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Our top choices for Santa Fe hotels

A spacious indoor dining area with multiple tables and chairs, large windows offering a view of palm trees and greenery outside.
A modern office space with a reception desk, several chairs, a large window, and a colorful abstract painting on the wall.
A Holiday Inn Express & Suites hotel with a modern design, multiple floors, and a parking lot.
A lobby with a patterned carpet, two green armchairs, a white sofa, a small round table with a plant, and framed artwork on the wall.

1. Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Alachua
United States
Tobias
CA $150
CA $169 total
includes taxes & fees
Oct 5 - Oct 6
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
A modern kitchen area with a central counter, various food stations, and a chalkboard menu.
A reception desk with a "Welcome to the Sun Shine State" sign, a "Treats" sign, and a minibar area with a "Hilton" sign.

2. Hampton Inn & Suites Alachua I-75

Hampton Inn & Suites Alachua I-75
Alachua
United States
Pamela
CA $150
CA $168 total
includes taxes & fees
Oct 11 - Oct 12
Hampton Inn & Suites Alachua I-75
A swimming pool with a 5 ft 8 in depth marker, surrounded by lounge chairs and red umbrellas, with a fence and trees in the background.
A workspace with two chairs, a desk, a computer monitor, and a wall-mounted sign reading 'BUSINESS CENTER'.
A modern hotel lobby with a reception desk, seating area, and a wall-mounted television.
A fitness center with treadmills, exercise bikes, and weights.

3. Clarion Pointe Alachua - Gainesville Area

Clarion Pointe Alachua - Gainesville Area
Alachua
United States
María Teresa
CA $85
CA $103 total
includes taxes & fees
Oct 18 - Oct 19
Clarion Pointe Alachua - Gainesville Area
A large, multi-story hotel with a central courtyard, palm trees, and an American flag.
A spacious lobby with a large painting, a fireplace, a piano, and multiple seating areas.
A bar area with wooden chairs, a bar counter, and a television mounted on the wall.
A living room with a brown leather sofa, a glass-top coffee table, and a framed picture on the wall.

4. Best Western Gateway Grand

Best Western Gateway Grand
Gainesville
United States
Jason
CA $131
CA $147 total
includes taxes & fees
Sep 29 - Sep 30
Best Western Gateway Grand
A cozy restaurant with wooden beams, yellow walls, and a bar area with coffee machines.
A reception desk with a sign reading "Quality by Choice Hotels," surrounded by various reptile decorations.
A spacious lobby with a dining area, a kitchen, and a large window providing a view of the outdoors.
A swimming pool with lounge chairs and umbrellas, a covered seating area, and a multi-story building with balconies.

5. Quality Inn Alachua - Gainesville Area

Quality Inn Alachua - Gainesville Area
Alachua
United States
Deborah
CA $107
CA $121 total
includes taxes & fees
Oct 18 - Oct 19
Quality Inn Alachua - Gainesville Area
A modern hotel with a prominent 'La Quinta' sign, a covered entrance, and a well-maintained outdoor area with a parking lot.
A hotel reception area with directional signs for elevators, floor 1, pool restrooms, and business center.
A hotel lobby with a seating area featuring sofas and armchairs, a central coffee table, and a flat-screen TV mounted on the wall.
A modern kitchen with blue-tiled walls, stainless steel appliances, and a central island.

6. La Quinta by Wyndham Gainesville

La Quinta by Wyndham Gainesville
Gainesville
United States
Elizabeth
CA $140
CA $158 total
includes taxes & fees
Sep 29 - Sep 30
La Quinta by Wyndham Gainesville
A stone water feature with cascading water, surrounded by a brick wall and greenery.
A reception desk with a modern design, a ceiling fan, and a seating area with chairs and a table.
A spacious living area with a wooden floor, a blue sofa, a round coffee table, and a ceiling fan.
A covered outdoor area with a paved walkway leading to a seating area, surrounded by greenery and a clear sky.

7. BlueGem Motel

BlueGem Motel
High Springs
United States
Wesley
CA $138
CA $156 total
includes taxes & fees
Sep 29 - Sep 30
BlueGem Motel
A hotel room with a bed, bedside tables, a desk, a chair, a mirror, and a window.
A reception area with a counter, a computer, and a bulletin board with pamphlets.
A bathroom with a large mirror, a sink, and a towel rack.
A building with a Coca-Cola vending machine, a window with a 'OPEN' sign, and a red awning.

8. Palms Garden Inn

Palms Garden Inn
Lake City
United States
Igor
CA $90
CA $101 total
includes taxes & fees
Oct 28 - Oct 29
Palms Garden Inn
A room with a wooden ceiling, two beds with patterned bedding, a desk, and a chair.
A row of motel buildings with a fire hydrant and trees in front.
A bedroom with a bed, a chair, a dresser, a ceiling fan, a window with blinds, and a wall-mounted air conditioner.
A small building with a green roof, a covered porch with wicker chairs, and a table.

9. High Springs Country Inn

High Springs Country Inn
High Springs
United States
Luis
CA $94
CA $106 total
includes taxes & fees
Oct 4 - Oct 5
High Springs Country Inn
A hotel room with two beds, a desk, a chair, and a television.
A parking lot with marked lanes and a grassy area on one side.
A motel with a two-story structure, a covered front entrance, and a parking lot with several cars.
A large, empty parking lot with marked parking spaces and a few trees in the background.

10. Royal Inn

Royal Inn
Alachua
United States
Alec
CA $102
CA $115 total
includes taxes & fees
Sep 29 - Sep 30
Royal Inn
A modern kitchen with a flat-screen TV, a microwave, and a coffee maker on a wooden cabinet. There is a window with a view of a green landscape.
A living room with a grey sofa, a wooden coffee table, and a framed horse picture on the wall.
A kitchen with a green refrigerator, a wooden countertop, a black kettle, and a wooden cutting board.

11. Vista Verde Farm Retreat

Vista Verde Farm Retreat
Lake City
United States
Stacy
CA $166
CA $287 total
includes taxes & fees
Sep 30 - Oct 1
Vista Verde Farm Retreat
A modern breakfast area with labeled dispensers for yogurt, eggs, and milk, a coffee machine, and a chalkboard menu.
A modern reception desk area with a blue geometric wall design, wooden accents, and a visible reception counter.
A Holiday Inn Express building with a modern design, featuring multiple windows and a flat roof.
An outdoor patio with tables and chairs, a stone wall, and a view of a street with trees and buildings.

12. Holiday Inn Express Starke by IHG

Holiday Inn Express Starke by IHG
Starke
United States
Judy
CA $156
CA $173 total
includes taxes & fees
Oct 4 - Oct 5
Holiday Inn Express Starke by IHG
A multi-story hotel with a central entrance, palm trees, and a clear sky.
A modern living room with a green sofa, a round coffee table, and a fireplace.
A spacious hotel lobby with a modern staircase, a seating area with a sofa and chairs, and a dining area in the background.
A hotel room with a bed, a desk, a television, a sofa, and artwork on the wall.

13. Country Inn & Suites by Radisson, Gainesville, FL

Country Inn & Suites by Radisson, Gainesville, FL
Gainesville
United States
sherry
CA $125
CA $141 total
includes taxes & fees
Oct 4 - Oct 5
Country Inn & Suites by Radisson, Gainesville, FL
An outdoor patio with wicker furniture, stone walls, and a barbecue grill.
A modern dining area with a wooden table, blue upholstered chairs, and pendant lighting.
A modern living room with a sectional sofa, a standing lamp, a large window with sheer curtains, a flat-screen TV, and a built-in air conditioning unit.
A modern hotel room with a flat-screen TV, a dining area with a table and chairs, a kitchenette, and a wardrobe with hanging space.

14. TownePlace Suites by Marriott Gainesville Northwest

TownePlace Suites by Marriott Gainesville Northwest
Gainesville
United States
Tanya
CA $148
CA $167 total
includes taxes & fees
Sep 30 - Oct 1
TownePlace Suites by Marriott Gainesville Northwest
A swimming pool with a metal ladder, surrounded by a white fence and green chairs.
A hotel room with a patterned carpet, a sofa, a small table, a lamp, and a door with a notice.
A living room with a curved sofa, a wooden cabinet, and a fish tank.
A refrigerated display case with beverages and snacks, and a shelf with bottled water and other beverages.

15. Best Western Waldo Inn and Suites

Best Western Waldo Inn and Suites
Waldo
United States
Ana Laura
CA $192
CA $216 total
includes taxes & fees
Oct 6 - Oct 7
Best Western Waldo Inn and Suites
A modern bar area with wooden bar stools, pendant lighting, and artwork on the walls.
A hotel room with a kitchenette, a bed, a desk with a chair, and a bathroom.
A hotel room with a living area, kitchenette, and a large mirror.
A hotel reception desk with a wooden panel design, a digital kiosk, and a "Welcome to the Sun Shine State" sign.

16. Hampton Inn Gainesville

Hampton Inn Gainesville
Gainesville
United States
Charles
CA $126
CA $142 total
includes taxes & fees
Oct 6 - Oct 7
Hampton Inn Gainesville
A modern bar area with a long counter, green bar stools, and a television displaying a golf game.
A modern living room with a fireplace, comfortable seating, and a large TV.
A modern hotel room with a large bed, a desk, a chair, and a TV mounted on the wall.
A modern kitchen with a central island, bar stools, pendant lighting, and a dining area with a sofa and chairs.

17. Fairfield Inn & Suites by Marriott Gainesville I-75

Fairfield Inn & Suites by Marriott Gainesville I-75
Gainesville
United States
Robert
CA $168
CA $189 total
includes taxes & fees
Oct 2 - Oct 3
Fairfield Inn & Suites by Marriott Gainesville I-75
A modern hotel lobby with a curved ceiling, a central seating area with a sofa and ottoman, a bar area, and a dining space with chairs and tables.
A hotel entrance with a sign reading "Springhill Suites by Marriott" and a modern building in the background.
A modern hotel lobby with a breakfast bar, seating area, and a large window.
A hotel reception area with a curved reception desk, a refrigerator stocked with beverages, and a wall with a blue abstract design.

18. SpringHill Suites by Marriott Gainesville

SpringHill Suites by Marriott Gainesville
Gainesville
United States
Robert
CA $121
CA $136 total
includes taxes & fees
Oct 4 - Oct 5
SpringHill Suites by Marriott Gainesville
A hotel entrance with a covered driveway, flag poles, and a well-lit facade.
An outdoor seating area with tables and chairs, surrounded by greenery and a building with large windows.
A grocery store interior with shelves stocked with snacks, beverages, and packaged goods.
A spacious lobby with a reception desk, seating areas, and potted plants.

19. Hilton Garden Inn Gainesville

Hilton Garden Inn Gainesville
Gainesville
United States
jose
CA $132
CA $148 total
includes taxes & fees
Oct 1 - Oct 2
Hilton Garden Inn Gainesville
A spacious lobby with a sectional sofa, a wooden cabinet, and a television mounted on the wall.
A hotel room with a large window offering a view of a cityscape, a blue armchair, and a small table with a lamp.
A hotel lobby with a stone wall, a flat-screen TV, orange upholstered seating, and a lamp.
A modern kitchen with wooden cabinets, a granite countertop, and pendant lighting.

20. Drury Inn & Suites Gainesville

Drury Inn & Suites Gainesville
Gainesville
United States
Joan
CA $148
CA $167 total
includes taxes & fees
Oct 4 - Oct 5
Drury Inn & Suites Gainesville
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Top Santa Fe Hotel Reviews

HOM Hotel Gainesville, SureStay Collection by Best Western

HOM Hotel Gainesville, SureStay Collection by Best Western

10/10 Excellent
"Excellent and renovated hotel. Everything was nice, very clean and a great location. Highly recommend."
Alfonso 2-night trip
Posted 4 hours ago
HOM Hotel Gainesville, SureStay Collection by Best Western
Drury Inn & Suites Gainesville

Drury Inn & Suites Gainesville

10/10 Excellent
"Clean room. Good friendly staff. Nice location."
Franklin 2-night trip
Posted 7 hours ago
Drury Inn & Suites Gainesville
Red Roof Inn PLUS+ Gainesville

Red Roof Inn PLUS+ Gainesville

8/10 Good
"The staff was excellent, prompt, and extremely helpful! We needed help with the TV and the staff was very attentive and quickly solved the problem. The room had an odd smell and felt damp, but understandable in humid Florida! It was a convenient location and the AC was cold!"
Kirsten 2-night trip
Posted 8 hours ago
Red Roof Inn PLUS+ Gainesville
Hyatt Place Gainesville Downtown

Hyatt Place Gainesville Downtown

10/10 Excellent
"Great service all around"
Michele 3-night trip
Posted 9 hours ago
Hyatt Place Gainesville Downtown
Sleep Inn & Suites University/Shands

Sleep Inn & Suites University/Shands

8/10 Good
"We stayed here for UF Family weekend. We booked early, and the rate wasn’t too inflated. Things really book up around that time and there is price gouging, so we chose an affordable hotel. The staff was very kind and helpful and made us aware of amenities. They offered a shuttle for the UF football game. Your stay includes free breakfast. Coffee, fresh popcorn and cookies are available most of the day. The condition of the elevator and the carpet and chair in our room needed some attention. The hotel has a bit of a damp or musty smell. We went nose blind to it pretty quickly, though. I know moisture is a big challenge in Florida. The bed and pillows were quite comfortable, and my teenage son said he slept like a baby on the sofa bed, for which the front desk gave us clean sheets, blanket and pillow. Overall, a positive experience. We would stay here again."
Erica 3-night trip
Posted 13 hours ago
Sleep Inn & Suites University/Shands
Country Inn & Suites by Radisson, Gainesville, FL

Country Inn & Suites by Radisson, Gainesville, FL

10/10 Excellent
"All good"
Sidney 1-night trip
Posted 14 hours ago
Country Inn & Suites by Radisson, Gainesville, FL
Hilton University of Florida Conference Center Gainesville

Hilton University of Florida Conference Center Gainesville

10/10 Excellent
"Only thing I didn’t like was the breakfast vouchers that essentially cover nothing so don’t feel like you’re getting any perk all I really want you to do is go down and buy their breakfast"
John 1-night trip
Posted 17 hours ago
Hilton University of Florida Conference Center Gainesville
Comfort Suites Gainesville near University

Comfort Suites Gainesville near University

8/10 Good
"Good breakfast but the trash bins by the elevators weren't cleaned out regularly and therefore smelled a bit funky."
Amanda 2-night trip
Posted 3 days ago
Comfort Suites Gainesville near University

More cheap stays in Santa Fe

Red Roof Inn PLUS+ Gainesville

Red Roof Inn PLUS+ Gainesville

3500 Southwest 42nd St Gainesville FL
CA $85
CA $96 total
Oct 1 - Oct 2
includes taxes & fees
Red Roof Inn PLUS+ Gainesville
Days Inn by Wyndham Gainesville University I-75

Days Inn by Wyndham Gainesville University I-75

920 Nw 69th Ter Gainesville FL
CA $102
CA $115 total
Sep 30 - Oct 1
includes taxes & fees
5.6/10 (1,007 reviews)
Days Inn by Wyndham Gainesville University I-75
HOM Hotel Gainesville, SureStay Collection by Best Western

HOM Hotel Gainesville, SureStay Collection by Best Western

3905 Sw 43Rd St Gainesville FL
CA $102
CA $115 total
Oct 5 - Oct 6
includes taxes & fees
8.6/10 Excellent! (2,146 reviews)
HOM Hotel Gainesville, SureStay Collection by Best Western
Sleep Inn & Suites University/Shands

Sleep Inn & Suites University/Shands

4110 SW 40th Boulevard Gainesville FL
CA $107
CA $128 total
Oct 18 - Oct 19
includes taxes & fees
8.8/10 Excellent! (1,303 reviews)
Sleep Inn & Suites University/Shands
Comfort Inn Gainesville - University Area

Comfort Inn Gainesville - University Area

3440 SW 40th Blvd Gainesville FL
CA $108
CA $129 total
Oct 18 - Oct 19
includes taxes & fees
8.2/10 Very good! (1,101 reviews)
Comfort Inn Gainesville - University Area
Comfort Suites Gainesville near University

Comfort Suites Gainesville near University

2603 SW 13TH STREET Gainesville FL
CA $115
CA $134 total
Oct 18 - Oct 19
includes taxes & fees
9.2/10 Wonderful! (1,504 reviews)
Comfort Suites Gainesville near University

Hotels in Santa Fe with star rating

Frequently asked questions

What's the best place for a stay in Santa Fe?
Located 18.6 mi (30 km) from the heart of Santa Fe, Drury Inn & Suites Gainesville is a top choice for your stay based on our traveler data. Other good choices for your visit to the area are Sleep Inn & Suites University/Shands and Country Inn & Suites by Radisson, Gainesville, FL. See all available top hotels, or vacation rentals in Santa Fe.
What are some of the best vacation rentals in Santa Fe?
Private Resort-Style Oasis, Pool, Lanai & Court – Backyard Paradise w/ BBQ: This vacation home rental outside of Santa Fe is located in the city center and has a patio, a garden, and a barbecue grill to put you at ease in your new surroundings. It has 4 bedrooms as well as a kitchen with a dishwasher, a stovetop, and a microwave, so you can cook with friends or family. See all vacation rentals in Santa Fe.
If I need to cancel my hotel reservation in Santa Fe, will I receive a refund?
Yes, most hotel bookings are fully refundable if cancelled before the hotel's cancellation deadline, which is often 24 or 48 hours before check in. If you have a non-refundable reservation, you might still have the option to cancel and get a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in Santa Fe.
What is staying in Santa Fe like?
Travelers to Santa Fe will find plenty to explore and enjoy. There are 802 hotels and other accommodations in the surrounding area. Find out more about Santa Fe.
What are the top places to visit in Santa Fe?
Places to visit in the wider area include O'Leno State Park, San Felasco Hammock Preserve State Park, and Devil's Milhopper Geological State Park. You'll also find Gainesville Raceway and Poe Springs Park in the area. Check out what more to see and do in Expedia's Santa Fe guide.
What's the seasonal weather like in Santa Fe?
The hottest months are usually July and August with an average temp of 80°F, while the coldest months are January and February with an average of 59°F. The rainiest months in Santa Fe are August, June, July, and September, with each month seeing an average of 7 inches of rainfall.

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