Title: 10 Best Hotels in Sanctuary, Sanibel for 2025 | Expedia.ca [Vacation Rentals in Sanibel](https://expedia.ca/Sanibel-Vacation-Rentals.d9791.Travel-Guide-VacationRentals)[Flights to Sanibel](https://expedia.ca/Cheap-Flights-To-Sanibel.d9791.Travel-Guide-Flights)[Things to do in Sanibel](https://expedia.ca/Things-To-Do-In-Sanibel.d9791.Travel-Guide-Activities)[Sanctuary Car Rentals](https://expedia.ca/Car-Rentals-In-Sanctuary.d553248635976469368.Car-Rental-Guide)[Sanctuary Vacations](https://expedia.ca/Sanctuary.d553248635976469368.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Hotels in Sanctuary, Sanibel ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in Sanctuary Apart hotel [](https://www.expedia.ca/Hotel-Search?destination=Sanctuary%2C+Wulfert%2C+Florida%2C+United+States+of+America®ionId=553248635976469368&latLong=26.482284%2C-82.168264&adults=2&startDate=2025-10-10&d1=2025-10-10&endDate=2025-10-12&d2=2025-10-12&lodging=APART_HOTEL) Spa [](https://www.expedia.ca/Hotel-Search?destination=Sanctuary%2C+Wulfert%2C+Florida%2C+United+States+of+America®ionId=553248635976469368&latLong=26.482284%2C-82.168264&adults=2&startDate=2025-10-10&d1=2025-10-10&endDate=2025-10-12&d2=2025-10-12&amenities=SPA_ON_SITE) Family friendly [](https://www.expedia.ca/Hotel-Search?destination=Sanctuary%2C+Wulfert%2C+Florida%2C+United+States+of+America®ionId=553248635976469368&latLong=26.482284%2C-82.168264&adults=2&startDate=2025-10-10&d1=2025-10-10&endDate=2025-10-12&d2=2025-10-12&travelerType=family_friendly) Resort [](https://www.expedia.ca/Hotel-Search?destination=Sanctuary%2C+Wulfert%2C+Florida%2C+United+States+of+America®ionId=553248635976469368&latLong=26.482284%2C-82.168264&adults=2&startDate=2025-10-10&d1=2025-10-10&endDate=2025-10-12&d2=2025-10-12&lodging=HOTEL_RESORT) Pool [](https://www.expedia.ca/Hotel-Search?destination=Sanctuary%2C+Wulfert%2C+Florida%2C+United+States+of+America®ionId=553248635976469368&latLong=26.482284%2C-82.168264&adults=2&startDate=2025-10-10&d1=2025-10-10&endDate=2025-10-12&d2=2025-10-12&amenities=POOL) Ocean view [](https://www.expedia.ca/Hotel-Search?destination=Sanctuary%2C+Wulfert%2C+Florida%2C+United+States+of+America®ionId=553248635976469368&latLong=26.482284%2C-82.168264&adults=2&startDate=2025-10-10&d1=2025-10-10&endDate=2025-10-12&d2=2025-10-12&amenities=OCEAN_VIEW) Hot tub [](https://www.expedia.ca/Hotel-Search?destination=Sanctuary%2C+Wulfert%2C+Florida%2C+United+States+of+America®ionId=553248635976469368&latLong=26.482284%2C-82.168264&adults=2&startDate=2025-10-10&d1=2025-10-10&endDate=2025-10-12&d2=2025-10-12&amenities=HOT_TUB) Apart­ment [](https://www.expedia.ca/Hotel-Search?destination=Sanctuary%2C+Wulfert%2C+Florida%2C+United+States+of+America®ionId=553248635976469368&latLong=26.482284%2C-82.168264&adults=2&startDate=2025-10-10&d1=2025-10-10&endDate=2025-10-12&d2=2025-10-12&lodging=APARTMENT) Cottage [](https://www.expedia.ca/Hotel-Search?destination=Sanctuary%2C+Wulfert%2C+Florida%2C+United+States+of+America®ionId=553248635976469368&latLong=26.482284%2C-82.168264&adults=2&startDate=2025-10-10&d1=2025-10-10&endDate=2025-10-12&d2=2025-10-12&lodging=COTTAGE) Condo [](https://www.expedia.ca/Hotel-Search?destination=Sanctuary%2C+Wulfert%2C+Florida%2C+United+States+of+America®ionId=553248635976469368&latLong=26.482284%2C-82.168264&adults=2&startDate=2025-10-10&d1=2025-10-10&endDate=2025-10-12&d2=2025-10-12&lodging=CONDO) Waterpark [](https://www.expedia.ca/Hotel-Search?destination=Sanctuary%2C+Wulfert%2C+Florida%2C+United+States+of+America®ionId=553248635976469368&latLong=26.482284%2C-82.168264&adults=2&startDate=2025-10-10&d1=2025-10-10&endDate=2025-10-12&d2=2025-10-12&amenities=WATER_PARK) Villa [](https://www.expedia.ca/Hotel-Search?destination=Sanctuary%2C+Wulfert%2C+Florida%2C+United+States+of+America®ionId=553248635976469368&latLong=26.482284%2C-82.168264&adults=2&startDate=2025-10-10&d1=2025-10-10&endDate=2025-10-12&d2=2025-10-12&lodging=VILLA) ## Check prices for these dates Tonight [Sep 26 - Sep 27](https://www.expedia.ca/Hotel-Search?regionId=553248635976469368&startDate=2025-09-26&endDate=2025-09-27&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Sep 27 - Sep 28](https://www.expedia.ca/Hotel-Search?regionId=553248635976469368&startDate=2025-09-27&endDate=2025-09-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Sep 26 - Sep 28](https://www.expedia.ca/Hotel-Search?regionId=553248635976469368&startDate=2025-09-26&endDate=2025-09-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 3 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=553248635976469368&startDate=2025-10-03&endDate=2025-10-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Recommended Price (low to high) Distance Star rating ## Sanctuary hotels and places to stay ![On the beach, white sand, kayaking, motor boating](https://images.trvl-media.com/lodging/1000000/10000/3100/3079/ac9a3a07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/10000/3100/3079/89736118.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, 3 outdoor pools, cabanas (surcharge), pool umbrellas](https://images.trvl-media.com/lodging/1000000/10000/3100/3079/17d9d33f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Water view](https://images.trvl-media.com/lodging/1000000/10000/3100/3079/4914d2c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Marriott Sanibel Harbour Resort & Spa 15.6 km from Sanctuary 8.4/10 Very good (1014) "Love the pool" CA $236 CA $298 total includes taxes & fees Sep 29 - Sep 30 [](https://www.expedia.ca/Fort-Myers-Hotels-Marriott-Sanibel-Harbour-Resort-Spa.h3079.Hotel-Information) ![Deluxe Studio, 1 King Bed, Marina View | View from room](https://images.trvl-media.com/lodging/17000000/16660000/16651900/16651890/bde78c89.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Superior Suite, Kitchen, Pool View | Living area](https://images.trvl-media.com/lodging/17000000/16660000/16651900/16651890/e75bb4c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bicycling](https://images.trvl-media.com/lodging/17000000/16660000/16651900/16651890/e693cbff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/17000000/16660000/16651900/16651890/w1995h1500x652y0-ac9ecb97.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Latitude 26 Waterfront Boutique Resort - Fort Myers Beach 21.5 km from Sanctuary 8.8/10 Excellent (1007) "This place is a gem! Rooms are so cute and the beach vibe is wonderful. Staff is very friendly and so accommodating. Looking forward to staying again." CA $129 CA $144 total includes taxes & fees Sep 28 - Sep 29 [](https://www.expedia.ca/Fort-Myers-Hotels-Latitude-26-Waterfront-Boutique-Resort-Fort-Myers-Beach.h16651890.Hotel-Information) ![Interior entrance](https://images.trvl-media.com/lodging/1000000/430000/421600/421546/0be36f55.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/430000/421600/421546/693ea816.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/430000/421600/421546/98f0aac3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/430000/421600/421546/a06607fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Allure Suites 27.2 km from Sanctuary 7.6/10 Good (1004) "I like my stays here. Super quiet. Rooms are big. Nice pool & heated hot tub. " CA $79 CA $89 total includes taxes & fees Oct 27 - Oct 28 [](https://www.expedia.ca/Fort-Myers-Hotels-Allure-Suites.h421546.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/3000000/2630000/2625800/2625745/83cb6bb9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/3000000/2630000/2625800/2625745/5f2e6784.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/3000000/2630000/2625800/2625745/2c14a98f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/3000000/2630000/2625800/2625745/432e75cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Residence Inn by Marriott Fort Myers Sanibel 19.3 km from Sanctuary 8.6/10 Excellent (1005) "We loved the staff attitude and the excellent breakfast." CA $121 CA $135 total includes taxes & fees Sep 27 - Sep 28 [](https://www.expedia.ca/Fort-Myers-Hotels-Residence-Inn-By-Marriott-Fort-Myers-Sanibel.h2625745.Hotel-Information) ![Aerial view](https://images.trvl-media.com/lodging/1000000/210000/200700/200632/814c4388.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/210000/200700/200632/c9ca07cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Beach bar](https://images.trvl-media.com/lodging/1000000/210000/200700/200632/e5cac435.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/1000000/210000/200700/200632/2fcdc994.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### DiamondHead Beach Resort 22.3 km from Sanctuary 9.0/10 Wonderful (1011) "Beach area around the property was great and the easy access was really nice." CA $210 CA $289 total includes taxes & fees Oct 27 - Oct 28 [](https://www.expedia.ca/Fort-Myers-Hotels-DiamondHead-Beach-Resort.h200632.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/50000000/49160000/49152700/49152700/a69cd385.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/50000000/49160000/49152700/49152700/9ecc1017.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/50000000/49160000/49152700/49152700/088bfb58.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/50000000/49160000/49152700/49152700/798de6a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG 23.1 km from Sanctuary 9.4/10 Exceptional (1004) "Easy to get to, easy check in, pleasant staff, good breakfast, easy checkout, clean rooms." CA $127 CA $141 total includes taxes & fees Sep 28 - Sep 29 [](https://www.expedia.ca/Fort-Myers-Hotels-Holiday-Inn-Express-Suites-Ft-Myers-Beach-Sanibel-Gateway.h49152700.Hotel-Information) ![View from room](https://images.trvl-media.com/lodging/93000000/92430000/92421800/92421769/ead25301.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Condo, 2 Bedrooms, Patio (waterview) | Private kitchen](https://images.trvl-media.com/lodging/93000000/92430000/92421800/92421769/1f1c096d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Condo, 1 Bedroom, Patio | Living area](https://images.trvl-media.com/lodging/93000000/92430000/92421800/92421769/5e014075.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Condo, 2 Bedrooms, Balcony (waterview) | Private kitchen](https://images.trvl-media.com/lodging/93000000/92430000/92421800/92421769/ed0e988e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Matlacha on Shoreview 20.2 km from Sanctuary 9.6/10 Exceptional (196) "Lovely little propery for the price!" CA $124 CA $240 total includes taxes & fees Sep 28 - Sep 29 [](https://www.expedia.ca/Cape-Coral-Hotels-Matlacha-At-Shoreview.h92421769.Hotel-Information) ![Suite with King Bed, Beachfront, Balcony | Terrace/patio](https://images.trvl-media.com/lodging/1000000/440000/438800/438796/b5b17142.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/440000/438800/438796/767ba460.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite with Two Doubles, Beachfront, Balcony](https://images.trvl-media.com/lodging/1000000/440000/438800/438796/2e8856cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Beachfront, Balcony, Two Doubles](https://images.trvl-media.com/lodging/1000000/440000/438800/438796/de245384.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lani Kai Beachfront Resort 21.8 km from Sanctuary 8.8/10 Excellent (1051) "All around great place to stay. " CA $138 CA $186 total includes taxes & fees Sep 28 - Sep 29 [](https://www.expedia.ca/Fort-Myers-Hotels-Lani-Kai-Beachfront-Resort.h438796.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/11200/11134/b06bf9be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/11200/11134/dd5699df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/11200/11134/4ec8c9b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/11200/11134/w3000h1997x0y3-c76bf6b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway 19.9 km from Sanctuary 8.0/10 Very good (1006) "Just a great place to stay on any getaway vacation " CA $110 CA $123 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Fort-Myers-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Ft-Myers-Sanibel-Gateway.h11134.Hotel-Information) ![Outdoor pool, open 8:00 AM to 10:00 PM, pool umbrellas](https://images.trvl-media.com/lodging/1000000/560000/551900/551886/8158a459.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/560000/551900/551886/e94c2dc1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 Queen Beds Study with Patio](https://images.trvl-media.com/lodging/1000000/560000/551900/551886/ea38270a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![42-inch LCD TV with cable channels, TV](https://images.trvl-media.com/lodging/1000000/560000/551900/551886/16da23a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway 22.9 km from Sanctuary 8.4/10 Very good (1010) "Great stay - really friendly staff" CA $129 CA $144 total includes taxes & fees Oct 5 - Oct 6 [](https://www.expedia.ca/Fort-Myers-Beach-Hotels-Hampton-Inn-Suites-Fort-Myers-BeachSanibel-Gateway.h551886.Hotel-Information) ![Apartment, Multiple Beds, Partial Ocean View | Beach/ocean view](https://images.trvl-media.com/lodging/12000000/11760000/11753200/11753200/fb0b7d7c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio, 1 Queen Bed, Partial Ocean View](https://images.trvl-media.com/lodging/12000000/11760000/11753200/11753200/96081da3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Apartment, Multiple Beds, Beach View | Living room](https://images.trvl-media.com/lodging/12000000/11760000/11753200/11753200/1081c4bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Apartment, 2 Bedrooms, Partial Ocean View](https://images.trvl-media.com/lodging/12000000/11760000/11753200/11753200/b348cef3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Edison Beach House 21.2 km from Sanctuary 9.4/10 Exceptional (1503) "Right on the beach and there are several shops and restaurants/bars with in close walking distance! " CA $179 CA $199 total includes taxes & fees Sep 28 - Sep 29 [](https://www.expedia.ca/Fort-Myers-Hotels-Edison-Beach-House.h11753200.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/850000/848800/848740/d8bd559a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/850000/848800/848740/044ddbbe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/850000/848800/848740/24e2211e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/850000/848800/848740/030c0a00.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Garden Inn Ft Myers 29.5 km from Sanctuary 8.6/10 Excellent (1018) "Staff is always helpful and place is always clean and quiet " CA $161 CA $179 total includes taxes & fees Oct 5 - Oct 6 [](https://www.expedia.ca/Fort-Myers-Hotels-Hilton-Garden-Inn-Ft-Myers.h848740.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/3000000/2300000/2292900/2292854/13e65390.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/3000000/2300000/2292900/2292854/7ac551f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/3000000/2300000/2292900/2292854/551a1a6a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/3000000/2300000/2292900/2292854/407fdb8d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Candlewood Suites Fort Myers Sanibel Gateway by IHG 25.4 km from Sanctuary 7.4/10 Good (1005) "It was a great place to stay" CA $106 CA $118 total includes taxes & fees Sep 28 - Sep 29 [](https://www.expedia.ca/Fort-Myers-Hotels-Candlewood-Suites-Fort-Myers-Sanibel-Gateway.h2292854.Hotel-Information) ![Outdoor pool, open 8:00 AM to 10:00 PM, cabanas (surcharge)](https://images.trvl-media.com/lodging/3000000/2730000/2721900/2721880/d961205e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Bedrooms, Non Smoking, River View (Balcony)](https://images.trvl-media.com/lodging/3000000/2730000/2721900/2721880/43311ff7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/3000000/2730000/2721900/2721880/b069fb2c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/3000000/2730000/2721900/2721880/4aba0d83.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Westin Cape Coral Resort At Marina Village 18.1 km from Sanctuary 9.0/10 Wonderful (1009) "It was absolutely a beautiful place!!!" CA $188 CA $263 total includes taxes & fees Sep 30 - Oct 1 [](https://www.expedia.ca/Fort-Myers-Hotels-The-Westin-Cape-Coral-Resort-At-Marina-Village.h2721880.Hotel-Information) ![Free buffet breakfast](https://images.trvl-media.com/lodging/1000000/30000/26900/26860/ab39b98c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/1000000/30000/26900/26860/3133721f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/26900/26860/3e67f3c3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/1000000/30000/26900/26860/42ce38d8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Cape Coral-Fort Myers Area by IHG 23.9 km from Sanctuary 9.2/10 Wonderful (1021) "Very nice place to stay " CA $149 CA $166 total includes taxes & fees Sep 28 - Sep 29 [](https://www.expedia.ca/Fort-Myers-Hotels-Holiday-Inn-Express-Cape-Coral-Fort-Myers-Area.h26860.Hotel-Information) ![Porch](https://images.trvl-media.com/lodging/12000000/11120000/11110800/11110703/2cabf1c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/12000000/11120000/11110800/11110703/a7182fcd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/12000000/11120000/11110800/11110703/fa05a99b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/12000000/11120000/11110800/11110703/5d80acb0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Angler's Inn 18.8 km from Sanctuary 9.4/10 Exceptional (317) "Really enjoyed everything about this stay." CA $194 CA $217 total includes taxes & fees Oct 9 - Oct 10 [](https://www.expedia.ca/Fort-Myers-Hotels-Anglers-Inn.h11110703.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/18000000/17300000/17298900/17298818/w2247h1500x326y0-2ea06bb5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![On the beach, sun loungers, beach towels](https://images.trvl-media.com/lodging/18000000/17300000/17298900/17298818/6b3a0fb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![On the beach, sun loungers, beach towels](https://images.trvl-media.com/lodging/18000000/17300000/17298900/17298818/86e902b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/18000000/17300000/17298900/17298818/2ab8abc8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sanibel Island Beach Resort 13.1 km from Sanctuary 9.0/10 Wonderful (1334) "Excellent stay great staff and excellent location. " CA $274 CA $341 total includes taxes & fees Oct 27 - Oct 28 [](https://www.expedia.ca/Fort-Myers-Hotels-Sanibel-Island-Beach-Resort.h17298818.Hotel-Information) ![2 outdoor pools](https://images.trvl-media.com/lodging/1000000/810000/800800/800715/w2800h1779x0y3-dbc2bfa3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Signature Cottage, 1 Queen Bed, Canal View | View from room](https://images.trvl-media.com/lodging/1000000/810000/800800/800715/w1978h1500x461y0-e23a57cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Offshore King Suite(Family Friendly, Not Pet Friendly)](https://images.trvl-media.com/lodging/1000000/810000/800800/800715/a8b337e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/1000000/810000/800800/800715/35893057.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Lighthouse Resort Inn & Suites 21.5 km from Sanctuary 8.6/10 Excellent (1508) "The staff was very friendly and helpful. " CA $139 CA $183 total includes taxes & fees Oct 5 - Oct 6 [](https://www.expedia.ca/Fort-Myers-Hotels-The-Lighthouse-Resort-Inn-Suites.h800715.Hotel-Information) ![Outdoor pool, open 7:30 AM to 9:30 PM, free cabanas, sun loungers](https://images.trvl-media.com/lodging/6000000/5110000/5107300/5107225/08406205.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Floating Coconut Cottage Houseboat](https://images.trvl-media.com/lodging/6000000/5110000/5107300/5107225/0badd225.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/6000000/5110000/5107300/5107225/91630e70.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/6000000/5110000/5107300/5107225/85d353d3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Latitude 26 Waterfront Resort & Marina 22 km from Sanctuary 8.6/10 Excellent (883) "Great place the property is older but well maintained. Pool was great free kayaks and bikes are neat! The breakfast was decent… Overall would recommend and will likely be back! The staff was also fantastic super laid back great little off fort Myers beach off season spot!" CA $129 CA $144 total includes taxes & fees Sep 28 - Sep 29 [](https://www.expedia.ca/Fort-Myers-Hotels-Tip-Top-Isles-Waterfront-Resort-Marina.h5107225.Hotel-Information) ![Bar (on property)](https://images.trvl-media.com/lodging/3000000/2670000/2665100/2665085/fc463bf9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Aerial view](https://images.trvl-media.com/lodging/3000000/2670000/2665100/2665085/a62366ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fishing](https://images.trvl-media.com/lodging/3000000/2670000/2665100/2665085/6e3a1f40.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/3000000/2670000/2665100/2665085/2a7931b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Matanzas Inn Bayside Resort and Marina 21.6 km from Sanctuary 9.2/10 Wonderful (1004) "Was a great place to stay! " CA $149 CA $201 total includes taxes & fees Sep 28 - Sep 29 [](https://www.expedia.ca/Fort-Myers-Hotels-Matanzas-Inn-Bayside-Resort-And-Marina.h2665085.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-10&endDate=2025-10-11®ionId=553248635976469368&adults=2&sort=RECOMMENDED&openPlayBack=true) ## Where to stay in Sanctuary Find the best Sanctuary areas and neighborhoods for the activities you enjoy most. - Beachview Country Club Estates - Shell Harbor - The Dunes - Del Sega - Ybel ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/496000/496031-periwinkle-way.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/496000/496033-southwest-coast-florida.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/496000/496099-periwinkle-way.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/496000/496100-periwinkle-way.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/496000/496067-periwinkle-way.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) [](https://www.expedia.ca/Hotel-Search?pwaOverlay=map®ionId=553248635976658737) ![Beachview Country Club Estates map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:_xi%60DnhzsN%7DF%7BKm%40qJo%60%40YcFeQsIGkFm%5BlPuIpCdJpU%3Fh%40cBhAh%40vCwAve%40zjAuVH&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=ESs5On7VSCxf11tjGccNpqYAiLA=) ### Beachview Country Club Estates If you're spending some time in Beachview Country Club Estates, Periwinkle Way and Sanibel Island Golf Club are top sights worth seeing. [See properties](https://www.expedia.ca/Hotel-Search?regionId=553248635976658737) [](https://www.expedia.ca/Hotel-Search?pwaOverlay=map®ionId=553248635976472731) ![Shell Harbor map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:ank%60DjcvsNaa%40c%40wAuGuDr%40yQeEJ%7DG%7CBuSnIh%40hAm%40nBtLx_%40m%40pGbZUvC&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=Ok2HLY1wE0-WmxsF8vs3E2SMAAU=) ### Shell Harbor Though Shell Harbor might not have many top sights, you can venture to the surrounding area to see attractions like Bailey's Beach and Sanibel Sea School. [See properties](https://www.expedia.ca/Hotel-Search?regionId=553248635976472731) [](https://www.expedia.ca/Hotel-Search?pwaOverlay=map®ionId=553248635976473424) ![The Dunes map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:gvl%60DjqysN%5Dc%40GmTiDmA%5DaKsAO_%40%60%40FnJUXoQGiJlEm%40%3F%7DEyCuX%3FWYNcW%5Ck%40jTOdAc%40%7ED_d%40rHkH%7CEqJ%7C%40q%40%7CWtE%5E%60%40_%40tAcHX%5Dj%40F%60S%5Cj%40zHF%5C%60%40fE%60V%60CXd%40j%40FvQ%3FzD%5Db%40kB%3F%5D%60%40%3FtTWX_EH&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=J2BYwBtUd-FDrooHxBGaemfIbgk=) ### The Dunes When in The Dunes, you can plan a visit to Dunes Golf and Tennis Club and Bailey's Beach, some noteworthy sights in the nearby area. [See properties](https://www.expedia.ca/Hotel-Search?regionId=553248635976473424) [](https://www.expedia.ca/Hotel-Search?pwaOverlay=map®ionId=553248635976469672) ![Del Sega map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:ins%60D%60%60rtNRuC%60FkApAcBiAmBaGeBuReMf%40qEhG_%40zGvD%60KcBbC%7DDpFj%40tBkDdFy%40FjSiGhTeFnD_QN&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=8wBDgrT9XJBz0HFjTO9pBW-DTr0=) ### Del Sega If you're spending some time in Del Sega, Blind Pass Beach and J. N. Ding Darling National Wildlife Refuge are top sights worth seeing. [See properties](https://www.expedia.ca/Hotel-Search?regionId=553248635976469672) ![](https://mediaim.expedia.com/destination/1/a6c0ed9b6d24d6c6ad71ca0a3d8d9a0a.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) [](https://www.expedia.ca/Hotel-Search?pwaOverlay=map®ionId=553248635975848029) ![Ybel map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:u_h%60Df%7B%7CsNcFmNz%40cJ%7EJ_BrBpM%7C%40pMiKL&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=lppEfM3B3u_ovP_atAAdnm6cPW0=) ### Ybel While Ybel might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Sanibel Island Southern Beach and Periwinkle Way. [See properties](https://www.expedia.ca/Hotel-Search?regionId=553248635975848029) ## Top Sanctuary Hotel Reviews ![DiamondHead Beach Resort](//images.trvl-media.com/lodging/1000000/210000/200700/200632/814c4388_y.jpg) ### DiamondHead Beach Resort 10/10 Excellent "Overall very pleasant experience " [](https://expedia.ca/Fort-Myers-Hotels-DiamondHead-Beach-Resort.h200632.Hotel-Information) ![Margaritaville Beach Resort Fort Myers ](//images.trvl-media.com/lodging/96000000/95130000/95127000/95126992/w3998h2821x0y0-a77e6574_y.jpg) ### Margaritaville Beach Resort Fort Myers 10/10 Excellent "It was great! " [](https://expedia.ca/Fort-Myers-Beach-Hotels-Margaritaville-Beach-Resort-Fort-Myers.h95126992.Hotel-Information) ![Sanibel Island Beach Resort](//images.trvl-media.com/lodging/18000000/17300000/17298900/17298818/w2247h1500x326y0-2ea06bb5_y.jpg) ### Sanibel Island Beach Resort 10/10 Excellent "Beach access, rooms clean. Had a family with small children next to our room. If the stay is for adults only, maybe put families in another area or adults too." [](https://expedia.ca/Fort-Myers-Hotels-Sanibel-Island-Beach-Resort.h17298818.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway](//images.trvl-media.com/lodging/1000000/20000/11200/11134/b06bf9be_y.jpg) ### La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway 10/10 Excellent "Newly renovated property just finishing the last upgrades like new exterior tiles. Lobby was spacious, staff helpful & check in prompt. Room was newly upgraded, excellent WiFi, great pool and breakfast was outstanding continental with hot options like sausages, scrambled egg, omelettes and waffle maker. Overall a great stay and would stay again." [](https://expedia.ca/Fort-Myers-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Ft-Myers-Sanibel-Gateway.h11134.Hotel-Information) ![Lani Kai Beachfront Resort](//images.trvl-media.com/lodging/1000000/440000/438800/438796/b5b17142_y.jpg) ### Lani Kai Beachfront Resort 10/10 Excellent "Love the property, parking not so much. " [](https://expedia.ca/Fort-Myers-Hotels-Lani-Kai-Beachfront-Resort.h438796.Hotel-Information) ![Doubletree by Hilton Fort Myers at Bell Tower Shops](//images.trvl-media.com/lodging/1000000/20000/12400/12375/704cf90c_y.jpg) ### Doubletree by Hilton Fort Myers at Bell Tower Shops 10/10 Excellent "Great location. " [](https://expedia.ca/Fort-Myers-Hotels-Doubletree-By-Hilton-Fort-Myers-At-Bell-Tower-Shops.h12375.Hotel-Information) ![Pink Shell Beach Resort and Marina](//images.trvl-media.com/lodging/1000000/20000/15700/15603/5f038ed2_y.jpg) ### Pink Shell Beach Resort and Marina 10/10 Excellent "Great place to stay. Town is a 10 minute walk with Tram and golf cart if you prefer not to walk. Events for the kids every morning. Italian restaurant on property is delicious. Plenty of other food options so you don’t need to leave. " [](https://expedia.ca/Fort-Myers-Hotels-Pink-Shell-Beach-Resort-And-Marina.h15603.Hotel-Information) ![Holiday Inn Express Cape Coral-Fort Myers Area by IHG](//images.trvl-media.com/lodging/1000000/30000/26900/26860/ab39b98c_y.jpg) ### Holiday Inn Express Cape Coral-Fort Myers Area by IHG 10/10 Excellent "I found our room clean and very comfortable. Enjoyed the balcony in the evenings. Breakfast was great! Everyone was very friendly." [](https://expedia.ca/Fort-Myers-Hotels-Holiday-Inn-Express-Cape-Coral-Fort-Myers-Area.h26860.Hotel-Information) ![Hilton Garden Inn Ft Myers](//images.trvl-media.com/lodging/1000000/850000/848800/848740/d8bd559a_y.jpg) ### Hilton Garden Inn Ft Myers 10/10 Excellent "Safe, quiet, and clean" [](https://expedia.ca/Fort-Myers-Hotels-Hilton-Garden-Inn-Ft-Myers.h848740.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - More ways to book - [Hotels near Alison Hagerup Beach Park](https://www.expedia.ca/Alison-Hagerup-Beach-Park-Hotels.0-l6182809-0.Travel-Guide-Filter-Hotels) - [Hotels near Bailey - Matthews Shell Museum](https://www.expedia.ca/Bailey-Matthews-Shell-Museum-Hotels.0-l6123901-0.Travel-Guide-Filter-Hotels) - [Hotels near Bowman's Beach](https://www.expedia.ca/Bowmans-Beach-Hotels.0-l6296151-0.Travel-Guide-Filter-Hotels) - [Bright Water Hotels](https://www.expedia.ca/Bright-Water-Sanibel-Hotels.0-n553248635976473851-0.Travel-Guide-Filter-Hotels) - 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[Hotels with a Lazy River in Gulf Shores](https://www.expedia.ca/Gulf-Shores-Sanibel-Hotels-Hotels-With-A-Lazy-River.0-n553248635976479667-0-tHotelswithaLazyRiver.Travel-Guide-Filter-Hotels) - [Hotels with an Indoor Pool in Gulf Shores](https://www.expedia.ca/Gulf-Shores-Sanibel-Hotels-Hotels-With-Indoor-Pool.0-n553248635976479667-0-tHotelswithIndoorPool.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Gulf Shores](https://www.expedia.ca/Gulf-Shores-Sanibel-Hotels-Pet-Friendly-Hotel.0-n553248635976479667-0-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Gulf Shores Hotels](https://www.expedia.ca/Gulf-Shores-Sanibel-Hotels.0-n553248635976479667-0.Travel-Guide-Filter-Hotels) - [Gumbo Limbo Hotels](https://www.expedia.ca/Gumbo-Limbo-Sanibel-Hotels.0-n553248635976480905-0.Travel-Guide-Filter-Hotels) - [Hotels near J. N. Ding Darling National Wildlife Refuge](https://www.expedia.ca/J-N-Ding-Darling-National-Wildlife-Refuge-Hotels.0-l6123903-0.Travel-Guide-Filter-Hotels) - [Hotels near Jensen’s Marina](https://www.expedia.ca/Jensens-Marina-Hotels.0-l553248621533115710-0.Travel-Guide-Filter-Hotels) - [Manatee Bay Hotels](https://www.expedia.ca/Manatee-Bay-Saint-James-City-Hotels.0-n553248635976473614-0.Travel-Guide-Filter-Hotels) - [Hotels near North Captiva Island Beach](https://www.expedia.ca/North-Captiva-Island-Beach-Hotels.0-l553248635976197835-0.Travel-Guide-Filter-Hotels) - [Hotels near Periwinkle Way](https://www.expedia.ca/Periwinkle-Way-Hotels.0-l6298863-0.Travel-Guide-Filter-Hotels) - [Pine Island Hotels](https://www.expedia.ca/Pine-Island-Hotels.d553248635083900600.Travel-Guide-Hotels) - [Safety Harbor Club Hotels](https://www.expedia.ca/Safety-Harbor-Club-Captiva-Hotels.0-n553248635976659096-0.Travel-Guide-Filter-Hotels) - [Saint James City Hotels](https://www.expedia.ca/Saint-James-City-Hotels.d6355652.Travel-Guide-Hotels) - [Hotels near Sanibel and Captiva Island Visitor's Center](https://www.expedia.ca/Sanibel-And-Captiva-Island-Visitors-Center-Hotels.0-l6295955-0.Travel-Guide-Filter-Hotels) - [Sanibel Captiva Island Hotels](https://www.expedia.ca/Sanibel-Captiva-Island-Hotels.d6326115.Travel-Guide-Hotels) - [Sanibel Harbours Hotels](https://www.expedia.ca/Sanibel-Harbours-Sanibel-Hotels.0-n553248635976473632-0.Travel-Guide-Filter-Hotels) - [Hotels near Sanibel Island Southern Beach](https://www.expedia.ca/Sanibel-Island-Southern-Beach-Hotels.0-l553248635976194887-0.Travel-Guide-Filter-Hotels) - [Sanibel Isles Hotels](https://www.expedia.ca/Sanibel-Isles-Sanibel-Hotels.0-n553248635976477245-0.Travel-Guide-Filter-Hotels) - [Shell Harbor Hotels](https://www.expedia.ca/Shell-Harbor-Sanibel-Hotels.0-n553248635976472731-0.Travel-Guide-Filter-Hotels) - [The Dunes Hotels](https://www.expedia.ca/The-Dunes-Sanibel-Hotels.0-n553248635976473424-0.Travel-Guide-Filter-Hotels) - [Adults Only Resorts & in Tradewinds](https://www.expedia.ca/Tradewinds-Sanibel-Hotels-Adults-Only-Resorts.0-n553248635976472762-0-tAdultsOnlyResorts.Travel-Guide-Filter-Hotels) - [All Inclusive Resorts and in Tradewinds](https://www.expedia.ca/Tradewinds-Sanibel-Hotels-All-Inclusive-Hotel.0-n553248635976472762-0-tAllInclusiveHotel.Travel-Guide-Filter-Hotels) - [Beach Hotel Hotels in Tradewinds](https://www.expedia.ca/Tradewinds-Sanibel-Hotels-Beach-Hotel.0-n553248635976472762-0-tBeachHotel.Travel-Guide-Filter-Hotels) - [Hotels & Resorts for Couples in Tradewinds](https://www.expedia.ca/Tradewinds-Sanibel-Hotels-Couples-Resorts-Hotels.0-n553248635976472762-0-tCouplesResortsHotels.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Tradewinds](https://www.expedia.ca/Tradewinds-Sanibel-Hotels-Luxury-Hotel.0-n553248635976472762-0-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Tradewinds](https://www.expedia.ca/Tradewinds-Sanibel-Hotels-Pet-Friendly-Hotel.0-n553248635976472762-0-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Tradewinds Hotels](https://www.expedia.ca/Tradewinds-Sanibel-Hotels.0-n553248635976472762-0.Travel-Guide-Filter-Hotels) - [Hotels near Turner Beach](https://www.expedia.ca/Turner-Beach-Hotels.0-l6182811-0.Travel-Guide-Filter-Hotels) - [Flights to Captiva Island](https://www.expedia.ca/Cheap-Flights-To-Captiva-Island.d553248635083900531.Travel-Guide-Flights) - [Bowman's Beach](https://www.expedia.ca/Bowmans-Beach-Sanibel.d6296151.Vacation-Attraction) - [Captiva Island Vacations](https://www.expedia.ca/Captiva-Island.d553248635083900531.Destination-Travel-Guides) - [Visit Captiva Island](https://www.expedia.ca/Captiva-Island.dx553248635083900531) - [Captiva Vacations](https://www.expedia.ca/Captiva.d86452.Destination-Travel-Guides) - [Visit Captiva](https://www.expedia.ca/Captiva.dx86452) - [J. N. Ding Darling National Wildlife Refuge](https://www.expedia.ca/J-N-Ding-Darling-National-Wildlife-Refuge-Sanibel.d6123903.Vacation-Attraction) - [Mccarthy's Marina](https://www.expedia.ca/McCarthys-Marina-Captiva.d6182960.Vacation-Attraction) - [Visit Sanibel Captiva Island](https://www.expedia.ca/Sanibel-Captiva-Island.dx6326115) - [Visit Wulfert](https://www.expedia.ca/Wulfert.dx3000748774) - [Car rentals near Captiva Island](https://www.expedia.ca/Car-Rentals-In-Captiva-Island.d553248635083900531.Car-Rental-Guide) - [Car rental Captiva](https://www.expedia.ca/Car-Rentals-In-Captiva.d86452.Car-Rental-Guide) - [Discount Car Rentals Rental Cars in Captiva Island](https://www.expedia.ca/Discount-Car-Rentals-Car-Rentals-In-Captiva-Island.d553248635083900531-c11.Car-Rental-Guide-Suppliers) - [Dollar Rental Cars in Captiva Island](https://www.expedia.ca/Dollar-Car-Rentals-In-Captiva-Island.d553248635083900531-c1091.Car-Rental-Guide-Suppliers) - [Foco Rental Cars in Captiva Island](https://www.expedia.ca/Foco-Car-Rentals-In-Captiva-Island.d553248635083900531-c1111.Car-Rental-Guide-Suppliers) - [Hertz Rental Cars in Captiva Island](https://www.expedia.ca/Hertz-Car-Rentals-In-Captiva-Island.d553248635083900531-c40.Car-Rental-Guide-Suppliers) - [Hertz Rental Cars in Captiva](https://www.expedia.ca/Hertz-Car-Rentals-In-Captiva.d86452-c40.Car-Rental-Guide-Suppliers) - [Ok Mobility Rental Cars in Captiva Island](https://www.expedia.ca/OK-Mobility-Car-Rentals-In-Captiva-Island.d553248635083900531-c1057.Car-Rental-Guide-Suppliers) - [Offer Car Hire Rental Cars in Captiva Island](https://www.expedia.ca/Offer-Car-Hire-Car-Rentals-In-Captiva-Island.d553248635083900531-c1141.Car-Rental-Guide-Suppliers) - [Captiva Island Vacation Rentals](https://www.expedia.ca/Captiva-Island-Vacation-Rentals.d553248635083900531.Travel-Guide-VacationRentals) - [Captiva Vacation Rentals](https://www.expedia.ca/Captiva-Vacation-Rentals.d86452.Travel-Guide-VacationRentals) - [Sanibel Captiva Island Vacation Rentals](https://www.expedia.ca/Sanibel-Captiva-Island-Vacation-Rentals.d6326115.Travel-Guide-VacationRentals) - [Book Hotels in Sanctuary on Expedia.com](https://www.expedia.com/Sanctuary-Sanibel-Hotels.0-n553248635976469368-0.Travel-Guide-Filter-Hotels) - Explore a world of travel with Expedia ### Hotels in top Sanibel neighborhoods - [Hotels in Beachview Country Club Estates](https://expedia.ca/Beachview-Country-Club-Estates-Sanibel-Hotels.0-n553248635976658737-0.Travel-Guide-Filter-Hotels) - [Hotels in Sanctuary](https://expedia.ca/Sanctuary-Sanibel-Hotels.0-n553248635976469368-0.Travel-Guide-Filter-Hotels) - [Hotels in Shell Harbor](https://expedia.ca/Shell-Harbor-Sanibel-Hotels.0-n553248635976472731-0.Travel-Guide-Filter-Hotels) - [Hotels in The Dunes](https://expedia.ca/The-Dunes-Sanibel-Hotels.0-n553248635976473424-0.Travel-Guide-Filter-Hotels) - [Hotels in Del Sega](https://expedia.ca/Del-Sega-Sanibel-Hotels.0-n553248635976469672-0.Travel-Guide-Filter-Hotels) - [Hotels in Ybel](https://expedia.ca/Ybel-Sanibel-Hotels.0-n553248635975848029-0.Travel-Guide-Filter-Hotels) - [Hotels in Murex Lakes](https://expedia.ca/Murex-Lakes-Sanibel-Hotels.0-n553248635976468770-0.Travel-Guide-Filter-Hotels) - [Hotels in Chateaux Sur Mer](https://expedia.ca/Chateaux-Sur-Mer-Sanibel-Hotels.0-n553248635976472800-0.Travel-Guide-Filter-Hotels) - [Hotels in Gulf Shores](https://expedia.ca/Gulf-Shores-Sanibel-Hotels.0-n553248635976479667-0.Travel-Guide-Filter-Hotels) - [Hotels in Heron's Landing](https://expedia.ca/Herons-Landing-Sanibel-Hotels.0-n553248635976479011-0.Travel-Guide-Filter-Hotels) - [Hotels in Sanibel Isles](https://expedia.ca/Sanibel-Isles-Sanibel-Hotels.0-n553248635976477245-0.Travel-Guide-Filter-Hotels) - [Hotels in Gulf Pines](https://expedia.ca/Gulf-Pines-Sanibel-Hotels.0-n553248635976472804-0.Travel-Guide-Filter-Hotels) - [Hotels in Butterknife](https://expedia.ca/Butterknife-Sanibel-Hotels.0-n553248635976478145-0.Travel-Guide-Filter-Hotels) - [Hotels in Tradewinds](https://expedia.ca/Tradewinds-Sanibel-Hotels.0-n553248635976472762-0.Travel-Guide-Filter-Hotels) - [Hotels in Gumbo Limbo](https://expedia.ca/Gumbo-Limbo-Sanibel-Hotels.0-n553248635976480905-0.Travel-Guide-Filter-Hotels) - [Hotels in East Rocks](https://expedia.ca/East-Rocks-Sanibel-Hotels.0-n553248635976470286-0.Travel-Guide-Filter-Hotels) - [Hotels in Bright Water](https://expedia.ca/Bright-Water-Sanibel-Hotels.0-n553248635976473851-0.Travel-Guide-Filter-Hotels) - [Hotels in Dinkins Bayou](https://expedia.ca/Dinkins-Bayou-Sanibel-Hotels.0-n553248635976472668-0.Travel-Guide-Filter-Hotels) - [Hotels in Island Woods](https://expedia.ca/Island-Woods-Sanibel-Hotels.0-n553248635976477725-0.Travel-Guide-Filter-Hotels) - [Hotels in Belle Meade](https://expedia.ca/Belle-Meade-Sanibel-Hotels.0-n553248635976470908-0.Travel-Guide-Filter-Hotels) ### Hotels near popular Sanibel Attractions - [Hotels near Key West Express](https://expedia.ca/Key-West-Express-Hotels.0-l665139109668356096-0.Travel-Guide-Filter-Hotels) - [Hotels near Sanibel Island Southern Beach](https://expedia.ca/Sanibel-Island-Southern-Beach-Hotels.0-l553248635976194887-0.Travel-Guide-Filter-Hotels) - [Hotels near Estero Boulevard Beach](https://expedia.ca/Estero-Boulevard-Beach-Hotels.0-l715320190101929984-0.Travel-Guide-Filter-Hotels) - [Hotels near Boca Grande Beach](https://expedia.ca/Boca-Grande-Beach-Hotels.0-l6341257-0.Travel-Guide-Filter-Hotels) - [Hotels near Captiva Beach](https://expedia.ca/Captiva-Beach-Hotels.0-l6296288-0.Travel-Guide-Filter-Hotels) - [Hotels near North Captiva Island Beach](https://expedia.ca/North-Captiva-Island-Beach-Hotels.0-l553248635976197835-0.Travel-Guide-Filter-Hotels) - [Hotels near Bowman's Beach](https://expedia.ca/Bowmans-Beach-Hotels.0-l6296151-0.Travel-Guide-Filter-Hotels) - [Hotels near Sanibel Harbour Beach](https://expedia.ca/Sanibel-Harbour-Beach-Hotels.0-l672759720237662208-0.Travel-Guide-Filter-Hotels) - [Hotels near Cape Coral Yacht Club Beach](https://expedia.ca/Cape-Coral-Yacht-Club-Beach-Hotels.0-l553248635983994300-0.Travel-Guide-Filter-Hotels) - [Hotels near Bunche Beach](https://expedia.ca/Bunche-Beach-Hotels.0-l6296159-0.Travel-Guide-Filter-Hotels) ### More Accommodation Types in Sanctuary - [Condo Rentals in Sanibel](https://expedia.ca/Sanibel-Condos.d9791-aaCondos.Travel-Guide-Accommodation) - [Vacation Homes in Sanibel](https://expedia.ca/Sanibel-Private-Vacation-Homes.d9791-aaPrivateVacationHomes.Travel-Guide-Accommodation) - [Cottages in Sanibel](https://expedia.ca/Sanibel-Cottages.d9791-aaCottages.Travel-Guide-Accommodation) - [Apartments in Sanibel](https://expedia.ca/Sanibel-Apartments.d9791-aaApartments.Travel-Guide-Accommodation) - [Villas in Sanibel](https://expedia.ca/Sanibel-Villas.d9791-aaVillas.Travel-Guide-Accommodation) - [Aparthotels in Sanibel](https://expedia.ca/Sanibel-Apart-Hotels.d9791-aaApartHotels.Travel-Guide-Accommodation) - [Motels in Sanibel](https://expedia.ca/Sanibel-Motels.d9791-aaMotels.Travel-Guide-Accommodation) - [Condo Resorts in Sanibel](https://expedia.ca/Sanibel-Condominium-Resort.d9791-aaCondominiumResort.Travel-Guide-Accommodation) - [Hostels in Sanibel](https://expedia.ca/Sanibel-Hostels.d9791-aaHostels.Travel-Guide-Accommodation) - [Resorts in Sanibel](https://expedia.ca/Sanibel-Resort-Hotels.d9791-aaResortHotels.Travel-Guide-Accommodation) - [Inns in Sanibel](https://expedia.ca/Sanibel-Inns.d9791-aaInns.Travel-Guide-Accommodation) ### Hotels Close to Nearby Airports - [Hotels near Southwest Florida Intl. Airport](https://expedia.ca/Southwest-Florida-Intl-Airport-Hotels.0-aRSW-0.Travel-Guide-Filter-Hotels) ### Sanctuary Hotels by Star Rating - [2 Star Hotels in Sanctuary](https://expedia.ca/2Star-Sanctuary-Sanibel-Hotels.s20-n553248635976469368-0.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Sanctuary](https://expedia.ca/3Star-Sanctuary-Sanibel-Hotels.s30-n553248635976469368-0.Travel-Guide-Filter-Hotels) - [4 Star Hotels in Sanctuary](https://expedia.ca/4Star-Sanctuary-Sanibel-Hotels.s40-n553248635976469368-0.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Sanctuary](https://expedia.ca/5Star-Sanctuary-Sanibel-Hotels.s50-n553248635976469368-0.Travel-Guide-Filter-Hotels) ### Sanctuary Hotels by Brand - [Independent Hotels](https://expedia.ca/Sanctuary-Sanibel-Hotels-Independent.0-n553248635976469368-0--bIndependent.Travel-Guide-Filter-Hotels) - [Sunstream Hotels Hotels](https://expedia.ca/Sanctuary-Sanibel-Hotels-Sunstream-Hotels.0-n553248635976469368-0--bSunstreamHotels.Travel-Guide-Filter-Hotels) ### Explore more hotels - [The Westin Cape Coral Resort At Marina Village](https://expedia.ca/Fort-Myers-Hotels-The-Westin-Cape-Coral-Resort-At-Marina-Village.h2721880.Hotel-Information) - [DiamondHead Beach Resort](https://expedia.ca/Fort-Myers-Hotels-DiamondHead-Beach-Resort.h200632.Hotel-Information) - [Dolphin Key Resort](https://expedia.ca/Fort-Myers-Hotels-Dolphin-Key-Resort.h1632691.Hotel-Information) - [La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway](https://expedia.ca/Fort-Myers-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Ft-Myers-Sanibel-Gateway.h11134.Hotel-Information) - [Edison Beach House](https://expedia.ca/Fort-Myers-Hotels-Edison-Beach-House.h11753200.Hotel-Information) - [Homewood Suites by Hilton - Fort Myers](https://expedia.ca/Fort-Myers-Hotels-Homewood-Suites-By-Hilton-Fort-Myers.h63247.Hotel-Information) - [Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG](https://expedia.ca/Fort-Myers-Hotels-Holiday-Inn-Express-Suites-Ft-Myers-Beach-Sanibel-Gateway.h49152700.Hotel-Information) - [Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway](https://expedia.ca/Fort-Myers-Beach-Hotels-Hampton-Inn-Suites-Fort-Myers-BeachSanibel-Gateway.h551886.Hotel-Information) - [Residence Inn by Marriott Fort Myers Sanibel](https://expedia.ca/Fort-Myers-Hotels-Residence-Inn-By-Marriott-Fort-Myers-Sanibel.h2625745.Hotel-Information) - [Tween Waters Island Resort & Spa](https://expedia.ca/Fort-Myers-Hotels-Tween-Waters-Island-Resort-Spa.h170769.Hotel-Information) - [Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral](https://expedia.ca/Fort-Myers-Hotels-Fairfield-Inn-Suites-By-Marriott-Ft-MyersCape-Coral.h129295.Hotel-Information) - [Sanibel Inn](https://expedia.ca/Fort-Myers-Hotels-Sanibel-Inn.h40711.Hotel-Information) [See a list of all hotels in Sanibel](https://expedia.ca/All-Sanibel-Hotels.d9791.Travel-Guide-City-All-Hotels) ### More ways to book - [Book Hotels in Sanctuary on Expedia.com](https://www.expedia.com/Sanctuary-Sanibel-Hotels.0-n553248635976469368-0.Travel-Guide-Filter-Hotels) ### Expedia's Latest Trends Hotels - [Brickell hotels](https://expedia.ca/Brickell-Miami-Hotels.0-n6240961-0.Travel-Guide-Filter-Hotels) - [Downtown Tampa hotels](https://expedia.ca/Downtown-Tampa-Tampa-Hotels.0-n6048134-0.Travel-Guide-Filter-Hotels) - [Coconut Grove hotels](https://expedia.ca/Coconut-Grove-Miami-Hotels.0-n11937-0.Travel-Guide-Filter-Hotels) - [Doral hotels](https://expedia.ca/Doral-Miami-Hotels.0-n6060126-0.Travel-Guide-Filter-Hotels) - [Downtown Miami hotels](https://expedia.ca/Downtown-Miami-Miami-Hotels.0-n800070-0.Travel-Guide-Filter-Hotels) - [Downtown Orlando hotels](https://expedia.ca/Downtown-Orlando-Orlando-Hotels.0-n800087-0.Travel-Guide-Filter-Hotels) - [Wynwood Art District hotels](https://expedia.ca/Wynwood-Art-District-Miami-Hotels.0-n6240011-0.Travel-Guide-Filter-Hotels) - [Cheap Hotels in South Beach](https://expedia.ca/South-Beach-Miami-Hotels-Cheap-Hotels.0-n6138745-0-tCheapHotels.Travel-Guide-Filter-Hotels) - [Boutique Hotels in South Beach](https://expedia.ca/South-Beach-Miami-Hotels-Boutique-Hotel.0-n6138745-0-tBoutiqueHotel.Travel-Guide-Filter-Hotels) - [Little Havana hotels](https://expedia.ca/Little-Havana-Miami-Hotels.0-n505226-0.Travel-Guide-Filter-Hotels) - [South Beach 5 Star Hotels](https://expedia.ca/5Star-South-Beach-Miami-Hotels.s50-n6138745-0.Travel-Guide-Filter-Hotels) - [South Beach hotels](https://expedia.ca/South-Beach-Miami-Hotels.0-n6138745-0.Travel-Guide-Filter-Hotels) - [Beach Hotel in South Beach](https://expedia.ca/South-Beach-Miami-Hotels-Beach-Hotel.0-n6138745-0-tBeachHotel.Travel-Guide-Filter-Hotels) - [Mid Beach hotels](https://expedia.ca/Mid-Beach-Miami-Hotels.0-n6203154-0.Travel-Guide-Filter-Hotels) - [Oceanfront Hotels in South Beach](https://expedia.ca/South-Beach-Miami-Hotels-Oceanfront-Hotels.0-n6138745-0-tOceanfrontHotels.Travel-Guide-Filter-Hotels) Packages - [South Beach Vacations](https://expedia.ca/South-Beach.d6138745.Destination-Travel-Guides) General - [Visit Downtown Orlando](https://expedia.ca/Orlando-Downtown-Orlando.dx800087) - [Visit Galt Mile](https://expedia.ca/Fort-Lauderdale-Galt-Mile.dx553248635976473854) - [Visit Siesta Key Village](https://expedia.ca/Siesta-Key-Siesta-Key-Village.dx6296072) - [Visit South Beach](https://expedia.ca/Miami-South-Beach.dx6138745) - [Visit North Beach](https://expedia.ca/Miami-North-Beach.dx6203157) - [Visit Sunset Beach](https://expedia.ca/St-Petersburg-Clearwater-Sunset-Beach.dx6159959) - [Visit Downtown Miami](https://expedia.ca/Miami-Downtown-Miami.dx800070) - [Visit Biltmore Beach](https://expedia.ca/Panama-City-Beach-Biltmore-Beach.dx553248635976471384) - [Visit Downtown Fort Lauderdale](https://expedia.ca/Fort-Lauderdale-Downtown-Fort-Lauderdale.dx800035) - [Visit Wynwood Art District](https://expedia.ca/Miami-Wynwood-Art-District.dx6240011) - [Visit Hollywood Beach](https://expedia.ca/Fort-Lauderdale-Hollywood-Beach.dx553248635975850057) - [Visit Little Havana](https://expedia.ca/Miami-Little-Havana.dx505226) - [Visit Coconut Grove](https://expedia.ca/Miami-Coconut-Grove.dx11937) - [Visit Brickell](https://expedia.ca/Miami-Brickell.dx6240961)