Title: 10 Best Hotels in Santa Maria, Guayaquil for 2025 | Expedia.ca [Vacation Rentals in Guayaquil](https://expedia.ca/Guayaquil-Vacation-Rentals.d1414.Travel-Guide-VacationRentals)[Flights to Guayaquil](https://expedia.ca/Cheap-Flights-To-Guayaquil.d1414.Travel-Guide-Flights)[Things to do in Guayaquil](https://expedia.ca/Things-To-Do-In-Guayaquil.d1414.Travel-Guide-Activities)[Santa Maria Car Rentals](https://expedia.ca/Car-Rentals-In-Santa-Maria.d553248635976397555.Car-Rental-Guide)[Santa Maria Vacations](https://expedia.ca/Santa-Maria.d553248635976397555.Destination-Travel-Guides) ![Default HTG hotel image](https://media.expedia.com/media/content/shared/images/travelguides/sem-hotels-tablet.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Hotels in Santa Maria, Guayaquil ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in Santa Maria Apart hotel [](https://www.expedia.ca/Hotel-Search?destination=Santa+Maria%2C+Guayaquil%2C+Guayas%2C+Ecuador®ionId=553248635976397555&latLong=-2.142682%2C-79.932849&adults=2&startDate=2025-10-17&d1=2025-10-17&endDate=2025-10-19&d2=2025-10-19&lodging=APART_HOTEL) Spa [](https://www.expedia.ca/Hotel-Search?destination=Santa+Maria%2C+Guayaquil%2C+Guayas%2C+Ecuador®ionId=553248635976397555&latLong=-2.142682%2C-79.932849&adults=2&startDate=2025-10-17&d1=2025-10-17&endDate=2025-10-19&d2=2025-10-19&amenities=SPA_ON_SITE) Family friendly [](https://www.expedia.ca/Hotel-Search?destination=Santa+Maria%2C+Guayaquil%2C+Guayas%2C+Ecuador®ionId=553248635976397555&latLong=-2.142682%2C-79.932849&adults=2&startDate=2025-10-17&d1=2025-10-17&endDate=2025-10-19&d2=2025-10-19&travelerType=family_friendly) Pool [](https://www.expedia.ca/Hotel-Search?destination=Santa+Maria%2C+Guayaquil%2C+Guayas%2C+Ecuador®ionId=553248635976397555&latLong=-2.142682%2C-79.932849&adults=2&startDate=2025-10-17&d1=2025-10-17&endDate=2025-10-19&d2=2025-10-19&amenities=POOL) Hot tub [](https://www.expedia.ca/Hotel-Search?destination=Santa+Maria%2C+Guayaquil%2C+Guayas%2C+Ecuador®ionId=553248635976397555&latLong=-2.142682%2C-79.932849&adults=2&startDate=2025-10-17&d1=2025-10-17&endDate=2025-10-19&d2=2025-10-19&amenities=HOT_TUB) Apart­ment [](https://www.expedia.ca/Hotel-Search?destination=Santa+Maria%2C+Guayaquil%2C+Guayas%2C+Ecuador®ionId=553248635976397555&latLong=-2.142682%2C-79.932849&adults=2&startDate=2025-10-17&d1=2025-10-17&endDate=2025-10-19&d2=2025-10-19&lodging=APARTMENT) Pet friendly [](https://www.expedia.ca/Hotel-Search?destination=Santa+Maria%2C+Guayaquil%2C+Guayas%2C+Ecuador®ionId=553248635976397555&latLong=-2.142682%2C-79.932849&adults=2&startDate=2025-10-17&d1=2025-10-17&endDate=2025-10-19&d2=2025-10-19&amenities=PETS) Condo [](https://www.expedia.ca/Hotel-Search?destination=Santa+Maria%2C+Guayaquil%2C+Guayas%2C+Ecuador®ionId=553248635976397555&latLong=-2.142682%2C-79.932849&adults=2&startDate=2025-10-17&d1=2025-10-17&endDate=2025-10-19&d2=2025-10-19&lodging=CONDO) ## Check prices for these dates Tonight [Oct 3 - Oct 4](https://www.expedia.ca/Hotel-Search?regionId=553248635976397555&startDate=2025-10-03&endDate=2025-10-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 4 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=553248635976397555&startDate=2025-10-04&endDate=2025-10-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 3 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=553248635976397555&startDate=2025-10-03&endDate=2025-10-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=553248635976397555&startDate=2025-10-10&endDate=2025-10-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Recommended Price (low to high) Distance Star rating ## Santa Maria hotels and places to stay ![Rooftop bar, alfresco dining, open daily](https://images.trvl-media.com/lodging/2000000/1280000/1273600/1273513/a22c50d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, Egyptian cotton sheets, premium bedding, down comforters](https://images.trvl-media.com/lodging/2000000/1280000/1273600/1273513/8dfc29dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1280000/1273600/1273513/996932e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pool](https://images.trvl-media.com/lodging/2000000/1280000/1273600/1273513/dd666b4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Wyndham Garden Guayaquil Simón Bolívar, 4.8 km from Santa Maria 9.0/10 Wonderful (1001) "great staff easy access and parking, nice location " CA $118 CA $132 total Oct 12 - Oct 13 [](https://www.expedia.ca/Guayaquil-Hotels-Wyndham-Garden-Guayaquil.h1273513.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/6000000/5960000/5959100/5959068/15d3bf82.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/6000000/5960000/5959100/5959068/2607cc6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/6000000/5960000/5959100/5959068/d1da0946.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![City view](https://images.trvl-media.com/lodging/6000000/5960000/5959100/5959068/985058ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Guayaquil Airport by IHG 5.5 km from Santa Maria 9.4/10 Exceptional (1003) "This was an absolutely fabulous hotel and stay from our arrival and pick up to the staff at the hotel to the restaurant wonderful!" CA $131 CA $148 total Nov 3 - Nov 4 [](https://www.expedia.ca/Guayaquil-Hotels-Holiday-Inn-Guayaquil-Airport.h5959068.Hotel-Information) ![2 restaurants, breakfast, lunch, dinner served; Regional cuisine](https://images.trvl-media.com/lodging/1000000/560000/556000/556000/97a1664b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 7:00 AM to 7:00 PM, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/560000/556000/556000/6c9a2b92.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/560000/556000/556000/9272e9d3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/560000/556000/556000/47299b68.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sheraton Guayaquil Hotel Simón Bolívar, 4.8 km from Santa Maria 9.0/10 Wonderful (586) "Excellent service from the staff and just seven minutes away from the airport. " CA $189 CA $212 total Nov 1 - Nov 2 [](https://www.expedia.ca/Guayaquil-Hotels-Sheraton-Guayaquil-Hotel.h556000.Hotel-Information) ![2 restaurants, breakfast served](https://images.trvl-media.com/lodging/5000000/4440000/4436100/4436047/w3840h2557x0y3-5bee1b7a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/5000000/4440000/4436100/4436047/4938f0cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/5000000/4440000/4436100/4436047/d18989f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/5000000/4440000/4436100/4436047/b38db63c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### TRYP by Wyndham Guayaquil Airport Simón Bolívar, 4.9 km from Santa Maria 8.8/10 Excellent (1000) "Covenient, many options for dinning on premises. " CA $147 CA $165 total Oct 12 - Oct 13 [](https://www.expedia.ca/Guayaquil-Hotels-TRYP-By-Wyndham-Guayaquil.h4436047.Hotel-Information) ![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/20000000/19400000/19391900/19391858/2b961da2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/20000000/19400000/19391900/19391858/56bc99a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Double Room, 1 Queen Bed](https://images.trvl-media.com/lodging/20000000/19400000/19391900/19391858/798ca00b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/20000000/19400000/19391900/19391858/54545bba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Patrimonial by Greenfield Downtown Guayaquil, 7.5 km from Santa Maria 8.6/10 Excellent (129) "Excellent location and close to the airport." CA $64 CA $66 total Oct 4 - Oct 5 [](https://www.expedia.ca/Guayaquil-Hotels-Hotel-Patrimonial-By-Greenfield.h19391858.Hotel-Information) ![In-room safe, blackout drapes, soundproofing, iron/ironing board](https://images.trvl-media.com/lodging/110000000/109390000/109388300/109388206/42bd7516.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/110000000/109390000/109388300/109388206/4fdf411d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/110000000/109390000/109388300/109388206/w3837h2562x3y3-e9547a41.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/110000000/109390000/109388300/109388206/w3840h2561x0y3-aa9d061b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Doubletree By Hilton Guayaquil Rocafuerte, 8.1 km from Santa Maria 9.0/10 Wonderful (51) "The staff is amazing and the hotel is so beautiful." CA $101 CA $112 total Nov 2 - Nov 3 [](https://www.expedia.ca/Guayaquil-Hotels-Doubletree-By-Hilton-Guayaquil.h109388206.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/18000000/17340000/17331400/17331318/2a010657.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bicycling](https://images.trvl-media.com/lodging/18000000/17340000/17331400/17331318/f979e551.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Daily continental breakfast (USD 5 per person)](https://images.trvl-media.com/lodging/18000000/17340000/17331400/17331318/c384b453.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/18000000/17340000/17331400/17331318/ef22dd38.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### DC Suites Aeropuerto Simón Bolívar, 5.2 km from Santa Maria 9.0/10 Wonderful (558) "Stayed for one night. Clean bathroom, easy to check in and very close to the airport. " CA $50 CA $52 total Oct 4 - Oct 5 [](https://www.expedia.ca/Guayaquil-Hotels-DC-Suites-Aeropuerto.h17331318.Hotel-Information) ![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/20000000/19220000/19213600/19213532/d700f6bc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/20000000/19220000/19213600/19213532/1f7cb6e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio Suite, 1 King Bed, Non Smoking | View from room](https://images.trvl-media.com/lodging/20000000/19220000/19213600/19213532/e4300ade.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/20000000/19220000/19213600/19213532/a654a5dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Radisson Hotel Guayaquil Kennedy, 4.9 km from Santa Maria 9.2/10 Wonderful (616) "Excellent staff." CA $113 CA $128 total Nov 1 - Nov 2 [](https://www.expedia.ca/Guayaquil-Hotels-Radisson-Guayaquil.h19213532.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/10000000/9550000/9542500/9542499/8325814e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/10000000/9550000/9542500/9542499/2abd3f02.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Superior Double Room | Terrace/patio](https://images.trvl-media.com/lodging/10000000/9550000/9542500/9542499/8de7a8c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Suite](https://images.trvl-media.com/lodging/10000000/9550000/9542500/9542499/4b0896d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Iguanazu Bed & Breakfast 2.9 km from Santa Maria 9.2/10 Wonderful (46) "Swimming pool" CA $137 CA $155 total Oct 14 - Oct 15 [](https://www.expedia.ca/Guayaquil-Hotels-Iguanazu-Bed-Breakfast.h9542499.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/94000000/93850000/93845100/93845075/22f53454.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Daily buffet breakfast (USD 11.99 per person)](https://images.trvl-media.com/lodging/94000000/93850000/93845100/93845075/d786af65.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/94000000/93850000/93845100/93845075/716f85e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/94000000/93850000/93845100/93845075/169cd786.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Ibis Styles El Malecon Guayaquil Downtown Guayaquil, 8 km from Santa Maria 9.4/10 Exceptional (254) "Great location and great hotel " CA $84 CA $94 total Oct 11 - Oct 12 [](https://www.expedia.ca/Guayaquil-Hotels-Ibis-Styles-El-Malecon-Guayaquil.h93845075.Hotel-Information) ![Outdoor pool, open 8:00 AM to 9:00 PM, sun loungers](https://images.trvl-media.com/lodging/7000000/6760000/6751000/6750908/1d447ff4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/7000000/6760000/6751000/6750908/940597ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/7000000/6760000/6751000/6750908/4beadb23.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, minibar, in-room safe, desk](https://images.trvl-media.com/lodging/7000000/6760000/6751000/6750908/51c29534.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Grand Hotel Guayaquil, an Ascend Collection Hotel Rocafuerte, 7.9 km from Santa Maria 9.2/10 Wonderful (961) "Great place to Stay.!" CA $106 CA $119 total Oct 16 - Oct 17 [](https://www.expedia.ca/Guayaquil-Hotels-Grand-Hotel-Guayaquil.h6750908.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/1000000/10000/4400/4375/0c30e684.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/10000/4400/4375/3055cce5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/10000/4400/4375/491cc7c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/1000000/10000/4400/4375/bfa2a5dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Unipark by Oro Verde Hotels Rocafuerte, 8 km from Santa Maria 9.2/10 Wonderful (1000) "I enjoyed much my staying in this hotel." CA $96 CA $109 total Nov 1 - Nov 2 [](https://www.expedia.ca/Guayaquil-Hotels-Unipark-By-Oro-Verde-Hotels.h4375.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/6000000/5080000/5074300/5074261/0dae506e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Double Room](https://images.trvl-media.com/lodging/6000000/5080000/5074300/5074261/bac7db86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/6000000/5080000/5074300/5074261/499d845d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/6000000/5080000/5074300/5074261/0845a13d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel GH Galeria Downtown Guayaquil, 6.9 km from Santa Maria 8.4/10 Very good (386) "Location " CA $78 CA $90 total Oct 5 - Oct 6 [](https://www.expedia.ca/Guayaquil-Hotels-Hotel-Galeria-Man-Ging.h5074261.Hotel-Information) ![Presidential Suite, 1 King Bed, Jetted Tub, River View](https://images.trvl-media.com/lodging/7000000/6320000/6312500/6312483/79b2b000.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/7000000/6320000/6312500/6312483/69ea8661.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/7000000/6320000/6312500/6312483/bf4ba68b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/7000000/6320000/6312500/6312483/664af8f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Wyndham Guayaquil Puerto Santa Ana Puerto Santa Ana, 7.5 km from Santa Maria 9.2/10 Wonderful (1000) "Very nice hotel " CA $153 CA $172 total Oct 12 - Oct 13 [](https://www.expedia.ca/Guayaquil-Hotels-Wyndham-Guayaquil.h6312483.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/3000000/2750000/2745100/2745088/e22d8e0e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/3000000/2750000/2745100/2745088/efe3ae94.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; international cuisine ](https://images.trvl-media.com/lodging/3000000/2750000/2745100/2745088/357201ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 Bedroom, Non Smoking, City View](https://images.trvl-media.com/lodging/3000000/2750000/2745100/2745088/d43fc9b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard by Marriott Guayaquil Kennedy, 4.8 km from Santa Maria 9.0/10 Wonderful (1001) "Great stay " CA $105 CA $117 total Oct 10 - Oct 11 [](https://www.expedia.ca/Guayaquil-Hotels-Courtyard-By-Marriott-Guayaquil.h2745088.Hotel-Information) ![Executive Suite, Kitchenette, City View | Private kitchen](https://images.trvl-media.com/lodging/105000000/104820000/104814100/104814029/74e7651f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room | Bathroom](https://images.trvl-media.com/lodging/105000000/104820000/104814100/104814029/ed09222f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/105000000/104820000/104814100/104814029/4c99206f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Executive Suite, Kitchenette, City View | Private kitchen](https://images.trvl-media.com/lodging/105000000/104820000/104814100/104814029/51248e19.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Suitesecu Guayaquil Simón Bolívar, 4.9 km from Santa Maria 9.6/10 Exceptional (5) "Great place! Close to everything. Fast host. " CA $34 CA $43 total Oct 6 - Oct 7 [](https://www.expedia.ca/Guayaquil-Hotels-Suitesecu-Guayaquil.h104814029.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/3000000/2220000/2211800/2211791/2f768d35.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down comforters, pillowtop beds, in-room safe](https://images.trvl-media.com/lodging/3000000/2220000/2211800/2211791/fbc24025.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/3000000/2220000/2211800/2211791/6dcc9954.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/3000000/2220000/2211800/2211791/9936b8cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Palace Guayaquil Rocafuerte, 7.9 km from Santa Maria 9.2/10 Wonderful (903) "Good place to stay " CA $88 CA $99 total Oct 11 - Oct 12 [](https://www.expedia.ca/Guayaquil-Hotels-Hotel-Palace-Guayaquil.h2211791.Hotel-Information) ![Children's activities](https://images.trvl-media.com/lodging/1000000/30000/23700/23682/104d895f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/23700/23682/7377f418.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 2 Single Beds](https://images.trvl-media.com/lodging/1000000/30000/23700/23682/4267a74d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/1000000/30000/23700/23682/5208cc59.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Oro Verde Guayaquil Downtown Guayaquil, 6.9 km from Santa Maria 9.4/10 Exceptional (1003) "Wonderful people,, great hotel . Very clean and comfortable stayed." CA $124 CA $140 total Oct 5 - Oct 6 [](https://www.expedia.ca/Guayaquil-Hotels-Oro-Verde-Guayaquil.h23682.Hotel-Information) ![Massages](https://images.trvl-media.com/lodging/49000000/48230000/48220700/48220680/188ae291.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Rooftop pool](https://images.trvl-media.com/lodging/49000000/48230000/48220700/48220680/9a9777fb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior detail](https://images.trvl-media.com/lodging/49000000/48230000/48220700/48220680/f72b4fc2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/49000000/48230000/48220700/48220680/03fad256.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Puerto Pacifico Guayaquil Airport Garzota, 4.8 km from Santa Maria 8.8/10 Excellent (210) "Loved my stay. It was very clean and close to the airport. " CA $78 CA $81 total Nov 2 - Nov 3 [](https://www.expedia.ca/Guayaquil-Hotels-Hotel-Puerto-Pacifico.h48220680.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/43000000/42410000/42407000/42406978/1bc3e847.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium Single Room, 1 Bedroom, Garden View](https://images.trvl-media.com/lodging/43000000/42410000/42407000/42406978/7c30f371.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/43000000/42410000/42407000/42406978/bfc806b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/43000000/42410000/42407000/42406978/8f1a8238.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Luxva Hotel Boutique Urdesa, 4.7 km from Santa Maria 9.4/10 Exceptional (163) "A very beautiful hotel and gardens with wonderful staff!" CA $84 CA $85 total Nov 1 - Nov 2 [](https://www.expedia.ca/Guayaquil-Hotels-Luxva-Hotel-Boutique.h42406978.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-17&endDate=2025-10-18®ionId=553248635976397555&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSanta-Maria-Guayaquil-Hotels.0-n553248635976397555-0.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSanta-Maria-Guayaquil-Hotels.0-n553248635976397555-0.Travel-Guide-Filter-Hotels) ## Where to stay in Santa Maria Find the best Santa Maria areas and neighborhoods for the activities you enjoy most. - Downtown Guayaquil - Ecuador - Puerto Santa Ana - Kennedy - Urdesa [](https://www.expedia.ca/Hotel-Search?pwaOverlay=map®ionId=6337572) ![Downtown Guayaquil map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:jfkLr%7BsfNws%40cOiEsJhA%7Bd%40vAcO%7EAoHqCi%40%7CMwf%40tWlJ%7Ch%40tO_YdgB&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=efYuk0Ril1wmcsuwYNvCseyS7mU=) ### Downtown Guayaquil Travelers come to Downtown Guayaquil for its abundant dining options, and you can see top attractions like Central Market and Sports Federation of Guayas while you're in town. [See properties](https://www.expedia.ca/Hotel-Search?regionId=6337572) [](https://www.expedia.ca/Hotel-Search?pwaOverlay=map®ionId=553248635976397513) ![Ecuador map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:%7E%60xLhvrfNgL%7DB%60BeFt%40BnAbAh%40ITPS%60%40pB%60BZYl%40Rg%40%5C%3FvB&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=ITAe6nXctcoLe9r_9tpkYiy1Tjw=) ### Ecuador Though Ecuador might not have many top sights, you can venture to the surrounding area to see attractions like C.C. Riocentro Sur and Mall del Sur. [See properties](https://www.expedia.ca/Hotel-Search?regionId=553248635976397513) [](https://www.expedia.ca/Hotel-Search?pwaOverlay=map®ionId=6338310) ![Puerto Santa Ana map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:%7CwgLbkpfN_GmS%7Cc%40%7BKdDvE%7DErUeZ%7CB&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=xj2tOWP-VhOsA14MKImU-pDvkUY=) ### Puerto Santa Ana Well-liked for its restaurants and river views, you might stop by Santa Ana Hill and La Perla while you're exploring Puerto Santa Ana and the surrounding neighborhoods. [See properties](https://www.expedia.ca/Hotel-Search?regionId=6338310) [](https://www.expedia.ca/Hotel-Search?pwaOverlay=map®ionId=553248633981744623) ![Kennedy map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:d%7CbLxnufNu%40YkJUz%40oGdLwWrh%40kf%40fE%7BBjHaBhpAoBv_%40t%40bWhAuHp%5BjZaJxEfNQfDqCpAcNdL_RfH_FxFwSkE%7Dc%40aEiFkA%7BKo%40kYnI%7DUd%40yKbBmHBoB%60BmAN%7DAkAa%40_IeAiAqBU_A%7E%40c%40%60EwAbD%3F%7EFuCv%40&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=XWwvskPj7fazk3NWYmm490jAt1Q=) ### Kennedy Unique features of Kennedy include the shopping and restaurants. Make a stop by San Marino Mall or Policentro while you're exploring the area. [See properties](https://www.expedia.ca/Hotel-Search?regionId=553248633981744623) [](https://www.expedia.ca/Hotel-Search?pwaOverlay=map®ionId=553248633981744847) ![Urdesa map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:%7CcfLntwfNeTaRaHtMyHbAeB%7DD_BfBiCgPii%40dBg%5CiKbDad%40%7EMb%40rDsDfCoMtHfJ%7CE%7DAlEX%7EI_CdTY%7EImAjWiG%60%5EhDvg%40zJp%40nEk%40%60IeGlUmMxAkFbI_NxDEzH_ELkOmA%7DA%7EI&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=SIVSialjYPTUNX-z_yOYk5Am1Ro=) ### Urdesa Urdesa is well-liked for its restaurants. If you'd like to do some sightseeing in the greater Guayaquil area, you might plan a trip to San Marino Mall or Policentro. [See properties](https://www.expedia.ca/Hotel-Search?regionId=553248633981744847) ## Top Santa Maria Hotel Reviews ![Hotel Palace Guayaquil](//images.trvl-media.com/lodging/3000000/2220000/2211800/2211791/2f768d35_y.jpg) ### Hotel Palace Guayaquil 10/10 Excellent "It’s a nice place to enjoy without complaining " [](https://expedia.ca/Guayaquil-Hotels-Hotel-Palace-Guayaquil.h2211791.Hotel-Information) ![Radisson Hotel Guayaquil](//images.trvl-media.com/lodging/20000000/19220000/19213600/19213532/d700f6bc_y.jpg) ### Radisson Hotel Guayaquil 10/10 Excellent "The best" [](https://expedia.ca/Guayaquil-Hotels-Radisson-Guayaquil.h19213532.Hotel-Information) ![Wyndham Guayaquil Puerto Santa Ana](//images.trvl-media.com/lodging/7000000/6320000/6312500/6312483/79b2b000_y.jpg) ### Wyndham Guayaquil Puerto Santa Ana 10/10 Excellent "Excelente hotel, valió cada centavo" [](https://expedia.ca/Guayaquil-Hotels-Wyndham-Guayaquil.h6312483.Hotel-Information) ![Ibis Styles El Malecon Guayaquil](//images.trvl-media.com/lodging/94000000/93850000/93845100/93845075/15fd17ab_y.jpg) ### Ibis Styles El Malecon Guayaquil 10/10 Excellent "Great location and great hotel " [](https://expedia.ca/Guayaquil-Hotels-Ibis-Styles-El-Malecon-Guayaquil.h93845075.Hotel-Information) ![Holiday Inn Guayaquil Airport by IHG](//images.trvl-media.com/lodging/6000000/5960000/5959100/5959068/15d3bf82_y.jpg) ### Holiday Inn Guayaquil Airport by IHG 10/10 Excellent "Excellent hotel with superb food and service. Shuttle service to and from airport a big plus. " [](https://expedia.ca/Guayaquil-Hotels-Holiday-Inn-Guayaquil-Airport.h5959068.Hotel-Information) ![Oro Verde Guayaquil](//images.trvl-media.com/lodging/1000000/30000/23700/23682/104d895f_y.jpg) ### Oro Verde Guayaquil 10/10 Excellent "The hotel was everything offered and more, the staff is extraordinary, from the outside security, front desk receptionists, servers throughout all the restaurants, housekeepers and more, these people know what it is to host. I’m planing my next trip to Ecuador and be certain that I won’t need to search for any other hotel, Oro Verde is it for me!!!" [](https://expedia.ca/Guayaquil-Hotels-Oro-Verde-Guayaquil.h23682.Hotel-Information) ![TRYP by Wyndham Guayaquil Airport](//images.trvl-media.com/lodging/5000000/4440000/4436100/4436047/a69cdc33_y.jpg) ### TRYP by Wyndham Guayaquil Airport 10/10 Excellent "Great hotel that never disappoints. The staff are all very friendly and welcoming and keep the hotel in great shape. The close proximity to the Mall del Sol allows us to pass time walking and shopping in our free time. The courtesy shuttle to the airport makes getting to/from our flights very easy." [](https://expedia.ca/Guayaquil-Hotels-TRYP-By-Wyndham-Guayaquil.h4436047.Hotel-Information) ![Wyndham Garden Guayaquil](//images.trvl-media.com/lodging/2000000/1280000/1273600/1273513/a22c50d5_y.jpg) ### Wyndham Garden Guayaquil 10/10 Excellent "Great service! Highly recommend " [](https://expedia.ca/Guayaquil-Hotels-Wyndham-Garden-Guayaquil.h1273513.Hotel-Information) ![Unipark by Oro Verde Hotels](//images.trvl-media.com/lodging/1000000/10000/4400/4375/0c30e684_y.jpg) ### Unipark by Oro Verde Hotels 10/10 Excellent "I enjoyed much my staying in this hotel." 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