Title: 10 Best Hotels in Santa Maria, Guayaquil for 2026 | Expedia.ca

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# Hotels in Santa Maria, Guayaquil 

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## Go beyond your typical stay in Santa Maria

Spa

[](https://www.expedia.ca/Hotel-Search?destination=Santa+Maria%2C+Guayaquil%2C+Guayas%2C+Ecuador&regionId=553248635976397555&latLong=-2.142682%2C-79.932849&adults=2&startDate=2025-12-28&d1=2025-12-28&endDate=2025-12-30&d2=2025-12-30&amenities=SPA_ON_SITE)

Apart hotel

[](https://www.expedia.ca/Hotel-Search?destination=Santa+Maria%2C+Guayaquil%2C+Guayas%2C+Ecuador&regionId=553248635976397555&latLong=-2.142682%2C-79.932849&adults=2&startDate=2025-12-28&d1=2025-12-28&endDate=2025-12-30&d2=2025-12-30&lodging=APART_HOTEL)

Family friendly

[](https://www.expedia.ca/Hotel-Search?destination=Santa+Maria%2C+Guayaquil%2C+Guayas%2C+Ecuador&regionId=553248635976397555&latLong=-2.142682%2C-79.932849&adults=2&startDate=2025-12-28&d1=2025-12-28&endDate=2025-12-30&d2=2025-12-30&travelerType=family_friendly)

Pool

[](https://www.expedia.ca/Hotel-Search?destination=Santa+Maria%2C+Guayaquil%2C+Guayas%2C+Ecuador&regionId=553248635976397555&latLong=-2.142682%2C-79.932849&adults=2&startDate=2025-12-28&d1=2025-12-28&endDate=2025-12-30&d2=2025-12-30&amenities=POOL)

Hot tub

[](https://www.expedia.ca/Hotel-Search?destination=Santa+Maria%2C+Guayaquil%2C+Guayas%2C+Ecuador&regionId=553248635976397555&latLong=-2.142682%2C-79.932849&adults=2&startDate=2025-12-28&d1=2025-12-28&endDate=2025-12-30&d2=2025-12-30&amenities=HOT_TUB)

Apart­ment

[](https://www.expedia.ca/Hotel-Search?destination=Santa+Maria%2C+Guayaquil%2C+Guayas%2C+Ecuador&regionId=553248635976397555&latLong=-2.142682%2C-79.932849&adults=2&startDate=2025-12-28&d1=2025-12-28&endDate=2025-12-30&d2=2025-12-30&lodging=APARTMENT)

Pet friendly

[](https://www.expedia.ca/Hotel-Search?destination=Santa+Maria%2C+Guayaquil%2C+Guayas%2C+Ecuador&regionId=553248635976397555&latLong=-2.142682%2C-79.932849&adults=2&startDate=2025-12-28&d1=2025-12-28&endDate=2025-12-30&d2=2025-12-30&amenities=PETS)

Condo

[](https://www.expedia.ca/Hotel-Search?destination=Santa+Maria%2C+Guayaquil%2C+Guayas%2C+Ecuador&regionId=553248635976397555&latLong=-2.142682%2C-79.932849&adults=2&startDate=2025-12-28&d1=2025-12-28&endDate=2025-12-30&d2=2025-12-30&lodging=CONDO)

## Check prices for these dates

Tonight

[Dec 14 - Dec 15](https://www.expedia.ca/Hotel-Search?regionId=553248635976397555&startDate=2025-12-14&endDate=2025-12-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Dec 15 - Dec 16](https://www.expedia.ca/Hotel-Search?regionId=553248635976397555&startDate=2025-12-15&endDate=2025-12-16&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=553248635976397555&startDate=2025-12-19&endDate=2025-12-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two weeks

[Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=553248635976397555&startDate=2025-12-26&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Recommended

Price (low to high)

Distance

Star rating

## Our top choices for Santa Maria hotels

![Outdoor pool, open 8:00 AM to 9:00 PM, sun loungers](https://images.trvl-media.com/lodging/7000000/6760000/6751000/6750908/1d447ff4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Coffee shop](https://images.trvl-media.com/lodging/7000000/6760000/6751000/6750908/6754254c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 2 Double Beds, Non Smoking](https://images.trvl-media.com/lodging/7000000/6760000/6751000/6750908/289f37b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/7000000/6760000/6751000/6750908/da93689c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Grand Hotel Guayaquil, an Ascend Collection Hotel

[](https://www.expedia.ca/Guayaquil-Hotels-Grand-Hotel-Guayaquil.h6750908.Hotel-Information)

Rocafuerte, 7.9 km from Santa Maria

9.2/10

Wonderful

(988)

"Great place to Stay.!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Erwin

CA $117

CA $131 total

Dec 20 - Dec 21

[](https://www.expedia.ca/Guayaquil-Hotels-Grand-Hotel-Guayaquil.h6750908.Hotel-Information)

![Presidential Suite, 1 King Bed, Jetted Tub, River View](https://images.trvl-media.com/lodging/7000000/6320000/6312500/6312483/79b2b000.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/7000000/6320000/6312500/6312483/664af8f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/7000000/6320000/6312500/6312483/69ea8661.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Presidential Suite, 1 King Bed, Jetted Tub, River View](https://images.trvl-media.com/lodging/7000000/6320000/6312500/6312483/8315afb5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Wyndham Guayaquil Puerto Santa Ana

[](https://www.expedia.ca/Guayaquil-Hotels-Wyndham-Guayaquil.h6312483.Hotel-Information)

Puerto Santa Ana, 7.5 km from Santa Maria

9.2/10

Wonderful

(1001)

"The hotel and service were great!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Rolando

CA $152

CA $170 total

Dec 19 - Dec 20

[](https://www.expedia.ca/Guayaquil-Hotels-Wyndham-Guayaquil.h6312483.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/106000000/105890000/105884300/105884261/24d4b9c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Deluxe Suite](https://images.trvl-media.com/lodging/106000000/105890000/105884300/105884261/65be67d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/106000000/105890000/105884300/105884261/dac3630a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Deluxe Suite](https://images.trvl-media.com/lodging/106000000/105890000/105884300/105884261/fc90d25c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Harmonie

[](https://www.expedia.ca/Guayaquil-Hotels-Harmonie.h105884261.Hotel-Information)

Simón Bolívar, 4.8 km from Santa Maria

9.0/10

Wonderful

(80)

"Great staff very friendly Good spot"

![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg)

Chelsea

CA $41

CA $41 total

Dec 15 - Dec 16

[](https://www.expedia.ca/Guayaquil-Hotels-Harmonie.h105884261.Hotel-Information)

![In-room safe, free WiFi](https://images.trvl-media.com/lodging/100000000/99980000/99979800/99979748/9195a1a3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room safe, free WiFi](https://images.trvl-media.com/lodging/100000000/99980000/99979800/99979748/8055c429.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room safe, free WiFi](https://images.trvl-media.com/lodging/100000000/99980000/99979800/99979748/771f37a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Economy Double Room](https://images.trvl-media.com/lodging/100000000/99980000/99979800/99979748/96f63d6f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Malecon Guesthouse

[](https://www.expedia.ca/Guayaquil-Hotels-Malecon-Guesthouse.h99979748.Hotel-Information)

7.9 km from Santa Maria

CA $19

CA $34 total

Dec 15 - Dec 16

[](https://www.expedia.ca/Guayaquil-Hotels-Malecon-Guesthouse.h99979748.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/18000000/17340000/17331400/17331318/2a010657.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property entrance](https://images.trvl-media.com/lodging/18000000/17340000/17331400/17331318/ef22dd38.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby sitting area](https://images.trvl-media.com/lodging/18000000/17340000/17331400/17331318/d29e2b28.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Daily continental breakfast (USD 5 per person)](https://images.trvl-media.com/lodging/18000000/17340000/17331400/17331318/c384b453.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### DC Suites Aeropuerto

[](https://www.expedia.ca/Guayaquil-Hotels-DC-Suites-Aeropuerto.h17331318.Hotel-Information)

Simón Bolívar, 5.2 km from Santa Maria

9.0/10

Wonderful

(580)

"Great location and clean hotel"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Elvin

[](https://www.expedia.ca/Guayaquil-Hotels-DC-Suites-Aeropuerto.h17331318.Hotel-Information)

![Children's activities](https://images.trvl-media.com/lodging/1000000/30000/23700/23682/104d895f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/30000/23700/23682/7377f418.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Deluxe Room, 2 Single Beds](https://images.trvl-media.com/lodging/1000000/30000/23700/23682/4267a74d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/1000000/30000/23700/23682/5208cc59.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Oro Verde Guayaquil

[](https://www.expedia.ca/Guayaquil-Hotels-Oro-Verde-Guayaquil.h23682.Hotel-Information)

Downtown Guayaquil, 6.9 km from Santa Maria

9.4/10

Exceptional

(1004)

"Staff, room cleanliness, bkfast and of course, the renovations look wonderful! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Iam

CA $117

CA $132 total

Dec 21 - Dec 22

[](https://www.expedia.ca/Guayaquil-Hotels-Oro-Verde-Guayaquil.h23682.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/5000000/4440000/4436100/4436047/26f25154.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/5000000/4440000/4436100/4436047/d2960c60.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 restaurants, breakfast served](https://images.trvl-media.com/lodging/5000000/4440000/4436100/4436047/w3840h2557x0y3-5bee1b7a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/5000000/4440000/4436100/4436047/w3837h2570x3y3-8d4064c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### TRYP by Wyndham Guayaquil Airport

[](https://www.expedia.ca/Guayaquil-Hotels-TRYP-By-Wyndham-Guayaquil.h4436047.Hotel-Information)

Simón Bolívar, 4.9 km from Santa Maria

9.0/10

Wonderful

(1000)

"💯"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Sreenidhi

CA $131

CA $148 total

Dec 21 - Dec 22

[](https://www.expedia.ca/Guayaquil-Hotels-TRYP-By-Wyndham-Guayaquil.h4436047.Hotel-Information)

![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/20000000/19400000/19391900/19391858/2b961da2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby sitting area](https://images.trvl-media.com/lodging/20000000/19400000/19391900/19391858/54545bba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Double Room, 1 Queen Bed](https://images.trvl-media.com/lodging/20000000/19400000/19391900/19391858/798ca00b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Presidential Studio Suite | Terrace/patio](https://images.trvl-media.com/lodging/20000000/19400000/19391900/19391858/4c177673.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hotel Patrimonial by Greenfield

[](https://www.expedia.ca/Guayaquil-Hotels-Hotel-Patrimonial-By-Greenfield.h19391858.Hotel-Information)

Downtown Guayaquil, 7.5 km from Santa Maria

8.6/10

Excellent

(134)

"Excellent location and close to the airport."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Martin Gerardo

[](https://www.expedia.ca/Guayaquil-Hotels-Hotel-Patrimonial-By-Greenfield.h19391858.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/3000000/2220000/2211800/2211791/2f768d35.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/3000000/2220000/2211800/2211791/9936b8cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Meeting facility](https://images.trvl-media.com/lodging/3000000/2220000/2211800/2211791/6dcc9954.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/3000000/2220000/2211800/2211791/78005c02.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hotel Palace Guayaquil

[](https://www.expedia.ca/Guayaquil-Hotels-Hotel-Palace-Guayaquil.h2211791.Hotel-Information)

Rocafuerte, 7.9 km from Santa Maria

9.2/10

Wonderful

(912)

"Good place to stay "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

GIOVANNY

CA $79

CA $90 total

Dec 19 - Dec 20

[](https://www.expedia.ca/Guayaquil-Hotels-Hotel-Palace-Guayaquil.h2211791.Hotel-Information)

![43-inch flat-screen TV with digital channels, TV, Netflix](https://images.trvl-media.com/lodging/33000000/32050000/32048100/32048032/42319f76.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor spa tub](https://images.trvl-media.com/lodging/33000000/32050000/32048100/32048032/04063cb7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Family Apartment, 2 Bedrooms, Kitchen, Hill View (2 Bedrooms with 3 Beds) | Living area](https://images.trvl-media.com/lodging/33000000/32050000/32048100/32048032/332f0478.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Family Apartment, 2 Bedrooms, Kitchen, Hill View (2 Bedrooms with 3 Beds) | Private kitchen](https://images.trvl-media.com/lodging/33000000/32050000/32048100/32048032/e88f5dd1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Luxury Suites Riverfront GYE

[](https://www.expedia.ca/Guayaquil-Hotels-Luxury-Suites-Riverfront-GYE.h32048032.Hotel-Information)

Puerto Santa Ana, 7.5 km from Santa Maria

9.4/10

Exceptional

(100)

"The apartment was in a great location and very clean and well maintained."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Rolando

CA $152

CA $154 total

Dec 25 - Dec 26

[](https://www.expedia.ca/Guayaquil-Hotels-Luxury-Suites-Riverfront-GYE.h32048032.Hotel-Information)

![Lobby lounge](https://images.trvl-media.com/lodging/13000000/12080000/12070900/12070859/536a4fbd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby lounge](https://images.trvl-media.com/lodging/13000000/12080000/12070900/12070859/d9e37e94.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/13000000/12080000/12070900/12070859/f2386846.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/13000000/12080000/12070900/12070859/3be7fa5a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Mansión del Río

[](https://www.expedia.ca/Guayaquil-Hotels-Mansion-Del-Rio.h12070859.Hotel-Information)

Las Peñas, 7.8 km from Santa Maria

8.8/10

Excellent

(133)

"Older but beautiful building. Very nice rooms. Good location. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Matthew

CA $82

CA $91 total

Dec 15 - Dec 16

[](https://www.expedia.ca/Guayaquil-Hotels-Mansion-Del-Rio.h12070859.Hotel-Information)

![Reception](https://images.trvl-media.com/lodging/84000000/83920000/83919600/83919535/6a3f2cec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Twin Room, 2 Double Beds | Room amenity](https://images.trvl-media.com/lodging/84000000/83920000/83919600/83919535/84846b7a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Cooked-to-order breakfast on weekdays (USD 3.00 per person)](https://images.trvl-media.com/lodging/84000000/83920000/83919600/83919535/w1650h2440x0y0-e4b6bf85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/84000000/83920000/83919600/83919535/764976b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hostal California Inn

[](https://www.expedia.ca/Guayaquil-Hotels-Hostal-California-Inn.h83919535.Hotel-Information)

7.4 km from Santa Maria

8.6/10

Excellent

(8)

"Me encantó, es muy cómoda, la habitación super amplia y limpia Si duda volveré "

![Mexico](https://a.travel-assets.com/egds/marks/flags/mx.svg)

Anita

[](https://www.expedia.ca/Guayaquil-Hotels-Hostal-California-Inn.h83919535.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/46000000/45180000/45173500/45173420/b6d5e5bf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Double Room, 1 King Bed, Private Bathroom](https://images.trvl-media.com/lodging/46000000/45180000/45173500/45173420/496d3338.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/46000000/45180000/45173500/45173420/b97bac8f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/46000000/45180000/45173500/45173420/eeaef3a6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hostal Macaw

[](https://www.expedia.ca/Guayaquil-Hotels-Hostal-Macaw.h45173420.Hotel-Information)

Kennedy, 4.6 km from Santa Maria

10/10

Exceptional

(9)

"Wonderful hosts and felt like home "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Tina

CA $96

CA $98 total

Jan 2 - Jan 3, 2026

[](https://www.expedia.ca/Guayaquil-Hotels-Hostal-Macaw.h45173420.Hotel-Information)

![Outdoor pool](https://images.trvl-media.com/lodging/6000000/5960000/5959100/5959068/15d3bf82.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Point of interest](https://images.trvl-media.com/lodging/6000000/5960000/5959100/5959068/d1da0946.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/6000000/5960000/5959100/5959068/2607cc6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Daily buffet breakfast (USD 20 per person)](https://images.trvl-media.com/lodging/6000000/5960000/5959100/5959068/64197a71.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Guayaquil Airport by IHG

[](https://www.expedia.ca/Guayaquil-Hotels-Holiday-Inn-Guayaquil-Airport.h5959068.Hotel-Information)

5.5 km from Santa Maria

9.4/10

Exceptional

(1002)

"Great stay"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Susan

CA $110

CA $125 total

Jan 5 - Jan 6, 2026

[](https://www.expedia.ca/Guayaquil-Hotels-Holiday-Inn-Guayaquil-Airport.h5959068.Hotel-Information)

![Restaurant](https://images.trvl-media.com/lodging/114000000/113770000/113765400/113765303/e7a717d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Restaurant](https://images.trvl-media.com/lodging/114000000/113770000/113765400/113765303/02d3f2d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool](https://images.trvl-media.com/lodging/114000000/113770000/113765400/113765303/4b92a37e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Restaurant](https://images.trvl-media.com/lodging/114000000/113770000/113765400/113765303/28f7fd75.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hotel Río Guayas by Art Hotels Ecuador 

[](https://www.expedia.ca/Guayaquil-Hotels-Hotel-Rio-Guayas.h113765303.Hotel-Information)

Las Peñas, 7.9 km from Santa Maria

10/10

Exceptional

(2)

"The staff was very friendly and helpful. The hotel is new and modern, it is a good place to relax and work. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Richard

CA $344

CA $384 total

Dec 21 - Dec 22

[](https://www.expedia.ca/Guayaquil-Hotels-Hotel-Rio-Guayas.h113765303.Hotel-Information)

![Reception](https://images.trvl-media.com/lodging/1000000/10000/4400/4375/0c30e684.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior entrance](https://images.trvl-media.com/lodging/1000000/10000/4400/4375/c5093448.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/1000000/10000/4400/4375/491cc7c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/1000000/10000/4400/4375/bfa2a5dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Unipark by Oro Verde Hotels

[](https://www.expedia.ca/Guayaquil-Hotels-Unipark-By-Oro-Verde-Hotels.h4375.Hotel-Information)

Rocafuerte, 8 km from Santa Maria

9.2/10

Wonderful

(1002)

"Very good staff, every one was very nice and the room very clean and very convenient to travel everywhere."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Leticia

CA $94

CA $107 total

Jan 12 - Jan 13, 2026

[](https://www.expedia.ca/Guayaquil-Hotels-Unipark-By-Oro-Verde-Hotels.h4375.Hotel-Information)

![2 restaurants, breakfast, lunch, dinner served; Regional cuisine](https://images.trvl-media.com/lodging/1000000/560000/556000/556000/97a1664b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool, open 7:00 AM to 7:00 PM, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/560000/556000/556000/6c9a2b92.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Meeting facility](https://images.trvl-media.com/lodging/1000000/560000/556000/556000/9272e9d3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Meeting facility](https://images.trvl-media.com/lodging/1000000/560000/556000/556000/3a4230bf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Sheraton Guayaquil Hotel

[](https://www.expedia.ca/Guayaquil-Hotels-Sheraton-Guayaquil-Hotel.h556000.Hotel-Information)

Simón Bolívar, 4.8 km from Santa Maria

9.0/10

Wonderful

(605)

"Very friendly front desk thank you for a comfortable and enjoyable stay. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Andrew

CA $102

CA $115 total

Dec 23 - Dec 24

[](https://www.expedia.ca/Guayaquil-Hotels-Sheraton-Guayaquil-Hotel.h556000.Hotel-Information)

![Executive Suite, Kitchenette, City View | Private kitchen](https://images.trvl-media.com/lodging/105000000/104820000/104814100/104814029/74e7651f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Executive Suite, Kitchenette, City View | Private kitchen](https://images.trvl-media.com/lodging/105000000/104820000/104814100/104814029/51248e19.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Deluxe Room | Bathroom](https://images.trvl-media.com/lodging/105000000/104820000/104814100/104814029/ed09222f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/105000000/104820000/104814100/104814029/4c99206f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Suitesecu Rentals Guayaquil

[](https://www.expedia.ca/Guayaquil-Hotels-Suitesecu-Guayaquil.h104814029.Hotel-Information)

Simón Bolívar, 4.9 km from Santa Maria

9.2/10

Wonderful

(7)

"You can walk to the airport."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Digna

CA $37

CA $46 total

Dec 22 - Dec 23

[](https://www.expedia.ca/Guayaquil-Hotels-Suitesecu-Guayaquil.h104814029.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/18000000/17170000/17163300/17163266/afc4e9f6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Signature Room, 1 King Bed, Garden View | Garden view](https://images.trvl-media.com/lodging/18000000/17170000/17163300/17163266/d5606279.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![52-inch Smart TV with cable channels, TV](https://images.trvl-media.com/lodging/18000000/17170000/17163300/17163266/0951714f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property entrance](https://images.trvl-media.com/lodging/18000000/17170000/17163300/17163266/572c82cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hotel del Parque

[](https://www.expedia.ca/Guayaquil-Hotels-Hotel-Del-Parque.h17163266.Hotel-Information)

7 km from Santa Maria

9.8/10

Exceptional

(106)

"I love"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Maria

CA $591

CA $650 total

Dec 29 - Dec 30

[](https://www.expedia.ca/Guayaquil-Hotels-Hotel-Del-Parque.h17163266.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/70000/69100/69054/de7e624e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Bar (on property)](https://images.trvl-media.com/lodging/1000000/70000/69100/69054/58ce83fb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/70000/69100/69054/0400ae81.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool, pool umbrellas](https://images.trvl-media.com/lodging/1000000/70000/69100/69054/8531ce07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hilton Colon Guayaquil

[](https://www.expedia.ca/Guayaquil-Hotels-Hilton-Colon-Guayaquil.h69054.Hotel-Information)

Kennedy, 4.2 km from Santa Maria

8.6/10

Excellent

(813)

"Great room"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Trevor

CA $130

CA $146 total

Dec 27 - Dec 28

[](https://www.expedia.ca/Guayaquil-Hotels-Hilton-Colon-Guayaquil.h69054.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-28&endDate=2025-12-29&regionId=553248635976397555&adults=2&sort=RECOMMENDED&openPlayBack=true)

## Where to stay in Santa Maria

Find the best Santa Maria areas and neighborhoods for the activities you enjoy most. 

- Ecuador
- Downtown Guayaquil
- Puerto Santa Ana
- Urdesa
- Kennedy

[](https://www.expedia.ca/Hotel-Search?pwaOverlay=map&regionId=553248635976397513)

![Ecuador map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:%7E%60xLhvrfNgL%7DB%60BeFt%40BnAbAh%40ITPS%60%40pB%60BZYl%40Rg%40%5C%3FvB&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=ITAe6nXctcoLe9r_9tpkYiy1Tjw=)

### Ecuador

Though Ecuador might not have many top sights, you can venture to the surrounding area to see attractions like C.C. Riocentro Sur and Mall del Sur. 

[See properties](https://www.expedia.ca/Hotel-Search?regionId=553248635976397513)

[](https://www.expedia.ca/Hotel-Search?pwaOverlay=map&regionId=6337572)

![Downtown Guayaquil map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:jfkLr%7BsfNws%40cOiEsJhA%7Bd%40vAcO%7EAoHqCi%40%7CMwf%40tWlJ%7Ch%40tO_YdgB&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=efYuk0Ril1wmcsuwYNvCseyS7mU=)

### Downtown Guayaquil

Travelers come to Downtown Guayaquil for its abundant dining options, and you can see top attractions like San Francisco Square and Central Market while you're in town. 

[See properties](https://www.expedia.ca/Hotel-Search?regionId=6337572)

[](https://www.expedia.ca/Hotel-Search?pwaOverlay=map&regionId=6338310)

![Puerto Santa Ana map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:%7CwgLbkpfN_GmS%7Cc%40%7BKdDvE%7DErUeZ%7CB&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=xj2tOWP-VhOsA14MKImU-pDvkUY=)

### Puerto Santa Ana

Well-liked for its restaurants and river views, you might stop by Santa Ana Hill and Botanical Garden while you're exploring Puerto Santa Ana and the surrounding neighborhoods. 

[See properties](https://www.expedia.ca/Hotel-Search?regionId=6338310)

[](https://www.expedia.ca/Hotel-Search?pwaOverlay=map&regionId=553248633981744847)

![Urdesa map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:%7CcfLntwfNeTaRaHtMyHbAeB%7DD_BfBiCgPii%40dBg%5CiKbDad%40%7EMb%40rDsDfCoMtHfJ%7CE%7DAlEX%7EI_CdTY%7EImAjWiG%60%5EhDvg%40zJp%40nEk%40%60IeGlUmMxAkFbI_NxDEzH_ELkOmA%7DA%7EI&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=SIVSialjYPTUNX-z_yOYk5Am1Ro=)

### Urdesa

Urdesa is well-liked for its restaurants. If you'd like to do some sightseeing in the greater Guayaquil area, you might plan a trip to San Marino Mall or Alban Borja Commercial Center. 

[See properties](https://www.expedia.ca/Hotel-Search?regionId=553248633981744847)

[](https://www.expedia.ca/Hotel-Search?pwaOverlay=map&regionId=553248633981744623)

![Kennedy map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:d%7CbLxnufNu%40YkJUz%40oGdLwWrh%40kf%40fE%7BBjHaBhpAoBv_%40t%40bWhAuHp%5BjZaJxEfNQfDqCpAcNdL_RfH_FxFwSkE%7Dc%40aEiFkA%7BKo%40kYnI%7DUd%40yKbBmHBoB%60BmAN%7DAkAa%40_IeAiAqBU_A%7E%40c%40%60EwAbD%3F%7EFuCv%40&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=XWwvskPj7fazk3NWYmm490jAt1Q=)

### Kennedy

Unique features of Kennedy include the shopping and restaurants. Make a stop by San Marino Mall or World Trade Center while you're exploring the area. 

[See properties](https://www.expedia.ca/Hotel-Search?regionId=553248633981744623)

## Top Santa Maria Hotel Reviews

![Grand Hotel Guayaquil, an Ascend Collection Hotel](https://images.trvl-media.com/lodging/7000000/6760000/6751000/6750908/1d447ff4_y.jpg)

### Grand Hotel Guayaquil, an Ascend Collection Hotel

10/10 Excellent

"The cleanliness of the room really stood out. Everything felt fresh, well‑maintained, and comfortable. The staff made the biggest difference. They were welcoming, attentive, and consistently helpful throughout my stay. The amenities stood out most — from the reliable Wi‑Fi to the fitness center and breakfast options, everything added convenience. What stood out was the overall atmosphere. The combination of location, quiet environment, and attention to detail made the experience unique."

[](https://expedia.ca/Guayaquil-Hotels-Grand-Hotel-Guayaquil.h6750908.Hotel-Information)

![Oro Verde Guayaquil](https://images.trvl-media.com/lodging/1000000/30000/23700/23682/104d895f_y.jpg)

### Oro Verde Guayaquil

10/10 Excellent

"Staff, room cleanliness, bkfast and of course, the renovations look wonderful! "

[](https://expedia.ca/Guayaquil-Hotels-Oro-Verde-Guayaquil.h23682.Hotel-Information)

![Holiday Inn Guayaquil Airport by IHG](https://images.trvl-media.com/lodging/6000000/5960000/5959100/5959068/15d3bf82_y.jpg)

### Holiday Inn Guayaquil Airport by IHG

10/10 Excellent

"I arrived at 12:15am and they had the shuttle I requested ready. I go upgraded to a suite which was very nice. "

[](https://expedia.ca/Guayaquil-Hotels-Holiday-Inn-Guayaquil-Airport.h5959068.Hotel-Information)

![Wyndham Guayaquil Puerto Santa Ana](https://images.trvl-media.com/lodging/7000000/6320000/6312500/6312483/79b2b000_y.jpg)

### Wyndham Guayaquil Puerto Santa Ana

10/10 Excellent

"Excelente lugar"

[](https://expedia.ca/Guayaquil-Hotels-Wyndham-Guayaquil.h6312483.Hotel-Information)

![Hilton Colon Guayaquil](https://images.trvl-media.com/lodging/1000000/70000/69100/69054/de7e624e_y.jpg)

### Hilton Colon Guayaquil

10/10 Excellent

"Great room"

[](https://expedia.ca/Guayaquil-Hotels-Hilton-Colon-Guayaquil.h69054.Hotel-Information)

![Sheraton Guayaquil Hotel](https://images.trvl-media.com/lodging/1000000/560000/556000/556000/97a1664b_y.jpg)

### Sheraton Guayaquil Hotel

10/10 Excellent

"Employees at the Sheraton were the best, and they made the stay better"

[](https://expedia.ca/Guayaquil-Hotels-Sheraton-Guayaquil-Hotel.h556000.Hotel-Information)

![Unipark by Oro Verde Hotels](https://images.trvl-media.com/lodging/1000000/10000/4400/4375/0c30e684_y.jpg)

### Unipark by Oro Verde Hotels

10/10 Excellent

"Everything "

[](https://expedia.ca/Guayaquil-Hotels-Unipark-By-Oro-Verde-Hotels.h4375.Hotel-Information)

![Wyndham Garden Guayaquil](https://images.trvl-media.com/lodging/2000000/1280000/1273600/1273513/a22c50d5_y.jpg)

### Wyndham Garden Guayaquil

10/10 Excellent

"Wonder "

[](https://expedia.ca/Guayaquil-Hotels-Wyndham-Garden-Guayaquil.h1273513.Hotel-Information)

![Hotel del Parque](https://images.trvl-media.com/lodging/18000000/17170000/17163300/17163266/afc4e9f6_y.jpg)

### Hotel del Parque

10/10 Excellent

"Good"

[](https://expedia.ca/Guayaquil-Hotels-Hotel-Del-Parque.h17163266.Hotel-Information)

## Frequently asked questions

### What is Santa Maria like?

### If I need to cancel my hotel reservation in Santa Maria, will I receive a refund?

### What can I see and do in this Guayaquil neighborhood?

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