Title: 10 Best Hotels in Santa Fé, Guarani das Missões for 2025 | Expedia.ca [Vacation Rentals in Guarani das Missões](https://expedia.ca/Guarani-Das-Missoes-Vacation-Rentals.d553248634664609476.Travel-Guide-VacationRentals)[Santa Fé Car Rentals](https://expedia.ca/Car-Rentals-In-Santa-Fe.d553248635318393892.Car-Rental-Guide)[Santa Fé Vacations](https://expedia.ca/Santa-Fe.d553248635318393892.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Hotels in Santa Fé, Guarani das Missões ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Oct 25 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=553248635318393892&startDate=2025-10-25&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 26 - Oct 27](https://www.expedia.ca/Hotel-Search?regionId=553248635318393892&startDate=2025-10-26&endDate=2025-10-27&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=553248635318393892&startDate=2025-10-31&endDate=2025-11-02&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=553248635318393892&startDate=2025-11-07&endDate=2025-11-09&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Recommended Price (low to high) Distance Star rating ## Santa Fé hotels and places to stay ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSanta-Fe-Guarani-Das-Missoes-Hotels.0-n553248635318393892-0.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSanta-Fe-Guarani-Das-Missoes-Hotels.0-n553248635318393892-0.Travel-Guide-Filter-Hotels) ## Where to stay in Santa Fé Find the best Santa Fé areas and neighborhoods for the activities you enjoy most. - Guarani das Missões Centro - Vila Esperança - Santa Tereza - Pampa [](https://www.expedia.ca/Hotel-Search?pwaOverlay=map®ionId=553248635318324713) ![Guarani das Missões Centro map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:flwjDjo%60lIsYKdFuF%60HaRaAoI%7E%40UTgAs%40cIoBqFJmA%7Ey%40w%40%40ms%40rRDGjRkJjeAyd%40x%40BlFqLHw%40jJL%7EB&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=4yVzzb2NDVcgxY50AT-u2p4qy7E=) ### Guarani das Missões Centro [See properties](https://www.expedia.ca/Hotel-Search?regionId=553248635318324713) [](https://www.expedia.ca/Hotel-Search?pwaOverlay=map®ionId=553248635318435509) ![Vila Esperança map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:x_wjDvi_lIa%40%7DGeB%7DFoBuBsEVcAfCa%40my%40bN%5Br%40zj%40h%40THdF%7BA%40KlAnBpFr%40bIUfA_AT&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=TwqYRio2heDn5IRwFrukX0ueFMQ=) ### Vila Esperança [See properties](https://www.expedia.ca/Hotel-Search?regionId=553248635318435509) [](https://www.expedia.ca/Hotel-Search?pwaOverlay=map®ionId=553248635318411795) ![Santa Tereza map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:r%60wjDrr%7EkIIeFi%40Us%40%7Bj%40lz%40kAAls%40cw%40t%40&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=zwLNPISpLGAE7kPVVwzkIH_-n4U=) ### Santa Tereza [See properties](https://www.expedia.ca/Hotel-Search?regionId=553248635318411795) [](https://www.expedia.ca/Hotel-Search?pwaOverlay=map®ionId=553248635318379875) ![Pampa map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:%7CrwjDno%60lIuECM_Cv%40kJpLICmFxd%40y%40_BzTwi%40PCrA&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=ozGuPpexvBxOxc2_ZgjVzin21uc=) ### Pampa [See properties](https://www.expedia.ca/Hotel-Search?regionId=553248635318379875) ## Top Santa Fé Hotel Reviews ## Frequently asked questions ### What is Santa Fé like? > Travelers to Guarani das Missões's Santa Fé neighborhood will be sure to enjoy a stay in this neighborhood. ### If I need to cancel my hotel reservation in Santa Fé, will I receive a refund? > Yes! Most room reservations are refundable provided that you cancel prior to the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of check in. If you have a non-refundable reservation, it may still be possible to cancel it and be given a refund within a 24-hour period of booking. Add dates, click "Search", then filter by "fully refundable" to get the best deals available in Santa Fé. ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - More ways to book - [Alecrim Hotels](https://www.expedia.ca/Alecrim-Hotels.d553248634664577739.Travel-Guide-Hotels) - [Augusto Pestana Hotels](https://www.expedia.ca/Augusto-Pestana-Hotels.d6352044.Travel-Guide-Hotels) - [Boa Vista do Burica Hotels](https://www.expedia.ca/Boa-Vista-Do-Burica-Hotels.d6352016.Travel-Guide-Hotels) - [Lgbt Friendly Hotels in Boqueirão](https://www.expedia.ca/Boqueirao-Passo-Fundo-Hotels-LGBT-Friendly-Hotel.0-n553248635318477682-0-tLGBTFriendlyHotel.Travel-Guide-Filter-Hotels) - [Caibaté Hotels](https://www.expedia.ca/Caibate-Hotels.d553248634664619721.Travel-Guide-Hotels) - [Cândido Godói Hotels](https://www.expedia.ca/Candido-Godoi-Hotels.d553248634664564911.Travel-Guide-Hotels) - [Cerro Largo Hotels](https://www.expedia.ca/Cerro-Largo-Hotels.d6352387.Travel-Guide-Hotels) - 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[Car rental Candelaria](https://www.expedia.ca/Car-Rentals-In-Candelaria.d6352390.Car-Rental-Guide) - [Car rentals near Country](https://www.expedia.ca/Car-Rentals-In-Country.d553248635318489703.Car-Rental-Guide) - [Car rentals near Fátima](https://www.expedia.ca/Car-Rentals-In-Fatima.d553248635318361542.Car-Rental-Guide) - [Car rentals near Gare Park](https://www.expedia.ca/Car-Rentals-In-Gare-Park.d6223109.Car-Rental-Guide) - [Car rentals near Our Lady Of Fatima Monument](https://www.expedia.ca/Car-Rentals-In-Our-Lady-Of-Fatima-Monument.d553248621562279830.Car-Rental-Guide) - [Car rentals near Santa Lúcia](https://www.expedia.ca/Car-Rentals-In-Santa-Lucia.d553248635318492928.Car-Rental-Guide) - [Itaqui Vacation Rentals](https://www.expedia.ca/Itaqui-Vacation-Rentals.d6352005.Travel-Guide-VacationRentals) - [Book Hotels in Santa Fé on Expedia.com.br](https://www.expedia.com.br/Santa-Fe-Guarani-Das-Missoes-Hoteis.0-n553248635318393892-0.Guia-de-Viagem-Filtrar-Hoteis) - Explore a world of travel with Expedia ### Hotels in top Guarani das Missões neighborhoods - 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