Title: Book the Best BUSINESS Hotels in Sanibel in 2026 | Expedia.ca [Sanibel Travel Guide](https://expedia.ca/Sanibel.dx9791)[Hotels in Sanibel](https://expedia.ca/Sanibel-Hotels.d9791.Travel-Guide-Hotels)[Vacation Rentals in Sanibel](https://expedia.ca/Sanibel-Vacation-Rentals.d9791.Travel-Guide-VacationRentals)[Flights to Sanibel](https://expedia.ca/Cheap-Flights-To-Sanibel.d9791.Travel-Guide-Flights)[Things to do in Sanibel](https://expedia.ca/Things-To-Do-In-Sanibel.d9791.Travel-Guide-Activities)[Sanibel Car Rentals](https://expedia.ca/Car-Rentals-In-Sanibel.d9791.Car-Rental-Guide)[Sanibel Vacation Packages](https://expedia.ca/Sanibel.d9791.Destination-Travel-Guides) ![Sanibel Island Lighthouse which includes a sunset and a lighthouse](https://images.trvl-media.com/place/6123905/f29c3c57-bfa6-4f38-95ba-a11a95bd6896.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6123905/f29c3c57-bfa6-4f38-95ba-a11a95bd6896.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Sanibel Business Hotels Tonight [Jan 27 - Jan 28](https://www.expedia.ca/Hotel-Search?regionId=9791&startDate=2026-01-27&endDate=2026-01-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [Jan 28 - Jan 29](https://www.expedia.ca/Hotel-Search?regionId=9791&startDate=2026-01-28&endDate=2026-01-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) This weekend [Jan 30 - Feb 1](https://www.expedia.ca/Hotel-Search?regionId=9791&startDate=2026-01-30&endDate=2026-02-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [Feb 6 - Feb 8](https://www.expedia.ca/Hotel-Search?regionId=9791&startDate=2026-02-06&endDate=2026-02-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Our top choices for Sanibel business-friendly hotels ![On the beach, sun loungers, beach towels](https://images.trvl-media.com/lodging/18000000/17300000/17298900/17298818/f97bdde8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/18000000/17300000/17298900/17298818/w2247h1500x326y0-2ea06bb5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Balcony (Gulf View)](https://images.trvl-media.com/lodging/18000000/17300000/17298900/17298818/f85ea0c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/18000000/17300000/17298900/17298818/aa9b23b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sanibel Island Beach Resort [](https://www.expedia.ca/Fort-Myers-Hotels-Sanibel-Island-Beach-Resort.h17298818.Hotel-Information) Mid Island 9.2/10 Wonderful (1,564 reviews) "Sweet staff, amazing beach access, pool, restaurant on site. Good value and great stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Freda CA $406 CA $488 total includes taxes & fees Jan 28 - Jan 29 [](https://www.expedia.ca/Fort-Myers-Hotels-Sanibel-Island-Beach-Resort.h17298818.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/104000000/103190000/103186900/103186827/3bf7e12d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/104000000/103190000/103186900/103186827/0afa75e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Full-size fridge, microwave, stovetop](https://images.trvl-media.com/lodging/104000000/103190000/103186900/103186827/01114515.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Queen Suite Two Queen Beds](https://images.trvl-media.com/lodging/104000000/103190000/103186900/103186827/74c618a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Woodspring Suites Fort Myers - Cape Coral [](https://www.expedia.ca/Fort-Myers-Hotels-Woodspring-Suites-Fort-Myers-Cape-Coral.h103186827.Hotel-Information) Fort Myers 7.2/10 Good (172 reviews) "The service at the front desk was exceptional, the new manager is doing an amazing job!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sandro CA $122 CA $136 total includes taxes & fees Jan 30 - Jan 31 [](https://www.expedia.ca/Fort-Myers-Hotels-Woodspring-Suites-Fort-Myers-Cape-Coral.h103186827.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/800000/798500/798422/46330a76.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/800000/798500/798422/1fa522a6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/800000/798500/798422/d3248701.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/800000/798500/798422/54014b0c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn & Suites by Wyndham Fort Myers Near JetBlue Park [](https://www.expedia.ca/Fort-Myers-Hotels-Days-Inn-Suites-By-Wyndham-Fort-Myers-Near-JetBlue-Park.h798422.Hotel-Information) Daniels Corridor 8.0/10 Very good (1,569 reviews) "Good room for a fair price in a good location " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) John CA $149 CA $166 total includes taxes & fees Jan 29 - Jan 30 [](https://www.expedia.ca/Fort-Myers-Hotels-Days-Inn-Suites-By-Wyndham-Fort-Myers-Near-JetBlue-Park.h798422.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/2000000/1750000/1746300/1746276/2deb021c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/2000000/1750000/1746300/1746276/06cf7d58.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/2000000/1750000/1746300/1746276/6f1c6d7b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1750000/1746300/1746276/eec3b567.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Fort Myers Airport [](https://www.expedia.ca/Fort-Myers-Hotels-Comfort-Inn-Suites-Airport.h1746276.Hotel-Information) Daniels Corridor 8.8/10 Excellent (1,121 reviews) "Great stay for early morning flight" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jay CA $147 CA $164 total includes taxes & fees Feb 1 - Feb 2 [](https://www.expedia.ca/Fort-Myers-Hotels-Comfort-Inn-Suites-Airport.h1746276.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/40900/40858/7d170878.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/40900/40858/bb6d486e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/1000000/50000/40900/40858/a9620a82.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lunch, dinner served; American cuisine, pool views ](https://images.trvl-media.com/lodging/1000000/50000/40900/40858/4088f841.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Trianon Bonita Bay [](https://www.expedia.ca/Naples-Hotels-Trianon-Bonita-Bay.h40858.Hotel-Information) Bonita Bay 9.2/10 Wonderful (1,747 reviews) "Clean and comfy rooms and staff was great" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jarrett CA $270 CA $302 total includes taxes & fees Feb 1 - Feb 2 [](https://www.expedia.ca/Naples-Hotels-Trianon-Bonita-Bay.h40858.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/110000000/109300000/109299300/109299203/a702090f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/110000000/109300000/109299300/109299203/54b129e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/110000000/109300000/109299300/109299203/f37d87d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/110000000/109300000/109299300/109299203/6a1456e5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Suites Fort Myers East I-75 [](https://www.expedia.ca/Fort-Myers-Hotels-Comfort-Suites.h109299203.Hotel-Information) Fort Myers 9.6/10 Exceptional (389 reviews) "Good hotel for the price " ![United Kingdom](https://a.travel-assets.com/egds/marks/flags/uk.svg) Paul CA $162 CA $181 total includes taxes & fees Feb 8 - Feb 9 [](https://www.expedia.ca/Fort-Myers-Hotels-Comfort-Suites.h109299203.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/17200/17131/5f870412.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/17200/17131/7cc18ae8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/17200/17131/42212932.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Non Smoking, Refrigerator & Microwave](https://images.trvl-media.com/lodging/1000000/20000/17200/17131/f6f6cea7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Fort Myers Inn & Suites [](https://www.expedia.ca/Fort-Myers-Hotels-Best-Western-Fort-Myers-Inn-Suites.h17131.Hotel-Information) Fort Myers 8.8/10 Excellent (1,136 reviews) "Clean room, old property and fresh, varied options for breakfast" ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) supriya CA $146 CA $162 total includes taxes & fees Feb 1 - Feb 2 [](https://www.expedia.ca/Fort-Myers-Hotels-Best-Western-Fort-Myers-Inn-Suites.h17131.Hotel-Information) ![View from room](https://images.trvl-media.com/lodging/1000000/10000/4900/4809/5633e2c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Condo](https://images.trvl-media.com/lodging/1000000/10000/4900/4809/71f6e520.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Condo | Private kitchen](https://images.trvl-media.com/lodging/1000000/10000/4900/4809/a04fe75c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/1000000/10000/4900/4809/f8a36bf8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Pointe Estero Beach Resort [](https://www.expedia.ca/Fort-Myers-Hotels-Pointe-Estero-Beach-Resort.h4809.Hotel-Information) South Island 9.2/10 Wonderful (1,003 reviews) "Nice place Clean rooms Friendly staff " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) SALMAN CA $399 CA $891 total includes taxes & fees Jan 28 - Jan 29 [](https://www.expedia.ca/Fort-Myers-Hotels-Pointe-Estero-Beach-Resort.h4809.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/20000/19100/19063/907bbde1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/1000000/20000/19100/19063/6322099c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, iron/ironing board, rollaway beds](https://images.trvl-media.com/lodging/1000000/20000/19100/19063/08ebead5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/20000/19100/19063/4d6357af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Bonita Springs Naples North [](https://www.expedia.ca/Naples-Hotels-Baymont-By-Wyndham-Bonita-Springs-Naples-North.h19063.Hotel-Information) Bonita Springs 8.0/10 Very good (1,015 reviews) "Was a good stay and good breakfast. " ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Erik CA $163 CA $181 total includes taxes & fees Jan 29 - Jan 30 [](https://www.expedia.ca/Naples-Hotels-Baymont-By-Wyndham-Bonita-Springs-Naples-North.h19063.Hotel-Information) ![Free continental breakfast on weekdays](https://images.trvl-media.com/lodging/2000000/1670000/1662000/1661939/dce1fc55.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, soundproofing, iron/ironing board](https://images.trvl-media.com/lodging/2000000/1670000/1662000/1661939/4739cec8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1670000/1662000/1661939/fa977bb2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, soundproofing, iron/ironing board](https://images.trvl-media.com/lodging/2000000/1670000/1662000/1661939/70be5c68.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Fort Myers - Colonial Blvd [](https://www.expedia.ca/Fort-Myers-Hotels-Hampton-Inn-Suites-Fort-Myers-Colonial-Blvd.h1661939.Hotel-Information) Fort Myers 9.4/10 Exceptional (1,001 reviews) "Great place to stay, will be back!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Douglas CA $201 CA $224 total includes taxes & fees Feb 8 - Feb 9 [](https://www.expedia.ca/Fort-Myers-Hotels-Hampton-Inn-Suites-Fort-Myers-Colonial-Blvd.h1661939.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-10&endDate=2026-02-11®ionId=9791&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Sanibel Hotel Reviews ![Sundial Beach Resort & Spa](https://images.trvl-media.com/lodging/1000000/10000/2000/1939/5481c209_y.jpg) ### Sundial Beach Resort & Spa 10/10 Excellent "Room was clean and was cleaned in the middle of our stay and staff was great." [](https://expedia.ca/Sanibel-Hotels-Sundial-Beach-Resort-Spa.h1939.Hotel-Information) ![Island Inn](https://images.trvl-media.com/lodging/2000000/1510000/1509800/1509747/57dffb5c_y.jpg) ### Island Inn 10/10 Excellent "Everything was wonderful." [](https://expedia.ca/Fort-Myers-Hotels-Island-Inn.h1509747.Hotel-Information) ![Casa Ybel Resort](https://images.trvl-media.com/lodging/2000000/1070000/1060300/1060289/33a6cafb_y.jpg) ### Casa Ybel Resort 10/10 Excellent "Clean rooms, great staff, beautiful view " [](https://expedia.ca/Fort-Myers-Hotels-Casa-Ybel-Resort.h1060289.Hotel-Information) ![Sanibel Island Beach Resort](https://images.trvl-media.com/lodging/18000000/17300000/17298900/17298818/w2247h1500x326y0-2ea06bb5_y.jpg) ### Sanibel Island Beach Resort 10/10 Excellent "Great beach access, pool side bar excellent. Best surprise was the bistro to get morning coffee and breakfast. Overall excelelnt hotel" [](https://expedia.ca/Fort-Myers-Hotels-Sanibel-Island-Beach-Resort.h17298818.Hotel-Information) ![Sanibel Inn](https://images.trvl-media.com/lodging/1000000/50000/40800/40711/55e96d4f_y.jpg) ### Sanibel Inn 10/10 Excellent "Clean, loved being right on the beach and the pool was great, the lanai was really nice…had to request a hair dryer, and one day I had to call to get the room cleaned by later in the afternoon. I thought $4 for a cup of coffee in the lobby while we were checking in after a full day of travel was a bit greedy especially because we paid a resort fee on top of a not cheap room rate. That could have and should have been complimentary. Bar food was great outside. Was here years ago, much upgraded and will definitely come again. " [](https://expedia.ca/Fort-Myers-Hotels-Sanibel-Inn.h40711.Hotel-Information) ![Kona Kai Motel](https://images.trvl-media.com/lodging/9000000/8080000/8078500/8078470/e1676e63_y.jpg) ### Kona Kai Motel 10/10 Excellent "It was clean and the staff was great!" [](https://expedia.ca/Sanibel-Hotels-Kona-Kai-Motel.h8078470.Hotel-Information) ## Frequently asked questions ### How much do business-friendly hotels in Sanibel cost? ### What are the best business-friendly hotels in Sanibel? ### How many business-friendly hotels are there in Sanibel? ### What are the best cheap business-friendly hotels in Sanibel? ### Are there any family-friendly hotels in Sanibel that are also business friendly? ### Why book your business-friendly hotel in Sanibel with Expedia? ### How can I find cheap business-friendly hotels in Sanibel? ### What is there to do in Sanibel near my business-friendly hotel? ## Explore a world of travel with Expedia - Lodging - More ways to book - [Cheap Hotels in Downtown Fort Myers Beach ](https://www.expedia.ca/Downtown-Fort-Myers-Beach-Fort-Myers-Beach-Hotels-Cheap-Hotels.0-n904326898430316544-0-tCheapHotels.Travel-Guide-Filter-Hotels) - [Golf Hotels in Downtown Fort Myers Beach ](https://www.expedia.ca/Downtown-Fort-Myers-Beach-Fort-Myers-Beach-Hotels-Golf-Hotel.0-n904326898430316544-0-tGolfHotel.Travel-Guide-Filter-Hotels) - 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