
The price is CA $151
CA $348 total
includes taxes & fees
Oct 26 - Oct 27
Our Nest, a well loved quiet retreat in Foxwood Hills Resort near Lake Hartwell.
A lakeside cabin with a dock, a floating platform, and a house in the background.

13. Lakefront Private Cove Retreat w/ Sandy Beach, Dock, Hot Tub + Boat & Ski Option

Lakefront Private Cove Retreat w/ Sandy Beach, Dock, Hot Tub + Boat & Ski Option
West Union
9.6 out of 10, Exceptional, (17 reviews)
"Great home. Neat and Clean. We had family 3-70 and there was something for everyone to do and enjoy during our stay. Host was very prompt with communication and answering my questions. Would stay here again."
United States
April O.
The price is CA $800
CA $1,803 total
includes taxes & fees
Oct 27 - Oct 28
Lakefront Private Cove Retreat w/ Sandy Beach, Dock, Hot Tub + Boat & Ski Option
A covered porch with a wicker chair, a sofa with patterned cushions, and a small table with a plant.

14. Dream Weaver Cottage • Private Hot Tub • Fenced Yard • Pets Stay Free

Dream Weaver Cottage • Private Hot Tub • Fenced Yard • Pets Stay Free
Westminster
10.0 out of 10, Exceptional, (33 reviews)
"Fantastic property that was very clean and decorated really cute. We will come again."
United States
Pamela S.
The price is CA $356
CA $713 total
includes taxes & fees
Nov 3 - Nov 4
Dream Weaver Cottage • Private Hot Tub • Fenced Yard • Pets Stay Free
A kitchen with white cabinets, a stainless steel refrigerator, and a countertop with a flower arrangement and a bag.

15. Large 3 Bedroom Townhome Downtown Clemson and garage! Walk to Clemson Stadium!

Large 3 Bedroom Townhome Downtown Clemson and garage! Walk to Clemson Stadium!
Clemson
The price is CA $352
CA $776 total
includes taxes & fees
Nov 1 - Nov 2
Large 3 Bedroom Townhome Downtown Clemson and garage! Walk to Clemson Stadium!
A covered porch with a blue door, a welcome mat, and a wooden deck.

16. Charming 2-bedroom house in Clemson 4mi. from Death Valley and 1mi. from Mac's

Charming 2-bedroom house in Clemson 4mi. from Death Valley and 1mi. from Mac's
Clemson
10.0 out of 10, Exceptional, (6 reviews)
"It was a cute house in a quiet area, but easy to get to campus . It has a nice kitchen and even a porch with an eating area overlooking the big back yard"
United States
Katherine
The price is CA $635
CA $1,074 total
includes taxes & fees
Oct 25 - Oct 26
Charming 2-bedroom house in Clemson 4mi. from Death Valley and 1mi. from Mac's
A wooden deck with a round table and chairs, overlooking a lake.

17. Lake Hartwell Covered Dock & Sunset Beach 3BD, 1BA

Lake Hartwell Covered Dock & Sunset Beach 3BD, 1BA
Fair Play
9.6 out of 10, Exceptional, (62 reviews)
"The cottage was very nice. Great view of the water. super easy walk to the water. Dock & kayaks were enjoyed. "
United States
Steve A.
Lake Hartwell Covered Dock & Sunset Beach 3BD, 1BA
A two-story house with a balcony, wooden deck, and string lights.

18. Clemson|SUPs|ParkPass|PizzaOven|PortmanMarina|EV

Clemson|SUPs|ParkPass|PizzaOven|PortmanMarina|EV
Anderson
10.0 out of 10, Exceptional, (13 reviews)
"Beautifully decorated and updated condo. It was so private it felt like a single home. Very thoughtful details throughout from the decor to the house supplies. We stayed to move my daughter into Clemson so didn’t take advantage of the lake or boards but there is a nice outdoor deck and even a fire pit. Very comfy vibe! About 15 to 20 minutes from campus, easy to get around."
United States
Diana
The price is CA $186
CA $640 total
includes taxes & fees
Oct 27 - Oct 28
Clemson|SUPs|ParkPass|PizzaOven|PortmanMarina|EV
A cabin-style building with a wooden exterior, large windows, and a view of the water.

19. 2 Bedroom Lake Front Tiny Home in Anderson, beside Legendary Green Pond Landing

2 Bedroom Lake Front Tiny Home in Anderson, beside Legendary Green Pond Landing
Anderson
10.0 out of 10, Exceptional, (4 reviews)
"The place was beautiful and immaculate. It was perfect for our family of 3. Loved that we could see the lake from the porch."
United States
Lisa B.
The price is CA $221
CA $486 total
includes taxes & fees
Oct 25 - Oct 26
2 Bedroom Lake Front Tiny Home in Anderson, beside Legendary Green Pond Landing
A covered outdoor seating area with large windows overlooking a lake and forest.

20. Lake Hartwell Georgia Cabin on the Lake

Lake Hartwell Georgia Cabin on the Lake
Hartwell
6.0 out of 10, (1 review)
"The inside of the property was clean, but the water had a smell to it and the yard looked like it hasn’t been mowed in quite some time. "
United States
Colby F.
The price is CA $140
CA $285 total
includes taxes & fees
Oct 22 - Oct 23
Lake Hartwell Georgia Cabin on the Lake
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Seneca Hotel Reviews

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area

10/10 Excellent
"Room was clean and staff was friendly and helpful."
Sasha 1-night trip
Posted 13 hours ago
Hampton Inn & Suites Seneca-Clemson Area

Find out more about Seneca

Seneca Vacation Homes information

Number of reviews
167
Accommodation
732 Vacation Homes
Lowest Price
CA $285
Highest Price
CA $1,803

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