Title: Book The Best Hotels in Santa Cruz Tlaxcala for 2026 from CA $43 - Fully Refundable Options - Expedia.ca [Santa Cruz Tlaxcala Travel Guide](https://expedia.ca/Santa-Cruz-Tlaxcala.dx553248635640693398)[Vacation Rentals in Santa Cruz Tlaxcala](https://expedia.ca/Santa-Cruz-Tlaxcala-Vacation-Rentals.d553248635640693398.Travel-Guide-VacationRentals)[Santa Cruz Tlaxcala Car Rentals](https://expedia.ca/Car-Rentals-In-Santa-Cruz-Tlaxcala.d553248635640693398.Car-Rental-Guide)[Santa Cruz Tlaxcala Vacation Packages](https://expedia.ca/Santa-Cruz-Tlaxcala.d553248635640693398.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in Santa Cruz Tlaxcala Spa [](https://www.expedia.ca/Hotel-Search?destination=Santa+Cruz+Tlaxcala%2C+Tlaxcala%2C+Mexico®ionId=553248635640693398&latLong=19.352941%2C-98.130564&adults=2&startDate=2026-02-03&d1=2026-02-03&endDate=2026-02-05&d2=2026-02-05&amenities=SPA_ON_SITE) Pool [](https://www.expedia.ca/Hotel-Search?destination=Santa+Cruz+Tlaxcala%2C+Tlaxcala%2C+Mexico®ionId=553248635640693398&latLong=19.352941%2C-98.130564&adults=2&startDate=2026-02-03&d1=2026-02-03&endDate=2026-02-05&d2=2026-02-05&amenities=POOL) Family friendly [](https://www.expedia.ca/Hotel-Search?destination=Santa+Cruz+Tlaxcala%2C+Tlaxcala%2C+Mexico®ionId=553248635640693398&latLong=19.352941%2C-98.130564&adults=2&startDate=2026-02-03&d1=2026-02-03&endDate=2026-02-05&d2=2026-02-05&travelerType=family_friendly) Pet friendly [](https://www.expedia.ca/Hotel-Search?destination=Santa+Cruz+Tlaxcala%2C+Tlaxcala%2C+Mexico®ionId=553248635640693398&latLong=19.352941%2C-98.130564&adults=2&startDate=2026-02-03&d1=2026-02-03&endDate=2026-02-05&d2=2026-02-05&amenities=PETS) Hot tub [](https://www.expedia.ca/Hotel-Search?destination=Santa+Cruz+Tlaxcala%2C+Tlaxcala%2C+Mexico®ionId=553248635640693398&latLong=19.352941%2C-98.130564&adults=2&startDate=2026-02-03&d1=2026-02-03&endDate=2026-02-05&d2=2026-02-05&amenities=HOT_TUB) Cabin [](https://www.expedia.ca/Hotel-Search?destination=Santa+Cruz+Tlaxcala%2C+Tlaxcala%2C+Mexico®ionId=553248635640693398&latLong=19.352941%2C-98.130564&adults=2&startDate=2026-02-03&d1=2026-02-03&endDate=2026-02-05&d2=2026-02-05&lodging=CABIN) Apart­ment [](https://www.expedia.ca/Hotel-Search?destination=Santa+Cruz+Tlaxcala%2C+Tlaxcala%2C+Mexico®ionId=553248635640693398&latLong=19.352941%2C-98.130564&adults=2&startDate=2026-02-03&d1=2026-02-03&endDate=2026-02-05&d2=2026-02-05&lodging=APARTMENT) ## Check prices for these dates Tonight [Jan 20 - Jan 21](https://www.expedia.ca/Hotel-Search?regionId=553248635640693398&startDate=2026-01-20&endDate=2026-01-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Jan 21 - Jan 22](https://www.expedia.ca/Hotel-Search?regionId=553248635640693398&startDate=2026-01-21&endDate=2026-01-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Jan 23 - Jan 25](https://www.expedia.ca/Hotel-Search?regionId=553248635640693398&startDate=2026-01-23&endDate=2026-01-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Jan 30 - Feb 1](https://www.expedia.ca/Hotel-Search?regionId=553248635640693398&startDate=2026-01-30&endDate=2026-02-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Santa Cruz Tlaxcala hotels ![Bar (on property)](https://images.trvl-media.com/lodging/73000000/72110000/72107800/72107791/w1179h1080x0y0-692ba688.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/73000000/72110000/72107800/72107791/6a1025b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/73000000/72110000/72107800/72107791/3a75e91c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/73000000/72110000/72107800/72107791/c465bb81.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel San Francisco Tlaxcala [](https://www.expedia.ca/Tlaxcala-Hotels-Hotel-San-Francisco-Tlaxcala.h72107791.Hotel-Information) Tlaxcala 9.0/10 Wonderful (391 reviews) "Loved everything about this place. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Margarita CA $108 CA $127 total includes taxes & fees Feb 1 - Feb 2 [](https://www.expedia.ca/Tlaxcala-Hotels-Hotel-San-Francisco-Tlaxcala.h72107791.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/82000000/81070000/81065700/81065697/c3f1d63f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/82000000/81070000/81065700/81065697/cf362393.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/82000000/81070000/81065700/81065697/a3f6d0de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Double Room, 2 Double Beds](https://images.trvl-media.com/lodging/82000000/81070000/81065700/81065697/e672b38d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Molino de los Reyes [](https://www.expedia.ca/Totolac-Hotels-Molino-De-Los-Reyes.h81065697.Hotel-Information) Totolac 8.8/10 Excellent (9 reviews) "Me gustó la habitación, el ambiente generado y la comodidad, con algunos detalles. la habitación no se obscurece completamente y y un escalón peligroso. El personal al muy atento y servicial." ![Mexico](https://a.travel-assets.com/egds/marks/flags/mx.svg) JESUS HERIBERTO [](https://www.expedia.ca/Totolac-Hotels-Molino-De-Los-Reyes.h81065697.Hotel-Information) ![Fountain](https://images.trvl-media.com/lodging/6000000/5450000/5449700/5449696/b9fc9e71.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Garden view](https://images.trvl-media.com/lodging/6000000/5450000/5449700/5449696/71a0ed1d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Garden view](https://images.trvl-media.com/lodging/6000000/5450000/5449700/5449696/3229754a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/6000000/5450000/5449700/5449696/2c42b21d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Posada La Casona de Cortes [](https://www.expedia.ca/Tlaxcala-Hotels-Hotel-Posada-La-Casona-De-Cortes.h5449696.Hotel-Information) Tlaxcala 8.4/10 Very good (201 reviews) "Beautiful hotel" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Atilio CA $55 CA $65 total includes taxes & fees Jan 27 - Jan 28 [](https://www.expedia.ca/Tlaxcala-Hotels-Hotel-Posada-La-Casona-De-Cortes.h5449696.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/16000000/15470000/15462700/15462646/ee2a031c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/16000000/15470000/15462700/15462646/5c8c2e55.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/16000000/15470000/15462700/15462646/w413h319x7y7-969e9ded.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/16000000/15470000/15462700/15462646/acf370b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Real Malintzi Tlaxcala [](https://www.expedia.ca/Tlaxcala-Hotels-HOTEL-REAL-MALINTZI-TLAXCALA.h15462646.Hotel-Information) Tlaxcala 7.2/10 Good (101 reviews) "X" ![Mexico](https://a.travel-assets.com/egds/marks/flags/mx.svg) Elvin CA $37 CA $43 total includes taxes & fees Jan 22 - Jan 23 [](https://www.expedia.ca/Tlaxcala-Hotels-HOTEL-REAL-MALINTZI-TLAXCALA.h15462646.Hotel-Information) ![Daily cooked-to-order breakfast for a fee](https://images.trvl-media.com/lodging/111000000/110900000/110895000/110894926/6374253d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Daily cooked-to-order breakfast for a fee](https://images.trvl-media.com/lodging/111000000/110900000/110895000/110894926/5b471c27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/111000000/110900000/110895000/110894926/ac2288a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Junior Room, Hill View | Balcony](https://images.trvl-media.com/lodging/111000000/110900000/110895000/110894926/9c04cbbb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### HOTEL XIADANI temazcal y SPA [](https://www.expedia.ca/Tlaxcala-Hotels-HOTEL-XIADANI-Temazcal-Y-SPA.h110894926.Hotel-Information) Tlaxcala 9.2/10 Wonderful (51 reviews) "excelente" ![Mexico](https://a.travel-assets.com/egds/marks/flags/mx.svg) Danae CA $47 CA $56 total includes taxes & fees Jan 25 - Jan 26 [](https://www.expedia.ca/Tlaxcala-Hotels-HOTEL-XIADANI-Temazcal-Y-SPA.h110894926.Hotel-Information) ![Family Quadruple Room, 2 Double Beds](https://images.trvl-media.com/lodging/96000000/95420000/95419700/95419673/e7f62c44.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/96000000/95420000/95419700/95419673/0c18efbe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/96000000/95420000/95419700/95419673/9d3239df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/96000000/95420000/95419700/95419673/2632e63e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Tlaxcala [](https://www.expedia.ca/Tlaxcala-Hotels-Hotel-Tlaxcala.h95419673.Hotel-Information) Tlaxcala 8.2/10 Very good (105 reviews) "👍" ![Mexico](https://a.travel-assets.com/egds/marks/flags/mx.svg) Gerardo CA $56 CA $66 total includes taxes & fees Jan 22 - Jan 23 [](https://www.expedia.ca/Tlaxcala-Hotels-Hotel-Tlaxcala.h95419673.Hotel-Information) ![Rooftop terrace](https://images.trvl-media.com/lodging/91000000/90160000/90151100/90151003/29e0a988.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/91000000/90160000/90151100/90151003/afaefe7e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/91000000/90160000/90151100/90151003/w2868h1920x0y0-075efa9b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Staircase](https://images.trvl-media.com/lodging/91000000/90160000/90151100/90151003/w2877h1920x3y0-7485b2ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Capital O Hotel Boutique Las Torres [](https://www.expedia.ca/Tlaxcala-Hotels-HOTEL-BOUTIQUE-LAS-TORRES.h90151003.Hotel-Information) Tlaxcala 9.0/10 Wonderful (68 reviews) "Safe and great stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ashley CA $45 CA $58 total includes taxes & fees Jan 25 - Jan 26 [](https://www.expedia.ca/Tlaxcala-Hotels-HOTEL-BOUTIQUE-LAS-TORRES.h90151003.Hotel-Information) ![Double Room](https://images.trvl-media.com/lodging/38000000/37410000/37407300/37407228/29599c93.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/38000000/37410000/37407300/37407228/a1fbba16.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![43-inch flat-screen TV with cable channels, TV](https://images.trvl-media.com/lodging/38000000/37410000/37407300/37407228/045a42e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Daily cooked-to-order breakfast for a fee](https://images.trvl-media.com/lodging/38000000/37410000/37407300/37407228/5608da42.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Mirante Tlaxcala [](https://www.expedia.ca/Tlaxcala-Hotels-Hotel-Mirante-Tlaxcala.h37407228.Hotel-Information) Tlaxcala 9.6/10 Exceptional (101 reviews) "Our stay in Tlaxcala was excellent. The breakfast and staff were top-notch and courteous. I will definitely stay here for future visits!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Janina CA $62 CA $73 total includes taxes & fees Jan 21 - Jan 22 [](https://www.expedia.ca/Tlaxcala-Hotels-Hotel-Mirante-Tlaxcala.h37407228.Hotel-Information) ![Indoor pool, open 7:00 AM to 9:00 PM, sun loungers](https://images.trvl-media.com/lodging/5000000/4930000/4922200/4922195/0ebc1863.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/5000000/4930000/4922200/4922195/ab42e04b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/5000000/4930000/4922200/4922195/4291fcfa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/5000000/4930000/4922200/4922195/569ed6b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Senorial Tlaxcala [](https://www.expedia.ca/Tlaxcala-Hotels-Hotel-Senorial-Tlaxcala.h4922195.Hotel-Information) Tlaxcala 8.8/10 Excellent (155 reviews) "Great option" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Maria [](https://www.expedia.ca/Tlaxcala-Hotels-Hotel-Senorial-Tlaxcala.h4922195.Hotel-Information) ![Breakfast and lunch served, Mexican cuisine](https://images.trvl-media.com/lodging/46000000/45980000/45970100/45970022/80400c58.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Iron/ironing board, bed sheets](https://images.trvl-media.com/lodging/46000000/45980000/45970100/45970022/196db6a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/46000000/45980000/45970100/45970022/a829d48d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/46000000/45980000/45970100/45970022/6fa7b727.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel de La Loma [](https://www.expedia.ca/Tlaxcala-Hotels-Hotel-De-La-Loma.h45970022.Hotel-Information) Tlaxcala 8.8/10 Excellent (229 reviews) "Good location and good service " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rolando [](https://www.expedia.ca/Tlaxcala-Hotels-Hotel-De-La-Loma.h45970022.Hotel-Information) ![Courtyard](https://images.trvl-media.com/lodging/1000000/540000/530800/530708/1b5f8af2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/540000/530800/530708/w3990h2065x5y0-dc79e0e5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; Mexican cuisine ](https://images.trvl-media.com/lodging/1000000/540000/530800/530708/w3990h2068x5y0-5a6d2f37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/540000/530800/530708/4be165cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel GS Jerocs [](https://www.expedia.ca/Tlaxcala-Hotels-Hoteles-GS-Jerocs.h530708.Hotel-Information) Tlaxcala 8.2/10 Very good (350 reviews) "Hotel is very nice and clean. The staff is very nice and accommodating." ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Marisu CA $135 CA $163 total includes taxes & fees Feb 3 - Feb 4 [](https://www.expedia.ca/Tlaxcala-Hotels-Hoteles-GS-Jerocs.h530708.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/37000000/36940000/36933900/36933818/a1086b54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/37000000/36940000/36933900/36933818/4bee8854.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; international cuisine ](https://images.trvl-media.com/lodging/37000000/36940000/36933900/36933818/2844c1b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; international cuisine ](https://images.trvl-media.com/lodging/37000000/36940000/36933900/36933818/42b7938a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Tlaxcala by IHG [](https://www.expedia.ca/Tlaxcala-Hotels-Holiday-Inn-Tlaxcala.h36933818.Hotel-Information) Yauhquemehcan 9.6/10 Exceptional (249 reviews) "Todo excelente" ![Mexico](https://a.travel-assets.com/egds/marks/flags/mx.svg) carlos CA $128 CA $152 total includes taxes & fees Jan 24 - Jan 25 [](https://www.expedia.ca/Tlaxcala-Hotels-Holiday-Inn-Tlaxcala.h36933818.Hotel-Information) ![Exclusive Apartment | Exterior](https://images.trvl-media.com/lodging/123000000/122380000/122372600/122372524/7ded671f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exclusive Apartment | Living area](https://images.trvl-media.com/lodging/123000000/122380000/122372600/122372524/d793e91f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exclusive Apartment | Living area](https://images.trvl-media.com/lodging/123000000/122380000/122372600/122372524/3a95d0b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exclusive Apartment | Dining](https://images.trvl-media.com/lodging/123000000/122380000/122372600/122372524/423433b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Departamento Sasha [](https://www.expedia.ca/Tetlatlahuca-Hotels-Departamento-Sasha.h122372524.Hotel-Information) Val'Quirico CA $241 CA $312 total includes taxes & fees Jan 22 - Jan 23 [](https://www.expedia.ca/Tetlatlahuca-Hotels-Departamento-Sasha.h122372524.Hotel-Information) ![Comfort Room, 1 Bedroom](https://images.trvl-media.com/lodging/85000000/84110000/84104200/84104174/de4418b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/85000000/84110000/84104200/84104174/45b20f31.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Grand Room, 1 Bedroom](https://images.trvl-media.com/lodging/85000000/84110000/84104200/84104174/b2da80e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![40-inch Smart TV with digital channels, TV](https://images.trvl-media.com/lodging/85000000/84110000/84104200/84104174/f0bdb69c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel de la Capilla [](https://www.expedia.ca/Tlaxcala-Hotels-Hotel-De-La-Capilla.h84104174.Hotel-Information) Tlaxcala 8.6/10 Excellent (59 reviews) "Quaint and super clean place, near everything, right in the middle of historic places, the market, cafés, museums. Lovely place to stay." ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Diana [](https://www.expedia.ca/Tlaxcala-Hotels-Hotel-De-La-Capilla.h84104174.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/79000000/78670000/78660800/78660800/c444e0ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Superior Room](https://images.trvl-media.com/lodging/79000000/78670000/78660800/78660800/w750h559x0y7-e616797d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down comforters, Tempur-Pedic beds, desk](https://images.trvl-media.com/lodging/79000000/78670000/78660800/78660800/64a8fc4c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/79000000/78670000/78660800/78660800/f67147d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Mesón Santa Rosa [](https://www.expedia.ca/Tlaxcala-Hotels-Meson-Santa-Rosa.h78660800.Hotel-Information) Tlaxcala 9.4/10 Exceptional (55 reviews) "Excellent location, quiet, wonderful service and great price. Would definitely stay there again. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mario [](https://www.expedia.ca/Tlaxcala-Hotels-Meson-Santa-Rosa.h78660800.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/109000000/108280000/108279800/108279765/f9bdf715.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/109000000/108280000/108279800/108279765/f72bb0c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Superior Studio Suite](https://images.trvl-media.com/lodging/109000000/108280000/108279800/108279765/e8561fb5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Superior Studio Suite](https://images.trvl-media.com/lodging/109000000/108280000/108279800/108279765/d4d3e98f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### HOTEL CANCALLI [](https://www.expedia.ca/Tlaxcala-Hotels-HOTEL-CANCALLI.h108279765.Hotel-Information) Tlaxcala 8.8/10 Excellent (6 reviews) "Se asignó habitación master, limpio, cómodo" ![Mexico](https://a.travel-assets.com/egds/marks/flags/mx.svg) Rocio [](https://www.expedia.ca/Tlaxcala-Hotels-HOTEL-CANCALLI.h108279765.Hotel-Information) ![Interior entrance](https://images.trvl-media.com/lodging/100000000/99480000/99472200/99472163/9cd9ee3d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/100000000/99480000/99472200/99472163/4392b262.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room](https://images.trvl-media.com/lodging/100000000/99480000/99472200/99472163/f59051ca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/100000000/99480000/99472200/99472163/40364bbf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Casa Tlaxcalli by Beddo Hoteles [](https://www.expedia.ca/Tlaxcala-Hotels-Casa-Tlaxcalli-By-Beddo-Hoteles.h99472163.Hotel-Information) Tlaxcala 9.0/10 Wonderful (58 reviews) "Excellent " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ponciano [](https://www.expedia.ca/Tlaxcala-Hotels-Casa-Tlaxcalli-By-Beddo-Hoteles.h99472163.Hotel-Information) ![Apartment | Exterior](https://images.trvl-media.com/lodging/85000000/84030000/84020700/84020693/77c986ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Comfort Loft | Living area](https://images.trvl-media.com/lodging/85000000/84030000/84020700/84020693/5b190bd5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Apartment | Property grounds](https://images.trvl-media.com/lodging/85000000/84030000/84020700/84020693/f8b44191.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Panoramic Loft | Living area](https://images.trvl-media.com/lodging/85000000/84030000/84020700/84020693/6a06be15.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Pietro Santo [](https://www.expedia.ca/Santeagueda-Hotels-Pietro-Santo.h84020693.Hotel-Information) Santeagueda 9.4/10 Exceptional (147 reviews) "Todo excelente." ![Mexico](https://a.travel-assets.com/egds/marks/flags/mx.svg) karina CA $443 CA $523 total includes taxes & fees Feb 13 - Feb 14 [](https://www.expedia.ca/Santeagueda-Hotels-Pietro-Santo.h84020693.Hotel-Information) ![Premium Double Room](https://images.trvl-media.com/lodging/106000000/105090000/105087800/105087765/deee3dbc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium Quadruple Room | Living area](https://images.trvl-media.com/lodging/106000000/105090000/105087800/105087765/390566b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium Quadruple Room | Living area](https://images.trvl-media.com/lodging/106000000/105090000/105087800/105087765/203390a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium Quadruple Room | Private kitchen](https://images.trvl-media.com/lodging/106000000/105090000/105087800/105087765/555e5316.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Posada Valquiria ValQuirico [](https://www.expedia.ca/Tetlatlahuca-Hotels-Posada-Valquiria-ValQuirico.h105087765.Hotel-Information) Tetlatlahuca 9.8/10 Exceptional (32 reviews) "Beautiful room and restaurant. Some service details like the pickup and and ride to the parking lot could be improve " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) OSCAR CA $289 CA $341 total includes taxes & fees Jan 22 - Jan 23 [](https://www.expedia.ca/Tetlatlahuca-Hotels-Posada-Valquiria-ValQuirico.h105087765.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/114000000/113890000/113882400/113882392/bbd64857.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/114000000/113890000/113882400/113882392/93cff4ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/114000000/113890000/113882400/113882392/3d0246ec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/114000000/113890000/113882400/113882392/0b69fa29.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Cuamanco [](https://www.expedia.ca/Huamantla-Hotels-Hotel-Cuamanco.h113882392.Hotel-Information) Huamantla 8.6/10 Excellent (108 reviews) "Todo excelente " ![Mexico](https://a.travel-assets.com/egds/marks/flags/mx.svg) GABRIELA CA $39 CA $46 total includes taxes & fees Jan 22 - Jan 23 [](https://www.expedia.ca/Huamantla-Hotels-Hotel-Cuamanco.h113882392.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-03&endDate=2026-02-04®ionId=553248635640693398&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSanta-Cruz-Tlaxcala-Hotels.d553248635640693398.Travel-Guide-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSanta-Cruz-Tlaxcala-Hotels.d553248635640693398.Travel-Guide-Hotels) ## More cheap stays in Santa Cruz Tlaxcala ![Hotel Royal Puebla](https://images.trvl-media.com/lodging/28000000/27580000/27574500/27574454/a1dc2252_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hotel Royal Puebla Atilac San Felipe Hueyotlipan Puebla PUE CA $39 CA $46 total Jan 22 - Jan 23 includes taxes & fees 7.4/10 Good! 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Venustiano Carranza #5 Tetlatlahuca TLAX [Get rates](https://expedia.ca/Hotel-Search?startDate=03%2F02%2F2026&endDate=04%2F02%2F2026&selected=29328741&PinnedHotelID=29328741&HadPinnedHotel=true®ionId=553248635640693398) 7.2/10 Good! (120 reviews) [](https://expedia.ca/Tetlatlahuca-Hotels-Hotel-Y-Centro-De-Convenciones-Cacaxtla.h29328741.Hotel-Information) ![La Bella Toscana Centro](https://images.trvl-media.com/lodging/99000000/98240000/98237700/98237666/2d6abe89_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### La Bella Toscana Centro Fundadores #92, Val'Quirico Santeagueda TLAX [Get rates](https://expedia.ca/Hotel-Search?startDate=03%2F02%2F2026&endDate=04%2F02%2F2026&selected=98237666&PinnedHotelID=98237666&HadPinnedHotel=true®ionId=553248635640693398) 9.6/10 Exceptional! (103 reviews) [](https://expedia.ca/Santeagueda-Hotels-La-Bella-Toscana-Centro.h98237666.Hotel-Information) ## Recent reviews of Santa Cruz Tlaxcala hotels ![Hotel Star Express Puebla - Central CAPU](https://images.trvl-media.com/lodging/17000000/16010000/16006900/16006816/b7897358_y.jpg) ### Hotel Star Express Puebla - Central CAPU 5/5 Excellent "Very clean,good price " A verified traveller stayed at Hotel Star Express Puebla - Central CAPU Posted 12 days ago [](https://expedia.ca/Puebla-Hotels-Hotel-Star-Express.h16006816.Hotel-Information) ![Villa Toscana ValQuirico Lofts & Suites Hotel Boutique](https://images.trvl-media.com/lodging/42000000/41840000/41831800/41831723/3ef426d5_y.jpg) ### Villa Toscana ValQuirico Lofts & Suites Hotel Boutique 5/5 Excellent "Excellent service" A verified traveller stayed at Villa Toscana ValQuirico Lofts & Suites Hotel Boutique Posted 3 weeks ago [](https://expedia.ca/Nativitas-Hotels-Villa-Toscana-Lofts-Suites.h41831723.Hotel-Information) ![Hotel del Angel, Apizaco](https://images.trvl-media.com/lodging/2000000/1680000/1674800/1674763/9e3e535e_y.jpg) ### Hotel del Angel, Apizaco 5/5 Excellent "Room wa a lean and they would come in everyday to make the beds and restock with water bottles. The staff was super nice and helpful and the staff in the restaurant were amazing super attentive and nice" A verified traveller stayed at Hotel del Angel, Apizaco Posted 3 weeks ago [](https://expedia.ca/Apizaco-Hotels-Hotel-Del-Angel.h1674763.Hotel-Information) ![Fiesta Inn Parque Puebla](https://images.trvl-media.com/lodging/34000000/34000000/33994500/33994459/58e9e48c_y.jpg) ### Fiesta Inn Parque Puebla 5/5 Excellent "The hotel ia very nice, clean, practical. Rooms are comfortable. Staff is very nice." A verified traveller stayed at Fiesta Inn Parque Puebla Posted 1 month ago [](https://expedia.ca/Puebla-Hotels-Fiesta-Inn-Parque-Puebla.h33994459.Hotel-Information) ![Plaza Poblana](https://images.trvl-media.com/lodging/2000000/1600000/1590100/1590099/3ffa018e_y.jpg) ### Plaza Poblana 5/5 Excellent "Room condition " A verified traveller stayed at Plaza Poblana Posted 2 months ago [](https://expedia.ca/Puebla-Hotels-Plaza-Poblana.h1590099.Hotel-Information) ![Marriott Puebla Hotel Meson del Angel](https://images.trvl-media.com/lodging/1000000/20000/12700/12608/3c6bb4a5_y.jpg) ### Marriott Puebla Hotel Meson del Angel 5/5 Excellent "Great amenities" A verified traveller stayed at Marriott Puebla Hotel Meson del Angel Posted 2 months ago [](https://expedia.ca/Puebla-Hotels-Marriott-Puebla-Hotel-Meson-Del-Angel.h12608.Hotel-Information) ![Ramada Encore Puebla Mexico](https://images.trvl-media.com/lodging/17000000/16610000/16608300/16608261/72886336_y.jpg) ### Ramada Encore Puebla Mexico 5/5 Excellent "Good" A verified traveller stayed at Ramada Encore Puebla Mexico Posted 2 months ago [](https://expedia.ca/Puebla-Hotels-Ramada-Encore-Puebla-Mexico.h16608261.Hotel-Information) ![Staybridge Suites Puebla by IHG](https://images.trvl-media.com/lodging/12000000/11640000/11638400/11638308/490ca66b_y.jpg) ### Staybridge Suites Puebla by IHG 5/5 Excellent "K" A verified traveller stayed at Staybridge Suites Puebla by IHG Posted 2 months ago [](https://expedia.ca/Puebla-Hotels-Staybridge-Suites-Puebla.h11638308.Hotel-Information) ![One Puebla Serdan](https://images.trvl-media.com/lodging/20000000/19090000/19088100/19088013/e27e61a8_y.jpg) ### One Puebla Serdan 5/5 Excellent "nice hotel" A verified traveller from Greensboro stayed at One Puebla Serdan Posted 3 months ago [](https://expedia.ca/Puebla-Hotels-One-Puebla-Serdan.h19088013.Hotel-Information) ## Frequently asked questions ### Where is the best place for a stay in Santa Cruz Tlaxcala? ### What are some of the best vacation home rentals that Santa Cruz Tlaxcala has to offer? ### If I need to cancel my hotel reservation in Santa Cruz Tlaxcala, will I receive a refund? ### How is it to stay in Santa Cruz Tlaxcala? ### What should I see while I'm in Santa Cruz Tlaxcala? ### What's the weather like in Santa Cruz Tlaxcala? ## Explore a world of travel with Expedia - 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