Title: Santo Tomé Vacation Packages & Trips 2026 | Expedia.ca [Hotels in Santo Tomé](https://expedia.ca/Santo-Tome-Hotels.d3000007162.Travel-Guide-Hotels)[Vacation Rentals in Santo Tomé](https://expedia.ca/Santo-Tome-Vacation-Rentals.d3000007162.Travel-Guide-VacationRentals)[Santo Tomé Car Rentals](https://expedia.ca/Car-Rentals-In-Santo-Tome.d3000007162.Car-Rental-Guide) ![](https://images.trvl-media.com/place/3000007162/78809fe8-a3db-4eb3-b838-1c5772d07683.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Santo Tomé Vacation Packages ## Book a Hotel + Flight or Car together to unlock savings - ## Plan, book, travel with confidence - ### Better together Save up to CA $1,096 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Plan, book, and manage your trip all in one place #### Your Santo Tomé Vacation Amazing adventures await when you reserve a Santo Tomé vacation package. Whether you're a foodie, art buff or just a traveler who loves discovering new places, there's something for everyone in this awesome city. You'll want to sightsee during your trip to Santo Tomé. Swing by leading attractions such as [National University of the Littoral](https://www.expedia.ca/National-University-Of-The-Littoral-Santa-Fe.d6096622.Vacation-Attraction), [Cervecería Santa Fe](https://www.expedia.ca/Cerveceria-Santa-Fe-Santa-Fe.d553248621532374254.Vacation-Attraction) and [Catedral Metropolitana](https://www.expedia.ca/Catedral-Metropolitana-Santa-Fe.d6096626.Vacation-Attraction). Stop daydreaming and start adventuring. Explore the wide range of options on Expedia today and finally put your Santo Tomé vacation plans into gear! ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.ca/deals?rfrr=PKG_SPRING_PROMO_3000007162) ## Ready to book your vacation to Santo Tomé? Choose your dates ## Santo Tomé Hotel Deals ![Hotel de Campo Colon](https://images.trvl-media.com/lodging/5000000/4670000/4663300/4663285/5c30d567_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hotel de Campo Colon Autopista Santa Fe - Rosario / KM 153 Santo Tomé Santa Fe 8.4/10 Very Good! (51 reviews) Hotel is OK, but not worth the price Pleasant and quiet rooms. Clean. But not a very friendly staff. The cafeteria has very few food/drink options, and it has a fly (the insect) problem. Oh, they overcharged my stay by 20% based on what Expedia quoted me, so read the bill before checking out... Reviewed on Feb 5, 2017 [Get rates](https://expedia.ca/Hotel-Search?startDate=17%2F03%2F2026&endDate=18%2F03%2F2026&selected=4663285&PinnedHotelID=4663285&HadPinnedHotel=true®ionId=3000007162) [](https://expedia.ca/Hotel-Search?startDate=17%2F03%2F2026&endDate=18%2F03%2F2026&selected=4663285&PinnedHotelID=4663285&HadPinnedHotel=true®ionId=3000007162) ![InterTower Hotel](https://images.trvl-media.com/lodging/10000000/9850000/9845300/9845278/13fc6ccf_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### InterTower Hotel San Jeronimo 2779 Santa Fe Santa Fe Fully refundableReserve now, pay when you stay CA $144 CA $144 total Mar 4 - Mar 5 [](https://expedia.ca/Hotel-Search?startDate=04%2F03%2F2026&endDate=05%2F03%2F2026&selected=9845278&PinnedHotelID=9845278&HadPinnedHotel=true®ionId=3000007162) ![Los Silos Hotel](https://images.trvl-media.com/lodging/50000000/49090000/49086600/49086569/c5d48d1b_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Los Silos Hotel Dique I Puerto Santa Fe Santa Fe Santa Fe CA $175 CA $175 total Mar 8 - Mar 9 [](https://expedia.ca/Hotel-Search?startDate=08%2F03%2F2026&endDate=09%2F03%2F2026&selected=49086569&PinnedHotelID=49086569&HadPinnedHotel=true®ionId=3000007162) [See all 65 properties in Santo Tomé](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=04%2F03%2F2026&endDate=05%2F03%2F2026®ionId=3000007162) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Vacations [](https://expedia.ca/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Vacations [](https://expedia.ca/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Family Vacations [](https://expedia.ca/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Family_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Golf Vacations [](https://expedia.ca/lp/theme-vacations/golf-vacations?rfrr=editorial.Golf_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Luxury Vacations [](https://expedia.ca/lp/theme-vacations/luxury-vacations?rfrr=editorial.Luxury_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Romantic Vacations [](https://expedia.ca/lp/theme-vacations/romantic-vacations?rfrr=editorial.Romantic_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Ski Vacations [](https://expedia.ca/lp/theme-vacations/ski-vacations?rfrr=editorial.Ski_Vacations.click) ## Explore a world of travel with Expedia \* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels and earn double points when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app